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The map label for this gene is hexB [H]

Identifier: 221633643

GI number: 221633643

Start: 1666564

End: 1668291

Strand: Reverse

Name: hexB [H]

Synonym: trd_1668

Alternate gene names: 221633643

Gene position: 1668291-1666564 (Counterclockwise)

Preceding gene: 221633654

Following gene: 221633639

Centisome position: 83.29

GC content: 67.13

Gene sequence:

>1728_bases
ATGCCGATCGTCCGGCTGGACGAGGCGACCGTTCGACGGATCGCTGCCGGTGAAGTCGTCGAGCGACCGGCATCGGTCGT
CAAGGAGCTCGTTGAGAATGCGTTGGATGCGGAGGCTCGGACGATCCGCGTCGAGATCGTCGCGGGTGGCCGAGAGTTGA
TCCGTGTCCAGGATGACGGGACGGGGATTCCACCGGACGAGCTGCCGCTGGCCGTCGAGCGGCATGCTACCTCCAAACTG
CACCGCTTCGAGGACTTGGCGAGGCTCGCGAGCTATGGCTTCCGCGGCGAGGCCCTGGCGGCGATCAGCGCGGTCAGCGA
GTGCGAGATCGTCTCGCGGGTACCGGATGCTCCCTATGGAGCGCGGTTGCTCGTTCGTTACGGACGCCCCGGGCGGGTCG
AGCCGATCGGGGCTGCGCCGGGAACCGTGGTGACCGTTCGCGATCTCTTCGCCAATGTCCCGGCTAGACGGCGTTTCTTG
CGCCAGGATGCGACCGAGGCTGCCCTCATCCAACGGACGCTCGCTGCGCTCGCTCTGGCTCGTCCGGAGGTCCGGTTCGA
ACTCACGAACGACGGACGAACGGTGCTGGCGACCGGCGGGAGCGGTGATCTCCTCGATGCGCTGATCGGAGTGTATGGAG
CCGAGACGGCGACGCAGATGCTCCGGCTCGAGGAGTACTGTGCGGGCGAGATCGTGGTCCAGGGGGCAGTCGGTCTACCC
CGCGTGTCTCGTCCCAACCGGCAAGCGCTGTTCGTGCTGGTCAATCAGCGTTGGGTGGAGAGCCGCACCCTGGTGGCAGC
GATCGAACAGGCCTATCACACCTTGTTGATGGTCGGACGCTACCCGATCGGGGTCGTGGCGGTGTCGCTGCCTGGGGATC
GGGTCGACGTCAATGTGCACCCGACTAAGCGCGAAGTGCGTTTCGCCGACGAGCGAGCGGTGGCCGCTGCGGTGTACGAG
GCAGTCCGCCGCACCCTCTTGGCTCACGTGCCGGAAAACCCGCCGCCACCGGTGACGTTCAGCCCGCTTTCGCCGTCAGT
CGTGCAACGTCGCCTCCAGGTCGCTGATCCGACGCGGGAACTCAGCAGCAGCCGCCCTGGCACGCCCGAAGAACTGGTCG
ATGCCCCATCGAGCACTCGCTCGGCCGACTCGGCGAACTGGCTGCCGGTCCTGCGCGTGTTGGGGCAAGTTCGGCAAGCC
TACATCATCGCCGAGGGGCCGGACGGCATGTATCTGATCGACCAGCATGCCGCCCATGAGCGGATCCTGCTGGATCGGTT
GCTCGCGCAGCTGGAGGCACGTGGTGTCGAGCAGCAAGCGCTCTTGGAGCCGCTGGTGCTCGAGCTTTCTCCCGTGCAAC
TGGCCACCGTCGAGCGCTACCGTGACGCGCTGGTCCAGCTCGGCTGGGAACTCGAGCCCTTCGGTGGGGCTGCGGTCGCT
GTCCGGGCGGTTCCGGCAGTGGTCCAACGCAGCATCGAGCAGGTCCTGATCGCCGTGCTCGACGACCTCGCAGCGGGTGG
GCGCGGCACGACCCCGCTCGAGCGCGTGGCCATCAGCACAGCCTGTCACTCAGCGATCCGGGCGGGACAGGAACTCTCGC
TTCCCGAGATGCGCGAACTCATTCGCCAACTCGAGCAGTGCCGCGTCCCCAACGCCTGCGCGCATGGGCGCCCGACGGTG
GTTCATCTGAGCACCGAGGAACTGGAGCGGCAATTCAGCCGGCGCTAG

Upstream 100 bases:

>100_bases
GGTGCGCACTGGTGGCTTCTCCCGGGTTCCGAGTGGGCGGGAGCGCTTGCCTCTTGCCGTGCTTCCCTAGGGGTATACTG
GCGCGAGGGGGAACGTCGTC

Downstream 100 bases:

>100_bases
CGTCGTCCGCGCTCGCGACCGAAACTGGGGGCGGGGCCAGGGAGACTGTCCTCGGTATCCTCCAGCTTGATCCAGCCGTG
GCGGAGCGCATAGATCACTG

Product: DNA mismatch repair protein HexB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MPIVRLDEATVRRIAAGEVVERPASVVKELVENALDAEARTIRVEIVAGGRELIRVQDDGTGIPPDELPLAVERHATSKL
HRFEDLARLASYGFRGEALAAISAVSECEIVSRVPDAPYGARLLVRYGRPGRVEPIGAAPGTVVTVRDLFANVPARRRFL
RQDATEAALIQRTLAALALARPEVRFELTNDGRTVLATGGSGDLLDALIGVYGAETATQMLRLEEYCAGEIVVQGAVGLP
RVSRPNRQALFVLVNQRWVESRTLVAAIEQAYHTLLMVGRYPIGVVAVSLPGDRVDVNVHPTKREVRFADERAVAAAVYE
AVRRTLLAHVPENPPPPVTFSPLSPSVVQRRLQVADPTRELSSSRPGTPEELVDAPSSTRSADSANWLPVLRVLGQVRQA
YIIAEGPDGMYLIDQHAAHERILLDRLLAQLEARGVEQQALLEPLVLELSPVQLATVERYRDALVQLGWELEPFGGAAVA
VRAVPAVVQRSIEQVLIAVLDDLAAGGRGTTPLERVAISTACHSAIRAGQELSLPEMRELIRQLEQCRVPNACAHGRPTV
VHLSTEELERQFSRR

Sequences:

>Translated_575_residues
MPIVRLDEATVRRIAAGEVVERPASVVKELVENALDAEARTIRVEIVAGGRELIRVQDDGTGIPPDELPLAVERHATSKL
HRFEDLARLASYGFRGEALAAISAVSECEIVSRVPDAPYGARLLVRYGRPGRVEPIGAAPGTVVTVRDLFANVPARRRFL
RQDATEAALIQRTLAALALARPEVRFELTNDGRTVLATGGSGDLLDALIGVYGAETATQMLRLEEYCAGEIVVQGAVGLP
RVSRPNRQALFVLVNQRWVESRTLVAAIEQAYHTLLMVGRYPIGVVAVSLPGDRVDVNVHPTKREVRFADERAVAAAVYE
AVRRTLLAHVPENPPPPVTFSPLSPSVVQRRLQVADPTRELSSSRPGTPEELVDAPSSTRSADSANWLPVLRVLGQVRQA
YIIAEGPDGMYLIDQHAAHERILLDRLLAQLEARGVEQQALLEPLVLELSPVQLATVERYRDALVQLGWELEPFGGAAVA
VRAVPAVVQRSIEQVLIAVLDDLAAGGRGTTPLERVAISTACHSAIRAGQELSLPEMRELIRQLEQCRVPNACAHGRPTV
VHLSTEELERQFSRR
>Mature_574_residues
PIVRLDEATVRRIAAGEVVERPASVVKELVENALDAEARTIRVEIVAGGRELIRVQDDGTGIPPDELPLAVERHATSKLH
RFEDLARLASYGFRGEALAAISAVSECEIVSRVPDAPYGARLLVRYGRPGRVEPIGAAPGTVVTVRDLFANVPARRRFLR
QDATEAALIQRTLAALALARPEVRFELTNDGRTVLATGGSGDLLDALIGVYGAETATQMLRLEEYCAGEIVVQGAVGLPR
VSRPNRQALFVLVNQRWVESRTLVAAIEQAYHTLLMVGRYPIGVVAVSLPGDRVDVNVHPTKREVRFADERAVAAAVYEA
VRRTLLAHVPENPPPPVTFSPLSPSVVQRRLQVADPTRELSSSRPGTPEELVDAPSSTRSADSANWLPVLRVLGQVRQAY
IIAEGPDGMYLIDQHAAHERILLDRLLAQLEARGVEQQALLEPLVLELSPVQLATVERYRDALVQLGWELEPFGGAAVAV
RAVPAVVQRSIEQVLIAVLDDLAAGGRGTTPLERVAISTACHSAIRAGQELSLPEMRELIRQLEQCRVPNACAHGRPTVV
HLSTEELERQFSRR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=333, Percent_Identity=35.4354354354354, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=29.5321637426901, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI310128478, Length=342, Percent_Identity=29.5321637426901, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4505911, Length=326, Percent_Identity=28.5276073619632, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI189458898, Length=325, Percent_Identity=28, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI189458896, Length=318, Percent_Identity=27.0440251572327, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI310128480, Length=309, Percent_Identity=27.5080906148867, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI91992162, Length=347, Percent_Identity=26.2247838616715, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI91992160, Length=347, Percent_Identity=26.2247838616715, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI263191589, Length=239, Percent_Identity=27.6150627615063, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1790612, Length=551, Percent_Identity=33.9382940108893, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71991825, Length=319, Percent_Identity=35.7366771159875, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=423, Percent_Identity=26.9503546099291, Blast_Score=142, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323819, Length=312, Percent_Identity=33.3333333333333, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=429, Percent_Identity=26.8065268065268, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6325093, Length=179, Percent_Identity=30.7262569832402, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=165, Percent_Identity=27.8787878787879, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136968, Length=393, Percent_Identity=34.6055979643766, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI17136970, Length=349, Percent_Identity=26.9340974212034, Blast_Score=118, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 62658; Mature: 62526

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVRLDEATVRRIAAGEVVERPASVVKELVENALDAEARTIRVEIVAGGRELIRVQDDG
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEEECCC
TGIPPDELPLAVERHATSKLHRFEDLARLASYGFRGEALAAISAVSECEIVSRVPDAPYG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
ARLLVRYGRPGRVEPIGAAPGTVVTVRDLFANVPARRRFLRQDATEAALIQRTLAALALA
CEEEEEECCCCCCCCCCCCCCCEEEHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHC
RPEVRFELTNDGRTVLATGGSGDLLDALIGVYGAETATQMLRLEEYCAGEIVVQGAVGLP
CCCEEEEEECCCCEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEECCCCCC
RVSRPNRQALFVLVNQRWVESRTLVAAIEQAYHTLLMVGRYPIGVVAVSLPGDRVDVNVH
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEC
PTKREVRFADERAVAAAVYEAVRRTLLAHVPENPPPPVTFSPLSPSVVQRRLQVADPTRE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHCCCHHH
LSSSRPGTPEELVDAPSSTRSADSANWLPVLRVLGQVRQAYIIAEGPDGMYLIDQHAAHE
HHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCEEEEECHHHHH
RILLDRLLAQLEARGVEQQALLEPLVLELSPVQLATVERYRDALVQLGWELEPFGGAAVA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
VRAVPAVVQRSIEQVLIAVLDDLAAGGRGTTPLERVAISTACHSAIRAGQELSLPEMREL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IRQLEQCRVPNACAHGRPTVVHLSTEELERQFSRR
HHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHCC
>Mature Secondary Structure 
PIVRLDEATVRRIAAGEVVERPASVVKELVENALDAEARTIRVEIVAGGRELIRVQDDG
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEEECCC
TGIPPDELPLAVERHATSKLHRFEDLARLASYGFRGEALAAISAVSECEIVSRVPDAPYG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
ARLLVRYGRPGRVEPIGAAPGTVVTVRDLFANVPARRRFLRQDATEAALIQRTLAALALA
CEEEEEECCCCCCCCCCCCCCCEEEHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHC
RPEVRFELTNDGRTVLATGGSGDLLDALIGVYGAETATQMLRLEEYCAGEIVVQGAVGLP
CCCEEEEEECCCCEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEECCCCCC
RVSRPNRQALFVLVNQRWVESRTLVAAIEQAYHTLLMVGRYPIGVVAVSLPGDRVDVNVH
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEC
PTKREVRFADERAVAAAVYEAVRRTLLAHVPENPPPPVTFSPLSPSVVQRRLQVADPTRE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHCCCHHH
LSSSRPGTPEELVDAPSSTRSADSANWLPVLRVLGQVRQAYIIAEGPDGMYLIDQHAAHE
HHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCEEEEECHHHHH
RILLDRLLAQLEARGVEQQALLEPLVLELSPVQLATVERYRDALVQLGWELEPFGGAAVA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
VRAVPAVVQRSIEQVLIAVLDDLAAGGRGTTPLERVAISTACHSAIRAGQELSLPEMREL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IRQLEQCRVPNACAHGRPTVVHLSTEELERQFSRR
HHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA