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The map label for this gene is bcr [H]

Identifier: 221633515

GI number: 221633515

Start: 1518062

End: 1519315

Strand: Reverse

Name: bcr [H]

Synonym: trd_1537

Alternate gene names: 221633515

Gene position: 1519315-1518062 (Counterclockwise)

Preceding gene: 221633518

Following gene: 221633509

Centisome position: 75.85

GC content: 64.99

Gene sequence:

>1254_bases
GTGATCATGGAAGATGGCCGATCAGCGACGGTTCCGAGCGAAACGGCTCGCAGCCGGGTACTCCCGGTCTGGGAACTGAC
AGCCGTGCTCGGTCTGCTCATGGCGATGAGCGCCTTCGCCATCGACATCATGCTCCCAGCTCTGCGCGACATCGCGTTCG
CCTTCCGGATCGACGAGACGCGCGCCCAGCTGGTCGTGAACGTCTACTTCCTCGGTTTCGCCATCGGTCAGCTGTTCTTC
GGTCCACTCAGTGACCAGATCGGGCGTCGTGTTCCCCTGCTCCTCGCTGCTGGTGGCTATGGGGTAACCGTTCTCGCAAT
GCTGTTCGCACCGACCTTCGGCCTGTTGCTCGTTCTGCGCTTCGTCCAAGGATGTTTCGCGTCCGGGCTGCGCGCGACGG
GAATTGCTATGGTCCGTGACGCCTCTCGTGGAGAGGCGATGGCACGGATTGTCTCTTTTGCCTCCGTGGTGCTCTTGGCG
GCTCCCCTGTTCGCTCCTTCGCTCGGTGTCCTGCTCTTGCGGTGGGGGTGGCGTGCTCCCTTCGCCTTCCTGGCGGTGCT
CGCCGTGGGTCTGCTCGGGTGGGTGTTCCTGCGCGTTCCGGAAACGTTGCCACCCAGTCGTCGCGCTCGTCAGAATCTAG
ATCATCTCTGGAGTGCGGCACGCGCTTTCTGGGCAGCGAAACCGAGCGTGGCCTTCACACTCATCCTGGGCATTAGCTAT
GGTGTGATGCAGGCCTATCTGGCCAGTGCCCCGCAGCTGGTCAAGGGATACTTCGGATTCTCGAACCAGGCATTCGCGCT
CGCCTTCGCGGCCGGTGGTCTGGCGCAGGTGGTGGGGACGCTCACCAACGGCTGGCTCATCACGCGGCTCGGACTCCGAC
GCGTTCTGCCGGCTGCGCTCGCGCTCCTCGCGCTGGCGACCACCGCGCTCGTCGTGACCAGCGCCGCGACCCCGCGGTTC
CTCTCTTTCTGGGCAGGTGTGGTGCTCATGTTTTTCGCGATCGCCTTGATCTTCCCGAATGCCAACAGCGCGGCGCTCGA
GCCGCTCGGCCGGATCGCCGGATTCGCCAGCAGCCTCGTCGGCTTTGGGAGCACGGTGCTGGCGAGCATGTTCGGCACAG
CGATCGGGCAACTCAGCGCCGGAGAGCCGCACCGTTTCGCGCTCGGCCTGTGGCTGCTCTCGCTCGTCAACCTGGTCGTG
CTGGCCTGGTTGTTCCGCCTCGGCTGGACACGCCAGCGACCAGCCCCGTCGTGA

Upstream 100 bases:

>100_bases
GACACCCGCGACGAATGGAGTGCTGTGGAGATTCCACGCTGAACTATCGTGTCCTTTTGCGTCGCTGTGCGGCGTATACT
CGCCCGGGCAGCGCGCGGGG

Downstream 100 bases:

>100_bases
CACCCCGAGGCGCTGGGTTCGCAGCCAGGGATCCTGCGCTCACGCGAGCGCAGCGGCGAGCACCAGAACGGAATCGAGAC
GGACTGGCAATTCTTCCCAG

Product: MFS permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MIMEDGRSATVPSETARSRVLPVWELTAVLGLLMAMSAFAIDIMLPALRDIAFAFRIDETRAQLVVNVYFLGFAIGQLFF
GPLSDQIGRRVPLLLAAGGYGVTVLAMLFAPTFGLLLVLRFVQGCFASGLRATGIAMVRDASRGEAMARIVSFASVVLLA
APLFAPSLGVLLLRWGWRAPFAFLAVLAVGLLGWVFLRVPETLPPSRRARQNLDHLWSAARAFWAAKPSVAFTLILGISY
GVMQAYLASAPQLVKGYFGFSNQAFALAFAAGGLAQVVGTLTNGWLITRLGLRRVLPAALALLALATTALVVTSAATPRF
LSFWAGVVLMFFAIALIFPNANSAALEPLGRIAGFASSLVGFGSTVLASMFGTAIGQLSAGEPHRFALGLWLLSLVNLVV
LAWLFRLGWTRQRPAPS

Sequences:

>Translated_417_residues
MIMEDGRSATVPSETARSRVLPVWELTAVLGLLMAMSAFAIDIMLPALRDIAFAFRIDETRAQLVVNVYFLGFAIGQLFF
GPLSDQIGRRVPLLLAAGGYGVTVLAMLFAPTFGLLLVLRFVQGCFASGLRATGIAMVRDASRGEAMARIVSFASVVLLA
APLFAPSLGVLLLRWGWRAPFAFLAVLAVGLLGWVFLRVPETLPPSRRARQNLDHLWSAARAFWAAKPSVAFTLILGISY
GVMQAYLASAPQLVKGYFGFSNQAFALAFAAGGLAQVVGTLTNGWLITRLGLRRVLPAALALLALATTALVVTSAATPRF
LSFWAGVVLMFFAIALIFPNANSAALEPLGRIAGFASSLVGFGSTVLASMFGTAIGQLSAGEPHRFALGLWLLSLVNLVV
LAWLFRLGWTRQRPAPS
>Mature_417_residues
MIMEDGRSATVPSETARSRVLPVWELTAVLGLLMAMSAFAIDIMLPALRDIAFAFRIDETRAQLVVNVYFLGFAIGQLFF
GPLSDQIGRRVPLLLAAGGYGVTVLAMLFAPTFGLLLVLRFVQGCFASGLRATGIAMVRDASRGEAMARIVSFASVVLLA
APLFAPSLGVLLLRWGWRAPFAFLAVLAVGLLGWVFLRVPETLPPSRRARQNLDHLWSAARAFWAAKPSVAFTLILGISY
GVMQAYLASAPQLVKGYFGFSNQAFALAFAAGGLAQVVGTLTNGWLITRLGLRRVLPAALALLALATTALVVTSAATPRF
LSFWAGVVLMFFAIALIFPNANSAALEPLGRIAGFASSLVGFGSTVLASMFGTAIGQLSAGEPHRFALGLWLLSLVNLVV
LAWLFRLGWTRQRPAPS

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=334, Percent_Identity=29.0419161676647, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI87082312, Length=342, Percent_Identity=27.4853801169591, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI48994889, Length=176, Percent_Identity=33.5227272727273, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790146, Length=338, Percent_Identity=25.1479289940828, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324264, Length=180, Percent_Identity=30.5555555555556, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44530; Mature: 44530

Theoretical pI: Translated: 12.02; Mature: 12.02

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMEDGRSATVPSETARSRVLPVWELTAVLGLLMAMSAFAIDIMLPALRDIAFAFRIDET
CCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
RAQLVVNVYFLGFAIGQLFFGPLSDQIGRRVPLLLAAGGYGVTVLAMLFAPTFGLLLVLR
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
FVQGCFASGLRATGIAMVRDASRGEAMARIVSFASVVLLAAPLFAPSLGVLLLRWGWRAP
HHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
FAFLAVLAVGLLGWVFLRVPETLPPSRRARQNLDHLWSAARAFWAAKPSVAFTLILGISY
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GVMQAYLASAPQLVKGYFGFSNQAFALAFAAGGLAQVVGTLTNGWLITRLGLRRVLPAAL
HHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ALLALATTALVVTSAATPRFLSFWAGVVLMFFAIALIFPNANSAALEPLGRIAGFASSLV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
GFGSTVLASMFGTAIGQLSAGEPHRFALGLWLLSLVNLVVLAWLFRLGWTRQRPAPS
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIMEDGRSATVPSETARSRVLPVWELTAVLGLLMAMSAFAIDIMLPALRDIAFAFRIDET
CCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
RAQLVVNVYFLGFAIGQLFFGPLSDQIGRRVPLLLAAGGYGVTVLAMLFAPTFGLLLVLR
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
FVQGCFASGLRATGIAMVRDASRGEAMARIVSFASVVLLAAPLFAPSLGVLLLRWGWRAP
HHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
FAFLAVLAVGLLGWVFLRVPETLPPSRRARQNLDHLWSAARAFWAAKPSVAFTLILGISY
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GVMQAYLASAPQLVKGYFGFSNQAFALAFAAGGLAQVVGTLTNGWLITRLGLRRVLPAAL
HHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ALLALATTALVVTSAATPRFLSFWAGVVLMFFAIALIFPNANSAALEPLGRIAGFASSLV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
GFGSTVLASMFGTAIGQLSAGEPHRFALGLWLLSLVNLVVLAWLFRLGWTRQRPAPS
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]