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The map label for this gene is cysM [H]

Identifier: 221633292

GI number: 221633292

Start: 1301313

End: 1302356

Strand: Reverse

Name: cysM [H]

Synonym: trd_1312

Alternate gene names: 221633292

Gene position: 1302356-1301313 (Counterclockwise)

Preceding gene: 221633296

Following gene: 221633291

Centisome position: 65.02

GC content: 62.36

Gene sequence:

>1044_bases
GTGCGGCTCGTGGATCGGCAAGCGCTTCGAGCGAGTTGCGCGGGTCATGCGGGGTACCTGTGGCAAGATGGAGTGGTGAA
GCGAGACGAAGGGTGGCGAGCCATGAGTTCTTCGCTCGGATGCCGATTGGGCGAGACAGTCACTGAGCGCATCGGACGCA
CGCCGCTCTTCTGTCTCCAACGCTTGCCGGCCATCTCTGGCATCTCGGATCGCGTCCAGTTGCTGGTCAAGGCGGAGTGG
TATAACCCGGGCGGCTCGGTGAAAGACCGTGCTGCCTGGAGGATCGTCCGCGAGGCGCTGCGCACGGGTGCGCTGGGATC
GAACCGACGGCTCCTCGATGCAACTTCCGGAAACACTGGCATTGCCTATGCCATGCTCGGTGCAGCACTCGGATTCGGTG
TCACACTGGTGGTTCCCGGAAGCATCGGCGAGGAGCGTCGGGCCATTCTGGGTGCCTACGGCGCTGAATTGATCTACAGC
GATCCGTACGAGGGAACGGACGGAGCCATCCGCCTGGCGCGTCAACTGGCTGCTGAGCAACCGGATCGCTATTACTATGC
GGACCAATACAGTAATCCAGCGAATTGGCTTGCCCATTACGAGGGCACTGGCCCAGAGATCCTGGAGCAGACGCGTGGGC
AGGTGACGCATTTCGTCGCGGGGCTCGGCACCACGGGAACGATGATGGGAACCGGGCGGTTTCTCAAGGAAGCGAATCCG
GACGTCGTCCTGGTCGGTGTCCAGCCAGACGATCCCTTCCATGGGTTAGAAGGACTGAAGCATCTGCCGACCGCTCTCAC
TCCTGCTATCTATGATCCCTCGCTCGTCGACCGTATGGAGTTCGTCGATACCGAAGAGGCCTACCGGTTGGCGCGCGACG
TTGCACGTTGCGAAGGACTGCTCCTCGGTCCCTCGGCGGCGGCAGCCATCGTTGCGGCGCTCCGTGTCGCCCGCGAGCTG
GATCAGGGCGTCATCGTGGCCATCCTGCCCGACAGTGGTTTGAAGTACCTGAGCACACCCTTGTGGCATCCCGAACGAGG
ATGA

Upstream 100 bases:

>100_bases
GTGCGTGCGCACTCGCGAGCGCCTCTCATGATCGATGGTCGGGCGTGCCAACCGGCACTCACGGGGGTTATCCTACTACG
GACCTCGTCTTGCCGGCCCC

Downstream 100 bases:

>100_bases
AGGCACACTGGTCGTCGAGAAAGGAGCGTGAGAACCGATGGCAGTGACGATTCTCATTCCGGCACCGTTGCGCCGCTTCA
CGGAGGACCGCGCAGCGGTG

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRLVDRQALRASCAGHAGYLWQDGVVKRDEGWRAMSSSLGCRLGETVTERIGRTPLFCLQRLPAISGISDRVQLLVKAEW
YNPGGSVKDRAAWRIVREALRTGALGSNRRLLDATSGNTGIAYAMLGAALGFGVTLVVPGSIGEERRAILGAYGAELIYS
DPYEGTDGAIRLARQLAAEQPDRYYYADQYSNPANWLAHYEGTGPEILEQTRGQVTHFVAGLGTTGTMMGTGRFLKEANP
DVVLVGVQPDDPFHGLEGLKHLPTALTPAIYDPSLVDRMEFVDTEEAYRLARDVARCEGLLLGPSAAAAIVAALRVAREL
DQGVIVAILPDSGLKYLSTPLWHPERG

Sequences:

>Translated_347_residues
MRLVDRQALRASCAGHAGYLWQDGVVKRDEGWRAMSSSLGCRLGETVTERIGRTPLFCLQRLPAISGISDRVQLLVKAEW
YNPGGSVKDRAAWRIVREALRTGALGSNRRLLDATSGNTGIAYAMLGAALGFGVTLVVPGSIGEERRAILGAYGAELIYS
DPYEGTDGAIRLARQLAAEQPDRYYYADQYSNPANWLAHYEGTGPEILEQTRGQVTHFVAGLGTTGTMMGTGRFLKEANP
DVVLVGVQPDDPFHGLEGLKHLPTALTPAIYDPSLVDRMEFVDTEEAYRLARDVARCEGLLLGPSAAAAIVAALRVAREL
DQGVIVAILPDSGLKYLSTPLWHPERG
>Mature_347_residues
MRLVDRQALRASCAGHAGYLWQDGVVKRDEGWRAMSSSLGCRLGETVTERIGRTPLFCLQRLPAISGISDRVQLLVKAEW
YNPGGSVKDRAAWRIVREALRTGALGSNRRLLDATSGNTGIAYAMLGAALGFGVTLVVPGSIGEERRAILGAYGAELIYS
DPYEGTDGAIRLARQLAAEQPDRYYYADQYSNPANWLAHYEGTGPEILEQTRGQVTHFVAGLGTTGTMMGTGRFLKEANP
DVVLVGVQPDDPFHGLEGLKHLPTALTPAIYDPSLVDRMEFVDTEEAYRLARDVARCEGLLLGPSAAAAIVAALRVAREL
DQGVIVAILPDSGLKYLSTPLWHPERG

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=322, Percent_Identity=33.2298136645963, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI295821200, Length=322, Percent_Identity=33.2298136645963, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI4557415, Length=322, Percent_Identity=33.2298136645963, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=41.6666666666667, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1788754, Length=311, Percent_Identity=38.2636655948553, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17535051, Length=310, Percent_Identity=39.3548387096774, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17562970, Length=303, Percent_Identity=37.953795379538, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI32566674, Length=292, Percent_Identity=38.013698630137, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI115535073, Length=312, Percent_Identity=37.1794871794872, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=38.2352941176471, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17534315, Length=333, Percent_Identity=32.1321321321321, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=32.5153374233129, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=36.6197183098592, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321594, Length=320, Percent_Identity=34.0625, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321449, Length=339, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24643623, Length=315, Percent_Identity=35.8730158730159, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129101, Length=315, Percent_Identity=35.8730158730159, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 37577; Mature: 37577

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVDRQALRASCAGHAGYLWQDGVVKRDEGWRAMSSSLGCRLGETVTERIGRTPLFCLQ
CCCCHHHHHHHHHCCCCCCEECCCEEECCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHH
RLPAISGISDRVQLLVKAEWYNPGGSVKDRAAWRIVREALRTGALGSNRRLLDATSGNTG
HCCCCCCCHHHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
IAYAMLGAALGFGVTLVVPGSIGEERRAILGAYGAELIYSDPYEGTDGAIRLARQLAAEQ
HHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCC
PDRYYYADQYSNPANWLAHYEGTGPEILEQTRGQVTHFVAGLGTTGTMMGTGRFLKEANP
CCCEEECCCCCCHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHCCCC
DVVLVGVQPDDPFHGLEGLKHLPTALTPAIYDPSLVDRMEFVDTEEAYRLARDVARCEGL
CEEEEEECCCCCHHHHHHHHHCCHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCE
LLGPSAAAAIVAALRVARELDQGVIVAILPDSGLKYLSTPLWHPERG
EECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCCCCCCCC
>Mature Secondary Structure
MRLVDRQALRASCAGHAGYLWQDGVVKRDEGWRAMSSSLGCRLGETVTERIGRTPLFCLQ
CCCCHHHHHHHHHCCCCCCEECCCEEECCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHH
RLPAISGISDRVQLLVKAEWYNPGGSVKDRAAWRIVREALRTGALGSNRRLLDATSGNTG
HCCCCCCCHHHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
IAYAMLGAALGFGVTLVVPGSIGEERRAILGAYGAELIYSDPYEGTDGAIRLARQLAAEQ
HHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCC
PDRYYYADQYSNPANWLAHYEGTGPEILEQTRGQVTHFVAGLGTTGTMMGTGRFLKEANP
CCCEEECCCCCCHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHCCCC
DVVLVGVQPDDPFHGLEGLKHLPTALTPAIYDPSLVDRMEFVDTEEAYRLARDVARCEGL
CEEEEEECCCCCHHHHHHHHHCCHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCE
LLGPSAAAAIVAALRVARELDQGVIVAILPDSGLKYLSTPLWHPERG
EECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]