| Definition | Thermomicrobium roseum DSM 5159 chromosome, complete genome. |
|---|---|
| Accession | NC_011959 |
| Length | 2,003,006 |
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The map label for this gene is nudF [H]
Identifier: 221633171
GI number: 221633171
Start: 1176755
End: 1177288
Strand: Reverse
Name: nudF [H]
Synonym: trd_1187
Alternate gene names: 221633171
Gene position: 1177288-1176755 (Counterclockwise)
Preceding gene: 221633172
Following gene: 221633170
Centisome position: 58.78
GC content: 63.48
Gene sequence:
>534_bases GTGGAGGTCGAACGGGTCGAGCGAAGCGAGACGGTTTTTGCGGGGCGGTTGTTGCAGGTCTCTCGTGATCATGTTCTGCT GGCCGACGGCCGGCGGGCGATCCGCGAGGTGGCGCACCATCCGGGGGCCGTTGCTATCCTCCCGATCCGGGACGACGGGC GGATCGTATTCGTTCGCCAATACCGGTATGCGGTCGGGAAGACGCTTCTGGAAATTCCTGCAGGAACGCGCGAAGCCAAC GAAGAGCCGGATGCCTGTGCCTTGCGGGAGCTCGAGGAGGAGACCGGTTATCGGGCGGGACGGCTCCGCGAGTTGATTCG CTTCTATGTGAGTCCGGGCTGGACGGACGAGGAACTCGTGGTATTCGTGGCCGAAGCGCTGAGTGCTGGTGCAGCACACC CGGCTGGTGACGAACGCTTGCACGTCGTCGAGCTCGCTCCAGAGGAGGCTCGGGAGGCTCTCCGCACTGGCTCGATCTGC GATGCCAAAAGCGTGATCGCACTGCTCGGATACTTCGGTTGGACGTTGCTCTGA
Upstream 100 bases:
>100_bases GGAAGGCACGGCGACGAGTCCCTGCGGGAGCGACACGATCCGGTAGAACTGTCCCACCAGCGAGGATGGTTTCGCTGCGT GAACGGGAAGGATGGACACG
Downstream 100 bases:
>100_bases TGTGCCCAGAGGGCACAGTACGTACATGAAGCATCAGTACTCATCATCCTTAGGAGTGTTGATTGAAGAAGGGTGACTGA TTCCGCATCGTCGAATCGTT
Product: NUDIX family hydrolase
Products: NA
Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]
Number of amino acids: Translated: 177; Mature: 177
Protein sequence:
>177_residues MEVERVERSETVFAGRLLQVSRDHVLLADGRRAIREVAHHPGAVAILPIRDDGRIVFVRQYRYAVGKTLLEIPAGTREAN EEPDACALRELEEETGYRAGRLRELIRFYVSPGWTDEELVVFVAEALSAGAAHPAGDERLHVVELAPEEAREALRTGSIC DAKSVIALLGYFGWTLL
Sequences:
>Translated_177_residues MEVERVERSETVFAGRLLQVSRDHVLLADGRRAIREVAHHPGAVAILPIRDDGRIVFVRQYRYAVGKTLLEIPAGTREAN EEPDACALRELEEETGYRAGRLRELIRFYVSPGWTDEELVVFVAEALSAGAAHPAGDERLHVVELAPEEAREALRTGSIC DAKSVIALLGYFGWTLL >Mature_177_residues MEVERVERSETVFAGRLLQVSRDHVLLADGRRAIREVAHHPGAVAILPIRDDGRIVFVRQYRYAVGKTLLEIPAGTREAN EEPDACALRELEEETGYRAGRLRELIRFYVSPGWTDEELVVFVAEALSAGAAHPAGDERLHVVELAPEEAREALRTGSIC DAKSVIALLGYFGWTLL
Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]
COG id: COG0494
COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 nudix hydrolase domain [H]
Homologues:
Organism=Escherichia coli, GI1788810, Length=166, Percent_Identity=34.3373493975904, Blast_Score=77, Evalue=5e-16, Organism=Escherichia coli, GI1789412, Length=167, Percent_Identity=34.7305389221557, Blast_Score=61, Evalue=5e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004385 - InterPro: IPR020476 - InterPro: IPR020084 - InterPro: IPR000086 - InterPro: IPR015797 [H]
Pfam domain/function: PF00293 NUDIX [H]
EC number: =3.6.1.13 [H]
Molecular weight: Translated: 19675; Mature: 19675
Theoretical pI: Translated: 4.99; Mature: 4.99
Prosite motif: PS00893 NUDIX
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 0.6 %Met (Translated Protein) 1.7 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 0.6 %Met (Mature Protein) 1.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEVERVERSETVFAGRLLQVSRDHVLLADGRRAIREVAHHPGAVAILPIRDDGRIVFVRQ CCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCEEEEEECCCCCEEEEEH YRYAVGKTLLEIPAGTREANEEPDACALRELEEETGYRAGRLRELIRFYVSPGWTDEELV HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHH VFVAEALSAGAAHPAGDERLHVVELAPEEAREALRTGSICDAKSVIALLGYFGWTLL HHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC >Mature Secondary Structure MEVERVERSETVFAGRLLQVSRDHVLLADGRRAIREVAHHPGAVAILPIRDDGRIVFVRQ CCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCEEEEEECCCCCEEEEEH YRYAVGKTLLEIPAGTREANEEPDACALRELEEETGYRAGRLRELIRFYVSPGWTDEELV HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHH VFVAEALSAGAAHPAGDERLHVVELAPEEAREALRTGSICDAKSVIALLGYFGWTLL HHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8969508; 9384377; 10542272 [H]