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The map label for this gene is degU [H]

Identifier: 221633170

GI number: 221633170

Start: 1175871

End: 1176656

Strand: Reverse

Name: degU [H]

Synonym: trd_1185

Alternate gene names: 221633170

Gene position: 1176656-1175871 (Counterclockwise)

Preceding gene: 221633171

Following gene: 221633167

Centisome position: 58.74

GC content: 62.6

Gene sequence:

>786_bases
TTGTCTCCCGGCGAAACTATTTCCGAGATTTCCGGTAACCGGAGGGGAGGGAAGACGATGCGGGGTAACGGGATAGGGCA
GCGCAGAGCACCCGTCAAAGTGCTCGTTGTCGATGATCACCCGCTGTTCCGTTTTGCGGTGCGTCAGTTCCTCGACCGAC
ACGAGCGTTTTCGCGTCGTGGCAGAAGCGGCATCAGCACACGAGGCGGTCCAGCAGGCTGAACTCCATCGGCCGGACCTT
GCCCTGGTCGATCTTCGCTTGCCCGGTATCAACGGGTTGCAGGTGACGCGCCTCCTCAAGCGGCAGAATGGGAAACTCCC
CGTCGTGTTGCTCTCGGCGGACGAAAACGAGTCTTGGTTGCTCGGTGCTCTGCAAGTCGGTGCTGCGGCTTTCCTGGCGA
AAGACAGTGAGCCCCGCGAGATGTTGGCGGTGTTGGAAGCCGTCGTTGCCGGCGAGGATCGCCTGCCGCAACAGATCCTC
GACCGACCCCACTTGGCTCGTCGGGTACTCGGTGAACTCCAGCGCTACGTGGTCGGAGAAGCCGGCCTCGAGAGCCCGGA
CGCGGTGCTCACGGTGCGCGAACTGCAAGTGCTCGACTGTGTGGCGCAGGGCATGTCCAACAAGGAGATCGCGGAGGCAC
TCTTCATCACGGAACAGACGGTGAAGAATCACATGACGTCGATCCTGCGCAAGCTCGGCGCTCAGGATCGCGTGGATGTC
ATTCTGGCAGCGGTGCGACAGGGGTGGGTCGCGATTACGCCGTCCCGCTCGGCGGCGTCGGCTTGA

Upstream 100 bases:

>100_bases
GATGTGCCCAGAGGGCACAGTACGTACATGAAGCATCAGTACTCATCATCCTTAGGAGTGTTGATTGAAGAAGGGTGACT
GATTCCGCATCGTCGAATCG

Downstream 100 bases:

>100_bases
AGTTCCCTCCCACTTCGGCGAGCGCGATGTCGCGGCGGAACGTCATTCCAGGGAAGGAGAGGTGCTCGATCGCGCGATAG
ACGCGCTCGCGCGCTTCGGC

Product: nitrate/nitrite response regulator protein

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSPGETISEISGNRRGGKTMRGNGIGQRRAPVKVLVVDDHPLFRFAVRQFLDRHERFRVVAEAASAHEAVQQAELHRPDL
ALVDLRLPGINGLQVTRLLKRQNGKLPVVLLSADENESWLLGALQVGAAAFLAKDSEPREMLAVLEAVVAGEDRLPQQIL
DRPHLARRVLGELQRYVVGEAGLESPDAVLTVRELQVLDCVAQGMSNKEIAEALFITEQTVKNHMTSILRKLGAQDRVDV
ILAAVRQGWVAITPSRSAASA

Sequences:

>Translated_261_residues
MSPGETISEISGNRRGGKTMRGNGIGQRRAPVKVLVVDDHPLFRFAVRQFLDRHERFRVVAEAASAHEAVQQAELHRPDL
ALVDLRLPGINGLQVTRLLKRQNGKLPVVLLSADENESWLLGALQVGAAAFLAKDSEPREMLAVLEAVVAGEDRLPQQIL
DRPHLARRVLGELQRYVVGEAGLESPDAVLTVRELQVLDCVAQGMSNKEIAEALFITEQTVKNHMTSILRKLGAQDRVDV
ILAAVRQGWVAITPSRSAASA
>Mature_260_residues
SPGETISEISGNRRGGKTMRGNGIGQRRAPVKVLVVDDHPLFRFAVRQFLDRHERFRVVAEAASAHEAVQQAELHRPDLA
LVDLRLPGINGLQVTRLLKRQNGKLPVVLLSADENESWLLGALQVGAAAFLAKDSEPREMLAVLEAVVAGEDRLPQQILD
RPHLARRVLGELQRYVVGEAGLESPDAVLTVRELQVLDCVAQGMSNKEIAEALFITEQTVKNHMTSILRKLGAQDRVDVI
LAAVRQGWVAITPSRSAASA

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=218, Percent_Identity=34.8623853211009, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788222, Length=217, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788712, Length=213, Percent_Identity=26.7605633802817, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787473, Length=220, Percent_Identity=35.9090909090909, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1786747, Length=214, Percent_Identity=25.2336448598131, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1790102, Length=209, Percent_Identity=29.6650717703349, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1788546, Length=210, Percent_Identity=23.8095238095238, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789809, Length=118, Percent_Identity=32.2033898305085, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 28557; Mature: 28426

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPGETISEISGNRRGGKTMRGNGIGQRRAPVKVLVVDDHPLFRFAVRQFLDRHERFRVV
CCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
AEAASAHEAVQQAELHRPDLALVDLRLPGINGLQVTRLLKRQNGKLPVVLLSADENESWL
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHH
LGALQVGAAAFLAKDSEPREMLAVLEAVVAGEDRLPQQILDRPHLARRVLGELQRYVVGE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCC
AGLESPDAVLTVRELQVLDCVAQGMSNKEIAEALFITEQTVKNHMTSILRKLGAQDRVDV
CCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ILAAVRQGWVAITPSRSAASA
HHHHHHCCCEEECCCCCCCCC
>Mature Secondary Structure 
SPGETISEISGNRRGGKTMRGNGIGQRRAPVKVLVVDDHPLFRFAVRQFLDRHERFRVV
CCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
AEAASAHEAVQQAELHRPDLALVDLRLPGINGLQVTRLLKRQNGKLPVVLLSADENESWL
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHH
LGALQVGAAAFLAKDSEPREMLAVLEAVVAGEDRLPQQILDRPHLARRVLGELQRYVVGE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCC
AGLESPDAVLTVRELQVLDCVAQGMSNKEIAEALFITEQTVKNHMTSILRKLGAQDRVDV
CCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ILAAVRQGWVAITPSRSAASA
HHHHHHCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]