Click here to switch to the map view.

The map label for this gene is dnaA

Identifier: 221633151

GI number: 221633151

Start: 1157859

End: 1159256

Strand: Reverse

Name: dnaA

Synonym: trd_1166

Alternate gene names: 221633151

Gene position: 1159256-1157859 (Counterclockwise)

Preceding gene: 221633160

Following gene: 221633141

Centisome position: 57.88

GC content: 61.44

Gene sequence:

>1398_bases
ATGCGGACGAAACAGCTTTGGCAGGTCGCTCTCGGGGATCTGGCCAAGCGGGTTTCGCGGGCTAACTTCGAGACGTGGCT
CAAGCATACGGAACTGGTCGCGCTCGAGGGGGAACGAGCCACCATCGCCGCACCCTCCAGCTTCGCTGCTGAGCAGTTAC
GCAATAAGTTCGCTGCGGATATTCAGGAAACCTTGTCGCTCCTCTTGGGGCGCCCGATCGCAGTGCACTTCACGGTTCAC
GGCCAGGACGACGAGGAACACCCGGTGCAGCGTCGCCCGCAGCGACGGGCACTCGCCAGTGAGGAAGGATCAGCCTCCAA
GCAACTCTCGCTGACACCTTCCCCGGAGCATGGCCTGAATCCCCGTTACACCTTCGAGAAGTTCGTGGTCGGGCCGAACA
ATCGCCTGGCTCATGCCGCGGCCCTGGCAGTCGCTGATCGGCCCGGTGAGAAATTCAACCCGTTGTTCATCTACGGGGGC
GTCGGTCTCGGGAAGACTCATCTTTTGCATGCCATCGGTCACCGCGCGCTGGCGAACCGACCCACCCTGAAGGTGTGCTA
CGTCTCGTCGGAAGTGTTTACGAACGAGCTGATCAATGCCATTCGTCATCAGCGGACCGACGACTTCCGTAATCGATACC
GAACTATCGACATTTTGATGATCGATGACATTCAGTTCATCGCCGGAAAAGAAAGCACGCAAGAAGAGTTCTTCCATACG
TTCAATGCACTCTACCAGTCGGGGAAGCAGATCGTCATTTCCAGTGATCGACCGCCGCGCCTGATTCCGGATCTAGCGGA
TCGCTTGCGGTCCCGCTTCGAGGGCGGGCTTCTCGCGGACATCCAGCCACCTGATCTCGAGACACGCCAAGCGATCCTGA
TCGAGAAGGGGCGCGAGCTTGGGGTTCAGATGCCGTCGGACGTCGTGGAGTTCGTGGCTCGGCGGATCGAGAGCAATATC
CGGGAGTTGGAAGGGGCGCTCAATCGGATCGTTGCGCTGGCCCAACTGACGCACCAGCCGATCACCCTCGCGCTCGCTGT
CGAGGCACTCCGGGAAGGGGACGCACGAGCAGTGCGCGAGCAGCTGACGCCAGAACTCGTGTTGCACGCCGTCTGCCAGC
ACTTCCGGGTTTCCTTGGCGGAACTCGTTGGCCCTGGCCGACGTCGCGAGATCGTACTGCCGCGCCAGATCGCGATGTAT
CTCTTGCGCGAAGAGCTGGGACTTTCCCTGGTGGAGATCGGCCAGCGGCTCGGAGGGCGAGACCACACGACCGTTCTCCA
CGGCGTGGACAAGGTGGAGGAACAGCTGCGGAGCGATGAGCAACTGCGAGCGGACGTGCTCGCCGTTCGGGCGCGACTCT
ACGAGGACGCGAAGGCACCACTGGCGAGCCGTCATTGA

Upstream 100 bases:

>100_bases
CAGCGTGTCAGTTGCGACATCCCGGCGCGGGTTGCCAGACGGGATACAGCATGCTAGGATGCAGCCAAGGTGTACGTACA
CATGGGTCAGGGGGGCGGCG

Downstream 100 bases:

>100_bases
CTCCGCAGCAGGAGCAGCGCGAGTGCGGTGAGTACGATCAGGCCGACCCAGACCACGATGATCCCGGTGACTCCGGTCGT
CGCACCAGCGACGAACGTGA

Product: chromosomal replication initiator protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MRTKQLWQVALGDLAKRVSRANFETWLKHTELVALEGERATIAAPSSFAAEQLRNKFAADIQETLSLLLGRPIAVHFTVH
GQDDEEHPVQRRPQRRALASEEGSASKQLSLTPSPEHGLNPRYTFEKFVVGPNNRLAHAAALAVADRPGEKFNPLFIYGG
VGLGKTHLLHAIGHRALANRPTLKVCYVSSEVFTNELINAIRHQRTDDFRNRYRTIDILMIDDIQFIAGKESTQEEFFHT
FNALYQSGKQIVISSDRPPRLIPDLADRLRSRFEGGLLADIQPPDLETRQAILIEKGRELGVQMPSDVVEFVARRIESNI
RELEGALNRIVALAQLTHQPITLALAVEALREGDARAVREQLTPELVLHAVCQHFRVSLAELVGPGRRREIVLPRQIAMY
LLREELGLSLVEIGQRLGGRDHTTVLHGVDKVEEQLRSDEQLRADVLAVRARLYEDAKAPLASRH

Sequences:

>Translated_465_residues
MRTKQLWQVALGDLAKRVSRANFETWLKHTELVALEGERATIAAPSSFAAEQLRNKFAADIQETLSLLLGRPIAVHFTVH
GQDDEEHPVQRRPQRRALASEEGSASKQLSLTPSPEHGLNPRYTFEKFVVGPNNRLAHAAALAVADRPGEKFNPLFIYGG
VGLGKTHLLHAIGHRALANRPTLKVCYVSSEVFTNELINAIRHQRTDDFRNRYRTIDILMIDDIQFIAGKESTQEEFFHT
FNALYQSGKQIVISSDRPPRLIPDLADRLRSRFEGGLLADIQPPDLETRQAILIEKGRELGVQMPSDVVEFVARRIESNI
RELEGALNRIVALAQLTHQPITLALAVEALREGDARAVREQLTPELVLHAVCQHFRVSLAELVGPGRRREIVLPRQIAMY
LLREELGLSLVEIGQRLGGRDHTTVLHGVDKVEEQLRSDEQLRADVLAVRARLYEDAKAPLASRH
>Mature_465_residues
MRTKQLWQVALGDLAKRVSRANFETWLKHTELVALEGERATIAAPSSFAAEQLRNKFAADIQETLSLLLGRPIAVHFTVH
GQDDEEHPVQRRPQRRALASEEGSASKQLSLTPSPEHGLNPRYTFEKFVVGPNNRLAHAAALAVADRPGEKFNPLFIYGG
VGLGKTHLLHAIGHRALANRPTLKVCYVSSEVFTNELINAIRHQRTDDFRNRYRTIDILMIDDIQFIAGKESTQEEFFHT
FNALYQSGKQIVISSDRPPRLIPDLADRLRSRFEGGLLADIQPPDLETRQAILIEKGRELGVQMPSDVVEFVARRIESNI
RELEGALNRIVALAQLTHQPITLALAVEALREGDARAVREQLTPELVLHAVCQHFRVSLAELVGPGRRREIVLPRQIAMY
LLREELGLSLVEIGQRLGGRDHTTVLHGVDKVEEQLRSDEQLRADVLAVRARLYEDAKAPLASRH

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=450, Percent_Identity=40.8888888888889, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI226510964, Length=236, Percent_Identity=28.8135593220339, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_THERP (B9L0U6)

Other databases:

- EMBL:   CP001275
- RefSeq:   YP_002522376.1
- GeneID:   7354592
- GenomeReviews:   CP001275_GR
- KEGG:   tro:trd_1166
- OMA:   CHTLNAL
- ProtClustDB:   CLSK2807870
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 52221; Mature: 52221

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTKQLWQVALGDLAKRVSRANFETWLKHTELVALEGERATIAAPSSFAAEQLRNKFAAD
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCEEEECCHHHHHHHHHHHHHHH
IQETLSLLLGRPIAVHFTVHGQDDEEHPVQRRPQRRALASEEGSASKQLSLTPSPEHGLN
HHHHHHHHHCCCEEEEEEEECCCCCCCHHHCCHHHHHHHCCCCCCCCEEECCCCCCCCCC
PRYTFEKFVVGPNNRLAHAAALAVADRPGEKFNPLFIYGGVGLGKTHLLHAIGHRALANR
CCEEHHEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCC
PTLKVCYVSSEVFTNELINAIRHQRTDDFRNRYRTIDILMIDDIQFIAGKESTQEEFFHT
CCEEEEEECHHHHHHHHHHHHHHCCCHHHHHHHEEEEEEEECCCHHHCCCCCHHHHHHHH
FNALYQSGKQIVISSDRPPRLIPDLADRLRSRFEGGLLADIQPPDLETRQAILIEKGREL
HHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHCCCCC
GVQMPSDVVEFVARRIESNIRELEGALNRIVALAQLTHQPITLALAVEALREGDARAVRE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH
QLTPELVLHAVCQHFRVSLAELVGPGRRREIVLPRQIAMYLLREELGLSLVEIGQRLGGR
HCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCHHHHHHHHHHCCC
DHTTVLHGVDKVEEQLRSDEQLRADVLAVRARLYEDAKAPLASRH
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRTKQLWQVALGDLAKRVSRANFETWLKHTELVALEGERATIAAPSSFAAEQLRNKFAAD
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCEEEECCHHHHHHHHHHHHHHH
IQETLSLLLGRPIAVHFTVHGQDDEEHPVQRRPQRRALASEEGSASKQLSLTPSPEHGLN
HHHHHHHHHCCCEEEEEEEECCCCCCCHHHCCHHHHHHHCCCCCCCCEEECCCCCCCCCC
PRYTFEKFVVGPNNRLAHAAALAVADRPGEKFNPLFIYGGVGLGKTHLLHAIGHRALANR
CCEEHHEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCC
PTLKVCYVSSEVFTNELINAIRHQRTDDFRNRYRTIDILMIDDIQFIAGKESTQEEFFHT
CCEEEEEECHHHHHHHHHHHHHHCCCHHHHHHHEEEEEEEECCCHHHCCCCCHHHHHHHH
FNALYQSGKQIVISSDRPPRLIPDLADRLRSRFEGGLLADIQPPDLETRQAILIEKGREL
HHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHCCCCC
GVQMPSDVVEFVARRIESNIRELEGALNRIVALAQLTHQPITLALAVEALREGDARAVRE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH
QLTPELVLHAVCQHFRVSLAELVGPGRRREIVLPRQIAMYLLREELGLSLVEIGQRLGGR
HCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCHHHHHHHHHHCCC
DHTTVLHGVDKVEEQLRSDEQLRADVLAVRARLYEDAKAPLASRH
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA