| Definition | Thermomicrobium roseum DSM 5159 chromosome, complete genome. |
|---|---|
| Accession | NC_011959 |
| Length | 2,003,006 |
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The map label for this gene is lon [H]
Identifier: 221633008
GI number: 221633008
Start: 985966
End: 988464
Strand: Reverse
Name: lon [H]
Synonym: trd_1023
Alternate gene names: 221633008
Gene position: 988464-985966 (Counterclockwise)
Preceding gene: 221633009
Following gene: 221633006
Centisome position: 49.35
GC content: 60.7
Gene sequence:
>2499_bases ATGATGGACGAACTGCGTAACCGAGAATTGGAAGCACGGAAAGAGGAAACGGTCGAGAACGAGGAGGCGGTCGAGCAGGA AGTCGCGCGTGAGCGGAAGCTCCTACCTGTCTTGCCGCTGCGCAACACGGTGGTCTTCCCGACGACCGTGGTTCCTTTGG CAGCAGGTCAGCCTCGATCGCTGCGCTTGATCGACGATGTCGCATCGGGTGACCGTCTGCTTGTCCTCGTTTTGCAGAAG GATCCGAAGAAGGAAGGGGCCGGTCCAGACGACGTTTATCAGGTTGGGACGATCGGCAGTATCCAGCAGATGATGCGCGT GCCCGATGGAACCGTGCGATTGGCTGTCCACGGGTTGCGTCGCGTACGCATCGTGGAATGGGTAGCTGAGGAACCCTACC TGAAGGCGCTCGTCGAGGAGATTCCTGAGCTGGTCGAGGATACGATCGAAGTCAAGGCGTTGACGCGGACAGCGCTCGAG CTATTCCAGCGACTGGTCTCGCTGGTTTCCAACTTGCCGGAGGAGTTGGTCACGGCGGCCCTCAACATCGACGATCCCTT GCACCTGGTTTATCTTTTGGCGTCCAACCTCCGGATGGACCCAGAGGAGCGCCAGGCGCTGCTCGAACTCGACAGTGTGC GTGACAAGCTGCTGCGTCTGAATGCCTTCATGAGTCGCGAGCTGGATCTCCTGGAATTGGGCAAGAAGATCCAGAGCGAA GTCCAGGAGGAGGTCGCTCGCTCGCAGCGCGAGTTCTACCTGCGCGAGCAGCTGAAGGCGATCCAACGCGAACTGGGGGA GACGAGCGAGCAGGAAGCAGAAATCAACGAGTTTCGGGCCAAGATCGAGCAGTCCGGGATGCCGGAGGAGGCTCGCCGCG AGGCATTGCGCGAACTCGAGCGGATGAGCAAACTGCCGCCGGCGTCAGCCGAATATGGTGTCATCCGGACCTATCTGGAC TGGTTGGTTTCGCTACCCTGGAACCGCAGCACTGAAGGCGAGATCGATATCGCTCGGGCGCGGCAAATTCTCGACGAGGA TCATTACAACCTGGAGAAAATCAAGGAGCGGATCCTGGAGTATCTGGCTGTCCGGCGCCTACGCAAGGAGCGCGGTGAGG ACAGCGAGCCTGGACGCGAGCCGATTCTCTGCTTCGTGGGACCGCCGGGTGTCGGCAAGACGAGTCTGGCCCAGTCGATC GCTCGCGCGCTCGGTCGAGCCTTCACTCGTATGTCGCTGGGTGGCGTTCGCGATGAGGCGGAGATCCGCGGGCACCGGCG TACGTACATCGGCGCAATGCCTGGTCGGATCATCCAGGCGATCCGCCGAGCGGGAACGAACGATCCGGTCTTCGTGTTGG ACGAAATCGATAAAGTCGGAACGGATTGGCGTGGTGATCCGGCTTCGGCACTGCTCGAGGTGCTCGACCCGGAGCAGAAC AGTACGTTCCGCGATCATTATCTGGACGTACCATTCGACCTTTCGAAGGTCATGTTCATCGCGACCGCCAACGTTTTGGA CACGATTCCGCCGGCCTTGCGCGACCGAATGGAGATCTTGGTGCTGTCCGGGTACACCGACGAAGAGAAGCTGCAGATCG CACGCCGCTATCTGATTCCGAAGCAGTTCCGTCGGCACGCGTTGAATCCGGAGGACTTCGTCTTCAGTGACGAGGCGATT CTCGAGATTATTCAGCATTACACGCGCGAGGCTGGCGTGCGGAACCTGGAGCGCGAGATCGCGGCGATCGCGCGCAAACT GGCGACGCGTCTCGCCGAGGGACAAGAAATTCCGCGCGAGATCACTGTGGACGTCGTGCACGAATTCCTCGGGAAGCGGC GATACCACTACGAGGAATTGTCGGAACGCACCTCGCAGCCGGGCGTGGCGATCGGTGTCGGGGTGACGCCGGTAGGTGGC GACATCATGTTCATCGAGGCGACCCGCATGCCTGGTCGCGGGAACCTGATCATCACTGGGCAACTCGGCGAGGTGATGCG CGAGTCGGCCCAGGCTGCTCTCAGCATCGTGCGGAGCCGGGCTGAGCAATTCGGTATCGAGCCGGACTTCATGAAGGACT CGGACATTCACATCCATGTTCCTTCGGGTGCGATTCCGAAGGATGGTCCCTCGGCAGGCGTCACGCTGGTGACAGCTCTG GTTTCCCTCCTCACCGGTATTCCGGTCCGGGAGGATGTGGCGATGACCGGAGAGATCACACTGCGTGGGCAAGTACTGCC GGTGGGGGGCATCAAAGAAAAGGCGCTAGCGGCTCAGCGAGCGGGAATCAAGGTGTTCATCTTGCCGAAGCGCAACGAAA TGGATCTCGACGAATTGCCGCCGACACTCCGCGAGAACATGCGGTTCGTGCTGGTGGAAACGATCGATGACGTTCTCAGA GCCGCCATGCCGGATGAGTTCCAGCAGCGACTCGCTCAGGTTAGTCGTCGCGGTGAGCAGACGGAAGCCGCCGTGGAATC GATCGTCGCGCTCGGCTGA
Upstream 100 bases:
>100_bases ACGAGCGTGGATTTCTGGAGGTTCGCCTGCCGCGGCTCAGTCATACGCGGACTGTCCCGCTCCGACCCGCGACTGAACCC TGAATTAGAGGAGTCGATCG
Downstream 100 bases:
>100_bases GTGGACGAGTCGATCACAGACCTTCTACGAGCGGGGCGGACAACGACCAGCCCCGCTCGCTCATGTTTCGCTGTCGATTC GCGCGAGTGCTGGCTGTTGA
Product: ATP-dependent protease La
Products: NA
Alternate protein names: ATP-dependent protease La [H]
Number of amino acids: Translated: 832; Mature: 832
Protein sequence:
>832_residues MMDELRNRELEARKEETVENEEAVEQEVARERKLLPVLPLRNTVVFPTTVVPLAAGQPRSLRLIDDVASGDRLLVLVLQK DPKKEGAGPDDVYQVGTIGSIQQMMRVPDGTVRLAVHGLRRVRIVEWVAEEPYLKALVEEIPELVEDTIEVKALTRTALE LFQRLVSLVSNLPEELVTAALNIDDPLHLVYLLASNLRMDPEERQALLELDSVRDKLLRLNAFMSRELDLLELGKKIQSE VQEEVARSQREFYLREQLKAIQRELGETSEQEAEINEFRAKIEQSGMPEEARREALRELERMSKLPPASAEYGVIRTYLD WLVSLPWNRSTEGEIDIARARQILDEDHYNLEKIKERILEYLAVRRLRKERGEDSEPGREPILCFVGPPGVGKTSLAQSI ARALGRAFTRMSLGGVRDEAEIRGHRRTYIGAMPGRIIQAIRRAGTNDPVFVLDEIDKVGTDWRGDPASALLEVLDPEQN STFRDHYLDVPFDLSKVMFIATANVLDTIPPALRDRMEILVLSGYTDEEKLQIARRYLIPKQFRRHALNPEDFVFSDEAI LEIIQHYTREAGVRNLEREIAAIARKLATRLAEGQEIPREITVDVVHEFLGKRRYHYEELSERTSQPGVAIGVGVTPVGG DIMFIEATRMPGRGNLIITGQLGEVMRESAQAALSIVRSRAEQFGIEPDFMKDSDIHIHVPSGAIPKDGPSAGVTLVTAL VSLLTGIPVREDVAMTGEITLRGQVLPVGGIKEKALAAQRAGIKVFILPKRNEMDLDELPPTLRENMRFVLVETIDDVLR AAMPDEFQQRLAQVSRRGEQTEAAVESIVALG
Sequences:
>Translated_832_residues MMDELRNRELEARKEETVENEEAVEQEVARERKLLPVLPLRNTVVFPTTVVPLAAGQPRSLRLIDDVASGDRLLVLVLQK DPKKEGAGPDDVYQVGTIGSIQQMMRVPDGTVRLAVHGLRRVRIVEWVAEEPYLKALVEEIPELVEDTIEVKALTRTALE LFQRLVSLVSNLPEELVTAALNIDDPLHLVYLLASNLRMDPEERQALLELDSVRDKLLRLNAFMSRELDLLELGKKIQSE VQEEVARSQREFYLREQLKAIQRELGETSEQEAEINEFRAKIEQSGMPEEARREALRELERMSKLPPASAEYGVIRTYLD WLVSLPWNRSTEGEIDIARARQILDEDHYNLEKIKERILEYLAVRRLRKERGEDSEPGREPILCFVGPPGVGKTSLAQSI ARALGRAFTRMSLGGVRDEAEIRGHRRTYIGAMPGRIIQAIRRAGTNDPVFVLDEIDKVGTDWRGDPASALLEVLDPEQN STFRDHYLDVPFDLSKVMFIATANVLDTIPPALRDRMEILVLSGYTDEEKLQIARRYLIPKQFRRHALNPEDFVFSDEAI LEIIQHYTREAGVRNLEREIAAIARKLATRLAEGQEIPREITVDVVHEFLGKRRYHYEELSERTSQPGVAIGVGVTPVGG DIMFIEATRMPGRGNLIITGQLGEVMRESAQAALSIVRSRAEQFGIEPDFMKDSDIHIHVPSGAIPKDGPSAGVTLVTAL VSLLTGIPVREDVAMTGEITLRGQVLPVGGIKEKALAAQRAGIKVFILPKRNEMDLDELPPTLRENMRFVLVETIDDVLR AAMPDEFQQRLAQVSRRGEQTEAAVESIVALG >Mature_832_residues MMDELRNRELEARKEETVENEEAVEQEVARERKLLPVLPLRNTVVFPTTVVPLAAGQPRSLRLIDDVASGDRLLVLVLQK DPKKEGAGPDDVYQVGTIGSIQQMMRVPDGTVRLAVHGLRRVRIVEWVAEEPYLKALVEEIPELVEDTIEVKALTRTALE LFQRLVSLVSNLPEELVTAALNIDDPLHLVYLLASNLRMDPEERQALLELDSVRDKLLRLNAFMSRELDLLELGKKIQSE VQEEVARSQREFYLREQLKAIQRELGETSEQEAEINEFRAKIEQSGMPEEARREALRELERMSKLPPASAEYGVIRTYLD WLVSLPWNRSTEGEIDIARARQILDEDHYNLEKIKERILEYLAVRRLRKERGEDSEPGREPILCFVGPPGVGKTSLAQSI ARALGRAFTRMSLGGVRDEAEIRGHRRTYIGAMPGRIIQAIRRAGTNDPVFVLDEIDKVGTDWRGDPASALLEVLDPEQN STFRDHYLDVPFDLSKVMFIATANVLDTIPPALRDRMEILVLSGYTDEEKLQIARRYLIPKQFRRHALNPEDFVFSDEAI LEIIQHYTREAGVRNLEREIAAIARKLATRLAEGQEIPREITVDVVHEFLGKRRYHYEELSERTSQPGVAIGVGVTPVGG DIMFIEATRMPGRGNLIITGQLGEVMRESAQAALSIVRSRAEQFGIEPDFMKDSDIHIHVPSGAIPKDGPSAGVTLVTAL VSLLTGIPVREDVAMTGEITLRGQVLPVGGIKEKALAAQRAGIKVFILPKRNEMDLDELPPTLRENMRFVLVETIDDVLR AAMPDEFQQRLAQVSRRGEQTEAAVESIVALG
Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced
COG id: COG0466
COG function: function code O; ATP-dependent Lon protease, bacterial type
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Lon domain [H]
Homologues:
Organism=Homo sapiens, GI31377667, Length=838, Percent_Identity=42.0047732696897, Blast_Score=607, Evalue=1e-173, Organism=Homo sapiens, GI21396489, Length=785, Percent_Identity=40.3821656050955, Blast_Score=566, Evalue=1e-161, Organism=Escherichia coli, GI1786643, Length=778, Percent_Identity=49.3573264781491, Blast_Score=755, Evalue=0.0, Organism=Caenorhabditis elegans, GI17556486, Length=544, Percent_Identity=45.4044117647059, Blast_Score=504, Evalue=1e-143, Organism=Caenorhabditis elegans, GI17505831, Length=704, Percent_Identity=40.0568181818182, Blast_Score=476, Evalue=1e-134, Organism=Saccharomyces cerevisiae, GI6319449, Length=724, Percent_Identity=38.2596685082873, Blast_Score=494, Evalue=1e-140, Organism=Drosophila melanogaster, GI24666867, Length=699, Percent_Identity=43.4907010014306, Blast_Score=559, Evalue=1e-159, Organism=Drosophila melanogaster, GI221513036, Length=699, Percent_Identity=43.4907010014306, Blast_Score=559, Evalue=1e-159,
Paralogues:
None
Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR003959 - InterPro: IPR008269 - InterPro: IPR004815 - InterPro: IPR003111 - InterPro: IPR008268 - InterPro: IPR001984 - InterPro: IPR015947 - InterPro: IPR020568 [H]
Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]
EC number: =3.4.21.53 [H]
Molecular weight: Translated: 93667; Mature: 93667
Theoretical pI: Translated: 4.87; Mature: 4.87
Prosite motif: PS01046 LON_SER
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.1 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.1 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MMDELRNRELEARKEETVENEEAVEQEVARERKLLPVLPLRNTVVFPTTVVPLAAGQPRS CCCCHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEECCCCEEEECCCCCCC LRLIDDVASGDRLLVLVLQKDPKKEGAGPDDVYQVGTIGSIQQMMRVPDGTVRLAVHGLR EEHHHHHCCCCEEEEEEECCCCCCCCCCCCHHEECCCHHHHHHHHHCCCCHHHHHHHHHH RVRIVEWVAEEPYLKALVEEIPELVEDTIEVKALTRTALELFQRLVSLVSNLPEELVTAA HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH LNIDDPLHLVYLLASNLRMDPEERQALLELDSVRDKLLRLNAFMSRELDLLELGKKIQSE HCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH VQEEVARSQREFYLREQLKAIQRELGETSEQEAEINEFRAKIEQSGMPEEARREALRELE HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH RMSKLPPASAEYGVIRTYLDWLVSLPWNRSTEGEIDIARARQILDEDHYNLEKIKERILE HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH YLAVRRLRKERGEDSEPGREPILCFVGPPGVGKTSLAQSIARALGRAFTRMSLGGVRDEA HHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH EIRGHRRTYIGAMPGRIIQAIRRAGTNDPVFVLDEIDKVGTDWRGDPASALLEVLDPEQN HHCCCHHHEECCCCHHHHHHHHHCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHCCCCC STFRDHYLDVPFDLSKVMFIATANVLDTIPPALRDRMEILVLSGYTDEEKLQIARRYLIP CCHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCEEEEEECCCCHHHHHHHHHHHCH KQFRRHALNPEDFVFSDEAILEIIQHYTREAGVRNLEREIAAIARKLATRLAEGQEIPRE HHHHHHCCCCHHCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHH ITVDVVHEFLGKRRYHYEELSERTSQPGVAIGVGVTPVGGDIMFIEATRMPGRGNLIITG HHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCEEEEC QLGEVMRESAQAALSIVRSRAEQFGIEPDFMKDSDIHIHVPSGAIPKDGPSAGVTLVTAL CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHH VSLLTGIPVREDVAMTGEITLRGQVLPVGGIKEKALAAQRAGIKVFILPKRNEMDLDELP HHHHHCCCCCCCCEEECEEEEEEEEEECCCCHHHHHHHHHCCEEEEEECCCCCCCHHHCC PTLRENMRFVLVETIDDVLRAAMPDEFQQRLAQVSRRGEQTEAAVESIVALG HHHHHCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCC >Mature Secondary Structure MMDELRNRELEARKEETVENEEAVEQEVARERKLLPVLPLRNTVVFPTTVVPLAAGQPRS CCCCHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEECCCCEEEECCCCCCC LRLIDDVASGDRLLVLVLQKDPKKEGAGPDDVYQVGTIGSIQQMMRVPDGTVRLAVHGLR EEHHHHHCCCCEEEEEEECCCCCCCCCCCCHHEECCCHHHHHHHHHCCCCHHHHHHHHHH RVRIVEWVAEEPYLKALVEEIPELVEDTIEVKALTRTALELFQRLVSLVSNLPEELVTAA HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH LNIDDPLHLVYLLASNLRMDPEERQALLELDSVRDKLLRLNAFMSRELDLLELGKKIQSE HCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH VQEEVARSQREFYLREQLKAIQRELGETSEQEAEINEFRAKIEQSGMPEEARREALRELE HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH RMSKLPPASAEYGVIRTYLDWLVSLPWNRSTEGEIDIARARQILDEDHYNLEKIKERILE HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH YLAVRRLRKERGEDSEPGREPILCFVGPPGVGKTSLAQSIARALGRAFTRMSLGGVRDEA HHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH EIRGHRRTYIGAMPGRIIQAIRRAGTNDPVFVLDEIDKVGTDWRGDPASALLEVLDPEQN HHCCCHHHEECCCCHHHHHHHHHCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHCCCCC STFRDHYLDVPFDLSKVMFIATANVLDTIPPALRDRMEILVLSGYTDEEKLQIARRYLIP CCHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCEEEEEECCCCHHHHHHHHHHHCH KQFRRHALNPEDFVFSDEAILEIIQHYTREAGVRNLEREIAAIARKLATRLAEGQEIPRE HHHHHHCCCCHHCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHH ITVDVVHEFLGKRRYHYEELSERTSQPGVAIGVGVTPVGGDIMFIEATRMPGRGNLIITG HHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCEEEEC QLGEVMRESAQAALSIVRSRAEQFGIEPDFMKDSDIHIHVPSGAIPKDGPSAGVTLVTAL CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHH VSLLTGIPVREDVAMTGEITLRGQVLPVGGIKEKALAAQRAGIKVFILPKRNEMDLDELP HHHHHCCCCCCCCEEECEEEEEEEEEECCCCHHHHHHHHHCCEEEEEECCCCCCCHHHCC PTLRENMRFVLVETIDDVLRAAMPDEFQQRLAQVSRRGEQTEAAVESIVALG HHHHHCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA