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The map label for this gene is pncB [H]

Identifier: 221632939

GI number: 221632939

Start: 920947

End: 922311

Strand: Reverse

Name: pncB [H]

Synonym: trd_0945

Alternate gene names: 221632939

Gene position: 922311-920947 (Counterclockwise)

Preceding gene: 221632940

Following gene: 221632938

Centisome position: 46.05

GC content: 59.63

Gene sequence:

>1365_bases
ATGAGTCCGACGCGCCTCGAAGTCGCCCTTTCGACCGATCTCTATGAATTGACCATGGCGTCGAGCTATCACACGCTGGG
TCATGCTGGCCGAGCGGTGTTCAGCCTTTTCGTGCGCAAGTTTCCCGAGAACCGTCACTTCCTCGTGGCTGCCGGAATCG
CCGAATTATTGGAGCGCCTCGTCGAGCTTCGTTTCGAAGAGGAGGCGCTCCGCTTCTTGGCGACTCTTCCGGGATTACGG
CGCAGCTTCGTCGACTCGCTTGTGCACTTTCGTTTTCGAGGCGATATCTGGGCAGTGCAGGAGGGGACGGTCGTCTTCCC
TGACGAGCCGATCCTGGAGGTGGAGGCGCCGATCGATCAGGCGCAGATCATCGAGACGCTGGTGTTGAATTCCGTTCACT
ATGCGACGCTCGTCGCAACAAAAGCTGCTCGTTGTGTTCTGGTCGCTCCCGGCAAGACGCTAGTTGATTTCGGCTTGCGA
CGAACACCGAGTCTGGATGCTGGATTGACTGCAGCGCGAGCAGCCTATCTAGCCGGGTTTGCTGCAACAAGCAATGTCTT
AGCCGGTGAACGGTATGGTATCCCGGTCAGCGGCACGGTCGCTCACTCGTACATCGAGTCGTTCCCGTCCGAACTGGATG
CGTTCCGGGCTTTCGCCCGCACCTATCCTGGTGATCCGATACTTCTCATCGATACCTACGACACATTGCGCGGAGCCGAA
CATGCCATCATCGTCGCACGCGAACTCACGCAGGAGGGACGCCGTGTCCGAGCTGTCCGTTTGGACAGTGGGGATCTGGC
TGAGCTGAGTCGCGCGGTTCGCGAGATTCTCGATCGTGCGGGATTCCGGGATATCCAGATTTTCGCCAGTGGGGGACTCG
ACGAGTACGAGATCGCTGAATTGGAAGCGAAGAGGGCTCCGATCGATGGCTATGGGGTAGGCTCCCGGTTGGGAACGTCC
GCGGATGCCCCTCTCGCTGACATGGCCTATAAACTGGTCGAGTATGAAGGGCAGCCGGTGCTCAAATTGAGTACCGGTAA
GCGAACACTGGTCGGTGCGAAGCAGGTCTGGCGTCGCGTGGGCGCAGATGGTCGTTATGTCGAGGACCTGATCGCGCTGC
GTGACGAACCAGCTCCAGGTCCCGACTGGATACCGTTGTTACGCCCAGTGATGCGAGACGGTGAAATCGTCGAAACGTCG
ACGCTTGGGCAGGCGCGGGCTCACCATCGGGAGGAGATGCAGCGGTTCCCAGAATGGATGCGCTCACTGAGGCCGGTGGA
ACGGTATCCGGTACGGCTGAGTCAGCGACTGGCCCAGTTGCAGAGCGAGGCAGAACGACGAGTCCGTTCGCGTGAAGGGC
TCTGA

Upstream 100 bases:

>100_bases
TCCGCGGATCATCGAGGCCAGTCGCCAGTTCCTGGCCGATCTTCTCCGCGAGCGCCGGCAGGACCTGGAAGCGTAGGTTT
GCTGTGCGATCGGGGGAAAG

Downstream 100 bases:

>100_bases
GCGATGCTGCACCGCGTGCGGCTCGCTCCGGTCACGATCGAGTCATATCGGGAGTTTGTGCCGACCGAGCAAATCGATGA
ACTGATCCGTCTCGGTAATC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB2 [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSPTRLEVALSTDLYELTMASSYHTLGHAGRAVFSLFVRKFPENRHFLVAAGIAELLERLVELRFEEEALRFLATLPGLR
RSFVDSLVHFRFRGDIWAVQEGTVVFPDEPILEVEAPIDQAQIIETLVLNSVHYATLVATKAARCVLVAPGKTLVDFGLR
RTPSLDAGLTAARAAYLAGFAATSNVLAGERYGIPVSGTVAHSYIESFPSELDAFRAFARTYPGDPILLIDTYDTLRGAE
HAIIVARELTQEGRRVRAVRLDSGDLAELSRAVREILDRAGFRDIQIFASGGLDEYEIAELEAKRAPIDGYGVGSRLGTS
ADAPLADMAYKLVEYEGQPVLKLSTGKRTLVGAKQVWRRVGADGRYVEDLIALRDEPAPGPDWIPLLRPVMRDGEIVETS
TLGQARAHHREEMQRFPEWMRSLRPVERYPVRLSQRLAQLQSEAERRVRSREGL

Sequences:

>Translated_454_residues
MSPTRLEVALSTDLYELTMASSYHTLGHAGRAVFSLFVRKFPENRHFLVAAGIAELLERLVELRFEEEALRFLATLPGLR
RSFVDSLVHFRFRGDIWAVQEGTVVFPDEPILEVEAPIDQAQIIETLVLNSVHYATLVATKAARCVLVAPGKTLVDFGLR
RTPSLDAGLTAARAAYLAGFAATSNVLAGERYGIPVSGTVAHSYIESFPSELDAFRAFARTYPGDPILLIDTYDTLRGAE
HAIIVARELTQEGRRVRAVRLDSGDLAELSRAVREILDRAGFRDIQIFASGGLDEYEIAELEAKRAPIDGYGVGSRLGTS
ADAPLADMAYKLVEYEGQPVLKLSTGKRTLVGAKQVWRRVGADGRYVEDLIALRDEPAPGPDWIPLLRPVMRDGEIVETS
TLGQARAHHREEMQRFPEWMRSLRPVERYPVRLSQRLAQLQSEAERRVRSREGL
>Mature_453_residues
SPTRLEVALSTDLYELTMASSYHTLGHAGRAVFSLFVRKFPENRHFLVAAGIAELLERLVELRFEEEALRFLATLPGLRR
SFVDSLVHFRFRGDIWAVQEGTVVFPDEPILEVEAPIDQAQIIETLVLNSVHYATLVATKAARCVLVAPGKTLVDFGLRR
TPSLDAGLTAARAAYLAGFAATSNVLAGERYGIPVSGTVAHSYIESFPSELDAFRAFARTYPGDPILLIDTYDTLRGAEH
AIIVARELTQEGRRVRAVRLDSGDLAELSRAVREILDRAGFRDIQIFASGGLDEYEIAELEAKRAPIDGYGVGSRLGTSA
DAPLADMAYKLVEYEGQPVLKLSTGKRTLVGAKQVWRRVGADGRYVEDLIALRDEPAPGPDWIPLLRPVMRDGEIVETST
LGQARAHHREEMQRFPEWMRSLRPVERYPVRLSQRLAQLQSEAERRVRSREGL

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=513, Percent_Identity=32.7485380116959, Blast_Score=214, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71997947, Length=519, Percent_Identity=33.718689788054, Blast_Score=238, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI71997952, Length=519, Percent_Identity=33.718689788054, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71997955, Length=226, Percent_Identity=41.1504424778761, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24581587, Length=431, Percent_Identity=35.9628770301624, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI161076680, Length=207, Percent_Identity=43.4782608695652, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24581595, Length=207, Percent_Identity=43.4782608695652, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI28574709, Length=207, Percent_Identity=43.4782608695652, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24581593, Length=207, Percent_Identity=43.4782608695652, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24581591, Length=207, Percent_Identity=43.4782608695652, Blast_Score=141, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 50506; Mature: 50375

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTRLEVALSTDLYELTMASSYHTLGHAGRAVFSLFVRKFPENRHFLVAAGIAELLERL
CCCCEEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHH
VELRFEEEALRFLATLPGLRRSFVDSLVHFRFRGDIWAVQEGTVVFPDEPILEVEAPIDQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCCEEEECCCCH
AQIIETLVLNSVHYATLVATKAARCVLVAPGKTLVDFGLRRTPSLDAGLTAARAAYLAGF
HHHHHHHHHCCHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AATSNVLAGERYGIPVSGTVAHSYIESFPSELDAFRAFARTYPGDPILLIDTYDTLRGAE
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCC
HAIIVARELTQEGRRVRAVRLDSGDLAELSRAVREILDRAGFRDIQIFASGGLDEYEIAE
CEEEEEHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
LEAKRAPIDGYGVGSRLGTSADAPLADMAYKLVEYEGQPVLKLSTGKRTLVGAKQVWRRV
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHH
GADGRYVEDLIALRDEPAPGPDWIPLLRPVMRDGEIVETSTLGQARAHHREEMQRFPEWM
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
RSLRPVERYPVRLSQRLAQLQSEAERRVRSREGL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPTRLEVALSTDLYELTMASSYHTLGHAGRAVFSLFVRKFPENRHFLVAAGIAELLERL
CCCEEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHH
VELRFEEEALRFLATLPGLRRSFVDSLVHFRFRGDIWAVQEGTVVFPDEPILEVEAPIDQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCCEEEECCCCH
AQIIETLVLNSVHYATLVATKAARCVLVAPGKTLVDFGLRRTPSLDAGLTAARAAYLAGF
HHHHHHHHHCCHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AATSNVLAGERYGIPVSGTVAHSYIESFPSELDAFRAFARTYPGDPILLIDTYDTLRGAE
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCC
HAIIVARELTQEGRRVRAVRLDSGDLAELSRAVREILDRAGFRDIQIFASGGLDEYEIAE
CEEEEEHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
LEAKRAPIDGYGVGSRLGTSADAPLADMAYKLVEYEGQPVLKLSTGKRTLVGAKQVWRRV
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHH
GADGRYVEDLIALRDEPAPGPDWIPLLRPVMRDGEIVETSTLGQARAHHREEMQRFPEWM
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
RSLRPVERYPVRLSQRLAQLQSEAERRVRSREGL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]