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The map label for this gene is hppA [H]

Identifier: 221632717

GI number: 221632717

Start: 696509

End: 698569

Strand: Reverse

Name: hppA [H]

Synonym: trd_0705

Alternate gene names: 221632717

Gene position: 698569-696509 (Counterclockwise)

Preceding gene: 221632718

Following gene: 221632712

Centisome position: 34.88

GC content: 61.14

Gene sequence:

>2061_bases
ATGGAAAACACGGCGTTGTACCTGGCGTTGGGCGCGGCAGTCCTCGCGCTCCTCTATGGGGCCATCCTGATCCGTTGGGT
TTTAGCCCAACCGCGTGGTGATGAACGCATGCAGGCGATCGCCCAGGCCATTCAGGAGGGCGCCGAGGCGTACATGCGTC
GGCAATACACGCTCGTGGCTATCGTCGCGGTGATCGTCGCCCTCATTCTCGGCTTCGCGGTCGACTGGACGACCGCTGTC
GGTTTCCTCGTCGGCGCGATCGCATCGGGACTCGCTGGTTTCATCGGCATGTCGATCGCCGTGCGAGCGAACGTGCGTAC
GGCGGAAGCTGCCAAACGCGGGCTCGAGCGAGCCCTAGCGGTCGCCTTTCGGGGCGGCGCTGTGACCGGCCTCCTCGTCG
CCGGTCTCGGTCTACTGAGTGTGACGCTGTTCTATCTCATCACGCGGAACGTGACTGCGCTGGTCGGTCTCGGCTTCGGT
GGAAGCCTCATTTCTGTCTTCGCGCGTATCGGTGGCGGTATCTACACGAAGGCAGCAGATGTCGGTGCCGACCTCGTCGG
CAAAGTGGAAGCTGGTATCCCGGAAGACGACCCGCGCAATCCTGCCGTCATCGCCGACAACGTCGGGGACAACGTCGGTG
ACTGCGCCGGTATGGCAGCCGACCTCTTCGAGACGTACGCCGTGACCGCCATCGCTGCGATGCTCCTCGGCCACCTCGTT
TTCGGTACCGAAGTGGCAGTGGTCTACCCACTCGCGCTCGGTGCTGTATCCATCCTCACTTCCATCATCGGCACCTTTTT
CGTACGCCTCGATGCGAGTCGCTCGATCATGCGTGCCCTCTATAAGGGGGTCATCGCGGCCATGCTTCTGGCCGCTATCC
TCTTCTTACCGGTCACGAGCTGGCTGATGGGTGACAACCCCGTCGTTACCAGCGGGCCCGTCTCCCTCTTCGGCTTCTCG
TTCGAGCTCTCCGCGGCGGCCAAGCTCTGGCTCAGTGCGCTGGTCGGTCTGGTGGTGACCATCGGCATGGTCGTTTTCAC
AGAATTCTTCACTTCGGAAAAGTACAGCCCGGTCAAGCGGATCGCCGCTGCCTCGGAAACCGGACATGCGACCAACATCA
TCAGTGGCCTGGCTGTCTCGATGCAAGCCACTTTTCCACCCATCGTCCTCATCGCTTTGGCGATTTATGTCGCTTACAAT
TTGACGCATTCTGCGTCGTCACCGTACAGCGGTCTCTACGGGCTGGCAGTTGCCGCTATGGCCATGCTCTCCATGACCGG
CATGATCGTCGCCGTCGATTCCTTCGGGCCCATTACCGATAACGCCGGAGGTATTGCCGAAATGGCCGAACTTCCAGATG
AAGTCCGGTCGGTCACCGACCCTCTCGACGCCGTAGGCAATACCACCAAGGCAGTCACCAAGGCGTACGCGATCGGCTCG
GCTGGTCTTGCGGCCCTCGTCCTCTTTGCCTCGTACTATTTGGAGCTCTCGGAGCAGCTCGTCTTCGAGTTGTCCAATCC
GCGCGTCGTGATCGGCATATTCATCGGCGCTGCACTTCCCTACTTTTTCGCAAGCTTTCTCATGGAAGCGGTGGGGAAAG
CCGGCGGCGCAGTCGTGCAAGAAGTACGACGACAGTTTCGCGAGATTCCTGGTTTGTTGGAAGGGAAGGCCCGTCCAGAG
TACGGTCGTGCCGTCGATATCGTGACCCGCGAAGCACTGCGCCAGATGCTGGTGCCGGTTCTCATCACGATCCTCGCCCC
CATCATCGTGGCCGTTCTTCTGGGCAAGGAGGCACTCGGCGGATTGCTCATCGGCTCCATCGTGACCGGACTCTTCGTCG
CCATCTCCATGACGACCGGGGGCGCTGCCTGGGACAACGCCAAGAAGTTCATCGAATCCGGTGCCCACGGCGGAAAGGGC
AGCTTCGCACATCAGGCGGCTGTAACCGGCGACACAGTCGGTGATCCGTACAAAGACACCGCCGGCCCCGCCATCAACCC
GATGATCAAGGTCGTCAATATCGTCGCACTCTTGATCGTGAAGGCGCTCGGCTGGGGTTGA

Upstream 100 bases:

>100_bases
CCATCTGGCCGGAGTATCGTGTGCAGTCCTTCATCCTCGCGACACTTCGGGGTGACGAAGAACTGGTGTTCCGACCGAAC
GAGGGAGGGGTAACAGGACC

Downstream 100 bases:

>100_bases
TGATCGTCACTGTAGCAGAACCTCGCGCGATCGCCCGGAGCTTCCTGCCCGGGCGATCGCGCTTGTGTCACCAGCGTTCG
ACGAGCAGTGGTCGCTCGGC

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MENTALYLALGAAVLALLYGAILIRWVLAQPRGDERMQAIAQAIQEGAEAYMRRQYTLVAIVAVIVALILGFAVDWTTAV
GFLVGAIASGLAGFIGMSIAVRANVRTAEAAKRGLERALAVAFRGGAVTGLLVAGLGLLSVTLFYLITRNVTALVGLGFG
GSLISVFARIGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTAIAAMLLGHLV
FGTEVAVVYPLALGAVSILTSIIGTFFVRLDASRSIMRALYKGVIAAMLLAAILFLPVTSWLMGDNPVVTSGPVSLFGFS
FELSAAAKLWLSALVGLVVTIGMVVFTEFFTSEKYSPVKRIAAASETGHATNIISGLAVSMQATFPPIVLIALAIYVAYN
LTHSASSPYSGLYGLAVAAMAMLSMTGMIVAVDSFGPITDNAGGIAEMAELPDEVRSVTDPLDAVGNTTKAVTKAYAIGS
AGLAALVLFASYYLELSEQLVFELSNPRVVIGIFIGAALPYFFASFLMEAVGKAGGAVVQEVRRQFREIPGLLEGKARPE
YGRAVDIVTREALRQMLVPVLITILAPIIVAVLLGKEALGGLLIGSIVTGLFVAISMTTGGAAWDNAKKFIESGAHGGKG
SFAHQAAVTGDTVGDPYKDTAGPAINPMIKVVNIVALLIVKALGWG

Sequences:

>Translated_686_residues
MENTALYLALGAAVLALLYGAILIRWVLAQPRGDERMQAIAQAIQEGAEAYMRRQYTLVAIVAVIVALILGFAVDWTTAV
GFLVGAIASGLAGFIGMSIAVRANVRTAEAAKRGLERALAVAFRGGAVTGLLVAGLGLLSVTLFYLITRNVTALVGLGFG
GSLISVFARIGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTAIAAMLLGHLV
FGTEVAVVYPLALGAVSILTSIIGTFFVRLDASRSIMRALYKGVIAAMLLAAILFLPVTSWLMGDNPVVTSGPVSLFGFS
FELSAAAKLWLSALVGLVVTIGMVVFTEFFTSEKYSPVKRIAAASETGHATNIISGLAVSMQATFPPIVLIALAIYVAYN
LTHSASSPYSGLYGLAVAAMAMLSMTGMIVAVDSFGPITDNAGGIAEMAELPDEVRSVTDPLDAVGNTTKAVTKAYAIGS
AGLAALVLFASYYLELSEQLVFELSNPRVVIGIFIGAALPYFFASFLMEAVGKAGGAVVQEVRRQFREIPGLLEGKARPE
YGRAVDIVTREALRQMLVPVLITILAPIIVAVLLGKEALGGLLIGSIVTGLFVAISMTTGGAAWDNAKKFIESGAHGGKG
SFAHQAAVTGDTVGDPYKDTAGPAINPMIKVVNIVALLIVKALGWG
>Mature_686_residues
MENTALYLALGAAVLALLYGAILIRWVLAQPRGDERMQAIAQAIQEGAEAYMRRQYTLVAIVAVIVALILGFAVDWTTAV
GFLVGAIASGLAGFIGMSIAVRANVRTAEAAKRGLERALAVAFRGGAVTGLLVAGLGLLSVTLFYLITRNVTALVGLGFG
GSLISVFARIGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTAIAAMLLGHLV
FGTEVAVVYPLALGAVSILTSIIGTFFVRLDASRSIMRALYKGVIAAMLLAAILFLPVTSWLMGDNPVVTSGPVSLFGFS
FELSAAAKLWLSALVGLVVTIGMVVFTEFFTSEKYSPVKRIAAASETGHATNIISGLAVSMQATFPPIVLIALAIYVAYN
LTHSASSPYSGLYGLAVAAMAMLSMTGMIVAVDSFGPITDNAGGIAEMAELPDEVRSVTDPLDAVGNTTKAVTKAYAIGS
AGLAALVLFASYYLELSEQLVFELSNPRVVIGIFIGAALPYFFASFLMEAVGKAGGAVVQEVRRQFREIPGLLEGKARPE
YGRAVDIVTREALRQMLVPVLITILAPIIVAVLLGKEALGGLLIGSIVTGLFVAISMTTGGAAWDNAKKFIESGAHGGKG
SFAHQAAVTGDTVGDPYKDTAGPAINPMIKVVNIVALLIVKALGWG

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 71116; Mature: 71116

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENTALYLALGAAVLALLYGAILIRWVLAQPRGDERMQAIAQAIQEGAEAYMRRQYTLVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVAVIVALILGFAVDWTTAVGFLVGAIASGLAGFIGMSIAVRANVRTAEAAKRGLERALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHH
VAFRGGAVTGLLVAGLGLLSVTLFYLITRNVTALVGLGFGGSLISVFARIGGGIYTKAAD
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHCCCHHHHHHH
VGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTAIAAMLLGHLV
HCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGTEVAVVYPLALGAVSILTSIIGTFFVRLDASRSIMRALYKGVIAAMLLAAILFLPVTS
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLMGDNPVVTSGPVSLFGFSFELSAAAKLWLSALVGLVVTIGMVVFTEFFTSEKYSPVKR
HHCCCCCCCCCCCHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
IAAASETGHATNIISGLAVSMQATFPPIVLIALAIYVAYNLTHSASSPYSGLYGLAVAAM
HHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
AMLSMTGMIVAVDSFGPITDNAGGIAEMAELPDEVRSVTDPLDAVGNTTKAVTKAYAIGS
HHHHHHHHEEEECCCCCCCCCCCCHHHHHHCHHHHHHHHCHHHHHCCHHHHHHHHHHHCH
AGLAALVLFASYYLELSEQLVFELSNPRVVIGIFIGAALPYFFASFLMEAVGKAGGAVVQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EVRRQFREIPGLLEGKARPEYGRAVDIVTREALRQMLVPVLITILAPIIVAVLLGKEALG
HHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLIGSIVTGLFVAISMTTGGAAWDNAKKFIESGAHGGKGSFAHQAAVTGDTVGDPYKDT
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCC
AGPAINPMIKVVNIVALLIVKALGWG
CCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MENTALYLALGAAVLALLYGAILIRWVLAQPRGDERMQAIAQAIQEGAEAYMRRQYTLVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVAVIVALILGFAVDWTTAVGFLVGAIASGLAGFIGMSIAVRANVRTAEAAKRGLERALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHH
VAFRGGAVTGLLVAGLGLLSVTLFYLITRNVTALVGLGFGGSLISVFARIGGGIYTKAAD
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHCCCHHHHHHH
VGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTAIAAMLLGHLV
HCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGTEVAVVYPLALGAVSILTSIIGTFFVRLDASRSIMRALYKGVIAAMLLAAILFLPVTS
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLMGDNPVVTSGPVSLFGFSFELSAAAKLWLSALVGLVVTIGMVVFTEFFTSEKYSPVKR
HHCCCCCCCCCCCHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
IAAASETGHATNIISGLAVSMQATFPPIVLIALAIYVAYNLTHSASSPYSGLYGLAVAAM
HHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
AMLSMTGMIVAVDSFGPITDNAGGIAEMAELPDEVRSVTDPLDAVGNTTKAVTKAYAIGS
HHHHHHHHEEEECCCCCCCCCCCCHHHHHHCHHHHHHHHCHHHHHCCHHHHHHHHHHHCH
AGLAALVLFASYYLELSEQLVFELSNPRVVIGIFIGAALPYFFASFLMEAVGKAGGAVVQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EVRRQFREIPGLLEGKARPEYGRAVDIVTREALRQMLVPVLITILAPIIVAVLLGKEALG
HHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLIGSIVTGLFVAISMTTGGAAWDNAKKFIESGAHGGKGSFAHQAAVTGDTVGDPYKDT
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCC
AGPAINPMIKVVNIVALLIVKALGWG
CCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]