| Definition | Thermomicrobium roseum DSM 5159 chromosome, complete genome. |
|---|---|
| Accession | NC_011959 |
| Length | 2,003,006 |
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The map label for this gene is polA [H]
Identifier: 221632712
GI number: 221632712
Start: 687543
End: 690296
Strand: Reverse
Name: polA [H]
Synonym: trd_0700
Alternate gene names: 221632712
Gene position: 690296-687543 (Counterclockwise)
Preceding gene: 221632717
Following gene: 221632711
Centisome position: 34.46
GC content: 59.44
Gene sequence:
>2754_bases ATGCCGGAGCGCTCACGTCGACCACGCCTGGTACTCGTTGATGGACATGGGCTCGCCTATCGCGCGTATCACGCGTTGCC CCCGACTCTCGCGACCAGTGCCGGCGAACCGACACATGTGGTGTTCGGATTCGCCAGCATGTTATTGGAAGTGCTGAACG ATTTCGAACCCGATTACGTCATCGTCTGTTTCGATACGGGACGGAGCTTTCGACAACAACTCTACGAGGAATACAAGGCT CACCGCCCTGAAACACCGGATGACCTCAAGCACCAGCTCGAGCGAATCCGCCAACTACTCGATGCGTTGGGAATCCCGAT CGTCACGCGCGAGGGCTACGAAGCTGATGACCTCATCGGGACACTCGCTGCTCGCGCCACTGCCAACGGGCTCGAAGTTC TGATCGTCACCGGCGATACCGATTTGCTCCAGCTCGTCGATGAAGATGTCCGTGTCATCCTTCCCGGTCGCCAACGCTTC GGCGATTACCGTGTTTATGACCGTCAAGCAGTCATCGAGCGGTACGGCTTTCCACCCGAACGGTTGCCCGAATACAAGGC ACTGGTCGGTGATCCGTCCGACAACATTCCTGGAGTCCCGGGAATCGGCGAGAAGACAGCGACACGACTCATCCAGCGAT TCTCCTCCCTCGAGGAGATGCTCGACCGCATCGACGAAGTCGAACCGCCGCGACTGCGCGAGGCGCTTCGGGCGGCCCGC GAAACCGTTCTCGCAAGTCGCCGCCTCGCCACCATCGTTCGCGATGCAGACATCACCCTCGACCTCGAACAGGCTCGCTT CGGCGATTTCGACCGGGAACGGGTCCTCCAGCTGTTTCGCGAACTCGAGTTCCGCAGCCTGGTTCCTCGACTTCCGCAAC CGCGCCAGCCGGTGCGGAAGACGGCGGCACCAGCGAGTCAGCGACGCGCCGTCCTGACCGATGCCGATTTGAGCGACCTT GTCCGGGATTTGGAAACCTGTCAGGCCTTTGCGCTCGATGTAGAGACGACAGCTTTGCATCCCATGTACGCCGACCTCGT GGGCATCGCGTTGGCGACAGCTCCCGACCGGAGCTATTACGTGCCGCTCGGACACACGACGGGTGATACCCAACTCGATA TCGAACAGGTGTTGCAACGACTGGCGCCCTTCCTGCGCCATCCAGAGAAGCAACGTTATGCGCACCACGGCAAATACGAT GCCCTGGTCTTGGAACGTGCCGGTTTTCCCCGACCACACATCGACTTCGATACGATGATCGCCGCCTACCTACTGGGCGA AAATGCTGTCGGCCTCAAAGAATTGGCATTCACGAAGCTCGGGTGGGAGATGGAGGAAATCACCGAGCTAATTGGACGGG GCAAGAAGCAACTCACGATGGATCGCGCCGAGATCGCACGGGTCACGCAATACGCCTGTGCCGACGTCGAGGCGACATAC CGGTTAGTCGAGGTACTTCGTCCACAACTCGAAGCCCACAATCAACTCCGGCTGTTCACCGAAATCGAACTTCCTCTCAT CGATGTACTGATCGACATGGAAAAGGCGGGAATCGCGATCGATGTGCCGTACCTCGAACAGCTCTCCATCATGCTGGACG GTCAGCTGCATGCGCTCGAGCGACGCATCTACGAACTGGCTGGGCATCCCTTCAACATCAACTCGCCACAACAGTTGAGC ACCCTGCTCTTCGACGAACTCGGCCTGCCTCGCGGCAAACGAACCAAGACTGGGTATTCAGTTTCTCAAGAAGTGCTCGA GAATCTCCGCGATACCCACCCCATCGTCGAGGCGATTTTGGAATACCGGCAACTCCTCAAATTGAAGTCGACGTACGTCG ATGCCTTACCGCGGCAAGTCCATCCCCAAACCGGACGCGTCCACACGATTTTCCATCAAACTGTCGCGGCCACCGGCCGC TTGAGCTCCTCCGACCCGAACCTTCAGAACATTCCTGCTCGCGGCGAGCTGGGACTCGCCGTTCGCCGCGCCTTCATCGC TGACAATCGCCCAGGTTATCGAATCGCCGATGAACCGATCCTGCTTCTTTCAGTTGACTACTCGCAGATCGAGCTTCGCC TGATGGCTCACTTCAGTCAGGATCCCGCACTCCTGCGTGCCTTCGCTGAAGGCAAGGACATTCACGCGGCTACCGCGTCT GAAGTGTTCGGGGTCCCACTCGACGCGGTCACGCCAGAGATGCGTCGCATCGCGAAAGTCGTCAATTTCGGCATCATGTA TGGGATGCAAGCGTACGGCCTCGCTCGCGACACCGGTATGAGCCGTCAAGACGCACAGCGCTTCATCGAAGCGTATTTTC AGCGCTTCCCCGGCGTCGCCCGTTATCTCGAAGAAACGAGACGCCGTGCGGCCGAACTCGGTTACGTCGAAACGCTCTTC GGCCGGCGGCGATACTTGCCCGAAATCACCTCCTCCAACCCGGCACGACGGCAGGCGGCCGAACGGATGGCGGTCAATAT GCCGCTGCAAGGCACCGCAGCCGATATTATGAAGTTGGCCATGATCGCTGTCCACCGAGCGCTGGCCGAACGCGGCTTGC GCAGCCGCATGCTGCTCCAGGTTCATGACGAACTCGTCCTGGAGGTACCGGAGTCGGAACTTGCGACGACAACGGAACTC GTCACGACACGCATGAGTCGCGTCGTCGAACTCAGCGTGCCACTCGAAGTCGATGCCAAAGCGGGGCCCAATTGGGCTGA CCTTGAGCCGGTTCGAGTGAAACTCTCCCACTAG
Upstream 100 bases:
>100_bases TCTGATCCTGCTCTTCACCGAGCCTACTCTTCCGGCCTGAGAAAATCCTGAGACGACGCCTTGGTCTCGTCTATAATCCC CGCGACGAGGAGAGGGTGCC
Downstream 100 bases:
>100_bases ACCTTGCTCAAGGATGCGACGGCGATTACAATTTTCCGGGCGGGACGCGATCGACTCTTGCCACGCAGGAGGGGTGGTCG ATGCCGATCTACGAATACGA
Product: DNA polymerase I
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 917; Mature: 916
Protein sequence:
>917_residues MPERSRRPRLVLVDGHGLAYRAYHALPPTLATSAGEPTHVVFGFASMLLEVLNDFEPDYVIVCFDTGRSFRQQLYEEYKA HRPETPDDLKHQLERIRQLLDALGIPIVTREGYEADDLIGTLAARATANGLEVLIVTGDTDLLQLVDEDVRVILPGRQRF GDYRVYDRQAVIERYGFPPERLPEYKALVGDPSDNIPGVPGIGEKTATRLIQRFSSLEEMLDRIDEVEPPRLREALRAAR ETVLASRRLATIVRDADITLDLEQARFGDFDRERVLQLFRELEFRSLVPRLPQPRQPVRKTAAPASQRRAVLTDADLSDL VRDLETCQAFALDVETTALHPMYADLVGIALATAPDRSYYVPLGHTTGDTQLDIEQVLQRLAPFLRHPEKQRYAHHGKYD ALVLERAGFPRPHIDFDTMIAAYLLGENAVGLKELAFTKLGWEMEEITELIGRGKKQLTMDRAEIARVTQYACADVEATY RLVEVLRPQLEAHNQLRLFTEIELPLIDVLIDMEKAGIAIDVPYLEQLSIMLDGQLHALERRIYELAGHPFNINSPQQLS TLLFDELGLPRGKRTKTGYSVSQEVLENLRDTHPIVEAILEYRQLLKLKSTYVDALPRQVHPQTGRVHTIFHQTVAATGR LSSSDPNLQNIPARGELGLAVRRAFIADNRPGYRIADEPILLLSVDYSQIELRLMAHFSQDPALLRAFAEGKDIHAATAS EVFGVPLDAVTPEMRRIAKVVNFGIMYGMQAYGLARDTGMSRQDAQRFIEAYFQRFPGVARYLEETRRRAAELGYVETLF GRRRYLPEITSSNPARRQAAERMAVNMPLQGTAADIMKLAMIAVHRALAERGLRSRMLLQVHDELVLEVPESELATTTEL VTTRMSRVVELSVPLEVDAKAGPNWADLEPVRVKLSH
Sequences:
>Translated_917_residues MPERSRRPRLVLVDGHGLAYRAYHALPPTLATSAGEPTHVVFGFASMLLEVLNDFEPDYVIVCFDTGRSFRQQLYEEYKA HRPETPDDLKHQLERIRQLLDALGIPIVTREGYEADDLIGTLAARATANGLEVLIVTGDTDLLQLVDEDVRVILPGRQRF GDYRVYDRQAVIERYGFPPERLPEYKALVGDPSDNIPGVPGIGEKTATRLIQRFSSLEEMLDRIDEVEPPRLREALRAAR ETVLASRRLATIVRDADITLDLEQARFGDFDRERVLQLFRELEFRSLVPRLPQPRQPVRKTAAPASQRRAVLTDADLSDL VRDLETCQAFALDVETTALHPMYADLVGIALATAPDRSYYVPLGHTTGDTQLDIEQVLQRLAPFLRHPEKQRYAHHGKYD ALVLERAGFPRPHIDFDTMIAAYLLGENAVGLKELAFTKLGWEMEEITELIGRGKKQLTMDRAEIARVTQYACADVEATY RLVEVLRPQLEAHNQLRLFTEIELPLIDVLIDMEKAGIAIDVPYLEQLSIMLDGQLHALERRIYELAGHPFNINSPQQLS TLLFDELGLPRGKRTKTGYSVSQEVLENLRDTHPIVEAILEYRQLLKLKSTYVDALPRQVHPQTGRVHTIFHQTVAATGR LSSSDPNLQNIPARGELGLAVRRAFIADNRPGYRIADEPILLLSVDYSQIELRLMAHFSQDPALLRAFAEGKDIHAATAS EVFGVPLDAVTPEMRRIAKVVNFGIMYGMQAYGLARDTGMSRQDAQRFIEAYFQRFPGVARYLEETRRRAAELGYVETLF GRRRYLPEITSSNPARRQAAERMAVNMPLQGTAADIMKLAMIAVHRALAERGLRSRMLLQVHDELVLEVPESELATTTEL VTTRMSRVVELSVPLEVDAKAGPNWADLEPVRVKLSH >Mature_916_residues PERSRRPRLVLVDGHGLAYRAYHALPPTLATSAGEPTHVVFGFASMLLEVLNDFEPDYVIVCFDTGRSFRQQLYEEYKAH RPETPDDLKHQLERIRQLLDALGIPIVTREGYEADDLIGTLAARATANGLEVLIVTGDTDLLQLVDEDVRVILPGRQRFG DYRVYDRQAVIERYGFPPERLPEYKALVGDPSDNIPGVPGIGEKTATRLIQRFSSLEEMLDRIDEVEPPRLREALRAARE TVLASRRLATIVRDADITLDLEQARFGDFDRERVLQLFRELEFRSLVPRLPQPRQPVRKTAAPASQRRAVLTDADLSDLV RDLETCQAFALDVETTALHPMYADLVGIALATAPDRSYYVPLGHTTGDTQLDIEQVLQRLAPFLRHPEKQRYAHHGKYDA LVLERAGFPRPHIDFDTMIAAYLLGENAVGLKELAFTKLGWEMEEITELIGRGKKQLTMDRAEIARVTQYACADVEATYR LVEVLRPQLEAHNQLRLFTEIELPLIDVLIDMEKAGIAIDVPYLEQLSIMLDGQLHALERRIYELAGHPFNINSPQQLST LLFDELGLPRGKRTKTGYSVSQEVLENLRDTHPIVEAILEYRQLLKLKSTYVDALPRQVHPQTGRVHTIFHQTVAATGRL SSSDPNLQNIPARGELGLAVRRAFIADNRPGYRIADEPILLLSVDYSQIELRLMAHFSQDPALLRAFAEGKDIHAATASE VFGVPLDAVTPEMRRIAKVVNFGIMYGMQAYGLARDTGMSRQDAQRFIEAYFQRFPGVARYLEETRRRAAELGYVETLFG RRRYLPEITSSNPARRQAAERMAVNMPLQGTAADIMKLAMIAVHRALAERGLRSRMLLQVHDELVLEVPESELATTTELV TTRMSRVVELSVPLEVDAKAGPNWADLEPVRVKLSH
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=470, Percent_Identity=34.0425531914894, Blast_Score=242, Evalue=1e-63, Organism=Homo sapiens, GI139394648, Length=546, Percent_Identity=28.7545787545788, Blast_Score=227, Evalue=5e-59, Organism=Escherichia coli, GI1790294, Length=933, Percent_Identity=42.3365487674169, Blast_Score=674, Evalue=0.0, Organism=Escherichia coli, GI226510970, Length=215, Percent_Identity=32.093023255814, Blast_Score=117, Evalue=3e-27, Organism=Caenorhabditis elegans, GI86563272, Length=437, Percent_Identity=31.5789473684211, Blast_Score=211, Evalue=1e-54, Organism=Drosophila melanogaster, GI17933644, Length=429, Percent_Identity=33.3333333333333, Blast_Score=214, Evalue=2e-55,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR012337 [H]
Pfam domain/function: PF01612 3_5_exonuc; PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 103539; Mature: 103408
Theoretical pI: Translated: 5.91; Mature: 5.91
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPERSRRPRLVLVDGHGLAYRAYHALPPTLATSAGEPTHVVFGFASMLLEVLNDFEPDYV CCCCCCCCEEEEECCCCCEEHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEE IVCFDTGRSFRQQLYEEYKAHRPETPDDLKHQLERIRQLLDALGIPIVTREGYEADDLIG EEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHH TLAARATANGLEVLIVTGDTDLLQLVDEDVRVILPGRQRFGDYRVYDRQAVIERYGFPPE HHHHHHCCCCCEEEEEECCHHHHHHHCCCCEEEECCHHHCCCCHHHHHHHHHHHCCCCHH RLPEYKALVGDPSDNIPGVPGIGEKTATRLIQRFSSLEEMLDRIDEVEPPRLREALRAAR HCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH ETVLASRRLATIVRDADITLDLEQARFGDFDRERVLQLFRELEFRSLVPRLPQPRQPVRK HHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHH TAAPASQRRAVLTDADLSDLVRDLETCQAFALDVETTALHPMYADLVGIALATAPDRSYY HCCCHHHCCEEECCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCCCCCEE VPLGHTTGDTQLDIEQVLQRLAPFLRHPEKQRYAHHGKYDALVLERAGFPRPHIDFDTMI EECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHH AAYLLGENAVGLKELAFTKLGWEMEEITELIGRGKKQLTMDRAEIARVTQYACADVEATY HHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH RLVEVLRPQLEAHNQLRLFTEIELPLIDVLIDMEKAGIAIDVPYLEQLSIMLDGQLHALE HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCHHHHHH RRIYELAGHPFNINSPQQLSTLLFDELGLPRGKRTKTGYSVSQEVLENLRDTHPIVEAIL HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHH EYRQLLKLKSTYVDALPRQVHPQTGRVHTIFHQTVAATGRLSSSDPNLQNIPARGELGLA HHHHHHHHHHHHHHHCCHHCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH VRRAFIADNRPGYRIADEPILLLSVDYSQIELRLMAHFSQDPALLRAFAEGKDIHAATAS HHHHHHHCCCCCCEECCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHH EVFGVPLDAVTPEMRRIAKVVNFGIMYGMQAYGLARDTGMSRQDAQRFIEAYFQRFPGVA HHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHCCHHH RYLEETRRRAAELGYVETLFGRRRYLPEITSSNPARRQAAERMAVNMPLQGTAADIMKLA HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH MIAVHRALAERGLRSRMLLQVHDELVLEVPESELATTTELVTTRMSRVVELSVPLEVDAK HHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCEEECCC AGPNWADLEPVRVKLSH CCCCCCCCCCEEEEECC >Mature Secondary Structure PERSRRPRLVLVDGHGLAYRAYHALPPTLATSAGEPTHVVFGFASMLLEVLNDFEPDYV CCCCCCCEEEEECCCCCEEHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEE IVCFDTGRSFRQQLYEEYKAHRPETPDDLKHQLERIRQLLDALGIPIVTREGYEADDLIG EEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHH TLAARATANGLEVLIVTGDTDLLQLVDEDVRVILPGRQRFGDYRVYDRQAVIERYGFPPE HHHHHHCCCCCEEEEEECCHHHHHHHCCCCEEEECCHHHCCCCHHHHHHHHHHHCCCCHH RLPEYKALVGDPSDNIPGVPGIGEKTATRLIQRFSSLEEMLDRIDEVEPPRLREALRAAR HCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH ETVLASRRLATIVRDADITLDLEQARFGDFDRERVLQLFRELEFRSLVPRLPQPRQPVRK HHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHH TAAPASQRRAVLTDADLSDLVRDLETCQAFALDVETTALHPMYADLVGIALATAPDRSYY HCCCHHHCCEEECCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCCCCCEE VPLGHTTGDTQLDIEQVLQRLAPFLRHPEKQRYAHHGKYDALVLERAGFPRPHIDFDTMI EECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHH AAYLLGENAVGLKELAFTKLGWEMEEITELIGRGKKQLTMDRAEIARVTQYACADVEATY HHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH RLVEVLRPQLEAHNQLRLFTEIELPLIDVLIDMEKAGIAIDVPYLEQLSIMLDGQLHALE HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCHHHHHH RRIYELAGHPFNINSPQQLSTLLFDELGLPRGKRTKTGYSVSQEVLENLRDTHPIVEAIL HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHH EYRQLLKLKSTYVDALPRQVHPQTGRVHTIFHQTVAATGRLSSSDPNLQNIPARGELGLA HHHHHHHHHHHHHHHCCHHCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH VRRAFIADNRPGYRIADEPILLLSVDYSQIELRLMAHFSQDPALLRAFAEGKDIHAATAS HHHHHHHCCCCCCEECCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHH EVFGVPLDAVTPEMRRIAKVVNFGIMYGMQAYGLARDTGMSRQDAQRFIEAYFQRFPGVA HHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHCCHHH RYLEETRRRAAELGYVETLFGRRRYLPEITSSNPARRQAAERMAVNMPLQGTAADIMKLA HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH MIAVHRALAERGLRSRMLLQVHDELVLEVPESELATTTELVTTRMSRVVELSVPLEVDAK HHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCEEECCC AGPNWADLEPVRVKLSH CCCCCCCCCCEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9526698 [H]