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The map label for this gene is sdhB [H]

Identifier: 221632359

GI number: 221632359

Start: 333169

End: 333864

Strand: Reverse

Name: sdhB [H]

Synonym: trd_0330

Alternate gene names: 221632359

Gene position: 333864-333169 (Counterclockwise)

Preceding gene: 221632360

Following gene: 221632358

Centisome position: 16.67

GC content: 60.06

Gene sequence:

>696_bases
ATGCAGGTGACGTTGCGTATCCAACGGTTCAATCCCGAAACCGATACCAAACCGTACTACCGCGAGTACACGGTCGAGGT
CGAACCGACTGATCGGGTCCTCGATGCGCTCAACTACGTCAAGTGGTACCAGGATGGCAGCTTGACCTTCCGCCGCAGCT
GCGCGCACGGCGTCTGTGGTTCCGACGCCATGCGTATCAATGGGCGCAATCGACTGGCCTGCAAGGTGCTCATCAAGGAC
CTCGGGCCGAAAATCACGATCGAGCCGTTGCTCGGCTTTCGCATCATCCGTGACCTCGTCGTGGACATGGAGCCCTTCTT
CGCCCAGTATCGCACCGTCATGCCTTACCTCATCAACGAGGAGCCACCACCGGTCCGCGAGCGCCTGCAATCACCGGAGG
AGCGCGCTCTCTACGACGATACGACCAAGTGCATTCTCTGCGCCTGTTGTACCTCCGCCTGCCCCATTTTCTGGACGAAC
GAATGGCTCGGCCCGGCCGCGATCGTGAACGCGCATCGCTTTTTGTTCGACTCGCGCGATCGGGCGACCGAGGAGCGACT
TGCGATTCTCAACCAGCGATTCGGTGTGTGGCGCTGCCGGACGATCTTCAATTGCACGGAAGCATGCCCGCGTGGTATCC
AGGTCACCAACGCGATCGAGCAGGTCAAGCGCCGTATCCTCTTCGAGCAAAGCTAG

Upstream 100 bases:

>100_bases
CTCAAGCACACCCTGATCGCTCGGACATCAGGTGGACTCCAGCTCTTCTACAAGCCAGTCGTCATCACGCGGTTCGAGCC
GAAGGAACGGGTGTACTGAG

Downstream 100 bases:

>100_bases
CGGGAGCCAGCGATGCGTAATCCGTTCGACTGGGACTACCTGACCGCTCCGCTCTGGCAAATGCCTACTTGGGGACCGCT
CTCGATCACGTACGTCGTCG

Product: succinate dehydrogenase iron-sulfur protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MQVTLRIQRFNPETDTKPYYREYTVEVEPTDRVLDALNYVKWYQDGSLTFRRSCAHGVCGSDAMRINGRNRLACKVLIKD
LGPKITIEPLLGFRIIRDLVVDMEPFFAQYRTVMPYLINEEPPPVRERLQSPEERALYDDTTKCILCACCTSACPIFWTN
EWLGPAAIVNAHRFLFDSRDRATEERLAILNQRFGVWRCRTIFNCTEACPRGIQVTNAIEQVKRRILFEQS

Sequences:

>Translated_231_residues
MQVTLRIQRFNPETDTKPYYREYTVEVEPTDRVLDALNYVKWYQDGSLTFRRSCAHGVCGSDAMRINGRNRLACKVLIKD
LGPKITIEPLLGFRIIRDLVVDMEPFFAQYRTVMPYLINEEPPPVRERLQSPEERALYDDTTKCILCACCTSACPIFWTN
EWLGPAAIVNAHRFLFDSRDRATEERLAILNQRFGVWRCRTIFNCTEACPRGIQVTNAIEQVKRRILFEQS
>Mature_231_residues
MQVTLRIQRFNPETDTKPYYREYTVEVEPTDRVLDALNYVKWYQDGSLTFRRSCAHGVCGSDAMRINGRNRLACKVLIKD
LGPKITIEPLLGFRIIRDLVVDMEPFFAQYRTVMPYLINEEPPPVRERLQSPEERALYDDTTKCILCACCTSACPIFWTN
EWLGPAAIVNAHRFLFDSRDRATEERLAILNQRFGVWRCRTIFNCTEACPRGIQVTNAIEQVKRRILFEQS

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=227, Percent_Identity=44.4933920704846, Blast_Score=186, Evalue=2e-47,
Organism=Escherichia coli, GI1786943, Length=235, Percent_Identity=47.6595744680851, Blast_Score=218, Evalue=3e-58,
Organism=Escherichia coli, GI1790596, Length=224, Percent_Identity=39.7321428571429, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17533915, Length=227, Percent_Identity=40.9691629955947, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6322987, Length=231, Percent_Identity=44.1558441558442, Blast_Score=195, Evalue=7e-51,
Organism=Drosophila melanogaster, GI17137106, Length=229, Percent_Identity=43.6681222707424, Blast_Score=180, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24643156, Length=231, Percent_Identity=41.5584415584416, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26907; Mature: 26907

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTLRIQRFNPETDTKPYYREYTVEVEPTDRVLDALNYVKWYQDGSLTFRRSCAHGVCG
CEEEEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCC
SDAMRINGRNRLACKVLIKDLGPKITIEPLLGFRIIRDLVVDMEPFFAQYRTVMPYLINE
CCEEEECCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHCCC
EPPPVRERLQSPEERALYDDTTKCILCACCTSACPIFWTNEWLGPAAIVNAHRFLFDSRD
CCCHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCC
RATEERLAILNQRFGVWRCRTIFNCTEACPRGIQVTNAIEQVKRRILFEQS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQVTLRIQRFNPETDTKPYYREYTVEVEPTDRVLDALNYVKWYQDGSLTFRRSCAHGVCG
CEEEEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCC
SDAMRINGRNRLACKVLIKDLGPKITIEPLLGFRIIRDLVVDMEPFFAQYRTVMPYLINE
CCEEEECCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHCCC
EPPPVRERLQSPEERALYDDTTKCILCACCTSACPIFWTNEWLGPAAIVNAHRFLFDSRD
CCCHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCC
RATEERLAILNQRFGVWRCRTIFNCTEACPRGIQVTNAIEQVKRRILFEQS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]