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The map label for this gene is gcvPB [H]

Identifier: 221632198

GI number: 221632198

Start: 168824

End: 170290

Strand: Reverse

Name: gcvPB [H]

Synonym: trd_0164

Alternate gene names: 221632198

Gene position: 170290-168824 (Counterclockwise)

Preceding gene: 221632204

Following gene: 221632197

Centisome position: 8.5

GC content: 63.39

Gene sequence:

>1467_bases
ATGCGCGTGGAACCGCTCATTTTCGAGCTTTCCAAGCCGGGACGGACGGGTACCTCGGTACCGGATCTCGATGTCCCGGA
GGCACCACTGCCCGTCGAACACGTGCGGGACGATTTGCCGCTCCCCGAAGTCAGCGAGATCGATGTCGTGCGGCACTTCA
CCCGCCTCTCGCAGCTCAACCATGCCGTCGATATCGACTTTTACCCGCTGGGCTCCTGCACCATGAAGTACAACCCGAAG
ATCAACGAGCTGGTGGCTCGCTTTCCCGGTTTCGCACATCTCCATCCGCTCCAGGATCCGCGAACCGTGCAAGGCATTCT
TCGCCTGATGTATGAACTGCAAGGGTTCCTGGCGGAGATCGCTGGCTTCGACGCCGTCTCGCTGCAGCCAGCCGCTGGCG
CGCACGGAGAACTCACCGGCATCCTCATCGCGCGAGCGTACTTCGATGCCCGCGGCGAACACGAGCGCCGGACCGTCATC
ATCCCGGATTCGGCACACGGCACCAATCCAGCCACCGCAGCCATGGCCGGATTCCGGGTCGTCGAAGTCAAGTCGGATGC
GCGTGGCAATGTGGATATCGAACAATTGCGGCAGCTCGTCGGGCCGGACACCGCAGCGATCATGATCACCAACCCTAACA
CGCTCGGTCTCTGGGACGAGAACATCACCGAGATCGTCGACCTGATCCACAGCGTCGGCGGACTCGTCTACAACGACGGT
GCGAACTTCAACGCGCTGCTCGGCATCGCGCGCCCCGGCGACTTCGGCGTCGACATTATGCACTTCAACTTGCACAAGAC
CTTCTCGACACCGCACGGCGGTGGCGGCCCGGGAAGTGGGCCGGTCGGGGTCAAAGCGCACCTCGCCGAGTTCCTCCCTG
GCCCGATCGTCGTACGACGCCCCGGCGAGGATCCCGAGTACACCTGGCACTGGCCTGAGCGCTCCATCGGCAAGATCCAT
TCCTTCCACGGGAATGTCGGGATGCACATCCGCGCCTATGCGTACATCCGTATGCACGGCGGGAGCGGACTCCGCCGAGT
CAGCGAGGACGCCGTGCTGGCAGCCAACTATCTCCTGGCCCGTCTGCGCGATGTGTACGAGGTGCCGTACGACCGGACCT
GCATGCACGAGTTCGTGCTCTCTGCTGTGCGCCAGAAGCGGCATGGTGTGCGAGCGATGGATATCGCCAAGCGCTTGCTC
GATTTCGGTCTCCACCCACCGACGGTCGCCTTCCCCTTGATCGTCCAGGAAGCGCTGATGATCGAGCCCACCGAGACGGA
GAGTCTGGAAACGCTCGACCGCTTCGTCGCGGCCATGCGGCAGATCGCCGAGGAAGTGGAGCGCGATCCAGAATTCGTGC
GTCAGGCACCGCACCAGACCTTCTACAAGCGATTGGACGAGGTGCGCGCCAATCGGGAACTGGATCTGCGCTGGCAACCG
GAGCGGGCGACTGCCGCCACTCCCTGA

Upstream 100 bases:

>100_bases
ACCACCGACTGCGGTGGACCAACATGTCCGCGATTGCTGAACTGAGGAACGACATGCTAGGCTACCGTCGAGGCTGGGAT
CTCGCCTGGGAGGATCAGCG

Downstream 100 bases:

>100_bases
GGCCGCACGAGCTATACTTCCCTCGTCGGGTTCAGGGAACTGGAGGGAAAACCATGGACAAGAAAACGCTCATCGATGGA
CTGAACCAGGATCTGGCGGG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MRVEPLIFELSKPGRTGTSVPDLDVPEAPLPVEHVRDDLPLPEVSEIDVVRHFTRLSQLNHAVDIDFYPLGSCTMKYNPK
INELVARFPGFAHLHPLQDPRTVQGILRLMYELQGFLAEIAGFDAVSLQPAAGAHGELTGILIARAYFDARGEHERRTVI
IPDSAHGTNPATAAMAGFRVVEVKSDARGNVDIEQLRQLVGPDTAAIMITNPNTLGLWDENITEIVDLIHSVGGLVYNDG
ANFNALLGIARPGDFGVDIMHFNLHKTFSTPHGGGGPGSGPVGVKAHLAEFLPGPIVVRRPGEDPEYTWHWPERSIGKIH
SFHGNVGMHIRAYAYIRMHGGSGLRRVSEDAVLAANYLLARLRDVYEVPYDRTCMHEFVLSAVRQKRHGVRAMDIAKRLL
DFGLHPPTVAFPLIVQEALMIEPTETESLETLDRFVAAMRQIAEEVERDPEFVRQAPHQTFYKRLDEVRANRELDLRWQP
ERATAATP

Sequences:

>Translated_488_residues
MRVEPLIFELSKPGRTGTSVPDLDVPEAPLPVEHVRDDLPLPEVSEIDVVRHFTRLSQLNHAVDIDFYPLGSCTMKYNPK
INELVARFPGFAHLHPLQDPRTVQGILRLMYELQGFLAEIAGFDAVSLQPAAGAHGELTGILIARAYFDARGEHERRTVI
IPDSAHGTNPATAAMAGFRVVEVKSDARGNVDIEQLRQLVGPDTAAIMITNPNTLGLWDENITEIVDLIHSVGGLVYNDG
ANFNALLGIARPGDFGVDIMHFNLHKTFSTPHGGGGPGSGPVGVKAHLAEFLPGPIVVRRPGEDPEYTWHWPERSIGKIH
SFHGNVGMHIRAYAYIRMHGGSGLRRVSEDAVLAANYLLARLRDVYEVPYDRTCMHEFVLSAVRQKRHGVRAMDIAKRLL
DFGLHPPTVAFPLIVQEALMIEPTETESLETLDRFVAAMRQIAEEVERDPEFVRQAPHQTFYKRLDEVRANRELDLRWQP
ERATAATP
>Mature_488_residues
MRVEPLIFELSKPGRTGTSVPDLDVPEAPLPVEHVRDDLPLPEVSEIDVVRHFTRLSQLNHAVDIDFYPLGSCTMKYNPK
INELVARFPGFAHLHPLQDPRTVQGILRLMYELQGFLAEIAGFDAVSLQPAAGAHGELTGILIARAYFDARGEHERRTVI
IPDSAHGTNPATAAMAGFRVVEVKSDARGNVDIEQLRQLVGPDTAAIMITNPNTLGLWDENITEIVDLIHSVGGLVYNDG
ANFNALLGIARPGDFGVDIMHFNLHKTFSTPHGGGGPGSGPVGVKAHLAEFLPGPIVVRRPGEDPEYTWHWPERSIGKIH
SFHGNVGMHIRAYAYIRMHGGSGLRRVSEDAVLAANYLLARLRDVYEVPYDRTCMHEFVLSAVRQKRHGVRAMDIAKRLL
DFGLHPPTVAFPLIVQEALMIEPTETESLETLDRFVAAMRQIAEEVERDPEFVRQAPHQTFYKRLDEVRANRELDLRWQP
ERATAATP

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=411, Percent_Identity=43.30900243309, Blast_Score=296, Evalue=4e-80,
Organism=Escherichia coli, GI1789269, Length=412, Percent_Identity=42.9611650485437, Blast_Score=298, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17535605, Length=432, Percent_Identity=41.8981481481481, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI32564013, Length=389, Percent_Identity=42.6735218508997, Blast_Score=278, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6323843, Length=431, Percent_Identity=42.92343387471, Blast_Score=324, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24645648, Length=413, Percent_Identity=41.8886198547215, Blast_Score=287, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 54270; Mature: 54270

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVEPLIFELSKPGRTGTSVPDLDVPEAPLPVEHVRDDLPLPEVSEIDVVRHFTRLSQLN
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
HAVDIDFYPLGSCTMKYNPKINELVARFPGFAHLHPLQDPRTVQGILRLMYELQGFLAEI
CEEEEEEEECCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AGFDAVSLQPAAGAHGELTGILIARAYFDARGEHERRTVIIPDSAHGTNPATAAMAGFRV
HCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHCEEE
VEVKSDARGNVDIEQLRQLVGPDTAAIMITNPNTLGLWDENITEIVDLIHSVGGLVYNDG
EEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCEECCCCCCHHHHHHHHHHHCCEEEECC
ANFNALLGIARPGDFGVDIMHFNLHKTFSTPHGGGGPGSGPVGVKAHLAEFLPGPIVVRR
CCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEC
PGEDPEYTWHWPERSIGKIHSFHGNVGMHIRAYAYIRMHGGSGLRRVSEDAVLAANYLLA
CCCCCCEEEECCCHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHH
RLRDVYEVPYDRTCMHEFVLSAVRQKRHGVRAMDIAKRLLDFGLHPPTVAFPLIVQEALM
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IEPTETESLETLDRFVAAMRQIAEEVERDPEFVRQAPHQTFYKRLDEVRANRELDLRWQP
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHCCCCCCEEECC
ERATAATP
CCCCCCCC
>Mature Secondary Structure
MRVEPLIFELSKPGRTGTSVPDLDVPEAPLPVEHVRDDLPLPEVSEIDVVRHFTRLSQLN
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
HAVDIDFYPLGSCTMKYNPKINELVARFPGFAHLHPLQDPRTVQGILRLMYELQGFLAEI
CEEEEEEEECCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AGFDAVSLQPAAGAHGELTGILIARAYFDARGEHERRTVIIPDSAHGTNPATAAMAGFRV
HCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHCEEE
VEVKSDARGNVDIEQLRQLVGPDTAAIMITNPNTLGLWDENITEIVDLIHSVGGLVYNDG
EEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCEECCCCCCHHHHHHHHHHHCCEEEECC
ANFNALLGIARPGDFGVDIMHFNLHKTFSTPHGGGGPGSGPVGVKAHLAEFLPGPIVVRR
CCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEC
PGEDPEYTWHWPERSIGKIHSFHGNVGMHIRAYAYIRMHGGSGLRRVSEDAVLAANYLLA
CCCCCCEEEECCCHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHH
RLRDVYEVPYDRTCMHEFVLSAVRQKRHGVRAMDIAKRLLDFGLHPPTVAFPLIVQEALM
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IEPTETESLETLDRFVAAMRQIAEEVERDPEFVRQAPHQTFYKRLDEVRANRELDLRWQP
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHCCCCCCEEECC
ERATAATP
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA