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The map label for this gene is uhpA [H]

Identifier: 22127903

GI number: 22127903

Start: 4469576

End: 4470238

Strand: Reverse

Name: uhpA [H]

Synonym: y4033

Alternate gene names: 22127903

Gene position: 4470238-4469576 (Counterclockwise)

Preceding gene: 22127904

Following gene: 22127902

Centisome position: 97.16

GC content: 50.83

Gene sequence:

>663_bases
GTGCCTCCTCATTGTTGTTTCACGGCTAAGGTATACTTTCAAATCCGATCCCCCTCCAGATGGAGCCACACCATGACTTA
CCGTGTTGTATTTATTGATGATCATGACATTGTGCGCTCGGGTTTTGCACAGCTACTCTCGCTGGAGGAGGATATCCAGG
TTGTTGGTGAGTTTAGCTCAGCCAAGCAGGCTCGTGCTGGGTTGCCGGGCTTACAGGCGAATATCTGTATTTGTGATATT
TCCATGCCTGATGAGAACGGATTAGATTTATTAAAAGGGTTACCTTCAGGGATGGGGGTCATCATGCTCTCTATGCATGA
CAGTCCTGCGTTGGTAGAAACGGCGCTGGAGCGTGGAGCACGCGGCTTTCTTTCTAAACGCTGTAAGCCCGAAGATCTGA
TCTCTGCCGTCCGAACGGTAGGCAGTGGCGGGGTGTATCTGATGCCTGAAATTGCCCAACAATTGGCACGGGTTGCTGTC
GATCCATTGACCCGCCGTGAGCGAGAGATCGCAGTGCTGTTGGCTGAAGGCATGGAAGTACGCGAGATTGCCGAGTCGCT
CGGGCTATCGCCAAAAACGGTCCATGTCCACCGGGCTAATTTATTTGCCAAGCTAGGCATCAGCAATAATGTTGAGCTGG
CTAAGAAAGTACTGAATCTATGA

Upstream 100 bases:

>100_bases
ATGCTAAAAATAACTGGTGCCAGGCCCCTGATCGCCATCTTACACCCGCAATTTAAGCCGTAACTGGCCAGGCTTACCCA
AGTCTGGCCCAATTTTTGAT

Downstream 100 bases:

>100_bases
TACAGCGCTTGGTGATGCTGCTGGCGTTATTCTTTATTTATTTTACTGCGGCTTTCTGCCTGTGGGCTATAGGGACACAA
TTAGCTGATCGGGCTTTACA

Product: two-component system response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MPPHCCFTAKVYFQIRSPSRWSHTMTYRVVFIDDHDIVRSGFAQLLSLEEDIQVVGEFSSAKQARAGLPGLQANICICDI
SMPDENGLDLLKGLPSGMGVIMLSMHDSPALVETALERGARGFLSKRCKPEDLISAVRTVGSGGVYLMPEIAQQLARVAV
DPLTRREREIAVLLAEGMEVREIAESLGLSPKTVHVHRANLFAKLGISNNVELAKKVLNL

Sequences:

>Translated_220_residues
MPPHCCFTAKVYFQIRSPSRWSHTMTYRVVFIDDHDIVRSGFAQLLSLEEDIQVVGEFSSAKQARAGLPGLQANICICDI
SMPDENGLDLLKGLPSGMGVIMLSMHDSPALVETALERGARGFLSKRCKPEDLISAVRTVGSGGVYLMPEIAQQLARVAV
DPLTRREREIAVLLAEGMEVREIAESLGLSPKTVHVHRANLFAKLGISNNVELAKKVLNL
>Mature_219_residues
PPHCCFTAKVYFQIRSPSRWSHTMTYRVVFIDDHDIVRSGFAQLLSLEEDIQVVGEFSSAKQARAGLPGLQANICICDIS
MPDENGLDLLKGLPSGMGVIMLSMHDSPALVETALERGARGFLSKRCKPEDLISAVRTVGSGGVYLMPEIAQQLARVAVD
PLTRREREIAVLLAEGMEVREIAESLGLSPKTVHVHRANLFAKLGISNNVELAKKVLNL

Specific function: Appears to be the positive activator of uhpT transcription [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=191, Percent_Identity=66.4921465968586, Blast_Score=258, Evalue=3e-70,
Organism=Escherichia coli, GI1788222, Length=197, Percent_Identity=35.5329949238579, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1788546, Length=198, Percent_Identity=31.3131313131313, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1787473, Length=184, Percent_Identity=36.4130434782609, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788521, Length=197, Percent_Identity=31.9796954314721, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1786747, Length=195, Percent_Identity=29.7435897435897, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788712, Length=185, Percent_Identity=25.4054054054054, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24094; Mature: 23963

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPHCCFTAKVYFQIRSPSRWSHTMTYRVVFIDDHDIVRSGFAQLLSLEEDIQVVGEFSS
CCCCEEEEEEEEEEEECCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
AKQARAGLPGLQANICICDISMPDENGLDLLKGLPSGMGVIMLSMHDSPALVETALERGA
HHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHH
RGFLSKRCKPEDLISAVRTVGSGGVYLMPEIAQQLARVAVDPLTRREREIAVLLAEGMEV
HHHHHCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHCHHHHHHHHHEEHHHCCCCH
REIAESLGLSPKTVHVHRANLFAKLGISNNVELAKKVLNL
HHHHHHHCCCCCEEEEEEHHEEEECCCCCCHHHHHHHHCC
>Mature Secondary Structure 
PPHCCFTAKVYFQIRSPSRWSHTMTYRVVFIDDHDIVRSGFAQLLSLEEDIQVVGEFSS
CCCEEEEEEEEEEEECCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
AKQARAGLPGLQANICICDISMPDENGLDLLKGLPSGMGVIMLSMHDSPALVETALERGA
HHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHH
RGFLSKRCKPEDLISAVRTVGSGGVYLMPEIAQQLARVAVDPLTRREREIAVLLAEGMEV
HHHHHCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHCHHHHHHHHHEEHHHCCCCH
REIAESLGLSPKTVHVHRANLFAKLGISNNVELAKKVLNL
HHHHHHHCCCCCEEEEEEHHEEEECCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]