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The map label for this gene is citT [C]

Identifier: 22127310

GI number: 22127310

Start: 3821819

End: 3823198

Strand: Reverse

Name: citT [C]

Synonym: y3435

Alternate gene names: 22127310

Gene position: 3823198-3821819 (Counterclockwise)

Preceding gene: 22127311

Following gene: 22127300

Centisome position: 83.1

GC content: 50.87

Gene sequence:

>1380_bases
ATGGCTGACGCACCTTTATCGACTGCTGCACCGCCCTCAATCTCCAGGCGTAATTTAGCGATTCTGATTACTGATATTCT
GCTATTTATTCTTCTACTTAACGTTCTACCTTTCGACACTAACGCCAATCGCGGCCTGGCCATCTTGGCCTTTATTGGCA
TCCTCTGGCTGACCGAAGCCCTTCACGTCACGATCACCGCGCTGTTGGTTCCCCTGATCGCCGTGGGTACGGGGCTAATG
GACGTTAACACGGGGTTGAGATCCTTCGCTAACCCCATCATCTTTCTATTCTTTGGTGGCTTTGCTCTGGCAACGGCACT
GCATATTCAAGGTCTGGATAAACTGATTGCCAACCGCCTGCTACTTGCGGCGAAGGGGCAATTGATGGTTGCGGTGCTGA
TGCTGTTTGGTGCCACGGCATTAGTGTCCATGTGGATTAGTAATACCGCGACGACGGCGATGATGCTGCCGCTGGCATTA
GGTGTCATCGGTAACCTGAACCTGGAACGAGAACGTAATACCTATGTCTTTATTCTGCTGGGTATTGCCTATAGCGCCAG
TATCGGTGGGTTGGGTACCTTGGTGGGGAGCCCGCCTAATGCCATTGCAGCGGCACAGTTGGGGTTAGATTTTGTCGGTT
GGATGAAATATGGCACTCCCGCCATGATCATTCTGATGCCACTAATGGTGGCGACGCTGTACGTCATTCTGCGGCCTAAT
CTTAAGCATCATTTTGATATCGAACTGGAGCAACTGCCTTGGACGGCCGCACGCAGAATCACGATAGGTATTTTCGGTAT
GACGGTCATTGGCTGGATTTTCAGCAGTCAATTGAGCCAAATGCTCGGTGGGGTGAAACAGTTTGATACGCTGGTCGCAC
TGAGTGCAGTCGTCCTGATTGGCATTAGCGGCGTCGCCAGTTGGCGTCAGATTCAGCAAAATACCGGATGGGGGGTATTG
CTGCTATTTGGTGGGGGCTTGACGTTAAGTGTTATTCTGCGCGATTCCGGTGCCAGCGCCGTCATGGCACAAGGCATTGT
CTCCATTTTTGGTGCCTATCACTGGTTTATTATTATTCTGGCAGTAGCGACTTTTATCATCTTCCTAACCGAACTTACCA
GTAATACAGCCAGTGCGGCTTTGCTCGTGCCGGTGTTTGCCACTGTCTCTGAGGCGTTAGGTATGCCACCGCTTCTGCTC
ACCATGATCATTGGTATCGGTGCGTCCTGCGCATTTATGCTGCCGGTCGCCACGCCACCAAATGCCATTGTTTATGGTAC
GGGTTTTATCAGGCAACCCGAGATGGTGAAGGTTGGTTTTTGGTTAAATATCATCTGCATCATCGTTGTCTCGCTGTTAG
CCTGGTATCTCTGGTATTAA

Upstream 100 bases:

>100_bases
CCATAACGAATTGCTCATTTATTATACTAAAAAACAAACGCAACGATATAACCCCATGAGGTTCACGTGATCTAACGATA
AAAAATGAGGATACTTTGTT

Downstream 100 bases:

>100_bases
GCGCTGAACCTGGCGGTACATTACGCCGTCAGGGAATTAGGCCCCTGCATGGGCCTAATTTATGGGGCAATGACAAAAGG
CGCGCTTATCGGTGATCAGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MADAPLSTAAPPSISRRNLAILITDILLFILLLNVLPFDTNANRGLAILAFIGILWLTEALHVTITALLVPLIAVGTGLM
DVNTGLRSFANPIIFLFFGGFALATALHIQGLDKLIANRLLLAAKGQLMVAVLMLFGATALVSMWISNTATTAMMLPLAL
GVIGNLNLERERNTYVFILLGIAYSASIGGLGTLVGSPPNAIAAAQLGLDFVGWMKYGTPAMIILMPLMVATLYVILRPN
LKHHFDIELEQLPWTAARRITIGIFGMTVIGWIFSSQLSQMLGGVKQFDTLVALSAVVLIGISGVASWRQIQQNTGWGVL
LLFGGGLTLSVILRDSGASAVMAQGIVSIFGAYHWFIIILAVATFIIFLTELTSNTASAALLVPVFATVSEALGMPPLLL
TMIIGIGASCAFMLPVATPPNAIVYGTGFIRQPEMVKVGFWLNIICIIVVSLLAWYLWY

Sequences:

>Translated_459_residues
MADAPLSTAAPPSISRRNLAILITDILLFILLLNVLPFDTNANRGLAILAFIGILWLTEALHVTITALLVPLIAVGTGLM
DVNTGLRSFANPIIFLFFGGFALATALHIQGLDKLIANRLLLAAKGQLMVAVLMLFGATALVSMWISNTATTAMMLPLAL
GVIGNLNLERERNTYVFILLGIAYSASIGGLGTLVGSPPNAIAAAQLGLDFVGWMKYGTPAMIILMPLMVATLYVILRPN
LKHHFDIELEQLPWTAARRITIGIFGMTVIGWIFSSQLSQMLGGVKQFDTLVALSAVVLIGISGVASWRQIQQNTGWGVL
LLFGGGLTLSVILRDSGASAVMAQGIVSIFGAYHWFIIILAVATFIIFLTELTSNTASAALLVPVFATVSEALGMPPLLL
TMIIGIGASCAFMLPVATPPNAIVYGTGFIRQPEMVKVGFWLNIICIIVVSLLAWYLWY
>Mature_458_residues
ADAPLSTAAPPSISRRNLAILITDILLFILLLNVLPFDTNANRGLAILAFIGILWLTEALHVTITALLVPLIAVGTGLMD
VNTGLRSFANPIIFLFFGGFALATALHIQGLDKLIANRLLLAAKGQLMVAVLMLFGATALVSMWISNTATTAMMLPLALG
VIGNLNLERERNTYVFILLGIAYSASIGGLGTLVGSPPNAIAAAQLGLDFVGWMKYGTPAMIILMPLMVATLYVILRPNL
KHHFDIELEQLPWTAARRITIGIFGMTVIGWIFSSQLSQMLGGVKQFDTLVALSAVVLIGISGVASWRQIQQNTGWGVLL
LFGGGLTLSVILRDSGASAVMAQGIVSIFGAYHWFIIILAVATFIIFLTELTSNTASAALLVPVFATVSEALGMPPLLLT
MIIGIGASCAFMLPVATPPNAIVYGTGFIRQPEMVKVGFWLNIICIIVVSLLAWYLWY

Specific function: Responsible For The Uptake Of Citrate In Exchange To The Efflux Of Succinate. Has A Relatively Broad Specificity For C(4)- Dicarboxylates And Tricarboxylates. [C]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily [H]

Homologues:

Organism=Homo sapiens, GI29171306, Length=514, Percent_Identity=28.5992217898833, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI301069349, Length=332, Percent_Identity=28.0120481927711, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI19923838, Length=346, Percent_Identity=26.3005780346821, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4506979, Length=152, Percent_Identity=36.1842105263158, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI225637552, Length=152, Percent_Identity=36.1842105263158, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI225637549, Length=152, Percent_Identity=36.1842105263158, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI31377715, Length=146, Percent_Identity=33.5616438356164, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI301069353, Length=146, Percent_Identity=33.5616438356164, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI58761541, Length=146, Percent_Identity=33.5616438356164, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI301069346, Length=146, Percent_Identity=33.5616438356164, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI31795546, Length=151, Percent_Identity=31.1258278145695, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI219802232, Length=451, Percent_Identity=26.1640798226164, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551790, Length=508, Percent_Identity=25, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71988385, Length=447, Percent_Identity=27.2930648769575, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71989118, Length=505, Percent_Identity=25.5445544554455, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI32565804, Length=469, Percent_Identity=26.6524520255864, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32564681, Length=504, Percent_Identity=24.0079365079365, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322263, Length=434, Percent_Identity=25.5760368663594, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324340, Length=426, Percent_Identity=25.8215962441315, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319885, Length=438, Percent_Identity=26.2557077625571, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45551633, Length=238, Percent_Identity=28.1512605042017, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281366409, Length=238, Percent_Identity=28.1512605042017, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737623, Length=238, Percent_Identity=28.1512605042017, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24666468, Length=238, Percent_Identity=28.1512605042017, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281362116, Length=120, Percent_Identity=34.1666666666667, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281362114, Length=264, Percent_Identity=26.5151515151515, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281362112, Length=264, Percent_Identity=26.5151515151515, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 49066; Mature: 48934

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS01271 NA_SULFATE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADAPLSTAAPPSISRRNLAILITDILLFILLLNVLPFDTNANRGLAILAFIGILWLTEA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
LHVTITALLVPLIAVGTGLMDVNTGLRSFANPIIFLFFGGFALATALHIQGLDKLIANRL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAAKGQLMVAVLMLFGATALVSMWISNTATTAMMLPLALGVIGNLNLERERNTYVFILL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEE
GIAYSASIGGLGTLVGSPPNAIAAAQLGLDFVGWMKYGTPAMIILMPLMVATLYVILRPN
EHHHHCCCCCCHHHCCCCCCHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
LKHHFDIELEQLPWTAARRITIGIFGMTVIGWIFSSQLSQMLGGVKQFDTLVALSAVVLI
CCCCCCCCHHHCCCHHHHEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GISGVASWRQIQQNTGWGVLLLFGGGLTLSVILRDSGASAVMAQGIVSIFGAYHWFIIIL
HHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
AVATFIIFLTELTSNTASAALLVPVFATVSEALGMPPLLLTMIIGIGASCAFMLPVATPP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCC
NAIVYGTGFIRQPEMVKVGFWLNIICIIVVSLLAWYLWY
CEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADAPLSTAAPPSISRRNLAILITDILLFILLLNVLPFDTNANRGLAILAFIGILWLTEA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
LHVTITALLVPLIAVGTGLMDVNTGLRSFANPIIFLFFGGFALATALHIQGLDKLIANRL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAAKGQLMVAVLMLFGATALVSMWISNTATTAMMLPLALGVIGNLNLERERNTYVFILL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEE
GIAYSASIGGLGTLVGSPPNAIAAAQLGLDFVGWMKYGTPAMIILMPLMVATLYVILRPN
EHHHHCCCCCCHHHCCCCCCHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
LKHHFDIELEQLPWTAARRITIGIFGMTVIGWIFSSQLSQMLGGVKQFDTLVALSAVVLI
CCCCCCCCHHHCCCHHHHEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GISGVASWRQIQQNTGWGVLLLFGGGLTLSVILRDSGASAVMAQGIVSIFGAYHWFIIIL
HHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
AVATFIIFLTELTSNTASAALLVPVFATVSEALGMPPLLLTMIIGIGASCAFMLPVATPP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCC
NAIVYGTGFIRQPEMVKVGFWLNIICIIVVSLLAWYLWY
CEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]