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The map label for this gene is ipaH9.8 [H]

Identifier: 22127276

GI number: 22127276

Start: 3762650

End: 3764467

Strand: Reverse

Name: ipaH9.8 [H]

Synonym: y3400

Alternate gene names: 22127276

Gene position: 3764467-3762650 (Counterclockwise)

Preceding gene: 22127282

Following gene: 22127275

Centisome position: 81.82

GC content: 46.15

Gene sequence:

>1818_bases
ATGAATCTATCAAATATAACGTCGAACGAGTCAATGCCGAACATCGAGCCAGACCGTGAAATCCATTCTGCACGGACATC
AACAGCAGCCTTAACTCCGGCTGACTATTATGCAATATGGGAAAAATGGGAAAATGATCCAAGAACTGTTGCTGGTGAAC
AACGGGGCCAGGCCGTAGCGAGAATGAAAGAGTGTTTGGAAAACAATACCGAACGCCTCGATCTCGATGAGCTTGGTTTG
ACCTCATTACCCGATACCCTGCCACCGTGTAATAAACTGAATATTATTGAAAATAAGTTAACTGAGTTGCCGACAACACT
GCCAGACAACCTGCAAACACTGAATGCTGCTTTTAATCAACTGCGTACATTACCGAATACATTACCGGCCTCGCTGTTAT
CTCTAAATGTGTACGGAAATGAACTAGAACGGCTCCCTGAGTCGCTACCTGAAGGGTTGAAAAAATTAGACGTTGGTCGT
AATGAGTCACTGCAACGCCCAAACCGCTTGCCCCCGAATCTGGAGTCTCTTGGTATGGCAAACTGTCGCTTAACTGAACT
GCCTACATTGCCGAACAGTTTAGAAAAACTGGAGGTGGATAATAATCAACTGCACACATTGCCCGATACATTGCCCGCCC
TTCTGTCATCTTTACTGGTATCGAGCAATAGACTCACAGCACTACCGGAAAATTTACCCGGTAGTTTAAGGGATATATAT
GCTAAAGATAATCAATTATCCCAACTTCCCGACCTAGCCCACCTGCCCCAAAATTGTAGCATTCGCTTAGACGGTAACCC
TTTTTCTACCAGTACGCTGCAGGCACTACAGCATCTCTATATTAACCTGGATTATCAGGGGCCACGGATTAGCTGCCGCG
AATTAGACAATCTACCACCAGTGAGTCTCCGTAACATTGTTGCCACCTGGGTGCCGCCGGAACAACAAAAATCGTTGGCA
GAAGATTGGGCAAAGATCGAAAAAGAAACTAACTCAGGCGATTTTAACGTTTTTCTTTGCCGCTTGGCTACCACTCAAAA
CGTAAAGAATATCCCTGAATTTAAACAACAAATTGCAGCCTGGTTGTTGCAACTGGCTGGCTCATTTACTCTACGTGAGC
AGACCTTTCTTATCGCTCAGGAAGCTAGCGCGACCTGTGAAGACCGCATTACCTTGACGCATAACGATATGCAAAAGGCA
GTCATGCTCCATGAGGTCGAAAAGGGGAAATATGATGAAAAACTACCTGAACTGATAGCGCGTGGCCGAGAGATGTTCCG
TCTGGAACAACTTGAGAATATTGCCCGCGAAAAAGTAAAAACACTAAAAACACTGAATGTACATTCTGTCGACGACATCG
AAGTCTATCTCGCCTATCAGGTTAAACTACGTGGGTCCTTAGAGCTCTCCTCGGTAAACAAAGAAATGCGCTTCTTTGGC
GTATCGGATGTGACAACAGACGATTTACTGAGCGCAGAAACCCGGGTGAAAACTGCGGAAAACCAAGATTTCCCGCGCTG
GCTATCACAATGGTCTCCGTGGAAAAGCGTGGTGCAACGTATTGAGCCTGAACGTTATGCTGCTGCGGTCGAAAAGCAGT
ACCACGCACTGGAGAATATTTACCCAGATAAACTGGCGGCTGAATTGGCAGCCAACGGGATGACGGGCGATGTGGATGCC
AACCGCATTGTCGGCAAAAGAATCAACGATGAGATAATGGAGGAGATCGATATGGCCCTGACTCATGAGGTTCTCTCTGC
CAAAGGAGCCTCCTCCTTATTAGATAATCTGTGGATGGAATCTCTAATCTCGTTTTAA

Upstream 100 bases:

>100_bases
CAATGAGTTAAAAATACCAGTAGTAGACCTTATCCACCCCCTGTTATTTATCAGCCAAAATAATACCTATAAGGCTTATT
AAGGGAGAGGTTTTAATACA

Downstream 100 bases:

>100_bases
TACTACACAGCTCGTATCCCATAAAAAACGGCGCATATTCTGTCCTGCAATATGCGCCGCAGATAGGTCATTCTTCTCCC
TCCCCCCCCGCTCGTTTGGC

Product: leucine-rich repeat-containing protein

Products: NA

Alternate protein names: Invasion plasmid antigen ipaH9.8 [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MNLSNITSNESMPNIEPDREIHSARTSTAALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENNTERLDLDELGL
TSLPDTLPPCNKLNIIENKLTELPTTLPDNLQTLNAAFNQLRTLPNTLPASLLSLNVYGNELERLPESLPEGLKKLDVGR
NESLQRPNRLPPNLESLGMANCRLTELPTLPNSLEKLEVDNNQLHTLPDTLPALLSSLLVSSNRLTALPENLPGSLRDIY
AKDNQLSQLPDLAHLPQNCSIRLDGNPFSTSTLQALQHLYINLDYQGPRISCRELDNLPPVSLRNIVATWVPPEQQKSLA
EDWAKIEKETNSGDFNVFLCRLATTQNVKNIPEFKQQIAAWLLQLAGSFTLREQTFLIAQEASATCEDRITLTHNDMQKA
VMLHEVEKGKYDEKLPELIARGREMFRLEQLENIAREKVKTLKTLNVHSVDDIEVYLAYQVKLRGSLELSSVNKEMRFFG
VSDVTTDDLLSAETRVKTAENQDFPRWLSQWSPWKSVVQRIEPERYAAAVEKQYHALENIYPDKLAAELAANGMTGDVDA
NRIVGKRINDEIMEEIDMALTHEVLSAKGASSLLDNLWMESLISF

Sequences:

>Translated_605_residues
MNLSNITSNESMPNIEPDREIHSARTSTAALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENNTERLDLDELGL
TSLPDTLPPCNKLNIIENKLTELPTTLPDNLQTLNAAFNQLRTLPNTLPASLLSLNVYGNELERLPESLPEGLKKLDVGR
NESLQRPNRLPPNLESLGMANCRLTELPTLPNSLEKLEVDNNQLHTLPDTLPALLSSLLVSSNRLTALPENLPGSLRDIY
AKDNQLSQLPDLAHLPQNCSIRLDGNPFSTSTLQALQHLYINLDYQGPRISCRELDNLPPVSLRNIVATWVPPEQQKSLA
EDWAKIEKETNSGDFNVFLCRLATTQNVKNIPEFKQQIAAWLLQLAGSFTLREQTFLIAQEASATCEDRITLTHNDMQKA
VMLHEVEKGKYDEKLPELIARGREMFRLEQLENIAREKVKTLKTLNVHSVDDIEVYLAYQVKLRGSLELSSVNKEMRFFG
VSDVTTDDLLSAETRVKTAENQDFPRWLSQWSPWKSVVQRIEPERYAAAVEKQYHALENIYPDKLAAELAANGMTGDVDA
NRIVGKRINDEIMEEIDMALTHEVLSAKGASSLLDNLWMESLISF
>Mature_605_residues
MNLSNITSNESMPNIEPDREIHSARTSTAALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENNTERLDLDELGL
TSLPDTLPPCNKLNIIENKLTELPTTLPDNLQTLNAAFNQLRTLPNTLPASLLSLNVYGNELERLPESLPEGLKKLDVGR
NESLQRPNRLPPNLESLGMANCRLTELPTLPNSLEKLEVDNNQLHTLPDTLPALLSSLLVSSNRLTALPENLPGSLRDIY
AKDNQLSQLPDLAHLPQNCSIRLDGNPFSTSTLQALQHLYINLDYQGPRISCRELDNLPPVSLRNIVATWVPPEQQKSLA
EDWAKIEKETNSGDFNVFLCRLATTQNVKNIPEFKQQIAAWLLQLAGSFTLREQTFLIAQEASATCEDRITLTHNDMQKA
VMLHEVEKGKYDEKLPELIARGREMFRLEQLENIAREKVKTLKTLNVHSVDDIEVYLAYQVKLRGSLELSSVNKEMRFFG
VSDVTTDDLLSAETRVKTAENQDFPRWLSQWSPWKSVVQRIEPERYAAAVEKQYHALENIYPDKLAAELAANGMTGDVDA
NRIVGKRINDEIMEEIDMALTHEVLSAKGASSLLDNLWMESLISF

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilit

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm (By similarity). Host nucleus (By similarity). Note=Secreted via Mxi- Spa type III secretion system (TTSS), and delivered into the host cytoplasm. Transported into the host nucleus (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 8 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 68207; Mature: 68207

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSNITSNESMPNIEPDREIHSARTSTAALTPADYYAIWEKWENDPRTVAGEQRGQAVA
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
RMKECLENNTERLDLDELGLTSLPDTLPPCNKLNIIENKLTELPTTLPDNLQTLNAAFNQ
HHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
LRTLPNTLPASLLSLNVYGNELERLPESLPEGLKKLDVGRNESLQRPNRLPPNLESLGMA
HHHCCHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCC
NCRLTELPTLPNSLEKLEVDNNQLHTLPDTLPALLSSLLVSSNRLTALPENLPGSLRDIY
CCEEECCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHH
AKDNQLSQLPDLAHLPQNCSIRLDGNPFSTSTLQALQHLYINLDYQGPRISCRELDNLPP
HCCCHHHHCCHHHHCCCCCEEEECCCCCCHHHHHHHHHHHEEECCCCCCCCHHHHCCCCC
VSLRNIVATWVPPEQQKSLAEDWAKIEKETNSGDFNVFLCRLATTQNVKNIPEFKQQIAA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
WLLQLAGSFTLREQTFLIAQEASATCEDRITLTHNDMQKAVMLHEVEKGKYDEKLPELIA
HHHHHHCCCEECHHEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHH
RGREMFRLEQLENIAREKVKTLKTLNVHSVDDIEVYLAYQVKLRGSLELSSVNKEMRFFG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCEEHHHHCCHHHEEC
VSDVTTDDLLSAETRVKTAENQDFPRWLSQWSPWKSVVQRIEPERYAAAVEKQYHALENI
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHC
YPDKLAAELAANGMTGDVDANRIVGKRINDEIMEEIDMALTHEVLSAKGASSLLDNLWME
CHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
SLISF
HHHCC
>Mature Secondary Structure
MNLSNITSNESMPNIEPDREIHSARTSTAALTPADYYAIWEKWENDPRTVAGEQRGQAVA
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
RMKECLENNTERLDLDELGLTSLPDTLPPCNKLNIIENKLTELPTTLPDNLQTLNAAFNQ
HHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
LRTLPNTLPASLLSLNVYGNELERLPESLPEGLKKLDVGRNESLQRPNRLPPNLESLGMA
HHHCCHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCC
NCRLTELPTLPNSLEKLEVDNNQLHTLPDTLPALLSSLLVSSNRLTALPENLPGSLRDIY
CCEEECCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHH
AKDNQLSQLPDLAHLPQNCSIRLDGNPFSTSTLQALQHLYINLDYQGPRISCRELDNLPP
HCCCHHHHCCHHHHCCCCCEEEECCCCCCHHHHHHHHHHHEEECCCCCCCCHHHHCCCCC
VSLRNIVATWVPPEQQKSLAEDWAKIEKETNSGDFNVFLCRLATTQNVKNIPEFKQQIAA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
WLLQLAGSFTLREQTFLIAQEASATCEDRITLTHNDMQKAVMLHEVEKGKYDEKLPELIA
HHHHHHCCCEECHHEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHH
RGREMFRLEQLENIAREKVKTLKTLNVHSVDDIEVYLAYQVKLRGSLELSSVNKEMRFFG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCEEHHHHCCHHHEEC
VSDVTTDDLLSAETRVKTAENQDFPRWLSQWSPWKSVVQRIEPERYAAAVEKQYHALENI
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHC
YPDKLAAELAANGMTGDVDANRIVGKRINDEIMEEIDMALTHEVLSAKGASSLLDNLWME
CHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
SLISF
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA