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The map label for this gene is slrP [H]

Identifier: 22127275

GI number: 22127275

Start: 3761566

End: 3762441

Strand: Reverse

Name: slrP [H]

Synonym: y3399

Alternate gene names: 22127275

Gene position: 3762441-3761566 (Counterclockwise)

Preceding gene: 22127276

Following gene: 22127274

Centisome position: 81.78

GC content: 45.66

Gene sequence:

>876_bases
ATGTATCTATCAAATATAACCTCGAACGTGTCAATGCCGAACATAGGACCAGACCGTGAAATCCATGCTGACCGGCCAGC
GGCAACAGCCTTAACTCCGGCTGACTATCATGCAATATGGGAAAAGTGGGAAAATGATCCAAGAACTGTTGCTGGTGAAC
AACGGGGCCAAGCCGTAGCGAGAATGAAAGAGTGTTTGGAAAACAATGCCGAGCGCCTCAATCTCTCTTCTCTTGATTTG
ACCTCATTACCCGATACCCTGCCACCGTGTAATGAACTGAATATTATATGCAATAATTTAACTGAGTTACCAACAACACT
GCCAGACAATCTGCAAACACTGAAGGCTTCTTATAATCAGCTGCGTACATTACCGAATACATTACCGGCCTCGCTGTTAT
CTCTAAAGGTGCACATGAATGAACTGGAGCGGCTCCCTGAGCCACTACCTGAAGGGTTGAAAACATTAGACGTTGGTTGT
AATACGTCACTGCAACTCCCAAGCCGCTTGCCCCCGGTTCTGGAGTCTCTTGATATTTCAAACTGTAACTTAACTGAACT
GCCTACACTGCCGAACAGTTTGAAAGAACTGGATGCGCATGGTAATCAACTGCGCATATTGCCCGATACATTGCCGATAT
CGCTGTTAAGGTTAAATGTAGCCTATAATCAACTCACAGCATTACCGGAAAATTTACCCGGTAGTTTAAGGTGTATATAT
ACTGAATATAATCAATTATCCCAGCTTCCCGACCTGGCCCATCTGCGCCAAAATTGTAACATTTGCTTAGACGGTAACCC
TCTTTCTCCCAGCACGCTGCTGGCACTACTGCGTCTCAGTACTAAGCCGAATTATCAGGGGCCACGGATTAGCTGA

Upstream 100 bases:

>100_bases
ACCACCAGTTAGCTAAAAATACCAGTAGTAGACCTTAGTATCCCCTGTTATTTATCAGCCAAAATAATGCTTCTAAAACT
TATTAAGGGAGCGTAATACA

Downstream 100 bases:

>100_bases
ATCGACTTAAACAATATGCAAAAGCAGTCATGAATCATGGGGGCTAGAAGGGAAAGTATGATGAAAAATCACCTGAACTG
ATGGCGCGTGGCCGGGAGAT

Product: leucine-rich repeat-containing protein

Products: NA

Alternate protein names: Secreted effector protein slrP [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MYLSNITSNVSMPNIGPDREIHADRPAATALTPADYHAIWEKWENDPRTVAGEQRGQAVARMKECLENNAERLNLSSLDL
TSLPDTLPPCNELNIICNNLTELPTTLPDNLQTLKASYNQLRTLPNTLPASLLSLKVHMNELERLPEPLPEGLKTLDVGC
NTSLQLPSRLPPVLESLDISNCNLTELPTLPNSLKELDAHGNQLRILPDTLPISLLRLNVAYNQLTALPENLPGSLRCIY
TEYNQLSQLPDLAHLRQNCNICLDGNPLSPSTLLALLRLSTKPNYQGPRIS

Sequences:

>Translated_291_residues
MYLSNITSNVSMPNIGPDREIHADRPAATALTPADYHAIWEKWENDPRTVAGEQRGQAVARMKECLENNAERLNLSSLDL
TSLPDTLPPCNELNIICNNLTELPTTLPDNLQTLKASYNQLRTLPNTLPASLLSLKVHMNELERLPEPLPEGLKTLDVGC
NTSLQLPSRLPPVLESLDISNCNLTELPTLPNSLKELDAHGNQLRILPDTLPISLLRLNVAYNQLTALPENLPGSLRCIY
TEYNQLSQLPDLAHLRQNCNICLDGNPLSPSTLLALLRLSTKPNYQGPRIS
>Mature_291_residues
MYLSNITSNVSMPNIGPDREIHADRPAATALTPADYHAIWEKWENDPRTVAGEQRGQAVARMKECLENNAERLNLSSLDL
TSLPDTLPPCNELNIICNNLTELPTTLPDNLQTLKASYNQLRTLPNTLPASLLSLKVHMNELERLPEPLPEGLKTLDVGC
NTSLQLPSRLPPVLESLDISNCNLTELPTLPNSLKELDAHGNQLRILPDTLPISLLRLNVAYNQLTALPENLPGSLRCIY
TEYNQLSQLPDLAHLRQNCNICLDGNPLSPSTLLALLRLSTKPNYQGPRIS

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin).

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 10 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 32225; Mature: 32225

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLSNITSNVSMPNIGPDREIHADRPAATALTPADYHAIWEKWENDPRTVAGEQRGQAVA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
RMKECLENNAERLNLSSLDLTSLPDTLPPCNELNIICNNLTELPTTLPDNLQTLKASYNQ
HHHHHHHCCHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LRTLPNTLPASLLSLKVHMNELERLPEPLPEGLKTLDVGCNTSLQLPSRLPPVLESLDIS
HHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEECCCCCCCCCCCCCCCHHHHHCCCC
NCNLTELPTLPNSLKELDAHGNQLRILPDTLPISLLRLNVAYNQLTALPENLPGSLRCIY
CCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEEE
TEYNQLSQLPDLAHLRQNCNICLDGNPLSPSTLLALLRLSTKPNYQGPRIS
ECHHHHHHCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MYLSNITSNVSMPNIGPDREIHADRPAATALTPADYHAIWEKWENDPRTVAGEQRGQAVA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
RMKECLENNAERLNLSSLDLTSLPDTLPPCNELNIICNNLTELPTTLPDNLQTLKASYNQ
HHHHHHHCCHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LRTLPNTLPASLLSLKVHMNELERLPEPLPEGLKTLDVGCNTSLQLPSRLPPVLESLDIS
HHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEECCCCCCCCCCCCCCCHHHHHCCCC
NCNLTELPTLPNSLKELDAHGNQLRILPDTLPISLLRLNVAYNQLTALPENLPGSLRCIY
CCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEEE
TEYNQLSQLPDLAHLRQNCNICLDGNPLSPSTLLALLRLSTKPNYQGPRIS
ECHHHHHHCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10861017 [H]