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The map label for this gene is zitB

Identifier: 22126926

GI number: 22126926

Start: 3358172

End: 3359110

Strand: Direct

Name: zitB

Synonym: y3050

Alternate gene names: 22126926

Gene position: 3358172-3359110 (Clockwise)

Preceding gene: 22126924

Following gene: 22126948

Centisome position: 72.99

GC content: 47.39

Gene sequence:

>939_bases
ATGGCTGTATCCACAATTTTCTCGCAAGATAGCAACAGCAAACGCCTATTGATAGCCTTCGCCATCACCACATTATTTAT
GGTGACGGAAGCGATTGGCGGCTGGTTATCTGGTTCTCTGGCATTATTGGCTGATGCCGGACACATGTTGACCGACTCTG
CAGCATTATTTATCGCGTTGATGGCAGTACACTTCTCCCAGAGAAAACCAGACCCCCGCCATACTTTTGGCTACCTACGG
CTGACGACACTCGCGGCCTTTGTTAACGCAGCGGCATTATTGCTGATTGTTATATTGATCGTCTGGGAGGCCGTTCATCG
CTTCTTTTCACCTCATGAGGTGATGGGTACCCCGATGTTAATCATCGCTATCGCCGGACTGTTGGCGAATATTTTTTGTT
TTTGGATCCTGCATAAGGGAGAAGAAGAGAAAAACATCAATGTACGGGCAGCAGCCTTGCATGTGCTAAGTGATTTATTA
GGTTCAGTGGGCGCGATGATTGCGGCTATCGTGATTTTAACCACGGGCTGGACACCAATAGACCCCATTCTCTCGGTATT
GGTGTCGGTACTGATTTTGCGTAGCGCCTGGCGATTACTGAAAGAAAGTTTTCACGAATTATTGGAGGGTGCGCCGCAAG
AGATTGATATCAACAAGCTGCGTAAAGACCTATGTACCAATATTTATGAAGTCCGGAACATTCATCATGTTCACTTATGG
CAAGTGGGTGAACAACGGCTAATGACCCTTCATGCCCAAGTGATACCGCCACTGGACCATGATGCGTTATTACAACGCAT
CCAAGACTATTTACTGCATCACTACCGCATCAGTCATGCCACAGTTCAAATGGAGTATCAACATTGTGGAACACCGGATT
GTGGTATCAATCAAGCGGCCCCTGCCGACGGACATCACCGTCATCATCACCACGAATAA

Upstream 100 bases:

>100_bases
GTGGAGAGGACATAGCTTGTAGATAAAACATAGCCTGTAGAAAAAACATAGCTTGCGCCTATTTGCACAATAAAACCGTG
ATGGAAACAAAGGATAAATA

Downstream 100 bases:

>100_bases
CCGCTGACACAGTCATATACCCAAAGTTATTGTTGCTGCAGGCAGTAAACGAAACCGAATCAGGAACTGATTTGAACCGT
ATTTATGCTATCCCGCAGGT

Product: zinc transporter ZitB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MAVSTIFSQDSNSKRLLIAFAITTLFMVTEAIGGWLSGSLALLADAGHMLTDSAALFIALMAVHFSQRKPDPRHTFGYLR
LTTLAAFVNAAALLLIVILIVWEAVHRFFSPHEVMGTPMLIIAIAGLLANIFCFWILHKGEEEKNINVRAAALHVLSDLL
GSVGAMIAAIVILTTGWTPIDPILSVLVSVLILRSAWRLLKESFHELLEGAPQEIDINKLRKDLCTNIYEVRNIHHVHLW
QVGEQRLMTLHAQVIPPLDHDALLQRIQDYLLHHYRISHATVQMEYQHCGTPDCGINQAAPADGHHRHHHHE

Sequences:

>Translated_312_residues
MAVSTIFSQDSNSKRLLIAFAITTLFMVTEAIGGWLSGSLALLADAGHMLTDSAALFIALMAVHFSQRKPDPRHTFGYLR
LTTLAAFVNAAALLLIVILIVWEAVHRFFSPHEVMGTPMLIIAIAGLLANIFCFWILHKGEEEKNINVRAAALHVLSDLL
GSVGAMIAAIVILTTGWTPIDPILSVLVSVLILRSAWRLLKESFHELLEGAPQEIDINKLRKDLCTNIYEVRNIHHVHLW
QVGEQRLMTLHAQVIPPLDHDALLQRIQDYLLHHYRISHATVQMEYQHCGTPDCGINQAAPADGHHRHHHHE
>Mature_311_residues
AVSTIFSQDSNSKRLLIAFAITTLFMVTEAIGGWLSGSLALLADAGHMLTDSAALFIALMAVHFSQRKPDPRHTFGYLRL
TTLAAFVNAAALLLIVILIVWEAVHRFFSPHEVMGTPMLIIAIAGLLANIFCFWILHKGEEEKNINVRAAALHVLSDLLG
SVGAMIAAIVILTTGWTPIDPILSVLVSVLILRSAWRLLKESFHELLEGAPQEIDINKLRKDLCTNIYEVRNIHHVHLWQ
VGEQRLMTLHAQVIPPLDHDALLQRIQDYLLHHYRISHATVQMEYQHCGTPDCGINQAAPADGHHRHHHHE

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily

Homologues:

Organism=Homo sapiens, GI52352805, Length=303, Percent_Identity=30.3630363036304, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI21359890, Length=325, Percent_Identity=27.6923076923077, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI289803013, Length=290, Percent_Identity=29.3103448275862, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI289803009, Length=290, Percent_Identity=29.3103448275862, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI289803007, Length=290, Percent_Identity=29.3103448275862, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI289803003, Length=290, Percent_Identity=29.3103448275862, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI64762489, Length=290, Percent_Identity=29.3103448275862, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI21361112, Length=314, Percent_Identity=28.6624203821656, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI20070323, Length=332, Percent_Identity=25.3012048192771, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI14210520, Length=233, Percent_Identity=27.4678111587983, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI52352803, Length=130, Percent_Identity=39.2307692307692, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI52351208, Length=160, Percent_Identity=30, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI222080086, Length=129, Percent_Identity=28.6821705426357, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40255009, Length=129, Percent_Identity=28.6821705426357, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786966, Length=293, Percent_Identity=67.2354948805461, Blast_Score=367, Evalue=1e-103,
Organism=Escherichia coli, GI1790349, Length=246, Percent_Identity=26.0162601626016, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193210990, Length=312, Percent_Identity=31.4102564102564, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17555794, Length=284, Percent_Identity=30.9859154929577, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17555796, Length=287, Percent_Identity=31.0104529616725, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32564488, Length=311, Percent_Identity=29.2604501607717, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17550440, Length=126, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17550442, Length=126, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=187, Percent_Identity=32.620320855615, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323899, Length=127, Percent_Identity=34.6456692913386, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=136, Percent_Identity=34.5588235294118, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24656728, Length=341, Percent_Identity=29.9120234604106, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24656724, Length=341, Percent_Identity=29.9120234604106, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24656720, Length=341, Percent_Identity=29.9120234604106, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24656715, Length=341, Percent_Identity=29.9120234604106, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21357035, Length=341, Percent_Identity=29.9120234604106, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24583858, Length=327, Percent_Identity=25.0764525993884, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585900, Length=140, Percent_Identity=32.1428571428571, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585898, Length=140, Percent_Identity=32.1428571428571, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585896, Length=140, Percent_Identity=32.1428571428571, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921672, Length=140, Percent_Identity=32.1428571428571, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24584409, Length=119, Percent_Identity=35.2941176470588, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28574430, Length=119, Percent_Identity=35.2941176470588, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24645863, Length=126, Percent_Identity=34.1269841269841, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ZITB_YERPE (Q8ZGY6)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AI0138
- RefSeq:   NP_670349.1
- RefSeq:   NP_992400.1
- RefSeq:   YP_002346172.1
- ProteinModelPortal:   Q8ZGY6
- SMR:   Q8ZGY6
- GeneID:   1147997
- GeneID:   1173980
- GeneID:   2763241
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1129
- KEGG:   ypk:y3050
- KEGG:   ypm:YP_1027
- HOGENOM:   HBG317426
- OMA:   KEKFHVE
- ProtClustDB:   PRK03557
- BioCyc:   YPES187410:Y3050-MONOMER
- BioCyc:   YPES214092:YPO1129-MONOMER
- HAMAP:   MF_00552
- InterPro:   IPR002524
- PANTHER:   PTHR11562
- TIGRFAMs:   TIGR01297

Pfam domain/function: PF01545 Cation_efflux

EC number: NA

Molecular weight: Translated: 34828; Mature: 34697

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00511 CRF

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x117b4fd0)-; HASH(0x11935e54)-; HASH(0x11a8f4a4)-; HASH(0xf621084)-; HASH(0x107e6908)-; HASH(0x11a14bac)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSTIFSQDSNSKRLLIAFAITTLFMVTEAIGGWLSGSLALLADAGHMLTDSAALFIAL
CCCCHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHH
MAVHFSQRKPDPRHTFGYLRLTTLAAFVNAAALLLIVILIVWEAVHRFFSPHEVMGTPML
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHH
IIAIAGLLANIFCFWILHKGEEEKNINVRAAALHVLSDLLGSVGAMIAAIVILTTGWTPI
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DPILSVLVSVLILRSAWRLLKESFHELLEGAPQEIDINKLRKDLCTNIYEVRNIHHVHLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEHHH
QVGEQRLMTLHAQVIPPLDHDALLQRIQDYLLHHYRISHATVQMEYQHCGTPDCGINQAA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCCCC
PADGHHRHHHHE
CCCCCCCCCCCH
>Mature Secondary Structure 
AVSTIFSQDSNSKRLLIAFAITTLFMVTEAIGGWLSGSLALLADAGHMLTDSAALFIAL
CCCHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHH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CCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430