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The map label for this gene is sdaC [H]

Identifier: 22126739

GI number: 22126739

Start: 3160478

End: 3161800

Strand: Direct

Name: sdaC [H]

Synonym: y2862

Alternate gene names: 22126739

Gene position: 3160478-3161800 (Clockwise)

Preceding gene: 22126738

Following gene: 22126747

Centisome position: 68.69

GC content: 47.24

Gene sequence:

>1323_bases
GTGTTCACAATGGAGATTTTCATGGACACTACGCAAACAAGCACTCTTGCCTCGGCAAGAAAAATCTCATCAAGTACATG
GCGCAAAAGTGACACCATGTGGATGTTGGGTCTGTACGGTACAGCGATTGGCGCAGGTGTACTCTTTTTGCCCATCAACG
CCGGTATTGGTGGCCTGCTACCACTGATTGTTATGGCTATCATTGCTTTCCCAATGACCTACTACGCTCACCGTGGCCTG
TGCCGATTCGTGTTATCCGGTAAAAATCCAGGTGAAGATATTACTGAGGTGGTTGAAGAACATTTCGGTGTAGGCGCAGG
TAAACTGATTACCCTGCTTTACTTCTTCGCTATCTACCCCATTCTCTTGGTGTACAGCGTAGCAATTACCAATACCGTGG
ATAGTTTCATTACACATCAGATACACCTGCCATCACCACCACGCGCCATTTTGTCCCTGATTCTGATTGTGGGCCTGATG
GCTATCGTGCGCTTTGGTGAACAGACCATCGTCAAAGCCATGAGCATCTTGGTATTCCCGTTTGTTGCCGTATTGATGAT
GTTGGCGATATACCTGATCCCAAACTGGTCAGGTGCAATATTCGAAAACGTATCCATGGACGGTAACGGCACAGGTAGCG
GCCTGTGGATGACAATGTGGCTAATCATTCCCGTCATGGTGTTCTCTTTCAACCACTCACCGATCATCTCAGCCTTTGCT
GTAGCAAAGCGCGAAGAGTACGGGGTGGATGCAGAGAAAAAATGTTCACGCATTTTGAGCTTTGCCCACATCATGATGGT
TATCACCGTCATGTTCTTCGTCTTCAGTTGCGTACTGAGCCTGTCTCCTGCGGATCTGATGGATGCAAAAAACCAAAACA
TCTCCATTTTGTCTTATCTGGCAAACCATTTTAATACGCCAGTAATTGCCTATATGGCACCGGTTATTGCCTTTATTGCC
ATCACTAAATCATTCCTGGGCCACTATCTGGGCGCCCGTGAAGGTTTTAACGGTATGGTCATTAAGTCTCTGCGTAGTAG
AGGCAAAACCATTGAGCAGAACAAACTGAACCGCATTACTGCGTTGTTCATGTTAGTCACCACCTGGGCTGTCGCGACCT
TAAACCCAAGTATCTTGGGGATGATCGAAACATTGGGCGGCCCTATCATCGCGATGCTCCTGTTCCTGATGCCGATGTAT
GCCATTCATAAAGTCCCGGCCATGCGTAAATACAGCGGCCAGATCAGTAACGTATTCGTGGTACTCATGGGCTTGATCGC
CATCTCTGGGATCTTATTCAACTTAAGCAACTTGTTTAATTAG

Upstream 100 bases:

>100_bases
ACCATTTTAAACGCATCGTTTTGACTGAATGCTTACCTGATGATGTCATTCAATAATGCATTCCGGGTCTCTAAATTTCG
GTTATTCATTTTAAATTAAC

Downstream 100 bases:

>100_bases
TCGATGGCTTGATTAACTGATCGTTTGATTAACCGCTCCAGGCTGGCCACTTCCACGGCCAGCCTGTTATTTTTCTTCTT
TTTTTCATTGATATTGCGGT

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MFTMEIFMDTTQTSTLASARKISSSTWRKSDTMWMLGLYGTAIGAGVLFLPINAGIGGLLPLIVMAIIAFPMTYYAHRGL
CRFVLSGKNPGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSVAITNTVDSFITHQIHLPSPPRAILSLILIVGLM
AIVRFGEQTIVKAMSILVFPFVAVLMMLAIYLIPNWSGAIFENVSMDGNGTGSGLWMTMWLIIPVMVFSFNHSPIISAFA
VAKREEYGVDAEKKCSRILSFAHIMMVITVMFFVFSCVLSLSPADLMDAKNQNISILSYLANHFNTPVIAYMAPVIAFIA
ITKSFLGHYLGAREGFNGMVIKSLRSRGKTIEQNKLNRITALFMLVTTWAVATLNPSILGMIETLGGPIIAMLLFLMPMY
AIHKVPAMRKYSGQISNVFVVLMGLIAISGILFNLSNLFN

Sequences:

>Translated_440_residues
MFTMEIFMDTTQTSTLASARKISSSTWRKSDTMWMLGLYGTAIGAGVLFLPINAGIGGLLPLIVMAIIAFPMTYYAHRGL
CRFVLSGKNPGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSVAITNTVDSFITHQIHLPSPPRAILSLILIVGLM
AIVRFGEQTIVKAMSILVFPFVAVLMMLAIYLIPNWSGAIFENVSMDGNGTGSGLWMTMWLIIPVMVFSFNHSPIISAFA
VAKREEYGVDAEKKCSRILSFAHIMMVITVMFFVFSCVLSLSPADLMDAKNQNISILSYLANHFNTPVIAYMAPVIAFIA
ITKSFLGHYLGAREGFNGMVIKSLRSRGKTIEQNKLNRITALFMLVTTWAVATLNPSILGMIETLGGPIIAMLLFLMPMY
AIHKVPAMRKYSGQISNVFVVLMGLIAISGILFNLSNLFN
>Mature_440_residues
MFTMEIFMDTTQTSTLASARKISSSTWRKSDTMWMLGLYGTAIGAGVLFLPINAGIGGLLPLIVMAIIAFPMTYYAHRGL
CRFVLSGKNPGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSVAITNTVDSFITHQIHLPSPPRAILSLILIVGLM
AIVRFGEQTIVKAMSILVFPFVAVLMMLAIYLIPNWSGAIFENVSMDGNGTGSGLWMTMWLIIPVMVFSFNHSPIISAFA
VAKREEYGVDAEKKCSRILSFAHIMMVITVMFFVFSCVLSLSPADLMDAKNQNISILSYLANHFNTPVIAYMAPVIAFIA
ITKSFLGHYLGAREGFNGMVIKSLRSRGKTIEQNKLNRITALFMLVTTWAVATLNPSILGMIETLGGPIIAMLLFLMPMY
AIHKVPAMRKYSGQISNVFVVLMGLIAISGILFNLSNLFN

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=429, Percent_Identity=82.983682983683, Blast_Score=704, Evalue=0.0,
Organism=Escherichia coli, GI1789504, Length=443, Percent_Identity=48.9841986455982, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1789211, Length=415, Percent_Identity=37.5903614457831, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI145693183, Length=436, Percent_Identity=28.2110091743119, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1789961, Length=394, Percent_Identity=26.3959390862944, Blast_Score=115, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 48396; Mature: 48396

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTMEIFMDTTQTSTLASARKISSSTWRKSDTMWMLGLYGTAIGAGVLFLPINAGIGGLL
CEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCEEEEEECCCHHHHH
PLIVMAIIAFPMTYYAHRGLCRFVLSGKNPGEDITEVVEEHFGVGAGKLITLLYFFAIYP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ILLVYSVAITNTVDSFITHQIHLPSPPRAILSLILIVGLMAIVRFGEQTIVKAMSILVFP
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
FVAVLMMLAIYLIPNWSGAIFENVSMDGNGTGSGLWMTMWLIIPVMVFSFNHSPIISAFA
HHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
VAKREEYGVDAEKKCSRILSFAHIMMVITVMFFVFSCVLSLSPADLMDAKNQNISILSYL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHH
ANHFNTPVIAYMAPVIAFIAITKSFLGHYLGAREGFNGMVIKSLRSRGKTIEQNKLNRIT
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHH
ALFMLVTTWAVATLNPSILGMIETLGGPIIAMLLFLMPMYAIHKVPAMRKYSGQISNVFV
HHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHH
VLMGLIAISGILFNLSNLFN
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFTMEIFMDTTQTSTLASARKISSSTWRKSDTMWMLGLYGTAIGAGVLFLPINAGIGGLL
CEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCEEEEEECCCHHHHH
PLIVMAIIAFPMTYYAHRGLCRFVLSGKNPGEDITEVVEEHFGVGAGKLITLLYFFAIYP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ILLVYSVAITNTVDSFITHQIHLPSPPRAILSLILIVGLMAIVRFGEQTIVKAMSILVFP
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
FVAVLMMLAIYLIPNWSGAIFENVSMDGNGTGSGLWMTMWLIIPVMVFSFNHSPIISAFA
HHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
VAKREEYGVDAEKKCSRILSFAHIMMVITVMFFVFSCVLSLSPADLMDAKNQNISILSYL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHH
ANHFNTPVIAYMAPVIAFIAITKSFLGHYLGAREGFNGMVIKSLRSRGKTIEQNKLNRIT
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHH
ALFMLVTTWAVATLNPSILGMIETLGGPIIAMLLFLMPMYAIHKVPAMRKYSGQISNVFV
HHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHH
VLMGLIAISGILFNLSNLFN
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]