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The map label for this gene is deoR [H]

Identifier: 22126738

GI number: 22126738

Start: 3158635

End: 3159399

Strand: Direct

Name: deoR [H]

Synonym: y2861

Alternate gene names: 22126738

Gene position: 3158635-3159399 (Clockwise)

Preceding gene: 22126737

Following gene: 22126739

Centisome position: 68.65

GC content: 44.84

Gene sequence:

>765_bases
ATGGAAACTCGTCGCGCAGAACGAATCAATAAACTTATTCAGGCCCTTAAGCGTTCCGACAAAATCCATTTGAAAGATGC
GGCCAATCTGTTGCGTGTATCTGAAATGACTATTCGGCGAGATCTCAGTGCCGAACCCACGTCCGTCATTTTGCTGGGCG
GTTACGTGGTGATGGACCCTAAGAGTAACAATGCCAACAACTATTTTGTTTCTGATCAACAAGCTAAGCAGGTAGAAGAA
AAACGTCGTATCGGCCAGTTAGCGGCACAACTGATTATTGAAAATGATACCGTCTTTTTTGACTGTGGGACGACTATCCC
CTGGATTATTGATGAGATAGATGAAGAGCTGGCATTTACTGCCATCTGTTACTCTCTCAACACCTTCCTTGCCTTACAAG
ATAAGCCTAACTGCAAAGTGATCCTGTGCGGTGGGGAGTTCAAACCCAATAACTGCATTTTCACCCCCCTCAGCCAGCAG
AGCGAACTGGATAATATTTGCCCAAACAAAGCCTTTATCTCAGCCGCCGGTGTTTCCATTGAGTACGGTGCAACTTGTTT
TAACTTTGATGAAATCTTGCTAAAACACCGTGCTATGGCTAAGTCGCAATATAAAATACTGGTGGCGGATCACAGTAAGT
TTGGCAAGATTAAACCAGCAAGCATAGGTACTTTGGCGCAATTTGATGCTCTGGTGACGGACCGCCCCCCAGTAGCTGAA
TTCTACCTGTTCTTTTCCCAACACAGTGTAAAAATCTACTGTTAA

Upstream 100 bases:

>100_bases
TGTCAGTAGTCTAAGCCCGGTCCACAATTACCGGGCTTATTTATTATCGTACTGTGTATATAATAAGTTGAATTACAACA
TATAACCTTGGGAATCGCTG

Downstream 100 bases:

>100_bases
CCCCACTCTTTCACCATGATGCGTGTAATGCGCATCTGCTGCACTTAACGGTAACCCCGCGTTCACTTTCGACACATTTG
TCGACTGCACCTTGGTTTGA

Product: DNA-binding transcriptional repressor DeoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
METRRAERINKLIQALKRSDKIHLKDAANLLRVSEMTIRRDLSAEPTSVILLGGYVVMDPKSNNANNYFVSDQQAKQVEE
KRRIGQLAAQLIIENDTVFFDCGTTIPWIIDEIDEELAFTAICYSLNTFLALQDKPNCKVILCGGEFKPNNCIFTPLSQQ
SELDNICPNKAFISAAGVSIEYGATCFNFDEILLKHRAMAKSQYKILVADHSKFGKIKPASIGTLAQFDALVTDRPPVAE
FYLFFSQHSVKIYC

Sequences:

>Translated_254_residues
METRRAERINKLIQALKRSDKIHLKDAANLLRVSEMTIRRDLSAEPTSVILLGGYVVMDPKSNNANNYFVSDQQAKQVEE
KRRIGQLAAQLIIENDTVFFDCGTTIPWIIDEIDEELAFTAICYSLNTFLALQDKPNCKVILCGGEFKPNNCIFTPLSQQ
SELDNICPNKAFISAAGVSIEYGATCFNFDEILLKHRAMAKSQYKILVADHSKFGKIKPASIGTLAQFDALVTDRPPVAE
FYLFFSQHSVKIYC
>Mature_254_residues
METRRAERINKLIQALKRSDKIHLKDAANLLRVSEMTIRRDLSAEPTSVILLGGYVVMDPKSNNANNYFVSDQQAKQVEE
KRRIGQLAAQLIIENDTVFFDCGTTIPWIIDEIDEELAFTAICYSLNTFLALQDKPNCKVILCGGEFKPNNCIFTPLSQQ
SELDNICPNKAFISAAGVSIEYGATCFNFDEILLKHRAMAKSQYKILVADHSKFGKIKPASIGTLAQFDALVTDRPPVAE
FYLFFSQHSVKIYC

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=252, Percent_Identity=56.7460317460317, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI1789829, Length=254, Percent_Identity=25.9842519685039, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790753, Length=267, Percent_Identity=25.8426966292135, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87082344, Length=233, Percent_Identity=25.7510729613734, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI226510968, Length=230, Percent_Identity=25.6521739130435, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789519, Length=235, Percent_Identity=25.1063829787234, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789059, Length=232, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787540, Length=251, Percent_Identity=25.0996015936255, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28553; Mature: 28553

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METRRAERINKLIQALKRSDKIHLKDAANLLRVSEMTIRRDLSAEPTSVILLGGYVVMDP
CCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEECC
KSNNANNYFVSDQQAKQVEEKRRIGQLAAQLIIENDTVFFDCGTTIPWIIDEIDEELAFT
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCHHHHHHHHHHHHHH
AICYSLNTFLALQDKPNCKVILCGGEFKPNNCIFTPLSQQSELDNICPNKAFISAAGVSI
HHHHHHHHEEEEECCCCEEEEEECCCCCCCCEEECCCCCCHHHHHCCCCCCEEEECCCEE
EYGATCFNFDEILLKHRAMAKSQYKILVADHSKFGKIKPASIGTLAQFDALVTDRPPVAE
ECCCEEECHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCHHH
FYLFFSQHSVKIYC
EEEEEECCCEEEEC
>Mature Secondary Structure
METRRAERINKLIQALKRSDKIHLKDAANLLRVSEMTIRRDLSAEPTSVILLGGYVVMDP
CCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEECC
KSNNANNYFVSDQQAKQVEEKRRIGQLAAQLIIENDTVFFDCGTTIPWIIDEIDEELAFT
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCHHHHHHHHHHHHHH
AICYSLNTFLALQDKPNCKVILCGGEFKPNNCIFTPLSQQSELDNICPNKAFISAAGVSI
HHHHHHHHEEEEECCCCEEEEEECCCCCCCCEEECCCCCCHHHHHCCCCCCEEEECCCEE
EYGATCFNFDEILLKHRAMAKSQYKILVADHSKFGKIKPASIGTLAQFDALVTDRPPVAE
ECCCEEECHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCHHH
FYLFFSQHSVKIYC
EEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]