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The map label for this gene is thiK [H]

Identifier: 22125667

GI number: 22125667

Start: 1953804

End: 1954691

Strand: Direct

Name: thiK [H]

Synonym: y1773

Alternate gene names: 22125667

Gene position: 1953804-1954691 (Clockwise)

Preceding gene: 22125666

Following gene: 22125668

Centisome position: 42.47

GC content: 49.55

Gene sequence:

>888_bases
GTGAAATCATTTGGTCTGGTAATGCGCCTGTCCAATATTGATTCTTCTCTGTCTGCCTTAATAGCAAACATCAATCCGGC
GGTGAAAACCGCCGATTGTCATATTAGCCCGGTATCAGGATTAACCGGTGAAAGTTGGCGTATTACTGGCCCAGGGATTG
ACTGGCTGGCGCGTGAGCAATCGCCGCACAAAAGTCAGTTGGGGGTCAACCGACGACGTGAGCGTAAATTCCTGCAACAT
ATTGCTGGCAATGGGCTGTCTCCAGCGGTGATTGCTGCTAATCAGCGTTGGCTAGTGGTGAACTGGCTTGAAGGTGACGT
TGTCACTAATGAGCAGTTCATCCCATTGGTGAATCATGGGCAATTAGCGCGGTTACTGGCCCGCTTGCATCATTTGCCCG
CGAGTGGTTACCGTCTGGATTTGCGTGCTCAGATTGCCCGCTATGGGGCGCTTATTGATCCTACGCGCCGTTCACCTGGC
GGAGTGCGGCTACAGCATGATTTTCTTCGTAGGCCATTACCAGCGATAACAAAAATTGCTCCTTTGCATATGGATATTCA
CCCCGGCAATTTGTTAACAACCCCCGTTGGGCTGAAATTAATTGACTGGGAATATGCGGCAGATGGCGATATTGCTTTGG
AAATTGCCGCGCTATTTCGCGGTAATCATTGGTCAATGCTACAACAACAGGCTTTTTTGCAGGACTATTGCAACAATGAG
CACGGTTATCATGACATCGCTCGTTTATCCCGTCAGATTCAGCAATGGTTGCCCTGGGTCGATTACCTGATGTTGATGTG
GTTTGAAGTGCGTTGGCAGCAAACCGCGGACCCAATATTCTTGGCATGGGCCGCGCCGTTGCGCCAACGTTTTAATTTGT
CTTTTTAA

Upstream 100 bases:

>100_bases
TTGGCCCGTTACGTCGGTGCGCAATATGTGCTGTACAGTGATGTCAGTGGCGATGTGAAATCTCCGACCATTGAAATGCA
ATTGATGCAGACACAAACCG

Downstream 100 bases:

>100_bases
GCCCTGCGGCACCAAGCCCGCCGCTTCAAGCACGAAGGGTCGTTATCAATCTGAATAAAGTGAGGTGACCGTGGGTCCCG
TGATGTTAGATGTTGCCAGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKSFGLVMRLSNIDSSLSALIANINPAVKTADCHISPVSGLTGESWRITGPGIDWLAREQSPHKSQLGVNRRRERKFLQH
IAGNGLSPAVIAANQRWLVVNWLEGDVVTNEQFIPLVNHGQLARLLARLHHLPASGYRLDLRAQIARYGALIDPTRRSPG
GVRLQHDFLRRPLPAITKIAPLHMDIHPGNLLTTPVGLKLIDWEYAADGDIALEIAALFRGNHWSMLQQQAFLQDYCNNE
HGYHDIARLSRQIQQWLPWVDYLMLMWFEVRWQQTADPIFLAWAAPLRQRFNLSF

Sequences:

>Translated_295_residues
MKSFGLVMRLSNIDSSLSALIANINPAVKTADCHISPVSGLTGESWRITGPGIDWLAREQSPHKSQLGVNRRRERKFLQH
IAGNGLSPAVIAANQRWLVVNWLEGDVVTNEQFIPLVNHGQLARLLARLHHLPASGYRLDLRAQIARYGALIDPTRRSPG
GVRLQHDFLRRPLPAITKIAPLHMDIHPGNLLTTPVGLKLIDWEYAADGDIALEIAALFRGNHWSMLQQQAFLQDYCNNE
HGYHDIARLSRQIQQWLPWVDYLMLMWFEVRWQQTADPIFLAWAAPLRQRFNLSF
>Mature_295_residues
MKSFGLVMRLSNIDSSLSALIANINPAVKTADCHISPVSGLTGESWRITGPGIDWLAREQSPHKSQLGVNRRRERKFLQH
IAGNGLSPAVIAANQRWLVVNWLEGDVVTNEQFIPLVNHGQLARLLARLHHLPASGYRLDLRAQIARYGALIDPTRRSPG
GVRLQHDFLRRPLPAITKIAPLHMDIHPGNLLTTPVGLKLIDWEYAADGDIALEIAALFRGNHWSMLQQQAFLQDYCNNE
HGYHDIARLSRQIQQWLPWVDYLMLMWFEVRWQQTADPIFLAWAAPLRQRFNLSF

Specific function: Catalyzes the phosphorylation of thiamine to thiamine phosphate [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787349, Length=248, Percent_Identity=37.5, Blast_Score=135, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002575
- InterPro:   IPR011009
- InterPro:   IPR014093 [H]

Pfam domain/function: PF01636 APH [H]

EC number: =2.7.1.89 [H]

Molecular weight: Translated: 33559; Mature: 33559

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFGLVMRLSNIDSSLSALIANINPAVKTADCHISPVSGLTGESWRITGPGIDWLAREQ
CCCCCEEEEECCCCHHHHHHHHCCCCCEEECCCEEECCCCCCCCCEEEECCCCHHHHCCC
SPHKSQLGVNRRRERKFLQHIAGNGLSPAVIAANQRWLVVNWLEGDVVTNEQFIPLVNHG
CCCHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCEECCCCEEEEECCC
QLARLLARLHHLPASGYRLDLRAQIARYGALIDPTRRSPGGVRLQHDFLRRPLPAITKIA
HHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHCCCHHHHHCC
PLHMDIHPGNLLTTPVGLKLIDWEYAADGDIALEIAALFRGNHWSMLQQQAFLQDYCNNE
CEEEEECCCCEEECCCCEEEEEEEECCCCCHHEEEEEHHCCCCHHHHHHHHHHHHHHCCC
HGYHDIARLSRQIQQWLPWVDYLMLMWFEVRWQQTADPIFLAWAAPLRQRFNLSF
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCC
>Mature Secondary Structure
MKSFGLVMRLSNIDSSLSALIANINPAVKTADCHISPVSGLTGESWRITGPGIDWLAREQ
CCCCCEEEEECCCCHHHHHHHHCCCCCEEECCCEEECCCCCCCCCEEEECCCCHHHHCCC
SPHKSQLGVNRRRERKFLQHIAGNGLSPAVIAANQRWLVVNWLEGDVVTNEQFIPLVNHG
CCCHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCEECCCCEEEEECCC
QLARLLARLHHLPASGYRLDLRAQIARYGALIDPTRRSPGGVRLQHDFLRRPLPAITKIA
HHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHCCCHHHHHCC
PLHMDIHPGNLLTTPVGLKLIDWEYAADGDIALEIAALFRGNHWSMLQQQAFLQDYCNNE
CEEEEECCCCEEECCCCEEEEEEEECCCCCHHEEEEEHHCCCCHHHHHHHHHHHHHHCCC
HGYHDIARLSRQIQQWLPWVDYLMLMWFEVRWQQTADPIFLAWAAPLRQRFNLSF
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA