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The map label for this gene is apbE [H]

Identifier: 22124864

GI number: 22124864

Start: 1077906

End: 1078988

Strand: Direct

Name: apbE [H]

Synonym: y0957

Alternate gene names: 22124864

Gene position: 1077906-1078988 (Clockwise)

Preceding gene: 22124863

Following gene: 161484857

Centisome position: 23.43

GC content: 48.2

Gene sequence:

>1083_bases
TTGATGATTTCGGTGGCTGATCCGGTCATCACTCGGGAATTCACAGTGGTTGGGGCGATTGTGCGCAAGTATATAACACG
TTGTTTAATGTTGGTGATAGGGGGCCTGCTGCTGAGTGGCTGTGGCCCTGAGCAGGTCAGCCTTGAAGGCAAAACGATGG
GAACCTCCTATTCTATTAAGTATGTGAGTGATTCATCAACGGCTGCCCCAGAGACGTTACAACAGGAAATAGACCTCATA
CTTGAAGAGGTTAATGACCAGATGTCGACTTATCGGCCACATTCTGAATTGAGCCGCTTTAATCAAAGCCGAGAGGTGAA
TCAACCTTTCCCTGTATCGGCGGCGACGGCCAAAGTAGTACAAGAGGCTATCCGTATTAACCGTCTGACCGATGGTGCCT
TAGATGTGACTGTGGGGCCGTTAGTCAATTTATGGGGTTTTGGCCCTGAAGGGCGCCCGGATACTGTCCCTACCGAGGAT
GAAATCACTCGGCGTCGTGCGTGGGTAGGGATTGATAAGCTGGCAGTGGATAAGAATGCATTAATAAAACGTGTTCCTGA
ACTGTATGTTGATCTCTCTTCTATCGCCAAAGGCTACGGCGTCGATGTAGTAGCTGAATATCTGGAGGCGCAGAATATCA
AGGATTATATGGTTGATATCGGGGGGGAAGTCCGTACCCGTGGTAACAATGGAGAAAATAAACCTTGGCGTATCGCCATT
GAAAAGCCAGTCGCGGGTTCTACACAACGTGCCCAGGAAATTATTGAACCAGGGCGGATGGCGGTAGCCACCTCTGGTGA
TTATCGTAATTATTTTGAGCAGGACGGGATCCGTTATTCTCATACTATTGATCCTGATACCGGGCGGCCTATTAACCACC
GGTTAGTCTCTATCACTGTTTTAGACCCAAGCTGTATGACTGCTGATGGCCTCTCTACCGGGTTAGGTGTCCTTGGGCCA
GAGCGGGGAATGGCATTAGCCAATTTATTGGGCATCCCGGTCTTGATGATAATCAAAACAGATGATGGGTTTGAAGAGCA
GTATTCAGATGCATTTAAACCCTATCTACAAGTAAAACATTAG

Upstream 100 bases:

>100_bases
CCAGAGGATTGTGAATTTTATATGTGTGGGCCGCCAATGATGAACGCTGCAGTGATCAAGATGCTGAAAGATCTTGGTGT
AGAAGACGAAAATATTATGC

Downstream 100 bases:

>100_bases
CCAGGAGGGGATATGTTGACTGTCTTTATCGCATCCTTTGTATTTTTTCTGTTAGCTATAGCGGGAATGTCGCTAGGTTA
TATCGTCAAAAATAAAACCA

Product: thiamine biosynthesis lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MMISVADPVITREFTVVGAIVRKYITRCLMLVIGGLLLSGCGPEQVSLEGKTMGTSYSIKYVSDSSTAAPETLQQEIDLI
LEEVNDQMSTYRPHSELSRFNQSREVNQPFPVSAATAKVVQEAIRINRLTDGALDVTVGPLVNLWGFGPEGRPDTVPTED
EITRRRAWVGIDKLAVDKNALIKRVPELYVDLSSIAKGYGVDVVAEYLEAQNIKDYMVDIGGEVRTRGNNGENKPWRIAI
EKPVAGSTQRAQEIIEPGRMAVATSGDYRNYFEQDGIRYSHTIDPDTGRPINHRLVSITVLDPSCMTADGLSTGLGVLGP
ERGMALANLLGIPVLMIIKTDDGFEEQYSDAFKPYLQVKH

Sequences:

>Translated_360_residues
MMISVADPVITREFTVVGAIVRKYITRCLMLVIGGLLLSGCGPEQVSLEGKTMGTSYSIKYVSDSSTAAPETLQQEIDLI
LEEVNDQMSTYRPHSELSRFNQSREVNQPFPVSAATAKVVQEAIRINRLTDGALDVTVGPLVNLWGFGPEGRPDTVPTED
EITRRRAWVGIDKLAVDKNALIKRVPELYVDLSSIAKGYGVDVVAEYLEAQNIKDYMVDIGGEVRTRGNNGENKPWRIAI
EKPVAGSTQRAQEIIEPGRMAVATSGDYRNYFEQDGIRYSHTIDPDTGRPINHRLVSITVLDPSCMTADGLSTGLGVLGP
ERGMALANLLGIPVLMIIKTDDGFEEQYSDAFKPYLQVKH
>Mature_360_residues
MMISVADPVITREFTVVGAIVRKYITRCLMLVIGGLLLSGCGPEQVSLEGKTMGTSYSIKYVSDSSTAAPETLQQEIDLI
LEEVNDQMSTYRPHSELSRFNQSREVNQPFPVSAATAKVVQEAIRINRLTDGALDVTVGPLVNLWGFGPEGRPDTVPTED
EITRRRAWVGIDKLAVDKNALIKRVPELYVDLSSIAKGYGVDVVAEYLEAQNIKDYMVDIGGEVRTRGNNGENKPWRIAI
EKPVAGSTQRAQEIIEPGRMAVATSGDYRNYFEQDGIRYSHTIDPDTGRPINHRLVSITVLDPSCMTADGLSTGLGVLGP
ERGMALANLLGIPVLMIIKTDDGFEEQYSDAFKPYLQVKH

Specific function: Involved in the conversion of aminoimidazole ribotide (AIR), a purine intermediate, to the 4-amino-5-hydroxymethyl-2- methyl pyrimidine (HMP) moiety of thiamine [H]

COG id: COG1477

COG function: function code H; Membrane-associated lipoprotein involved in thiamine biosynthesis

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ApbE family [H]

Homologues:

Organism=Escherichia coli, GI1788543, Length=346, Percent_Identity=41.6184971098266, Blast_Score=266, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003374 [H]

Pfam domain/function: PF02424 ApbE [H]

EC number: NA

Molecular weight: Translated: 39576; Mature: 39576

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMISVADPVITREFTVVGAIVRKYITRCLMLVIGGLLLSGCGPEQVSLEGKTMGTSYSIK
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEE
YVSDSSTAAPETLQQEIDLILEEVNDQMSTYRPHSELSRFNQSREVNQPFPVSAATAKVV
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHH
QEAIRINRLTDGALDVTVGPLVNLWGFGPEGRPDTVPTEDEITRRRAWVGIDKLAVDKNA
HHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCHHH
LIKRVPELYVDLSSIAKGYGVDVVAEYLEAQNIKDYMVDIGGEVRTRGNNGENKPWRIAI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCEEECCCCCCCCCEEEEE
EKPVAGSTQRAQEIIEPGRMAVATSGDYRNYFEQDGIRYSHTIDPDTGRPINHRLVSITV
ECCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEE
LDPSCMTADGLSTGLGVLGPERGMALANLLGIPVLMIIKTDDGFEEQYSDAFKPYLQVKH
ECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMISVADPVITREFTVVGAIVRKYITRCLMLVIGGLLLSGCGPEQVSLEGKTMGTSYSIK
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEE
YVSDSSTAAPETLQQEIDLILEEVNDQMSTYRPHSELSRFNQSREVNQPFPVSAATAKVV
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHH
QEAIRINRLTDGALDVTVGPLVNLWGFGPEGRPDTVPTEDEITRRRAWVGIDKLAVDKNA
HHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCHHH
LIKRVPELYVDLSSIAKGYGVDVVAEYLEAQNIKDYMVDIGGEVRTRGNNGENKPWRIAI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCEEECCCCCCCCCEEEEE
EKPVAGSTQRAQEIIEPGRMAVATSGDYRNYFEQDGIRYSHTIDPDTGRPINHRLVSITV
ECCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEE
LDPSCMTADGLSTGLGVLGPERGMALANLLGIPVLMIIKTDDGFEEQYSDAFKPYLQVKH
ECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]