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The map label for this gene is fabG [H]

Identifier: 221230855

GI number: 221230855

Start: 3058832

End: 3060196

Strand: Direct

Name: fabG [H]

Synonym: MLBr_02565

Alternate gene names: 221230855

Gene position: 3058832-3060196 (Clockwise)

Preceding gene: 221230853

Following gene: 221230856

Centisome position: 93.6

GC content: 61.47

Gene sequence:

>1365_bases
GTGGCCCCCAAGTGCTCATCGGATCTGTTCTCACAGATTGTCAGCTCCGGTCCGGGATCGTTTGTGGCGAAACAACTTGG
CGTTCCGCGGCCCGAAACACTTCGACGCTACCGGCCGAGCGATGCACCGCTATGCGGATCCCTGCTAATCGGCGGTGACG
GCAGGCTGGTAGAGCCGTTGCGTGCGACGCTAGAAAAGGACTACGACCTGGTAAGTAACAACCTGGGCGGTCGTTGGACC
GACTCATTCGGCGGGCTCGTCTTCGACGCCACCGGTATTACAGCGCCGGCCGAGCTTAAAGGACTGCACAACTTTTTCAC
TCCCCTACTGCGCAATCTTGGCCGCTGTGCACGCGTCGTGGTCATCGGCACGACACCCGACGCGACCACCAGCACCGACG
AACGAATCGCGCAGCGCGCGTTGGAGGGTTTCAGCCGCTCACTGGGCAAGGAATTGCGCCGCGGCGCCACCGTGGCGCTG
GTGTATCTATCACCGGACGCCAAACCGGCCGCCACGGGCCTGGAGTCCACCATGCGGTTCATCCTGTCGGCCAAGTCGGC
CTACGTCAACGGCCAGGTTTTCTATGTCGGGGCAGCCGACTCCACCCCACCGACCAATTGGGACCGGCCGCTGGAGAACA
AGGTAGCCATCGTGACCGGTGCCGCACGCGGTATCGGCGCGGCCATCGCCGAGGTGGTCGCCAGGGATGGCGCCCGGGTC
GTCGCGATCGACGTGGAATCCGCAGCTGAGGCGCTGGATGAAACCGCCAATCGGGTCGGTGGCACCACACTGTCACTCGA
CGTCACCGCGGATGATGCCGTCGACAAAATCACCGAGCACCTACATGACTATCAAGGCGGGCACGCCGACATCTTGGTCA
ACAACGCTGGTATCACCCGTGACAAACTGTTGGCCAACATGGACGATTGCAGATGGGATGCCGTCTTGGAAGTCAATCTT
CTTGCCCCGCAACGTCTTACCGAAGGATTAGTCGGGAACGGCAGCATAAGCAAAGGCGGTAGGGTGATCGTCCTGTCGTC
AATGGCCGGCATTGCGGGCAACCGCGGTCAGACGAACTACGCCACCGCTAAGGCCGGGGTGATTGGTCTCACCCAAGCAC
TAGCACCGGGACTGGCCGAGAAGGGCATCACGATCAACGCCGTCGCACCGGGATTCATCGAAACTCAAATGACGGCAGCT
ATCCCGCTGGCCACCCGCGAGGTAGGACGCCGACTGAACTCGTTGCTGCAGGGTGGCCTGCCCGTAGATGTTGCTGAGAC
CATTGCCTACTTCGCTATACCGGCGTCCAACGCGGTGACAGGAAACGTTATTCGTGTATGTGGCCAGGCAATGCTCGGTG
CATGA

Upstream 100 bases:

>100_bases
GTTAGGGGATAAGCTGTTGGGAGTCACACTACCCGCTGTTCTTACTCTCAAGTAAGTTTATTTACCTCGATAAGGTTTGG
CTTAAACGGAAGGCAGCTCA

Downstream 100 bases:

>100_bases
CCTCACCGAATCGTTCCACCCGACGCTAAAACGAAAATCTCTGTGCGAAAACACTTACACCAACATAGTCAGATCAACCA
AATGCTATGATAATTTGGCT

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLIGGDGRLVEPLRATLEKDYDLVSNNLGGRWT
DSFGGLVFDATGITAPAELKGLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGKELRRGATVAL
VYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAADSTPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARV
VAIDVESAAEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITRDKLLANMDDCRWDAVLEVNL
LAPQRLTEGLVGNGSISKGGRVIVLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTAA
IPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA

Sequences:

>Translated_454_residues
MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLIGGDGRLVEPLRATLEKDYDLVSNNLGGRWT
DSFGGLVFDATGITAPAELKGLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGKELRRGATVAL
VYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAADSTPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARV
VAIDVESAAEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITRDKLLANMDDCRWDAVLEVNL
LAPQRLTEGLVGNGSISKGGRVIVLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTAA
IPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA
>Mature_453_residues
APKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLIGGDGRLVEPLRATLEKDYDLVSNNLGGRWTD
SFGGLVFDATGITAPAELKGLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGKELRRGATVALV
YLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAADSTPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVV
AIDVESAAEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITRDKLLANMDDCRWDAVLEVNLL
APQRLTEGLVGNGSISKGGRVIVLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTAAI
PLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=37.007874015748, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=34.1666666666667, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=30.5220883534137, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4504505, Length=190, Percent_Identity=33.6842105263158, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI31542939, Length=204, Percent_Identity=34.3137254901961, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI5031737, Length=252, Percent_Identity=30.952380952381, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI66933014, Length=186, Percent_Identity=32.258064516129, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI33667109, Length=209, Percent_Identity=33.9712918660287, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI126723191, Length=187, Percent_Identity=32.0855614973262, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI19923817, Length=260, Percent_Identity=28.8461538461538, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=33.8983050847458, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI4758504, Length=209, Percent_Identity=31.1004784688995, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI7657478, Length=240, Percent_Identity=26.25, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI157739938, Length=202, Percent_Identity=26.2376237623762, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI20149619, Length=239, Percent_Identity=28.0334728033473, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=246, Percent_Identity=40.2439024390244, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=31.7829457364341, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789208, Length=247, Percent_Identity=32.7935222672065, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1790717, Length=196, Percent_Identity=31.1224489795918, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=30.1204819277108, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1789057, Length=262, Percent_Identity=28.2442748091603, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI2367365, Length=242, Percent_Identity=31.404958677686, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=30.2040816326531, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=31.0756972111554, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789378, Length=258, Percent_Identity=27.906976744186, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788459, Length=252, Percent_Identity=27.3809523809524, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=38.1147540983607, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17555706, Length=241, Percent_Identity=36.5145228215768, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=32.8125, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17568967, Length=190, Percent_Identity=34.2105263157895, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=29.296875, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=242, Percent_Identity=31.8181818181818, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=207, Percent_Identity=30.9178743961353, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=197, Percent_Identity=31.4720812182741, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=240, Percent_Identity=29.5833333333333, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=251, Percent_Identity=29.4820717131474, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=254, Percent_Identity=29.9212598425197, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=243, Percent_Identity=29.2181069958848, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=239, Percent_Identity=28.8702928870293, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=205, Percent_Identity=28.780487804878, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=28.7449392712551, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=261, Percent_Identity=29.5019157088123, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=253, Percent_Identity=28.0632411067194, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=206, Percent_Identity=25.7281553398058, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=193, Percent_Identity=29.5336787564767, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=271, Percent_Identity=26.5682656826568, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=28.3018867924528, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=212, Percent_Identity=30.6603773584906, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=36.3265306122449, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=35.8870967741936, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI18859837, Length=189, Percent_Identity=32.8042328042328, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=30.1960784313725, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21357041, Length=194, Percent_Identity=33.5051546391753, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355319, Length=200, Percent_Identity=31.5, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571526, Length=198, Percent_Identity=32.8282828282828, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644339, Length=236, Percent_Identity=31.7796610169492, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24640442, Length=196, Percent_Identity=31.6326530612245, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24643142, Length=191, Percent_Identity=31.413612565445, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 47358; Mature: 47227

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLIGGDGRLVEPL
CCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHH
RATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELKGLHNFFTPLLRNLGRCARVV
HHHHHHHHHHHHCCCCCEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEE
VIGTTPDATTSTDERIAQRALEGFSRSLGKELRRGATVALVYLSPDAKPAATGLESTMRF
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
ILSAKSAYVNGQVFYVGAADSTPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARV
HHHHHHHEECCEEEEEECCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEE
VAIDVESAAEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
EEEEHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEECCCCCH
DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMAGIAGNRGQTNY
HHHHHCCCCCCEEEEEEEEECCHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
ATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGGL
HHHHHHHHHHHHHHCCCHHHCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
PVDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA
CCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
APKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLIGGDGRLVEPL
CCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHH
RATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELKGLHNFFTPLLRNLGRCARVV
HHHHHHHHHHHHCCCCCEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEE
VIGTTPDATTSTDERIAQRALEGFSRSLGKELRRGATVALVYLSPDAKPAATGLESTMRF
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
ILSAKSAYVNGQVFYVGAADSTPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARV
HHHHHHHEECCEEEEEECCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEE
VAIDVESAAEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
EEEEHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEECCCCCH
DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMAGIAGNRGQTNY
HHHHHCCCCCCEEEEEEEEECCHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
ATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGGL
HHHHHHHHHHHHHHCCCHHHCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
PVDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA
CCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]