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The map label for this gene is purC

Identifier: 221230670

GI number: 221230670

Start: 2644956

End: 2645849

Strand: Reverse

Name: purC

Synonym: MLBr_02227

Alternate gene names: 221230670

Gene position: 2645849-2644956 (Counterclockwise)

Preceding gene: 221230672

Following gene: 221230669

Centisome position: 80.96

GC content: 57.16

Gene sequence:

>894_bases
ATGCGTCCCGCATTGTTCGACTACCGGCATTTGGCCAGCGGCAAGGTCCGCGAGATATACCGCATCGACGACGAGCACCT
CTTAATGGTTGCGTCGGATCGGATATCGGCGTTCGACTACGTTCTGGACAGCACGATTCCGGACAAAGGCCGGATCCTGA
CCGCGATGAGTGTGTTTTTCTTTAGCTTCGTAGACGCTCCCAACCACCTGGCCGGGCCGCCCGACGACCCGCGCATTCCC
GAGGAGGTGCTTGGCCGCGCGCTGGTGGTTCGGCAGCTGGACATGCTGCCGATGGAGTGTGTAGCTCGCGGTTACCTGAC
CGGTTCGGGACTATTGGATTATCAGGCGACCGGGAAGGTTTGCGGCATCCCGTTGCCGCCAGGCCTGGTCGAAGCCAGCA
GGTTCGCCGCTCCGCTTTTCACCCCGGCTATGAAAGCTGTTCTAGGAGAACATGATGAGAACATTTCGTTTTCCAGGATG
ATTGAGATGGTGGGTGTGGTGCGTGCCAACCAGCTACGCGACCGGACTTTGCAGATTTACCTTCAGGCAGCTGATCACGC
ACTGAAGACCGGAATAATCATAGCTGACACTAAGTTTGAATTTGGTATCGACCGCGACGGCAACCTGCTTCTGGCCGATG
AGATTTTCACACCGGACTCCTCGCGGTACTGGTCAGTCGACGACTACCGGGTCGGTGTGGTTCAGAGAAGCTTCGACAAG
CAGTTCGTCCGTAACTGGCTTGTCAGTCCTGAGTCGGGTTGGGTCCGCGCTGGAGCATTGTCCCCGCCGTCGCTACCGGA
TGACATTATCGAGGCCACCCGTCTATGCTATGTCGAAGTTTATGAACGGATTTCCGGTATGAGCTTCGACGATTGGATCG
GTCCAGGAGCATGA

Upstream 100 bases:

>100_bases
GGGCTAGTAGCGTAGGGTAAAAACCGTGAGTTCATAGTTCTGATCCCAACACAGAGCCAGTCTGAAAGCGCGTTTGGGGG
TTCCGGATAGGCTAAGCCTT

Downstream 100 bases:

>100_bases
CAAAGACATCCAGGGGTACACCCGTACCGCCCATCGCCAAGCGCGTGGAGACTCGCAGGGAGCGCCACGGAGACGTCTTT
TTTGATCCGTATGAATGGTT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MRPALFDYRHLASGKVREIYRIDDEHLLMVASDRISAFDYVLDSTIPDKGRILTAMSVFFFSFVDAPNHLAGPPDDPRIP
EEVLGRALVVRQLDMLPMECVARGYLTGSGLLDYQATGKVCGIPLPPGLVEASRFAAPLFTPAMKAVLGEHDENISFSRM
IEMVGVVRANQLRDRTLQIYLQAADHALKTGIIIADTKFEFGIDRDGNLLLADEIFTPDSSRYWSVDDYRVGVVQRSFDK
QFVRNWLVSPESGWVRAGALSPPSLPDDIIEATRLCYVEVYERISGMSFDDWIGPGA

Sequences:

>Translated_297_residues
MRPALFDYRHLASGKVREIYRIDDEHLLMVASDRISAFDYVLDSTIPDKGRILTAMSVFFFSFVDAPNHLAGPPDDPRIP
EEVLGRALVVRQLDMLPMECVARGYLTGSGLLDYQATGKVCGIPLPPGLVEASRFAAPLFTPAMKAVLGEHDENISFSRM
IEMVGVVRANQLRDRTLQIYLQAADHALKTGIIIADTKFEFGIDRDGNLLLADEIFTPDSSRYWSVDDYRVGVVQRSFDK
QFVRNWLVSPESGWVRAGALSPPSLPDDIIEATRLCYVEVYERISGMSFDDWIGPGA
>Mature_297_residues
MRPALFDYRHLASGKVREIYRIDDEHLLMVASDRISAFDYVLDSTIPDKGRILTAMSVFFFSFVDAPNHLAGPPDDPRIP
EEVLGRALVVRQLDMLPMECVARGYLTGSGLLDYQATGKVCGIPLPPGLVEASRFAAPLFTPAMKAVLGEHDENISFSRM
IEMVGVVRANQLRDRTLQIYLQAADHALKTGIIIADTKFEFGIDRDGNLLLADEIFTPDSSRYWSVDDYRVGVVQRSFDK
QFVRNWLVSPESGWVRAGALSPPSLPDDIIEATRLCYVEVYERISGMSFDDWIGPGA

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=295, Percent_Identity=41.0169491525424, Blast_Score=240, Evalue=2e-64,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_MYCLB (B8ZSW0)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002504086.1
- ProteinModelPortal:   B8ZSW0
- SMR:   B8ZSW0
- EnsemblBacteria:   EBMYCT00000085632
- GeneID:   7325031
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000017539
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- ProtClustDB:   PRK13961
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 33163; Mature: 33163

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPALFDYRHLASGKVREIYRIDDEHLLMVASDRISAFDYVLDSTIPDKGRILTAMSVFF
CCCCHHHHHHHCCCCHHHHEEECCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHH
FSFVDAPNHLAGPPDDPRIPEEVLGRALVVRQLDMLPMECVARGYLTGSGLLDYQATGKV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCCE
CGIPLPPGLVEASRFAAPLFTPAMKAVLGEHDENISFSRMIEMVGVVRANQLRDRTLQIY
ECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEH
LQAADHALKTGIIIADTKFEFGIDRDGNLLLADEIFTPDSSRYWSVDDYRVGVVQRSFDK
HHHHHHHHHCCEEEEECCEEECCCCCCCEEEEEEEECCCCCCEECCCCEEEHHHHHHHHH
QFVRNWLVSPESGWVRAGALSPPSLPDDIIEATRLCYVEVYERISGMSFDDWIGPGA
HHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCC
>Mature Secondary Structure
MRPALFDYRHLASGKVREIYRIDDEHLLMVASDRISAFDYVLDSTIPDKGRILTAMSVFF
CCCCHHHHHHHCCCCHHHHEEECCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHH
FSFVDAPNHLAGPPDDPRIPEEVLGRALVVRQLDMLPMECVARGYLTGSGLLDYQATGKV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCCE
CGIPLPPGLVEASRFAAPLFTPAMKAVLGEHDENISFSRMIEMVGVVRANQLRDRTLQIY
ECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEH
LQAADHALKTGIIIADTKFEFGIDRDGNLLLADEIFTPDSSRYWSVDDYRVGVVQRSFDK
HHHHHHHHHCCEEEEECCEEECCCCCCCEEEEEEEECCCCCCEECCCCEEEHHHHHHHHH
QFVRNWLVSPESGWVRAGALSPPSLPDDIIEATRLCYVEVYERISGMSFDDWIGPGA
HHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA