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The map label for this gene is mshD

Identifier: 221230650

GI number: 221230650

Start: 2608038

End: 2608973

Strand: Reverse

Name: mshD

Synonym: MLBr_02193

Alternate gene names: 221230650

Gene position: 2608973-2608038 (Counterclockwise)

Preceding gene: 221230657

Following gene: 221230649

Centisome position: 79.83

GC content: 61.22

Gene sequence:

>936_bases
ATGGTACTTAACTGGCGTTTCGCACTTTCCGCCGATGAGCAGCGGTTAGTGCGCGAGATTATTTCGGCGGCAACCGAATT
CGATGAGGTATCACCCGTTGGAGAGCAGGTGTTGCGGGAACTCGGCTACGACCGCACCGAGCACCTTCTGGTCACGGATT
CGAGACCCTACGCACCGATTATCGGCTATCTCAATCTCAGCTCGCCACGTGATGCGGGCGTTGCTATGGCCGAGTTGGTG
GTGCATCCGCGGGAGCGCCGTCGCGGTGTTGGCGCCGCAATGGTACGTGCGGCGCTGGCGAAGACCGGGGGGCGCAACAG
GTTTTGGGCGCACGGCACGCTAGCATCGGCCCGGGCAACTGCGTCTGTGCTGGGTCTGGTACCGGTACGTGAACTGGTGC
AGATGCAACGTTCGCTGCGAACTATCCCTGACCCGATGGTCCCCGATCAGTTGGGGGTGTGGGTACGGACCTACGTGGGT
ACGGTTGATGACGCTGAGTTGTTACGGGTCAACAACGCCGCGTTTGCCGGCCATCCGGAACAGGGCGGTTGGACTGCAAC
CCAGTTAGCGGAGCGCCGCAGCGAACCGTGGTTTGACCCGGCGGGCTTATTCTTGGCTTTCGGTGACTCCTCGAGCAACC
AACCGGGCAAACTATTGGGTTTCCACTGGACCAAGGTGCATGCAGCTCACCCAGGCCTAGGTGAGGTCTATGTCCTAGGC
GTCGACCCGTCCGCTCAGGGCCGTGGCCTGGGACAGATGTTGACATCGATCGGTATCGCTTCGCTGGCGCAGCGGCTTGT
TGGGCCTTCGGCCGAACCCACCGTGATGCTCTATGTGGAATCGGACAACGTCGCCGCGGCGCGGACCTACGAGCGGCTAG
GCTTTACCACGTACAGTGTTGACACTGCTTACGCACTAGCCCGGATCGATGACTGA

Upstream 100 bases:

>100_bases
AGCCGGTGCTCGGCTGTGCGACGATCGCGGGGCCCTACGATCAGGACATCAAACCTGACGATTTCGATCACCCGATGGTC
GACTCGTTACATAGTCAGTG

Downstream 100 bases:

>100_bases
GCGAAAGCCCAGTTTCATGCAGTATTCACCGGTGTTGTTCACCCCAATAGCGATGTTTCTGGGTTCCTGCGGTGCATACT
TTCCGGGTGACCAGGCCACT

Product: putative acetyltransferase

Products: NA

Alternate protein names: MSH acetyltransferase; Mycothiol synthase

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MVLNWRFALSADEQRLVREIISAATEFDEVSPVGEQVLRELGYDRTEHLLVTDSRPYAPIIGYLNLSSPRDAGVAMAELV
VHPRERRRGVGAAMVRAALAKTGGRNRFWAHGTLASARATASVLGLVPVRELVQMQRSLRTIPDPMVPDQLGVWVRTYVG
TVDDAELLRVNNAAFAGHPEQGGWTATQLAERRSEPWFDPAGLFLAFGDSSSNQPGKLLGFHWTKVHAAHPGLGEVYVLG
VDPSAQGRGLGQMLTSIGIASLAQRLVGPSAEPTVMLYVESDNVAAARTYERLGFTTYSVDTAYALARIDD

Sequences:

>Translated_311_residues
MVLNWRFALSADEQRLVREIISAATEFDEVSPVGEQVLRELGYDRTEHLLVTDSRPYAPIIGYLNLSSPRDAGVAMAELV
VHPRERRRGVGAAMVRAALAKTGGRNRFWAHGTLASARATASVLGLVPVRELVQMQRSLRTIPDPMVPDQLGVWVRTYVG
TVDDAELLRVNNAAFAGHPEQGGWTATQLAERRSEPWFDPAGLFLAFGDSSSNQPGKLLGFHWTKVHAAHPGLGEVYVLG
VDPSAQGRGLGQMLTSIGIASLAQRLVGPSAEPTVMLYVESDNVAAARTYERLGFTTYSVDTAYALARIDD
>Mature_311_residues
MVLNWRFALSADEQRLVREIISAATEFDEVSPVGEQVLRELGYDRTEHLLVTDSRPYAPIIGYLNLSSPRDAGVAMAELV
VHPRERRRGVGAAMVRAALAKTGGRNRFWAHGTLASARATASVLGLVPVRELVQMQRSLRTIPDPMVPDQLGVWVRTYVG
TVDDAELLRVNNAAFAGHPEQGGWTATQLAERRSEPWFDPAGLFLAFGDSSSNQPGKLLGFHWTKVHAAHPGLGEVYVLG
VDPSAQGRGLGQMLTSIGIASLAQRLVGPSAEPTVMLYVESDNVAAARTYERLGFTTYSVDTAYALARIDD

Specific function: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol

COG id: COG0456

COG function: function code R; Acetyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSHD_MYCLB (B8ZSU0)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002504066.1
- ProteinModelPortal:   B8ZSU0
- SMR:   B8ZSU0
- EnsemblBacteria:   EBMYCT00000085043
- GeneID:   7327398
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016611
- HOGENOM:   HBG292446
- OMA:   GFHWTKI
- ProtClustDB:   CLSK790760
- HAMAP:   MF_01698
- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR017813
- Gene3D:   G3DSA:3.40.630.30
- TIGRFAMs:   TIGR03448

Pfam domain/function: PF00583 Acetyltransf_1; SSF55729 Acyl_CoA_acyltransferase

EC number: =2.3.1.189

Molecular weight: Translated: 33820; Mature: 33820

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS51186 GNAT

Important sites: BINDING 35-35 BINDING 180-180 BINDING 225-225 BINDING 235-235 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLNWRFALSADEQRLVREIISAATEFDEVSPVGEQVLRELGYDRTEHLLVTDSRPYAPI
CEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCCCE
IGYLNLSSPRDAGVAMAELVVHPRERRRGVGAAMVRAALAKTGGRNRFWAHGTLASARAT
EEEEECCCCCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCCCEEECCCHHHHHHH
ASVLGLVPVRELVQMQRSLRTIPDPMVPDQLGVWVRTYVGTVDDAELLRVNNAAFAGHPE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHEEECCCEECCCCC
QGGWTATQLAERRSEPWFDPAGLFLAFGDSSSNQPGKLLGFHWTKVHAAHPGLGEVYVLG
CCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEE
VDPSAQGRGLGQMLTSIGIASLAQRLVGPSAEPTVMLYVESDNVAAARTYERLGFTTYSV
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCEEEEH
DTAYALARIDD
HHHEEEEEECC
>Mature Secondary Structure
MVLNWRFALSADEQRLVREIISAATEFDEVSPVGEQVLRELGYDRTEHLLVTDSRPYAPI
CEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCCCE
IGYLNLSSPRDAGVAMAELVVHPRERRRGVGAAMVRAALAKTGGRNRFWAHGTLASARAT
EEEEECCCCCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCCCEEECCCHHHHHHH
ASVLGLVPVRELVQMQRSLRTIPDPMVPDQLGVWVRTYVGTVDDAELLRVNNAAFAGHPE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHEEECCCEECCCCC
QGGWTATQLAERRSEPWFDPAGLFLAFGDSSSNQPGKLLGFHWTKVHAAHPGLGEVYVLG
CCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEE
VDPSAQGRGLGQMLTSIGIASLAQRLVGPSAEPTVMLYVESDNVAAARTYERLGFTTYSV
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCEEEEH
DTAYALARIDD
HHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA