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The map label for this gene is serC

Identifier: 221230623

GI number: 221230623

Start: 2538660

End: 2539790

Strand: Direct

Name: serC

Synonym: MLBr_02136

Alternate gene names: 221230623

Gene position: 2538660-2539790 (Clockwise)

Preceding gene: 221230617

Following gene: 221230624

Centisome position: 77.68

GC content: 61.36

Gene sequence:

>1131_bases
ATGGCCGACCAGTTAACTCCTTCCCTTGACATTCCCGCCGCGCTGAAGCCCCGTGACGGCCGCTTCGGGTCGGGACCGTC
GAAGGTCCGGCCCGAACAATTGCAGGCGCTTACCAACACCGCGGCCACGTTGTTCGGCACCTCGCATCGGCAGGCGCCGG
TCAAAAATCTGGTAGGTCGGGTTCGGGCGGGGCTGGCCGAGCTGTTCAGCTTGCCAGACGGTTACCAGGTCATTCTGGGC
AATGGTGGCGCAACGGCGTTCTGGGATGCCGCAGCTTTCGGGTTGATCGACAAGCGCTCGCTACACCTGACGTACGGTGA
GTTCAGCTCGAAGTTTGCCTCCGCCGTCGCTAAAAACCCGTTCATCGACGAACCCATCGTCATCAAATCGGATCCGGGCA
GCGCGCCCAAACCAACAGGCGATCCGTCAGTCGATGTGATCGCGTGGGCACACAACGAGACGTCAACTGGCGTCGCGGTA
CCGGTCCGCCGTCCAACCGGTTCGGGTGGCGCGCTGATCGCCATCGATGCGACCTCTGGCGCCGGCGGGCTACCCGTCGA
CATCGCGCAAACCGATGCTTATTATTTCGCACCGCAGAAAAACTTCGCCAGCGACGGTGGCCTTTGGCTAGCCATCATGA
GTCCGGCCGCACTGGCCCGGGTCGACTCCATTACTGCGTCCGGTCGCTGGGTTCCTGACTTTCTTTCGCTGCCAATCGCG
GTAGAGAATAGCCTGAAAAACCAAACATACAATACGCCGGCAATCTGTACCCTGGCGCTGCTGGCCGAACAGCTCGACTG
GTTGCTGGGCAACGGGGGACTGGAGTGGGCCGTAAAGCGCACGGCAGACTCATCGCAACGGCTATACGCATGGGCGGAAG
ACCGGCCCTACACAACTCCGTTCGTCGTCGACCCAGCGCTGCGTTCTCAGGTGGTGGGTACAATCGACTTCACTGATGAC
GTCGACGCGGCGGCAGTCGCGAAGATCTTACGGGCCAACGGCATCATCGATACCGAGCCGTACCGTAAACTCGGCCGCAA
TCAGTTGCGGGTTGCGATGTTCCCCGCGGTCGAGCCCGATGACGTCAGAGCACTCACCGAGTGCGTTGACTGGATAGTCG
AGCGCCTTTAA

Upstream 100 bases:

>100_bases
GTGAATTGTCTCACTCTACAGCGCCGTCGCGCGTAGCTAGACTAACTTTCGGCGAATCCAGCTAATCGGCGTGCTGGAGC
AGCTCACTAACCTTGGTGGC

Downstream 100 bases:

>100_bases
CGCGGCGCTCATCGACCCCCAATAACTCAGCGTGTCAGCACGGCTCCGGGCATTTGCTGTACTAAAATGCGCAACAGGTT
CAGTGCTGACCCTGCACGGA

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MADQLTPSLDIPAALKPRDGRFGSGPSKVRPEQLQALTNTAATLFGTSHRQAPVKNLVGRVRAGLAELFSLPDGYQVILG
NGGATAFWDAAAFGLIDKRSLHLTYGEFSSKFASAVAKNPFIDEPIVIKSDPGSAPKPTGDPSVDVIAWAHNETSTGVAV
PVRRPTGSGGALIAIDATSGAGGLPVDIAQTDAYYFAPQKNFASDGGLWLAIMSPAALARVDSITASGRWVPDFLSLPIA
VENSLKNQTYNTPAICTLALLAEQLDWLLGNGGLEWAVKRTADSSQRLYAWAEDRPYTTPFVVDPALRSQVVGTIDFTDD
VDAAAVAKILRANGIIDTEPYRKLGRNQLRVAMFPAVEPDDVRALTECVDWIVERL

Sequences:

>Translated_376_residues
MADQLTPSLDIPAALKPRDGRFGSGPSKVRPEQLQALTNTAATLFGTSHRQAPVKNLVGRVRAGLAELFSLPDGYQVILG
NGGATAFWDAAAFGLIDKRSLHLTYGEFSSKFASAVAKNPFIDEPIVIKSDPGSAPKPTGDPSVDVIAWAHNETSTGVAV
PVRRPTGSGGALIAIDATSGAGGLPVDIAQTDAYYFAPQKNFASDGGLWLAIMSPAALARVDSITASGRWVPDFLSLPIA
VENSLKNQTYNTPAICTLALLAEQLDWLLGNGGLEWAVKRTADSSQRLYAWAEDRPYTTPFVVDPALRSQVVGTIDFTDD
VDAAAVAKILRANGIIDTEPYRKLGRNQLRVAMFPAVEPDDVRALTECVDWIVERL
>Mature_375_residues
ADQLTPSLDIPAALKPRDGRFGSGPSKVRPEQLQALTNTAATLFGTSHRQAPVKNLVGRVRAGLAELFSLPDGYQVILGN
GGATAFWDAAAFGLIDKRSLHLTYGEFSSKFASAVAKNPFIDEPIVIKSDPGSAPKPTGDPSVDVIAWAHNETSTGVAVP
VRRPTGSGGALIAIDATSGAGGLPVDIAQTDAYYFAPQKNFASDGGLWLAIMSPAALARVDSITASGRWVPDFLSLPIAV
ENSLKNQTYNTPAICTLALLAEQLDWLLGNGGLEWAVKRTADSSQRLYAWAEDRPYTTPFVVDPALRSQVVGTIDFTDDV
DAAAVAKILRANGIIDTEPYRKLGRNQLRVAMFPAVEPDDVRALTECVDWIVERL

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=381, Percent_Identity=23.6220472440945, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI10863955, Length=289, Percent_Identity=24.2214532871972, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21356589, Length=368, Percent_Identity=23.0978260869565, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_MYCLE (O33062)

Other databases:

- EMBL:   Z99494
- EMBL:   AL583924
- PIR:   T45349
- RefSeq:   NP_302409.1
- ProteinModelPortal:   O33062
- SMR:   O33062
- EnsemblBacteria:   EBMYCT00000028910
- GeneID:   908898
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2136
- NMPDR:   fig|272631.1.peg.1281
- Leproma:   ML2136
- GeneTree:   EBGT00050000017386
- HOGENOM:   HBG292317
- OMA:   SHRAKVG
- ProtClustDB:   PRK03080
- BioCyc:   MLEP272631:ML2136-MONOMER
- BRENDA:   2.6.1.52
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR022278
- InterPro:   IPR006272
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01366

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40114; Mature: 39982

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 50-50 BINDING 108-108 BINDING 154-154 BINDING 176-176 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADQLTPSLDIPAALKPRDGRFGSGPSKVRPEQLQALTNTAATLFGTSHRQAPVKNLVGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VRAGLAELFSLPDGYQVILGNGGATAFWDAAAFGLIDKRSLHLTYGEFSSKFASAVAKNP
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCC
FIDEPIVIKSDPGSAPKPTGDPSVDVIAWAHNETSTGVAVPVRRPTGSGGALIAIDATSG
CCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCEEEEEECCCC
AGGLPVDIAQTDAYYFAPQKNFASDGGLWLAIMSPAALARVDSITASGRWVPDFLSLPIA
CCCCEEEEECCCEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCHHHHHCCCH
VENSLKNQTYNTPAICTLALLAEQLDWLLGNGGLEWAVKRTADSSQRLYAWAEDRPYTTP
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCC
FVVDPALRSQVVGTIDFTDDVDAAAVAKILRANGIIDTEPYRKLGRNQLRVAMFPAVEPD
EEECHHHHHCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCCCH
DVRALTECVDWIVERL
HHHHHHHHHHHHHHHC
>Mature Secondary Structure 
ADQLTPSLDIPAALKPRDGRFGSGPSKVRPEQLQALTNTAATLFGTSHRQAPVKNLVGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VRAGLAELFSLPDGYQVILGNGGATAFWDAAAFGLIDKRSLHLTYGEFSSKFASAVAKNP
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCC
FIDEPIVIKSDPGSAPKPTGDPSVDVIAWAHNETSTGVAVPVRRPTGSGGALIAIDATSG
CCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCEEEEEECCCC
AGGLPVDIAQTDAYYFAPQKNFASDGGLWLAIMSPAALARVDSITASGRWVPDFLSLPIA
CCCCEEEEECCCEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCHHHHHCCCH
VENSLKNQTYNTPAICTLALLAEQLDWLLGNGGLEWAVKRTADSSQRLYAWAEDRPYTTP
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCC
FVVDPALRSQVVGTIDFTDDVDAAAVAKILRANGIIDTEPYRKLGRNQLRVAMFPAVEPD
EEECHHHHHCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCCCH
DVRALTECVDWIVERL
HHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002