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The map label for this gene is gnd [H]

Identifier: 221230591

GI number: 221230591

Start: 2452104

End: 2453555

Strand: Direct

Name: gnd [H]

Synonym: MLBr_02065

Alternate gene names: 221230591

Gene position: 2452104-2453555 (Clockwise)

Preceding gene: 221230590

Following gene: 221230592

Centisome position: 75.03

GC content: 60.88

Gene sequence:

>1452_bases
ATGAGTGCGCCGGAATCGAAGACGGCCATTGCGCAGATCGGCGTCACCGGGCTAGCCGTGATGGGTTCGAACATCGCCCG
GAATTTCGCCCGACACGGCTATACCGTGGCGTTGCACAATCGGTCAATCGCCAAGACCGACACACTGCTCAAAGAGCACG
GATCCGAAGGGAATTTCGTGCGAACCGAAACGATCCCCGAGTTCCTTGCCGCACTACAGACTCCGCGACGGGTGCTGATC
ATGGTAAAAGCCGGTGACGCCACCGATGCCGTCATCAATGAACTCGCCGATGTTATGGAACCCAGCGACATCATCATCGA
CGGCGGCAATTCGCTGTTCACCGACACCATTCGCCGCGAAAAAGCAATGCGTGAGCGTGGCCTGCACTTCGTCGGCGCCG
GGATCTCCGGCGGCGAGGAGGGTGCACTGAACGGACCGTCGATCATGCCCGGCGGGCCCGCCGAATCGTATACCTCGCTG
GGCCCGCTGCTTGAGGAGATTTCCGCGCACGTCGACGGGGTGTCGTGTTGCACCCACATCGGGCCAGGCGGGTCGGGCCA
CTTCGTCAAAATGGTCCACAACGGCATCGAGTACTCCGACATGCAGCTCATTGGCGAGGCCTACCAGCTGCTGCGCGACG
GATTGGGCATGAGTGCACCGCAAATCGCTGACGTGTTTACCGAATGGAACAGGGGCGATCTGAACAGCTACTTGGTAGAG
ATCACCGCTGAAGTGTTGCGCCAGACCGATATCAAGACCGGCAGGCCGCTGGTCGATGTCATCCTCGATAAGGCCGAGCA
AAAGGGTACCGGCCGGTGGACCGTACAGTCCGCCCTGGACTTGGGCGTGCCGATAACTGGAATAGCCGAGGCGGTGTTCG
CGCGCGCGCTGTCGGGTTCGGTGCTGCAACGCAAGGCCGCCATCGGGCTGGCCTCCGGCAAGTTGGGCAACAAACCCACA
GATCGCGAGACATTCATCGAAGACGTACGCCAGGCCCTGTATGCCTCCAAGATTGTGGCCTACGCGCAGGGGTTCAATCA
CATCCAAACCGGTAGTACCGAGTTCGGTTGGAACATCACACCGGGTGACTTGGCGACCATCTGGCGCGGCGGCTGCATCA
TCCGGGCGAAGTTTCTCAACCGCATCAAGGAAGCTTTCGACGCCGCCCCCGACCTGGCCAGCCTGATCGTTGCGCCGTAT
TTCCGCAGTGCTGTCGAATCGGCGATTGACAGTTGGCGGCGTGTGGTGTCCACAGCTACCCAGCTAGGTATCCCAAATCC
CGGCTTCTCGTCCGCGTTGTCGTACTACGATGCGCTGCGCACCGAGCGACTTCCGGCCGCACTGACCCAGGCTCAACGTG
ACTTTTTCGGCGCGCACAGCTACGGACGCGTCGACGCGCGGGGCAAATTCCACACACTATGGAGTGAAGACCGTAGCGAA
GTTACGGTCTAG

Upstream 100 bases:

>100_bases
ATGACCACAAGTACGCTATGCCACAGTGTGCCGGAATAGCGTTGGCGACAATTTGCCGCACAAGTTCTCCAACCTGAGAG
GCGCAAAGGAGATGCAGGAC

Downstream 100 bases:

>100_bases
TTGGCCAAGCTAAGAGACATCCGGTGGCCCCACACTAAATACAAAATCTTTTAGAGTGAAACGAGAGCGATGAGGTTTCT
GGACGGGCACCAGCCCAGGT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MSAPESKTAIAQIGVTGLAVMGSNIARNFARHGYTVALHNRSIAKTDTLLKEHGSEGNFVRTETIPEFLAALQTPRRVLI
MVKAGDATDAVINELADVMEPSDIIIDGGNSLFTDTIRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYTSL
GPLLEEISAHVDGVSCCTHIGPGGSGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGMSAPQIADVFTEWNRGDLNSYLVE
ITAEVLRQTDIKTGRPLVDVILDKAEQKGTGRWTVQSALDLGVPITGIAEAVFARALSGSVLQRKAAIGLASGKLGNKPT
DRETFIEDVRQALYASKIVAYAQGFNHIQTGSTEFGWNITPGDLATIWRGGCIIRAKFLNRIKEAFDAAPDLASLIVAPY
FRSAVESAIDSWRRVVSTATQLGIPNPGFSSALSYYDALRTERLPAALTQAQRDFFGAHSYGRVDARGKFHTLWSEDRSE
VTV

Sequences:

>Translated_483_residues
MSAPESKTAIAQIGVTGLAVMGSNIARNFARHGYTVALHNRSIAKTDTLLKEHGSEGNFVRTETIPEFLAALQTPRRVLI
MVKAGDATDAVINELADVMEPSDIIIDGGNSLFTDTIRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYTSL
GPLLEEISAHVDGVSCCTHIGPGGSGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGMSAPQIADVFTEWNRGDLNSYLVE
ITAEVLRQTDIKTGRPLVDVILDKAEQKGTGRWTVQSALDLGVPITGIAEAVFARALSGSVLQRKAAIGLASGKLGNKPT
DRETFIEDVRQALYASKIVAYAQGFNHIQTGSTEFGWNITPGDLATIWRGGCIIRAKFLNRIKEAFDAAPDLASLIVAPY
FRSAVESAIDSWRRVVSTATQLGIPNPGFSSALSYYDALRTERLPAALTQAQRDFFGAHSYGRVDARGKFHTLWSEDRSE
VTV
>Mature_482_residues
SAPESKTAIAQIGVTGLAVMGSNIARNFARHGYTVALHNRSIAKTDTLLKEHGSEGNFVRTETIPEFLAALQTPRRVLIM
VKAGDATDAVINELADVMEPSDIIIDGGNSLFTDTIRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYTSLG
PLLEEISAHVDGVSCCTHIGPGGSGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGMSAPQIADVFTEWNRGDLNSYLVEI
TAEVLRQTDIKTGRPLVDVILDKAEQKGTGRWTVQSALDLGVPITGIAEAVFARALSGSVLQRKAAIGLASGKLGNKPTD
RETFIEDVRQALYASKIVAYAQGFNHIQTGSTEFGWNITPGDLATIWRGGCIIRAKFLNRIKEAFDAAPDLASLIVAPYF
RSAVESAIDSWRRVVSTATQLGIPNPGFSSALSYYDALRTERLPAALTQAQRDFFGAHSYGRVDARGKFHTLWSEDRSEV
TV

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=49.1489361702128, Blast_Score=447, Evalue=1e-126,
Organism=Escherichia coli, GI1788341, Length=464, Percent_Identity=51.9396551724138, Blast_Score=498, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17542558, Length=478, Percent_Identity=46.234309623431, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321695, Length=455, Percent_Identity=47.9120879120879, Blast_Score=449, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6321977, Length=453, Percent_Identity=49.0066225165563, Blast_Score=438, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24639279, Length=467, Percent_Identity=45.610278372591, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52005; Mature: 51874

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPESKTAIAQIGVTGLAVMGSNIARNFARHGYTVALHNRSIAKTDTLLKEHGSEGNFV
CCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEE
RTETIPEFLAALQTPRRVLIMVKAGDATDAVINELADVMEPSDIIIDGGNSLFTDTIRRE
EHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
KAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYTSLGPLLEEISAHVDGVSCCTHI
HHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHC
GPGGSGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGMSAPQIADVFTEWNRGDLNSYLVE
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHH
ITAEVLRQTDIKTGRPLVDVILDKAEQKGTGRWTVQSALDLGVPITGIAEAVFARALSGS
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHHH
VLQRKAAIGLASGKLGNKPTDRETFIEDVRQALYASKIVAYAQGFNHIQTGSTEFGWNIT
HHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCC
PGDLATIWRGGCIIRAKFLNRIKEAFDAAPDLASLIVAPYFRSAVESAIDSWRRVVSTAT
CCHHHHHHCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGIPNPGFSSALSYYDALRTERLPAALTQAQRDFFGAHSYGRVDARGKFHTLWSEDRSE
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHCCCCCC
VTV
CCC
>Mature Secondary Structure 
SAPESKTAIAQIGVTGLAVMGSNIARNFARHGYTVALHNRSIAKTDTLLKEHGSEGNFV
CCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEE
RTETIPEFLAALQTPRRVLIMVKAGDATDAVINELADVMEPSDIIIDGGNSLFTDTIRRE
EHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
KAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYTSLGPLLEEISAHVDGVSCCTHI
HHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHC
GPGGSGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGMSAPQIADVFTEWNRGDLNSYLVE
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHH
ITAEVLRQTDIKTGRPLVDVILDKAEQKGTGRWTVQSALDLGVPITGIAEAVFARALSGS
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHHH
VLQRKAAIGLASGKLGNKPTDRETFIEDVRQALYASKIVAYAQGFNHIQTGSTEFGWNIT
HHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCC
PGDLATIWRGGCIIRAKFLNRIKEAFDAAPDLASLIVAPYFRSAVESAIDSWRRVVSTAT
CCHHHHHHCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGIPNPGFSSALSYYDALRTERLPAALTQAQRDFFGAHSYGRVDARGKFHTLWSEDRSE
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHCCCCCC
VTV
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]