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The map label for this gene is aceA [H]

Identifier: 221230551

GI number: 221230551

Start: 2369727

End: 2372123

Strand: Reverse

Name: aceA [H]

Synonym: MLBr_01985

Alternate gene names: 221230551

Gene position: 2372123-2369727 (Counterclockwise)

Preceding gene: 221230553

Following gene: 221230548

Centisome position: 72.58

GC content: 59.57

Gene sequence:

>2397_bases
TTGGCAGGCATACCGGCCACGGTCGTCCAGCGATGTAACTCAACTAACCTGGACGATAGACTACACTACTCTCCGTTAGG
GGACCGGGCTAAGGAGGAGCGCAATCCCATGGCCATCATGGACACGAACACCGAGGTCCACACACTGTTTACGCAGGAAG
TCGCCGCAACGCAGCAATACTTTGACGACCCACGGTTTGCCGGGATTATTCGCCTTTATACAGCCCGCCAGGTCGTAGAA
CAACGCGGCACCATCCCCACCGATTACACCGTGGCACGAGACGCCGCGACAGCTTTCTACGCTCGCTTGCGCGAGCTATT
CGCGGCCGGCAAGAGCGTTACGACGTTCGGCCCCTATTCGCCAGGGCAAGCAGTCAGCCTTAAGCGGATGGGCATCGAGG
CGATCTATCTAGGCGGCTGGGCAACCTCAGCTAAGGGTTCCATCACCGAAGATCCCGGTCCTGATCTCGCCAGCTACCCC
CTGAGCCAGGTGCCAGATGATGCCGCGGTACTGGTGCGCGCCCTGCTGGCTGCTGACCGCAATCAGCAGTACCTGCGGTT
ACACATGACTGAACAGCAGCGTGCCGCCACTCCGGCGTATGACTACCGCCCATTCATCATCGCCGACGCCGACACGGGAC
ATGGCGGTGACTCGCACGTACGCAACCTGATCCGCCGATTTGTTGAGATCGGCGTTCCAGGATACCACATCGAGGACCAG
CGCCCGGGTACCAAGAAGTGTGGCCATCAGGGCGGGAAGGTTCTAGTGCCTTCGGACGAACAAATCAAGCGCCTCAACGC
CGCCCGCTTCCAGCTCGACATTATGCGGGTGCCCGGCATCATCGTCGCGCGTACAGATGCCGAGGCGGCCAACTTGATCG
ACAGTCGCGCCGATGAGCGAGACCAGCCGTTCTTGCTGGGCGCCACCAATCTGAAGATTCCTTCTTACAAGGCTTGTTTC
CTGGCGTTGGTGCGGTGTTTCTACGAGCTGGGAGTTAAGGAACTCCATGGCCATCTCCTCTACGCGTTAGGCGATGGCGA
ATATGCTGCTGCGAGCGCGTGGCTTGATCGCCAAGGGATTCTGGCCCAGGTCTCCGGTACCGTCAATGCTTGGCAGGAAA
ACGGAAAGCAATCGATCGACGATCTCTTCGAACAAGTTGAATATCGGTTATTGGCCGCTTGGGAGAAGGACGCCGGGCTG
ATGACCTACGGCGAAGCCGTGGAAGAAATGCTCCAATTCGGCGAGAGCGAAGGCGAGCTGATCGGCATGAGCCCCGAGGA
GTGGCGGCGATTTGTTGGGCGGGCGTCTCTGTACGCTGCACGCGAAAAGGCCAAGGAATTGGGTGTCGACCCCGGTTGGG
ATTGCGAGCTGGCGAAGACTCCAGAAGGCTACTACCAAATCCGCGGCGGTATTCAGTATGCGATAGCCAAGTCGTTAGCG
GCAGCGCCGTTCGCCGACATCCTTTGGATGGAGACCAAGACCGCTGATTTGGCCGACGCCCGGCAGTTCGCCGAGGCGAT
CCACGCCGAGTTCCCAGAGCAAATGCTGGCTTACAATCTCTCGCCGTCGTTCAACTGGGATACCACCGGTATGAGTGATG
AGGAGATGAAGCGCTTTCCCGAAGAGCTTGGGAAAATGGGCTTCGTCTTCAACTTCATTACCTATGGCGGACATCAGATC
GACGGCGTCGCTGCCGAGGAGTTCGCCACCGCGCTGCGGCAGGACGGCATGCTGGCGTTGGCTCGGTTGCAACGCAAGAT
GCGCCTGGTCGAATCGCCCTACCGCACACCGCAGACCCTGGTCGGCGGCCCGCGTAGCGATGCAGCGCTGGCTGCGTCCT
CCGGACGTACGGCGACAACCAAGGCCATGGGCAAAGGTTCGACCCAGCACCAGCATCTTGTGCAGACCGAGGTGCCGAAG
AAGCTGCTAGAGGAATGGCTGGCATTGTGGAGTGAGCACTACCAGCTTGGCGAGAAACTCCGCGTGCAACTGCGGCCACG
CCGCGCCGGCTCGGATGTGCTCGAACTCGGGATCTACGGCAACGGTGACGAGCAGCTGGCCAACGTCATCGTTGATCCGA
TCAAGGATCGCCGCGGCCGCAGCATCCTTCAAGTGCGCGACCAGAACACCTTCGCCGAAAAGCTTCGCCAGAAGCGACTG
ATGACCTTGATCCATTTCTGGCTGGTGCACCGCTTCAAGGCTGACACGGTGATTTACGTCACTCCAACCGAGGATAATCT
CTATCAGACTTCCAAGATGAAATCTCACGGCATCTTCAGCGAGGTTTATCAGGAGGTGGGCGAGATCATCGTCGCTGAGG
TGAACCACCCGCGGCTTGTTGAGCTGCTTACCCCCGATCGCGTCGCGCTGCGGCGGTTGATCACCAAGGAGGGGTAA

Upstream 100 bases:

>100_bases
GTGCATCAACAGTCCGGGTGTCGTTGTCTAGCAACCCGCCTTCCTATCACTCTGGCAACCAACGTGATGGAGTAGTCCGC
GGGAATGCCCCCGATGTCGA

Downstream 100 bases:

>100_bases
AGGACACCGCTGACCGCCGGTCGGGGAAGGCCAAGCGGAATATCGGAGAAATATTGAATATTATATTGGAGTATTGGAAC
TTGCGATAGCGGTGCTAGGT

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 798; Mature: 797

Protein sequence:

>798_residues
MAGIPATVVQRCNSTNLDDRLHYSPLGDRAKEERNPMAIMDTNTEVHTLFTQEVAATQQYFDDPRFAGIIRLYTARQVVE
QRGTIPTDYTVARDAATAFYARLRELFAAGKSVTTFGPYSPGQAVSLKRMGIEAIYLGGWATSAKGSITEDPGPDLASYP
LSQVPDDAAVLVRALLAADRNQQYLRLHMTEQQRAATPAYDYRPFIIADADTGHGGDSHVRNLIRRFVEIGVPGYHIEDQ
RPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATNLKIPSYKACF
LALVRCFYELGVKELHGHLLYALGDGEYAAASAWLDRQGILAQVSGTVNAWQENGKQSIDDLFEQVEYRLLAAWEKDAGL
MTYGEAVEEMLQFGESEGELIGMSPEEWRRFVGRASLYAAREKAKELGVDPGWDCELAKTPEGYYQIRGGIQYAIAKSLA
AAPFADILWMETKTADLADARQFAEAIHAEFPEQMLAYNLSPSFNWDTTGMSDEEMKRFPEELGKMGFVFNFITYGGHQI
DGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPK
KLLEEWLALWSEHYQLGEKLRVQLRPRRAGSDVLELGIYGNGDEQLANVIVDPIKDRRGRSILQVRDQNTFAEKLRQKRL
MTLIHFWLVHRFKADTVIYVTPTEDNLYQTSKMKSHGIFSEVYQEVGEIIVAEVNHPRLVELLTPDRVALRRLITKEG

Sequences:

>Translated_798_residues
MAGIPATVVQRCNSTNLDDRLHYSPLGDRAKEERNPMAIMDTNTEVHTLFTQEVAATQQYFDDPRFAGIIRLYTARQVVE
QRGTIPTDYTVARDAATAFYARLRELFAAGKSVTTFGPYSPGQAVSLKRMGIEAIYLGGWATSAKGSITEDPGPDLASYP
LSQVPDDAAVLVRALLAADRNQQYLRLHMTEQQRAATPAYDYRPFIIADADTGHGGDSHVRNLIRRFVEIGVPGYHIEDQ
RPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATNLKIPSYKACF
LALVRCFYELGVKELHGHLLYALGDGEYAAASAWLDRQGILAQVSGTVNAWQENGKQSIDDLFEQVEYRLLAAWEKDAGL
MTYGEAVEEMLQFGESEGELIGMSPEEWRRFVGRASLYAAREKAKELGVDPGWDCELAKTPEGYYQIRGGIQYAIAKSLA
AAPFADILWMETKTADLADARQFAEAIHAEFPEQMLAYNLSPSFNWDTTGMSDEEMKRFPEELGKMGFVFNFITYGGHQI
DGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPK
KLLEEWLALWSEHYQLGEKLRVQLRPRRAGSDVLELGIYGNGDEQLANVIVDPIKDRRGRSILQVRDQNTFAEKLRQKRL
MTLIHFWLVHRFKADTVIYVTPTEDNLYQTSKMKSHGIFSEVYQEVGEIIVAEVNHPRLVELLTPDRVALRRLITKEG
>Mature_797_residues
AGIPATVVQRCNSTNLDDRLHYSPLGDRAKEERNPMAIMDTNTEVHTLFTQEVAATQQYFDDPRFAGIIRLYTARQVVEQ
RGTIPTDYTVARDAATAFYARLRELFAAGKSVTTFGPYSPGQAVSLKRMGIEAIYLGGWATSAKGSITEDPGPDLASYPL
SQVPDDAAVLVRALLAADRNQQYLRLHMTEQQRAATPAYDYRPFIIADADTGHGGDSHVRNLIRRFVEIGVPGYHIEDQR
PGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATNLKIPSYKACFL
ALVRCFYELGVKELHGHLLYALGDGEYAAASAWLDRQGILAQVSGTVNAWQENGKQSIDDLFEQVEYRLLAAWEKDAGLM
TYGEAVEEMLQFGESEGELIGMSPEEWRRFVGRASLYAAREKAKELGVDPGWDCELAKTPEGYYQIRGGIQYAIAKSLAA
APFADILWMETKTADLADARQFAEAIHAEFPEQMLAYNLSPSFNWDTTGMSDEEMKRFPEELGKMGFVFNFITYGGHQID
GVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPKK
LLEEWLALWSEHYQLGEKLRVQLRPRRAGSDVLELGIYGNGDEQLANVIVDPIKDRRGRSILQVRDQNTFAEKLRQKRLM
TLIHFWLVHRFKADTVIYVTPTEDNLYQTSKMKSHGIFSEVYQEVGEIIVAEVNHPRLVELLTPDRVALRRLITKEG

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=261, Percent_Identity=36.7816091954023, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17561814, Length=241, Percent_Identity=39.4190871369295, Blast_Score=163, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71982926, Length=241, Percent_Identity=39.4190871369295, Blast_Score=163, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6320908, Length=610, Percent_Identity=32.2950819672131, Blast_Score=290, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6325263, Length=596, Percent_Identity=30.5369127516779, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 89170; Mature: 89039

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGIPATVVQRCNSTNLDDRLHYSPLGDRAKEERNPMAIMDTNTEVHTLFTQEVAATQQY
CCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCEEHHHHHHHHHHHHH
FDDPRFAGIIRLYTARQVVEQRGTIPTDYTVARDAATAFYARLRELFAAGKSVTTFGPYS
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
PGQAVSLKRMGIEAIYLGGWATSAKGSITEDPGPDLASYPLSQVPDDAAVLVRALLAADR
CCCCEEHHHCCEEEEEECCEECCCCCCCCCCCCCCHHCCCHHHCCCHHHHHHHHHHHCCC
NQQYLRLHMTEQQRAATPAYDYRPFIIADADTGHGGDSHVRNLIRRFVEIGVPGYHIEDQ
CCCEEEEEECHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
RPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADER
CCCHHHHCCCCCEEECCCHHHHHHHHHHHHEEEEEECCCEEEEECCCHHHHHHHHCCCCC
DQPFLLGATNLKIPSYKACFLALVRCFYELGVKELHGHLLYALGDGEYAAASAWLDRQGI
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHCHHHHCCEEEEEECCCCHHHHHHHHCCCCC
LAQVSGTVNAWQENGKQSIDDLFEQVEYRLLAAWEKDAGLMTYGEAVEEMLQFGESEGEL
EEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCE
IGMSPEEWRRFVGRASLYAAREKAKELGVDPGWDCELAKTPEGYYQIRGGIQYAIAKSLA
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCEEECCCHHHHHHHHHH
AAPFADILWMETKTADLADARQFAEAIHAEFPEQMLAYNLSPSFNWDTTGMSDEEMKRFP
HCCHHHHHEEECCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHH
EELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTL
HHHCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHH
VGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPKKLLEEWLALWSEHYQLGEKL
CCCCCCCCCEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVQLRPRRAGSDVLELGIYGNGDEQLANVIVDPIKDRRGRSILQVRDQNTFAEKLRQKRL
EEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHH
MTLIHFWLVHRFKADTVIYVTPTEDNLYQTSKMKSHGIFSEVYQEVGEIIVAEVNHPRLV
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHEEEEECCCCEEE
ELLTPDRVALRRLITKEG
EEECCCHHHHHHHHHCCC
>Mature Secondary Structure 
AGIPATVVQRCNSTNLDDRLHYSPLGDRAKEERNPMAIMDTNTEVHTLFTQEVAATQQY
CCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCEEHHHHHHHHHHHHH
FDDPRFAGIIRLYTARQVVEQRGTIPTDYTVARDAATAFYARLRELFAAGKSVTTFGPYS
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
PGQAVSLKRMGIEAIYLGGWATSAKGSITEDPGPDLASYPLSQVPDDAAVLVRALLAADR
CCCCEEHHHCCEEEEEECCEECCCCCCCCCCCCCCHHCCCHHHCCCHHHHHHHHHHHCCC
NQQYLRLHMTEQQRAATPAYDYRPFIIADADTGHGGDSHVRNLIRRFVEIGVPGYHIEDQ
CCCEEEEEECHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
RPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADER
CCCHHHHCCCCCEEECCCHHHHHHHHHHHHEEEEEECCCEEEEECCCHHHHHHHHCCCCC
DQPFLLGATNLKIPSYKACFLALVRCFYELGVKELHGHLLYALGDGEYAAASAWLDRQGI
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHCHHHHCCEEEEEECCCCHHHHHHHHCCCCC
LAQVSGTVNAWQENGKQSIDDLFEQVEYRLLAAWEKDAGLMTYGEAVEEMLQFGESEGEL
EEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCE
IGMSPEEWRRFVGRASLYAAREKAKELGVDPGWDCELAKTPEGYYQIRGGIQYAIAKSLA
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCEEECCCHHHHHHHHHH
AAPFADILWMETKTADLADARQFAEAIHAEFPEQMLAYNLSPSFNWDTTGMSDEEMKRFP
HCCHHHHHEEECCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHH
EELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTL
HHHCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHH
VGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPKKLLEEWLALWSEHYQLGEKL
CCCCCCCCCEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVQLRPRRAGSDVLELGIYGNGDEQLANVIVDPIKDRRGRSILQVRDQNTFAEKLRQKRL
EEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHH
MTLIHFWLVHRFKADTVIYVTPTEDNLYQTSKMKSHGIFSEVYQEVGEIIVAEVNHPRLV
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHEEEEECCCCEEE
ELLTPDRVALRRLITKEG
EEECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002 [H]