BacMap

Definition	Mycobacterium leprae Br4923 chromosome, complete genome.
Accession	NC_011896
Length	3,268,071

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The map label for this gene is fabG [H]

Identifier: 221230412

GI number: 221230412

Start: 2099908

End: 2100846

Strand: Reverse

Name: fabG [H]

Synonym: MLBr_01740

Alternate gene names: 221230412

Gene position: 2100846-2099908 (Counterclockwise)

Preceding gene: 221230413

Following gene: 221230411

Centisome position: 64.28

GC content: 62.41

Gene sequence:

>939_bases
ATGGTGAAGACGGCACAATATTTCGTGGGGAAGCGGTGTTTTGTCACCGGCGCGGCTAGTGGTATTGGCCGAGCCACCGC
ATTGCGGCTCGCCGCCTACGGTGCTGAGCTGTATCTGACCGACCGCCACTGCGATGGTTTGGCCCAAACCGTGTCCGAAG
CACGGGCTCTCGGTGCACAGGTCCCCGAGTATCGTGCCCTGGACATTTCCGACTACGACGAGGTGGCGGCATTCGGCGCT
GACATCCACGCAAGGCATCCCAGCATGGATATCGTGATGAATATCGCTGGCGTCTCGGTCTGGGGGACTGTTGACCGACT
CACCCACGACCAGTGGAGCAACGTGGTCGCGATCAACCTGATGGGACCGATCCACATCATCGAGACGTTCGTGCCGGCGA
TCCTGGCCGCCGGCCGGGGTGGGCATTTGGTCAATGTCTCTTCGGCGGCTGGGCTGGTCGCCCTGCCCTGGCATGCGGCC
TACAGTGCCAGCAAGTACGGATTGCGCGGACTTTCTGAGGTGCTGCGCTTCGACCTAGCCCGGTACCGCATCGGGGTGTC
GGTTGTGGTGCCCGGTGCGGTACGGACGCCGCTAGTCGATACTATCGAAATTGCCGGGGTTGACCGCCAGGACCCGAGGT
TCAGTCGATGGGTTGACCGCTTCCGTGGTCATGCTGTGTCAGCGGAAAGGGCCGCCGAGAAGATCTTGGCCGGGGTCGCA
AAGAACCGGTACCTGATCTACACCTCGCACGATATTCGGGTGCTGTATGGGTTCAAGCGGCTGGCGTGGTGGCCGTACGG
AGTGGTGATGAAGCAAGTCAACGTAGTTTTCACGCGGGCACTTCGGCCCAGTCCGGCGACGATGCGGTGCGTGGAGCCGA
TCAAGGTGGGGGTGTACTCCCAGCCGCGCAGCGGTGAGGGGGGCAAGTCGGGCAATTGA

Upstream 100 bases:

>100_bases
TGCTGATCGGTTGCGACAGTGGTGTGGTACGGGGCGCTGCGTGCGGGTGCTCGAGCAGGTGTGGCTAAACGTTCTATGGT
GCGGCGGCCAAAGGTAAGCC

Downstream 100 bases:

>100_bases
ACCCGGACCGATACCATGCTGACGCTACGGGGGCGTCTCGAGTTCGAGCCGCCTACCGAGTAATCGGATCGGGCGGTCCA
GCTACGCCATAAACCCAGTA

Product: short chain dehydrogenase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDRHCDGLAQTVSEARALGAQVPEYRALDISDYDEVAAFGA
DIHARHPSMDIVMNIAGVSVWGTVDRLTHDQWSNVVAINLMGPIHIIETFVPAILAAGRGGHLVNVSSAAGLVALPWHAA
YSASKYGLRGLSEVLRFDLARYRIGVSVVVPGAVRTPLVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAERAAEKILAGVA
KNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPATMRCVEPIKVGVYSQPRSGEGGKSGN

Sequences:

>Translated_312_residues
MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDRHCDGLAQTVSEARALGAQVPEYRALDISDYDEVAAFGA
DIHARHPSMDIVMNIAGVSVWGTVDRLTHDQWSNVVAINLMGPIHIIETFVPAILAAGRGGHLVNVSSAAGLVALPWHAA
YSASKYGLRGLSEVLRFDLARYRIGVSVVVPGAVRTPLVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAERAAEKILAGVA
KNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPATMRCVEPIKVGVYSQPRSGEGGKSGN
>Mature_312_residues
MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDRHCDGLAQTVSEARALGAQVPEYRALDISDYDEVAAFGA
DIHARHPSMDIVMNIAGVSVWGTVDRLTHDQWSNVVAINLMGPIHIIETFVPAILAAGRGGHLVNVSSAAGLVALPWHAA
YSASKYGLRGLSEVLRFDLARYRIGVSVVVPGAVRTPLVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAERAAEKILAGVA
KNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPATMRCVEPIKVGVYSQPRSGEGGKSGN

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=237, Percent_Identity=30.8016877637131, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI142976729, Length=266, Percent_Identity=25.5639097744361, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4503817, Length=239, Percent_Identity=28.0334728033473, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI15277342, Length=210, Percent_Identity=30.4761904761905, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI223718074, Length=245, Percent_Identity=30.2040816326531, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7706318, Length=264, Percent_Identity=24.6212121212121, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI50726952, Length=193, Percent_Identity=33.6787564766839, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI32455239, Length=193, Percent_Identity=31.6062176165803, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI5031765, Length=193, Percent_Identity=31.6062176165803, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI7657478, Length=238, Percent_Identity=28.9915966386555, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI157739938, Length=186, Percent_Identity=26.3440860215054, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI40254992, Length=211, Percent_Identity=27.4881516587678, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI32483357, Length=192, Percent_Identity=29.1666666666667, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4758504, Length=199, Percent_Identity=29.6482412060301, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI210032110, Length=256, Percent_Identity=22.65625, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI31542939, Length=204, Percent_Identity=29.9019607843137, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40807363, Length=194, Percent_Identity=28.3505154639175, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI109715829, Length=191, Percent_Identity=28.2722513089005, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI7705925, Length=193, Percent_Identity=27.979274611399, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI209862901, Length=266, Percent_Identity=25.5639097744361, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI19923983, Length=266, Percent_Identity=25.5639097744361, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI44680136, Length=190, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI44680133, Length=190, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI17738292, Length=190, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI19743808, Length=199, Percent_Identity=28.1407035175879, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI150247226, Length=192, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI40548397, Length=200, Percent_Identity=28, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI214010158, Length=200, Percent_Identity=28, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI214010156, Length=200, Percent_Identity=28, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI22758144, Length=200, Percent_Identity=28, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=191, Percent_Identity=31.9371727748691, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788459, Length=187, Percent_Identity=28.8770053475936, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786812, Length=216, Percent_Identity=28.2407407407407, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786701, Length=233, Percent_Identity=29.1845493562232, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082100, Length=196, Percent_Identity=30.6122448979592, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787526, Length=190, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082160, Length=190, Percent_Identity=25.7894736842105, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790717, Length=211, Percent_Identity=22.7488151658768, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789208, Length=196, Percent_Identity=25, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI2367175, Length=189, Percent_Identity=31.2169312169312, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=205, Percent_Identity=30.2439024390244, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=197, Percent_Identity=29.4416243654822, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=27.1794871794872, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193203115, Length=195, Percent_Identity=27.1794871794872, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17564282, Length=240, Percent_Identity=25.4166666666667, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=202, Percent_Identity=30.6930693069307, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17567345, Length=194, Percent_Identity=28.3505154639175, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71997402, Length=190, Percent_Identity=29.4736842105263, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17570069, Length=165, Percent_Identity=29.6969696969697, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=199, Percent_Identity=33.6683417085427, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=199, Percent_Identity=31.6582914572864, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=215, Percent_Identity=32.093023255814, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=193, Percent_Identity=24.8704663212435, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=202, Percent_Identity=29.2079207920792, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17507613, Length=202, Percent_Identity=29.2079207920792, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=199, Percent_Identity=26.6331658291457, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=191, Percent_Identity=29.3193717277487, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=198, Percent_Identity=31.3131313131313, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=218, Percent_Identity=25.6880733944954, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17555612, Length=213, Percent_Identity=28.6384976525822, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=201, Percent_Identity=28.3582089552239, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=202, Percent_Identity=28.7128712871287, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322861, Length=192, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322067, Length=188, Percent_Identity=27.6595744680851, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21358495, Length=279, Percent_Identity=27.2401433691756, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24644339, Length=191, Percent_Identity=30.3664921465969, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355631, Length=245, Percent_Identity=28.1632653061224, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357041, Length=191, Percent_Identity=29.3193717277487, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21356301, Length=248, Percent_Identity=25.4032258064516, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24639444, Length=194, Percent_Identity=29.8969072164948, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571526, Length=215, Percent_Identity=26.9767441860465, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI281364892, Length=171, Percent_Identity=29.8245614035088, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24643142, Length=191, Percent_Identity=29.8429319371728, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649181, Length=191, Percent_Identity=26.7015706806283, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737361, Length=198, Percent_Identity=29.2929292929293, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24580925, Length=197, Percent_Identity=26.3959390862944, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI23397609, Length=189, Percent_Identity=30.6878306878307, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221510726, Length=261, Percent_Identity=26.4367816091954, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 33949; Mature: 33949

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDRHCDGLAQTVSEARALGAQ
CCCCHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCC
VPEYRALDISDYDEVAAFGADIHARHPSMDIVMNIAGVSVWGTVDRLTHDQWSNVVAINL
CCCCEEECCCCHHHHHHHCCCCCCCCCCCEEEEEECCEEEHHHHHHHHHHCCCCEEEEEE
MGPIHIIETFVPAILAAGRGGHLVNVSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLA
CCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCHHHHCCCHHHHHHHHHHHHHHHH
RYRIGVSVVVPGAVRTPLVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAERAAEKILAGVA
HHHEEEEEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
KNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPATMRCVEPIKVGVYS
CCCEEEEECCCEEEEEEHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCEEECCHHEECEEC
QPRSGEGGKSGN
CCCCCCCCCCCC
>Mature Secondary Structure
MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDRHCDGLAQTVSEARALGAQ
CCCCHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCC
VPEYRALDISDYDEVAAFGADIHARHPSMDIVMNIAGVSVWGTVDRLTHDQWSNVVAINL
CCCCEEECCCCHHHHHHHCCCCCCCCCCCEEEEEECCEEEHHHHHHHHHHCCCCEEEEEE
MGPIHIIETFVPAILAAGRGGHLVNVSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLA
CCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCHHHHCCCHHHHHHHHHHHHHHHH
RYRIGVSVVVPGAVRTPLVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAERAAEKILAGVA
HHHEEEEEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
KNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPATMRCVEPIKVGVYS
CCCEEEEECCCEEEEEEHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCEEECCHHEECEEC
QPRSGEGGKSGN
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]