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The map label for this gene is ctaD

Identifier: 221230404

GI number: 221230404

Start: 2084550

End: 2086274

Strand: Reverse

Name: ctaD

Synonym: MLBr_01728

Alternate gene names: 221230404

Gene position: 2086274-2084550 (Counterclockwise)

Preceding gene: 221230407

Following gene: 221230403

Centisome position: 63.84

GC content: 57.51

Gene sequence:

>1725_bases
TTGACAGCCGAAGCGCTCTCGTCGGGAGAACTCAAGGCCATCCGTCCATACCCGGCCCGCACTGGTCCCAAAGGGAACCT
CGTATATAAGCTGATCACCACTACCGATCACAAGATGATCGGTATCATGTACTGTGTTGCCTGCTTCATCTTCTTCTTTG
TGGGCGGCTTGCTGGCGTTGCTGATGCGTACCGAGTTGGCCGCACCTGGCTTGCAGTTCTTGTCCAATGAACAGTTCAAC
CAGCTGTTCACCATGCACGGCACGATCATGTTGCTTTTCTATGCCACCCCTATAGTGTTTGGCTTTGCCAACCTGGTGCT
GCCGCTGCAAATCGGTGCACCCGACGTGGCATTCCCACGGCTGAATGCCTTTTCGTTCTGGTTGTTCTTGTTCGGCGCCG
CCATCGGGATGGCCGGTTTCATCACACCAGGTGGGGCCGCCGACTTCGGCTGGACCGCCTATACGCCGTTGACCGACGCC
ATCCACTCTCCCGGTGTCGGCGGCGACCTGTGGATTATGGGTTTGATTGTCGCCGGTTTGGGCACCATCTTGGGTGCGGT
TAACATGATCACCACCGTGGTCTGCCTGCGCGCGCCCGGGATGACGATGTTCCGGATGCCGATCTTCACCTGGAATATCT
TGGTGACATCGATCCTGGTGCTGATTGCGTTCCCCCTGCTCACTGCTGCGCTTTTTGGGTTGGCCGCCGACCGGCATCTG
GGAGCTCACATCTACGACGCGGCCAACGGCGGAGTGCTGTTGTGGCAGCACCTGTTCTGGTTCTTCGGCCACCCCGAAGT
TTACATCATCGCGCTGCCGTTCTTCGGGATCGTCTCAGAGATCTTCCCGGTCTTTTCCCGCAAGCCCATCTTCGGCTACA
CCACGCTGGTTTACGCGACGTTGTCTATCGCTGCGTTATCGGTCGCGGTGTGGGCGCACCACATGTTCGCCACCGGTGCT
GTTCTGCTGCCGTTCTTTTCGTTTATGACGTATTTGATCGCGGTGCCGACCGGGATCAAATTCTTTAACTGGGTCGGCAC
AATGTGGAAGGGCCAGTTGACTTTTGAGACGCCGATGTTGTTTTCGGTCGGCTTCGCGGTCACTTTCTTGTTGGGTGGTT
TGACTGGCGTGTTGCTAGCCAGCCCGCCGCTGGATTTTCATGTGACTGACAGCTATTTCGTCGTAGCGCATTTCCATTAC
GTGCTGTTCGGCACTATCGTGTTCTCCACGTTTGCCGGTATCTACTTCTGGTTCCCCAAGATGACCGGTCGGCTGCTTGA
CGAGCAGCTGGGCAAGCTGCACTTCTGGCTGACGTTCATCGGTTTCCATACCACGTTCTTGGTGCAGCACTGGTTGGGTG
ACATGGGCATGCCTCGACGCTACGCCGACTATCTGCCCACCGACGGCTTCCAGGGTTTGAATGTTGTCTCGACTATCGGG
TCCTTCATCCTGGGTGCGTCGATGTTTCCGTTTGTGTGGAACGTATTTAAGAGTTGGCGCTACGGCGAGGTGGTGACCGT
GGACGACCCGTGGGGATACGGCAACTCCCTGGAATGGGCGACCAGTTGTCCGCCGCCGCGGCATAACTTCACTGAGCTGC
CCCGGATTCGTTCGGAGCGTCCGGCGTTTGAGCTGCACTACCCGCACATGGTGGAACGATTGCGCGACGAGGCATACGTT
GGGCGCCGTCACGCCGAGGAGCTCGTTGAGGTGAGTTTACACTGA

Upstream 100 bases:

>100_bases
GATCAGATCTACCGCCCACCTGTTCGGGGGCTAAAATTACAGTCTGTAATGCAATGCGTAGTGTGCGCCCCTGTCCGGAA
TGGATGTTTTGGAGGAGCTG

Downstream 100 bases:

>100_bases
TACGGCTCGGCTTGGCCGGCGCTGTCAGATGAGTCGCGAGTGAATACGCCACCCAAGGTGTCGGTGCTGATCACTGTCAC
CGGCGTGGATCAGCCAGGTG

Product: cytochrome C oxidase, polypeptide I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MTAEALSSGELKAIRPYPARTGPKGNLVYKLITTTDHKMIGIMYCVACFIFFFVGGLLALLMRTELAAPGLQFLSNEQFN
QLFTMHGTIMLLFYATPIVFGFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGAAIGMAGFITPGGAADFGWTAYTPLTDA
IHSPGVGGDLWIMGLIVAGLGTILGAVNMITTVVCLRAPGMTMFRMPIFTWNILVTSILVLIAFPLLTAALFGLAADRHL
GAHIYDAANGGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYATLSIAALSVAVWAHHMFATGA
VLLPFFSFMTYLIAVPTGIKFFNWVGTMWKGQLTFETPMLFSVGFAVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFHY
VLFGTIVFSTFAGIYFWFPKMTGRLLDEQLGKLHFWLTFIGFHTTFLVQHWLGDMGMPRRYADYLPTDGFQGLNVVSTIG
SFILGASMFPFVWNVFKSWRYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHMVERLRDEAYV
GRRHAEELVEVSLH

Sequences:

>Translated_574_residues
MTAEALSSGELKAIRPYPARTGPKGNLVYKLITTTDHKMIGIMYCVACFIFFFVGGLLALLMRTELAAPGLQFLSNEQFN
QLFTMHGTIMLLFYATPIVFGFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGAAIGMAGFITPGGAADFGWTAYTPLTDA
IHSPGVGGDLWIMGLIVAGLGTILGAVNMITTVVCLRAPGMTMFRMPIFTWNILVTSILVLIAFPLLTAALFGLAADRHL
GAHIYDAANGGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYATLSIAALSVAVWAHHMFATGA
VLLPFFSFMTYLIAVPTGIKFFNWVGTMWKGQLTFETPMLFSVGFAVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFHY
VLFGTIVFSTFAGIYFWFPKMTGRLLDEQLGKLHFWLTFIGFHTTFLVQHWLGDMGMPRRYADYLPTDGFQGLNVVSTIG
SFILGASMFPFVWNVFKSWRYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHMVERLRDEAYV
GRRHAEELVEVSLH
>Mature_573_residues
TAEALSSGELKAIRPYPARTGPKGNLVYKLITTTDHKMIGIMYCVACFIFFFVGGLLALLMRTELAAPGLQFLSNEQFNQ
LFTMHGTIMLLFYATPIVFGFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGAAIGMAGFITPGGAADFGWTAYTPLTDAI
HSPGVGGDLWIMGLIVAGLGTILGAVNMITTVVCLRAPGMTMFRMPIFTWNILVTSILVLIAFPLLTAALFGLAADRHLG
AHIYDAANGGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYATLSIAALSVAVWAHHMFATGAV
LLPFFSFMTYLIAVPTGIKFFNWVGTMWKGQLTFETPMLFSVGFAVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFHYV
LFGTIVFSTFAGIYFWFPKMTGRLLDEQLGKLHFWLTFIGFHTTFLVQHWLGDMGMPRRYADYLPTDGFQGLNVVSTIGS
FILGASMFPFVWNVFKSWRYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHMVERLRDEAYVG
RRHAEELVEVSLH

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family

Homologues:

Organism=Homo sapiens, GI251831109, Length=513, Percent_Identity=42.495126705653, Blast_Score=365, Evalue=1e-101,
Organism=Escherichia coli, GI1786634, Length=545, Percent_Identity=42.9357798165138, Blast_Score=417, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6226519, Length=538, Percent_Identity=38.6617100371747, Blast_Score=357, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=39.3846153846154, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6226523, Length=251, Percent_Identity=34.6613545816733, Blast_Score=140, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COX1_MYCLE (Q9CBQ5)

Other databases:

- EMBL:   AL583923
- PIR:   B87125
- RefSeq:   NP_302190.1
- ProteinModelPortal:   Q9CBQ5
- SMR:   Q9CBQ5
- EnsemblBacteria:   EBMYCT00000028170
- GeneID:   910765
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1728
- NMPDR:   fig|272631.1.peg.1062
- Leproma:   ML1728
- GeneTree:   EBGT00050000016673
- HOGENOM:   HBG603668
- OMA:   GLSVTVW
- ProtClustDB:   CLSK872133
- BioCyc:   MLEP272631:ML1728-MONOMER
- BRENDA:   1.9.3.1
- InterPro:   IPR000883
- InterPro:   IPR014241
- Gene3D:   G3DSA:1.20.210.10
- PANTHER:   PTHR10422
- PRINTS:   PR01165
- TIGRFAMs:   TIGR02891

Pfam domain/function: PF00115 COX1; SSF81442 COX1

EC number: =1.9.3.1

Molecular weight: Translated: 63958; Mature: 63827

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50855 COX1; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x29d574bc)-; HASH(0x2991ef04)-; HASH(0x2a544ba8)-; HASH(0x2a62f6a0)-; HASH(0x29896be4)-; HASH(0x2a4a3e08)-; HASH(0x2a5b11fc)-; HASH(0x2a197c88)-; HASH(0x2a60da7c)-; HASH(0x2a0efa30)-; HASH(0x2a4cce00)-; HASH(0x2a020070)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAEALSSGELKAIRPYPARTGPKGNLVYKLITTTDHKMIGIMYCVACFIFFFVGGLLAL
CCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLFYATPIVFGFANLVLPLQIGAPDVAFPR
HHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCC
LNAFSFWLFLFGAAIGMAGFITPGGAADFGWTAYTPLTDAIHSPGVGGDLWIMGLIVAGL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
GTILGAVNMITTVVCLRAPGMTMFRMPIFTWNILVTSILVLIAFPLLTAALFGLAADRHL
HHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GAHIYDAANGGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYAT
CCEEEECCCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHH
LSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWVGTMWKGQLTFETPML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCHH
FSVGFAVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFHYVLFGTIVFSTFAGIYFWFPK
HHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTGRLLDEQLGKLHFWLTFIGFHTTFLVQHWLGDMGMPRRYADYLPTDGFQGLNVVSTIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHH
SFILGASMFPFVWNVFKSWRYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSER
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCC
PAFELHYPHMVERLRDEAYVGRRHAEELVEVSLH
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
TAEALSSGELKAIRPYPARTGPKGNLVYKLITTTDHKMIGIMYCVACFIFFFVGGLLAL
CCCCCCCCCCEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLFYATPIVFGFANLVLPLQIGAPDVAFPR
HHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCC
LNAFSFWLFLFGAAIGMAGFITPGGAADFGWTAYTPLTDAIHSPGVGGDLWIMGLIVAGL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
GTILGAVNMITTVVCLRAPGMTMFRMPIFTWNILVTSILVLIAFPLLTAALFGLAADRHL
HHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GAHIYDAANGGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYAT
CCEEEECCCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHH
LSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWVGTMWKGQLTFETPML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCHH
FSVGFAVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFHYVLFGTIVFSTFAGIYFWFPK
HHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTGRLLDEQLGKLHFWLTFIGFHTTFLVQHWLGDMGMPRRYADYLPTDGFQGLNVVSTIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHH
SFILGASMFPFVWNVFKSWRYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSER
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCC
PAFELHYPHMVERLRDEAYVGRRHAEELVEVSLH
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002