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The map label for this gene is echA17 [H]

Identifier: 221230401

GI number: 221230401

Start: 2080718

End: 2081476

Strand: Reverse

Name: echA17 [H]

Synonym: MLBr_01724

Alternate gene names: 221230401

Gene position: 2081476-2080718 (Counterclockwise)

Preceding gene: 221230402

Following gene: 221230400

Centisome position: 63.69

GC content: 63.77

Gene sequence:

>759_bases
ATGAGCGAATTCGTCAATATTGTGGTTAGCGACGGCTCGCAGGATGCTGGCCTGGCCATATTGCTCCTCTCGCGACCGCC
CACCAACGCGATGACACGCCAGTTTTACAGGGAAATAGCGATGGCCGCCGACGAACTTGGACGTCGCGACGACGTTGCTG
CGGTTATATTGTTTGGCGGCCACGATATTTTCTCCGCCGGCGACGACATGCAAGAGCTGCGGACTCTGACCGCGGTGGAG
GCTGGCGTCGCTGCTGAGGTCCGCCGTCAGGCTGTTGACGCCGTAGCGACGATCCCGAAGCCGACCGTGGCCGCGATTAC
CGGATACGCGCTGGGAGCGGGCCTGACGTTGGCCCTGGCTGCCGATTGGCGGGTCAGCGGCGACAACGTGAAGTTCGGCG
CTACCGAGATCCTGGCCGACCTGGTCCCGGATGGTGATGGATTGGCCCGACTGACTCGCGTAGCCGGCGTGAGCAGGGCC
AAGGACCTGGTGTTCAGCGGGCGCTTCTTTGATGCGGCGGAGGCCTTGGCGTTGGGCCTGATCGACGACATGGTGGCTCC
CGACGACGTGTATGACATCGCCGCAGCTTGGGCGCGCCGCTTCCTCGACGGCCTGCCGCATGCGCTGGCCGCTGCCAAAG
CTGGCATCAACGAGGTCTTCGATCTGGAACCGGCTGAACGGATCGCTGCCGAACGTCGCCGTTATGTCGAGGTGTTCGCC
GCTGCTCAGCCCTCTTTGTTGCTAGGCGGCTGCGACTAG

Upstream 100 bases:

>100_bases
GCGCGGATTTCCGGTGGATCGTCGCGGTAGCCGTAGTGGTGAGCGCAAGCGCGGCGAAGCCGGGCACAGCCGGTAAACAC
CATCGACTTATGCGCTCGTC

Downstream 100 bases:

>100_bases
GGTGATCCGGGCGGCTCGTTAGGCTGCCCTTCATGACGAGGAGTACGGAAATCTCTGCAAATGCTGTGCCCAATCCGCAT
GCTACTGCGGAGCAAGTAGC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSEFVNIVVSDGSQDAGLAILLLSRPPTNAMTRQFYREIAMAADELGRRDDVAAVILFGGHDIFSAGDDMQELRTLTAVE
AGVAAEVRRQAVDAVATIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILADLVPDGDGLARLTRVAGVSRA
KDLVFSGRFFDAAEALALGLIDDMVAPDDVYDIAAAWARRFLDGLPHALAAAKAGINEVFDLEPAERIAAERRRYVEVFA
AAQPSLLLGGCD

Sequences:

>Translated_252_residues
MSEFVNIVVSDGSQDAGLAILLLSRPPTNAMTRQFYREIAMAADELGRRDDVAAVILFGGHDIFSAGDDMQELRTLTAVE
AGVAAEVRRQAVDAVATIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILADLVPDGDGLARLTRVAGVSRA
KDLVFSGRFFDAAEALALGLIDDMVAPDDVYDIAAAWARRFLDGLPHALAAAKAGINEVFDLEPAERIAAERRRYVEVFA
AAQPSLLLGGCD
>Mature_251_residues
SEFVNIVVSDGSQDAGLAILLLSRPPTNAMTRQFYREIAMAADELGRRDDVAAVILFGGHDIFSAGDDMQELRTLTAVEA
GVAAEVRRQAVDAVATIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILADLVPDGDGLARLTRVAGVSRAK
DLVFSGRFFDAAEALALGLIDDMVAPDDVYDIAAAWARRFLDGLPHALAAAKAGINEVFDLEPAERIAAERRRYVEVFAA
AQPSLLLGGCD

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=240, Percent_Identity=26.6666666666667, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI4502327, Length=232, Percent_Identity=33.6206896551724, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI68989263, Length=189, Percent_Identity=34.3915343915344, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI157694516, Length=224, Percent_Identity=24.5535714285714, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI213417737, Length=225, Percent_Identity=24.4444444444444, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI20127408, Length=178, Percent_Identity=29.7752808988764, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI70995211, Length=179, Percent_Identity=30.1675977653631, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI157694520, Length=192, Percent_Identity=24.4791666666667, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI45643119, Length=220, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI260275230, Length=220, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI260274832, Length=220, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787659, Length=225, Percent_Identity=31.5555555555556, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788597, Length=209, Percent_Identity=28.7081339712919, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI221142681, Length=221, Percent_Identity=31.2217194570136, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788682, Length=176, Percent_Identity=31.8181818181818, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1790281, Length=162, Percent_Identity=27.1604938271605, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082183, Length=212, Percent_Identity=25, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17540714, Length=227, Percent_Identity=31.7180616740088, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17554946, Length=235, Percent_Identity=28.5106382978723, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25145438, Length=235, Percent_Identity=26.8085106382979, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17558304, Length=177, Percent_Identity=27.683615819209, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=216, Percent_Identity=30.0925925925926, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=144, Percent_Identity=34.0277777777778, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144276, Length=213, Percent_Identity=27.6995305164319, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=213, Percent_Identity=27.6995305164319, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17534483, Length=171, Percent_Identity=30.4093567251462, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508953, Length=178, Percent_Identity=28.0898876404494, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20129971, Length=241, Percent_Identity=28.6307053941909, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24653477, Length=241, Percent_Identity=28.6307053941909, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24653139, Length=235, Percent_Identity=29.3617021276596, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19920382, Length=216, Percent_Identity=30.0925925925926, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 26586; Mature: 26455

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFVNIVVSDGSQDAGLAILLLSRPPTNAMTRQFYREIAMAADELGRRDDVAAVILFGG
CCCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEC
HDIFSAGDDMQELRTLTAVEAGVAAEVRRQAVDAVATIPKPTVAAITGYALGAGLTLALA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEE
ADWRVSGDNVKFGATEILADLVPDGDGLARLTRVAGVSRAKDLVFSGRFFDAAEALALGL
ECEEECCCCEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IDDMVAPDDVYDIAAAWARRFLDGLPHALAAAKAGINEVFDLEPAERIAAERRRYVEVFA
HHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHH
AAQPSLLLGGCD
HCCCCEEECCCC
>Mature Secondary Structure 
SEFVNIVVSDGSQDAGLAILLLSRPPTNAMTRQFYREIAMAADELGRRDDVAAVILFGG
CCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEC
HDIFSAGDDMQELRTLTAVEAGVAAEVRRQAVDAVATIPKPTVAAITGYALGAGLTLALA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEE
ADWRVSGDNVKFGATEILADLVPDGDGLARLTRVAGVSRAKDLVFSGRFFDAAEALALGL
ECEEECCCCEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IDDMVAPDDVYDIAAAWARRFLDGLPHALAAAKAGINEVFDLEPAERIAAERRRYVEVFA
HHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHH
AAQPSLLLGGCD
HCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]