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The map label for this gene is ung

Identifier: 221230363

GI number: 221230363

Start: 2019204

End: 2019887

Strand: Reverse

Name: ung

Synonym: MLBr_01675

Alternate gene names: 221230363

Gene position: 2019887-2019204 (Counterclockwise)

Preceding gene: 221230364

Following gene: 221230362

Centisome position: 61.81

GC content: 62.13

Gene sequence:

>684_bases
ATGACCGCACGTCCGTTGAGTGAACTTGTCGAGCAAGGGTGGGCGGCCGCGCTAGAGCCGGTCGTCGACCAGGTAGCTGA
GATGGGTCGATTTCTGCGGGCCGAGATCGCTGCCGGGCGCAGGTATCTACCTGCCGGGCATAGTGTTTTGCGCGCCTTTA
CTTATCCGTTCGACAACGTGCGCGTTTTGATCGTTGGGCAAGATCCGTATCCGACACCGGGACATGCTGTGGGCCTGAGT
TTTTCGGTGGCCCCCGATGTGCGTCCGCTGCCCCGCAGTCTTGCCAACGTCTTCGACGAGTACACTGCGGACCTAGGCTA
TCCTTTGCCTGTGTGTGGCGATCTGACACCTTGGGCGCAGCGTGGTGTGCTGCTGTTAAACAGGGTGCTCACGGTGCGCC
CTAGTAACCCGGCGTCTCATCGGGGCAAGGGCTGGGAAGTGATCACGGAGTGTGCGATCCGCGCGCTGGCTGCGCGGTCA
GAACCGATGGTGGCGATTTTGTGGGGTCGCGATGCTGCCACGCTGAAGCCGCTGCTGACTGTCGATAACTGTGTGGTGAT
CGAGTCGCCGCACCCTTCGCCGCTGTCGGCATCTCGCGGGTTCTTCGGCTCGCGCCCGTTCAGCCGTACCAACGAGATAC
TCGTCGGGATGGGTGCTGGGCCCATCAATTGGCGCCTACCCTGA

Upstream 100 bases:

>100_bases
CCGTCTACGCTATTGCCGCGCTGAAGTTCACCGACCGGCAATCACCTGAATACCGGAAAATCGTGAAGGACCTGCTGGTG
CTGTGTGCGCAGGGGCTGGG

Downstream 100 bases:

>100_bases
CCGACATGACAGCTCGGACAAGATCGAGGCCAGCCTGCGACACTTGCCGCGTTCGTCGGAAGCTGCCGGTGACCGGGCCG
GCCGCGGACAAGACCGTTCA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTARPLSELVEQGWAAALEPVVDQVAEMGRFLRAEIAAGRRYLPAGHSVLRAFTYPFDNVRVLIVGQDPYPTPGHAVGLS
FSVAPDVRPLPRSLANVFDEYTADLGYPLPVCGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKGWEVITECAIRALAARS
EPMVAILWGRDAATLKPLLTVDNCVVIESPHPSPLSASRGFFGSRPFSRTNEILVGMGAGPINWRLP

Sequences:

>Translated_227_residues
MTARPLSELVEQGWAAALEPVVDQVAEMGRFLRAEIAAGRRYLPAGHSVLRAFTYPFDNVRVLIVGQDPYPTPGHAVGLS
FSVAPDVRPLPRSLANVFDEYTADLGYPLPVCGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKGWEVITECAIRALAARS
EPMVAILWGRDAATLKPLLTVDNCVVIESPHPSPLSASRGFFGSRPFSRTNEILVGMGAGPINWRLP
>Mature_226_residues
TARPLSELVEQGWAAALEPVVDQVAEMGRFLRAEIAAGRRYLPAGHSVLRAFTYPFDNVRVLIVGQDPYPTPGHAVGLSF
SVAPDVRPLPRSLANVFDEYTADLGYPLPVCGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKGWEVITECAIRALAARSE
PMVAILWGRDAATLKPLLTVDNCVVIESPHPSPLSASRGFFGSRPFSRTNEILVGMGAGPINWRLP

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=168, Percent_Identity=45.2380952380952, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI6224979, Length=168, Percent_Identity=45.2380952380952, Blast_Score=142, Evalue=2e-34,
Organism=Escherichia coli, GI1788934, Length=193, Percent_Identity=40.9326424870466, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17556304, Length=223, Percent_Identity=38.5650224215247, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323620, Length=240, Percent_Identity=36.6666666666667, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_MYCLB (B8ZS02)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503779.1
- ProteinModelPortal:   B8ZS02
- SMR:   B8ZS02
- EnsemblBacteria:   EBMYCT00000086842
- GeneID:   7326665
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000017143
- HOGENOM:   HBG605450
- OMA:   VMLLNRV
- ProtClustDB:   PRK05254
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 24656; Mature: 24524

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 68-68

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARPLSELVEQGWAAALEPVVDQVAEMGRFLRAEIAAGRRYLPAGHSVLRAFTYPFDNV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCE
RVLIVGQDPYPTPGHAVGLSFSVAPDVRPLPRSLANVFDEYTADLGYPLPVCGDLTPWAQ
EEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RGVLLLNRVLTVRPSNPASHRGKGWEVITECAIRALAARSEPMVAILWGRDAATLKPLLT
HHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHEEE
VDNCVVIESPHPSPLSASRGFFGSRPFSRTNEILVGMGAGPINWRLP
ECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
TARPLSELVEQGWAAALEPVVDQVAEMGRFLRAEIAAGRRYLPAGHSVLRAFTYPFDNV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCE
RVLIVGQDPYPTPGHAVGLSFSVAPDVRPLPRSLANVFDEYTADLGYPLPVCGDLTPWAQ
EEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RGVLLLNRVLTVRPSNPASHRGKGWEVITECAIRALAARSEPMVAILWGRDAATLKPLLT
HHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHEEE
VDNCVVIESPHPSPLSASRGFFGSRPFSRTNEILVGMGAGPINWRLP
ECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA