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The map label for this gene is kasA [H]

Identifier: 221230350

GI number: 221230350

Start: 1994800

End: 1996050

Strand: Direct

Name: kasA [H]

Synonym: MLBr_01655

Alternate gene names: 221230350

Gene position: 1994800-1996050 (Clockwise)

Preceding gene: 221230349

Following gene: 221230351

Centisome position: 61.04

GC content: 64.27

Gene sequence:

>1251_bases
GTGACCATGCCTTCCACTGCTAATGGCGGTTTCCCCAGTGTTGTGGTGACCGCTGTCACAGCAACGACGTCAATCTCGCC
GGACATCGAAAGCACGTGGAAGGGTCTGTTGGCCGGCGAGAGCGGCATCCACGTACTCGAAGACGAGTACATCACCAAGT
GGGACCTGCCAGTCAAGATCGGCGGCCACCTCAAGGAGCCAGTCGATAGCCACATGAGCCGCCTGGACCTGCGGCGCATG
TCGTACGTCCAGCGGATGAGCAAGCTGCTCAGCGGTCGACTATGGGAGTCCACCGGCAGCCCGGAGGTCGATCCCGACCG
GTTCACCGTCGTGGTCGGCACCGGTCTGGGCGGCGCCGAGCGAATCGTGGAAAGCTACGACCTGATGAACGCGGGCGGAC
CCCGTAAGGTGTCCCCGCTCGCCGTTCAGATGATCATGCCCAACGGCGCCGCAGCGACCGTCGGGCTACAGCTTGGGGCA
TGCGCCGGGGTGATGACACCGGTGTCGGCCTGCTCGTCGGGCTCTGAGGCAATCGCACACGCCTGGCGCCAGATCATCAT
GGGAGATGCAGATGTCGCCGTCTGTGGCGGTGTCGAGGGCCCGATCGAGGCGCTGCCTATCGCGGCGTTCTCGATGATGC
GAGCCATGTCGACCCGTAACGACGACCCCGAGGGGGCATCTCGGCCATTCGACAAAAATCGTGACGGGTTTGTGTTCGGC
GAAGCCGGAGCCCTGATGCTCATCGAGACTGAGGAGCACGCCAAGGCTCGCGGCGCCAAGCCGCTGGCTCGGTTGCTTGG
TGCAGGCATCACCTCGGACGCCTTTCATATGGTGGCACCCGCGGCCGACGGCGTGCGAGCAGGGCGGGCAATGACCCGGT
CGCTGGAGCTGGCGGGTTTGTCGGCGAAGGACGTGGACCACGTCAACGCGCACGGGACAGCAACGCCGATCGGCGACAGC
GCGGAGGCCAACGCCATCAGGGTCGCCGGTTGCGAACAGGCTGCGGTGTATGCGCCAAAGTCAGCACTGGGCCACTCCAT
CGGCGCGGTCGGCGCGCTTGAGTCTGTCCTGACGGTGCTGGCCCTTCGCGACGGTGTCATCCCACCCACACTGAACTACC
AAACCCCAGATCCCGAGATCGACCTAGACATTGTCGCAGGTGAACCTCGCTACGGCGACTACCGTTACGCGATCAATAAC
TCCTTCGGGTTCGGTGGCCACAACGTGGCGCTCGCTTTTGGGCGCTACTAA

Upstream 100 bases:

>100_bases
AAGAGAATCCTGAGGCCGCCGAGGCGCTGCGCGCCAAGATCGTGTCGGAGAACCCCGAGGCCGCCGCGAACGTTCAGGCA
AGGCTAGAAACAGAAAGTAA

Downstream 100 bases:

>100_bases
GCACGGGAAGGAATGATCGCTAGACTCATGACCACATCGCCGGAGCTGGTTACAGGGAAAGCCTTTCCCAATGTGGTCGT
CACCGGCATTGCTATGACGA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: Beta-ketoacyl-ACP synthase 1; KAS 1 [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTMPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHVLEDEYITKWDLPVKIGGHLKEPVDSHMSRLDLRRM
SYVQRMSKLLSGRLWESTGSPEVDPDRFTVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAATVGLQLGA
CAGVMTPVSACSSGSEAIAHAWRQIIMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDDPEGASRPFDKNRDGFVFG
EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSAKDVDHVNAHGTATPIGDS
AEANAIRVAGCEQAAVYAPKSALGHSIGAVGALESVLTVLALRDGVIPPTLNYQTPDPEIDLDIVAGEPRYGDYRYAINN
SFGFGGHNVALAFGRY

Sequences:

>Translated_416_residues
MTMPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHVLEDEYITKWDLPVKIGGHLKEPVDSHMSRLDLRRM
SYVQRMSKLLSGRLWESTGSPEVDPDRFTVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAATVGLQLGA
CAGVMTPVSACSSGSEAIAHAWRQIIMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDDPEGASRPFDKNRDGFVFG
EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSAKDVDHVNAHGTATPIGDS
AEANAIRVAGCEQAAVYAPKSALGHSIGAVGALESVLTVLALRDGVIPPTLNYQTPDPEIDLDIVAGEPRYGDYRYAINN
SFGFGGHNVALAFGRY
>Mature_415_residues
TMPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHVLEDEYITKWDLPVKIGGHLKEPVDSHMSRLDLRRMS
YVQRMSKLLSGRLWESTGSPEVDPDRFTVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAATVGLQLGAC
AGVMTPVSACSSGSEAIAHAWRQIIMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDDPEGASRPFDKNRDGFVFGE
AGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSAKDVDHVNAHGTATPIGDSA
EANAIRVAGCEQAAVYAPKSALGHSIGAVGALESVLTVLALRDGVIPPTLNYQTPDPEIDLDIVAGEPRYGDYRYAINNS
FGFGGHNVALAFGRY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=35.3365384615385, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=41.0958904109589, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI41872631, Length=257, Percent_Identity=28.7937743190661, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=40.8312958435208, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI1788663, Length=406, Percent_Identity=33.0049261083744, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71983541, Length=411, Percent_Identity=33.8199513381995, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71983535, Length=260, Percent_Identity=38.8461538461538, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI212642053, Length=289, Percent_Identity=29.0657439446367, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17550940, Length=253, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=441, Percent_Identity=30.1587301587302, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=37.2315035799523, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI221330659, Length=256, Percent_Identity=28.515625, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19920632, Length=256, Percent_Identity=28.515625, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24581345, Length=254, Percent_Identity=28.740157480315, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43471; Mature: 43340

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHVLEDEYITKWDLPVKI
CCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEECCCCEEEECCCEEE
GGHLKEPVDSHMSRLDLRRMSYVQRMSKLLSGRLWESTGSPEVDPDRFTVVVGTGLGGAE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHH
RIVESYDLMNAGGPRKVSPLAVQMIMPNGAAATVGLQLGACAGVMTPVSACSSGSEAIAH
HHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHH
AWRQIIMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDDPEGASRPFDKNRDGFVFG
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEE
EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGL
CCCEEEEEECHHHHHHCCCCHHHHHHCCCCCCCCHHEECCCCCCHHHHHHHHHHHHCCCC
SAKDVDHVNAHGTATPIGDSAEANAIRVAGCEQAAVYAPKSALGHSIGAVGALESVLTVL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
ALRDGVIPPTLNYQTPDPEIDLDIVAGEPRYGDYRYAINNSFGFGGHNVALAFGRY
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
TMPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHVLEDEYITKWDLPVKI
CCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEECCCCEEEECCCEEE
GGHLKEPVDSHMSRLDLRRMSYVQRMSKLLSGRLWESTGSPEVDPDRFTVVVGTGLGGAE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHH
RIVESYDLMNAGGPRKVSPLAVQMIMPNGAAATVGLQLGACAGVMTPVSACSSGSEAIAH
HHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHH
AWRQIIMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDDPEGASRPFDKNRDGFVFG
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEE
EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGL
CCCEEEEEECHHHHHHCCCCHHHHHHCCCCCCCCHHEECCCCCCHHHHHHHHHHHHCCCC
SAKDVDHVNAHGTATPIGDSAEANAIRVAGCEQAAVYAPKSALGHSIGAVGALESVLTVL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
ALRDGVIPPTLNYQTPDPEIDLDIVAGEPRYGDYRYAINNSFGFGGHNVALAFGRY
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]