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The map label for this gene is ffh

Identifier: 221230331

GI number: 221230331

Start: 1943727

End: 1945292

Strand: Reverse

Name: ffh

Synonym: MLBr_01622

Alternate gene names: 221230331

Gene position: 1945292-1943727 (Counterclockwise)

Preceding gene: 221230334

Following gene: 221230330

Centisome position: 59.52

GC content: 62.26

Gene sequence:

>1566_bases
GTGTTTGAATCGCTCTCTAACCGGTTGACTGGCGTCATACAGGGGTTGCGTGGCAAAGGCCGGCTGACCGACGCCGATAT
CGAGGCCACCACCCGCGAAATCCGGTTGGCGCTGTTTGAAGCCGACGTTTCACTACCTGTGGTGCGGGCGTTTGTGCATC
GGATCAAAGAACGCGCTCGGGGCACCGAAGTGTCTGCTGCTCTCAACCCGGCGCAACAGATTGTCAAGATCGTCAACGAA
GAACTGATCGGCATCCTCGGTGGCGAGACCCGCCAGCTGGCGTTCGCTAAGACACCGCCGACGGTAGTGATGCTGGCCGG
CCTGCAGGGATCCGGCAAGACAACGCTGGCTGGCAAATTGGCAGTACGCCTTCGCAGGCAAGGACACACACCGCTTCTGG
TGGCCTGTGACCTTCAGCGGCCGGCGGCAGTCAACCAGCTGCAAGTTGTCGGCGAGCGTGCCGGGGTGCCGGTATTCGCC
CCGCATCCTGGGGCCTCGCCCGATTCAGGTCCCGGTGATCCGGTCGCTGTCGCGTCGGCAGGGCTGGTCGAAGCCCGGGC
CAAACACTTCGACGTCGTGATCGTCGACACCGCCGGGCGACTGGGCATCGACGACGAGTTGATGGCCCAGGCCGGGGCAA
TCCGGGAGGCCATCAACCCCGACGAGGTGTTGTTCGTCCTCGACGCGATGATCGGCCAGGACGCTGTCACCACCGCTGCG
GCATTCGGTGCTGGAGTCGGCTTCACCGGTGTGGTTCTGACCAAGCTCGATGGTGACGCCCGCGGTGGAGCCGCTTTGTC
GGTCCGCGAGGTGACAGGTGTGCCAATCCTTTTTGCCACCACCGGTGAGAAGTTGGACGACTTCGACGTCTTTCACCCTG
ATCGGATGGCCAGCCGCATCCTGGGCATGGGAGATGTGCTGAGCTTGATCGAACAAGCCGAGCAGGTCTTTGACGCCGAA
CAGGCCGAGGCAGCCGCTGCGAAGATCGTCGCCGGTGAACTGACGCTAGAGGATTTCCTCGAGCAGATGCTTGCGGTACG
CAAGATGGGTCTAATCGGCAACCTGTTGGGCATGCTACCCGGCGCGGGTCAGGTGAAGGAGGTACTGGAACAAGTCGATG
ACAAACAGCTCGACCGGTTGCAGGCCATCATCCGCGGAATGACGCCACAGGAGCGGGCCGACCCCAAGATCATCAACGCG
TCCCGGCGACTGCGTATCGCCAACGGCTCCGGGGTGACGGTGTCTGAGGTCAACCAACTGGTCGACCGGTTCTTCGAAGC
CCGTAAGATGATGTCCTCCGTGCTCGGCGGCATGGGTATACCCGGTATGGGACGCAAGTCTGCCACACGAAAGTCCAAGG
GAGGCAAAGGCAAGAAAAGGGCACGCGGTCCGACGTCACCGAAGGTCAGGAGTCCTTTCGGGCCTGCCAGGCCCGGAATG
CCGGACATGATGAACATGCCGCCAAGCTTCCCGGATCTGTCGCAGATGCCAGACGGTCTCAACGAGCTGCCGCCTGGGCT
GGCCGCTTTCGACTTGTCCAAACTGAAGTTCCCAGGCAAGACGTAG

Upstream 100 bases:

>100_bases
ACCAGTTATACCCAGACGATGATCGATCCGCTGCGCCTGGCTCGGACATGACTGGCGCCGCTGCTCCCCGCTTCCGCGGT
ACTACCACTAGGCTGGTGGG

Downstream 100 bases:

>100_bases
CCGCGCTGTGCGCATGCACGTGCGGGATTTGGTGCTGCCCGACGAGGCGGTGACCGAACTGTGGATCGTTGATGTTTGCA
TCAGCACCGCGCCGGTCGTG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MFESLSNRLTGVIQGLRGKGRLTDADIEATTREIRLALFEADVSLPVVRAFVHRIKERARGTEVSAALNPAQQIVKIVNE
ELIGILGGETRQLAFAKTPPTVVMLAGLQGSGKTTLAGKLAVRLRRQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFA
PHPGASPDSGPGDPVAVASAGLVEARAKHFDVVIVDTAGRLGIDDELMAQAGAIREAINPDEVLFVLDAMIGQDAVTTAA
AFGAGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFATTGEKLDDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAE
QAEAAAAKIVAGELTLEDFLEQMLAVRKMGLIGNLLGMLPGAGQVKEVLEQVDDKQLDRLQAIIRGMTPQERADPKIINA
SRRLRIANGSGVTVSEVNQLVDRFFEARKMMSSVLGGMGIPGMGRKSATRKSKGGKGKKRARGPTSPKVRSPFGPARPGM
PDMMNMPPSFPDLSQMPDGLNELPPGLAAFDLSKLKFPGKT

Sequences:

>Translated_521_residues
MFESLSNRLTGVIQGLRGKGRLTDADIEATTREIRLALFEADVSLPVVRAFVHRIKERARGTEVSAALNPAQQIVKIVNE
ELIGILGGETRQLAFAKTPPTVVMLAGLQGSGKTTLAGKLAVRLRRQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFA
PHPGASPDSGPGDPVAVASAGLVEARAKHFDVVIVDTAGRLGIDDELMAQAGAIREAINPDEVLFVLDAMIGQDAVTTAA
AFGAGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFATTGEKLDDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAE
QAEAAAAKIVAGELTLEDFLEQMLAVRKMGLIGNLLGMLPGAGQVKEVLEQVDDKQLDRLQAIIRGMTPQERADPKIINA
SRRLRIANGSGVTVSEVNQLVDRFFEARKMMSSVLGGMGIPGMGRKSATRKSKGGKGKKRARGPTSPKVRSPFGPARPGM
PDMMNMPPSFPDLSQMPDGLNELPPGLAAFDLSKLKFPGKT
>Mature_521_residues
MFESLSNRLTGVIQGLRGKGRLTDADIEATTREIRLALFEADVSLPVVRAFVHRIKERARGTEVSAALNPAQQIVKIVNE
ELIGILGGETRQLAFAKTPPTVVMLAGLQGSGKTTLAGKLAVRLRRQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFA
PHPGASPDSGPGDPVAVASAGLVEARAKHFDVVIVDTAGRLGIDDELMAQAGAIREAINPDEVLFVLDAMIGQDAVTTAA
AFGAGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFATTGEKLDDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAE
QAEAAAAKIVAGELTLEDFLEQMLAVRKMGLIGNLLGMLPGAGQVKEVLEQVDDKQLDRLQAIIRGMTPQERADPKIINA
SRRLRIANGSGVTVSEVNQLVDRFFEARKMMSSVLGGMGIPGMGRKSATRKSKGGKGKKRARGPTSPKVRSPFGPARPGM
PDMMNMPPSFPDLSQMPDGLNELPPGLAAFDLSKLKFPGKT

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=494, Percent_Identity=31.3765182186235, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI226371618, Length=385, Percent_Identity=34.025974025974, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI89061728, Length=144, Percent_Identity=41.6666666666667, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI295424842, Length=312, Percent_Identity=29.8076923076923, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI23308697, Length=312, Percent_Identity=29.8076923076923, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=50.1170960187354, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1789874, Length=271, Percent_Identity=35.7933579335793, Blast_Score=151, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=425, Percent_Identity=31.0588235294118, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI193206261, Length=298, Percent_Identity=28.8590604026846, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=485, Percent_Identity=32.7835051546392, Blast_Score=239, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6320498, Length=213, Percent_Identity=30.5164319248826, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17647949, Length=442, Percent_Identity=30.5429864253394, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24641198, Length=321, Percent_Identity=26.791277258567, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_MYCLE (O33013)

Other databases:

- EMBL:   Z97369
- EMBL:   AL583922
- PIR:   H87111
- RefSeq:   NP_302117.1
- ProteinModelPortal:   O33013
- SMR:   O33013
- EnsemblBacteria:   EBMYCT00000028562
- GeneID:   909829
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1622
- NMPDR:   fig|272631.1.peg.989
- Leproma:   ML1622
- GeneTree:   EBGT00050000014984
- HOGENOM:   HBG562580
- OMA:   IINGSRR
- ProtClustDB:   PRK10867
- BioCyc:   MLEP272631:ML1622-MONOMER
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- PANTHER:   PTHR11564:SF7
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963
- TIGRFAMs:   TIGR00959

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 55113; Mature: 55113

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLSNRLTGVIQGLRGKGRLTDADIEATTREIRLALFEADVSLPVVRAFVHRIKERAR
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GTEVSAALNPAQQIVKIVNEELIGILGGETRQLAFAKTPPTVVMLAGLQGSGKTTLAGKL
CCCHHHHHCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCHHHHHH
AVRLRRQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPDSGPGDPVAVASA
HHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHH
GLVEARAKHFDVVIVDTAGRLGIDDELMAQAGAIREAINPDEVLFVLDAMIGQDAVTTAA
HHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHH
AFGAGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFATTGEKLDDFDVFHPDRMASRI
HHHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHH
LGMGDVLSLIEQAEQVFDAEQAEAAAAKIVAGELTLEDFLEQMLAVRKMGLIGNLLGMLP
HCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GAGQVKEVLEQVDDKQLDRLQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQL
CCHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHCCCCEECCCCEEEEECCCCCCHHHHHHH
VDRFFEARKMMSSVLGGMGIPGMGRKSATRKSKGGKGKKRARGPTSPKVRSPFGPARPGM
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PDMMNMPPSFPDLSQMPDGLNELPPGLAAFDLSKLKFPGKT
CHHHCCCCCCCCHHHCCCCHHHCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFESLSNRLTGVIQGLRGKGRLTDADIEATTREIRLALFEADVSLPVVRAFVHRIKERAR
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GTEVSAALNPAQQIVKIVNEELIGILGGETRQLAFAKTPPTVVMLAGLQGSGKTTLAGKL
CCCHHHHHCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCHHHHHH
AVRLRRQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPDSGPGDPVAVASA
HHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHH
GLVEARAKHFDVVIVDTAGRLGIDDELMAQAGAIREAINPDEVLFVLDAMIGQDAVTTAA
HHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHH
AFGAGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFATTGEKLDDFDVFHPDRMASRI
HHHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHH
LGMGDVLSLIEQAEQVFDAEQAEAAAAKIVAGELTLEDFLEQMLAVRKMGLIGNLLGMLP
HCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GAGQVKEVLEQVDDKQLDRLQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQL
CCHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHCCCCEECCCCEEEEECCCCCCHHHHHHH
VDRFFEARKMMSSVLGGMGIPGMGRKSATRKSKGGKGKKRARGPTSPKVRSPFGPARPGM
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PDMMNMPPSFPDLSQMPDGLNELPPGLAAFDLSKLKFPGKT
CHHHCCCCCCCCHHHCCCCHHHCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002