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The map label for this gene is mapB [H]

Identifier: 221230304

GI number: 221230304

Start: 1900811

End: 1901668

Strand: Reverse

Name: mapB [H]

Synonym: MLBr_01576

Alternate gene names: 221230304

Gene position: 1901668-1900811 (Counterclockwise)

Preceding gene: 221230305

Following gene: 221230303

Centisome position: 58.19

GC content: 58.62

Gene sequence:

>858_bases
ATGCCTGCCCGCACCGCGCTTTCGCCCGGCTTTTTGTCCCCGACCCTGCCGGTGCCCGCATGGATTCCGCGCCCCGAATA
CGTCGGCAAGCCGACCGCACAGGAGGGCAGCGAGTCTTGGGTGCAGACGCCGGAGGTGGTCGAGAAGATGCGTGTCGCCG
GCCGGATAGCGGCTGGTGCGTTGACTGAGGCCGGCAAGGCAGTCGCACCCGGAGTGACGACCGACGAGCTGGATCGGATT
GTCCATGAATACATGGTCAACCACGGTGCCTACCCGTCAACGCTCGGCTACAAGGGCTACCCGAAGTCGTGCTGTACGTC
GCTCAACGAGGTCATCTGTCACGGCATTCCAGACTCGACGGTGATCGCTGACGGTGACATCGTCAACATTGATGTCACTG
CCTATATCGATGGCGTGCACGGCGACACTAATGCGACTTTTCTGTCCGGCGATGTCTCCGAATCCCATCGGCTACTCGTT
GAGCGAACGCGTGAGGCGACGATGCGAGCGATCAACGCCGTCAAACCTGGGCGTGCGTTGTCCATCATTGGTCGGGTCAT
CGAGTCCTATGCAAACCGGTTCGGGTACAACGTTGTTCGTCACTTCACTGGTCATGGCATCGGTACCACGTTTCACAATG
GGCTGGTTGTTTTGCATTACGACCAGCCCTTTGTCACGACAATCATGCAGCCGGGGATGACATTCACCATCGAGCCAATG
ATCAACCTGGGAACGCTAGATTATGAAGTCTGGGACGACGGCTGGACAGTGGTTACCAAGGACCGCAAATGGACAGCACA
GTTTGAGCACACGTTGTTGGTGACCGACACCGGCGTCGAGATACTCACCGTGCAGTGA

Upstream 100 bases:

>100_bases
TTTGCTCCCAGCTACTGCGGGACTGGCAGGTGGCCTTCACCTCACACCGTTGATGTGGCGCGCATCGTCGCTGAAAGAAT
CGTGTGACTAAGCTTGCGGC

Downstream 100 bases:

>100_bases
TCTGGCCGGGTAATCGCGCCTCGACCTGGGTATTTGGTCGTTGATATGCATGATTGCCCCACCGCCGCGGCGACTGTTGG
TGCACGTGCAACTCGGTGAT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MPARTALSPGFLSPTLPVPAWIPRPEYVGKPTAQEGSESWVQTPEVVEKMRVAGRIAAGALTEAGKAVAPGVTTDELDRI
VHEYMVNHGAYPSTLGYKGYPKSCCTSLNEVICHGIPDSTVIADGDIVNIDVTAYIDGVHGDTNATFLSGDVSESHRLLV
ERTREATMRAINAVKPGRALSIIGRVIESYANRFGYNVVRHFTGHGIGTTFHNGLVVLHYDQPFVTTIMQPGMTFTIEPM
INLGTLDYEVWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTVQ

Sequences:

>Translated_285_residues
MPARTALSPGFLSPTLPVPAWIPRPEYVGKPTAQEGSESWVQTPEVVEKMRVAGRIAAGALTEAGKAVAPGVTTDELDRI
VHEYMVNHGAYPSTLGYKGYPKSCCTSLNEVICHGIPDSTVIADGDIVNIDVTAYIDGVHGDTNATFLSGDVSESHRLLV
ERTREATMRAINAVKPGRALSIIGRVIESYANRFGYNVVRHFTGHGIGTTFHNGLVVLHYDQPFVTTIMQPGMTFTIEPM
INLGTLDYEVWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTVQ
>Mature_284_residues
PARTALSPGFLSPTLPVPAWIPRPEYVGKPTAQEGSESWVQTPEVVEKMRVAGRIAAGALTEAGKAVAPGVTTDELDRIV
HEYMVNHGAYPSTLGYKGYPKSCCTSLNEVICHGIPDSTVIADGDIVNIDVTAYIDGVHGDTNATFLSGDVSESHRLLVE
RTREATMRAINAVKPGRALSIIGRVIESYANRFGYNVVRHFTGHGIGTTFHNGLVVLHYDQPFVTTIMQPGMTFTIEPMI
NLGTLDYEVWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTVQ

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=286, Percent_Identity=47.9020979020979, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI40385867, Length=280, Percent_Identity=43.9285714285714, Blast_Score=238, Evalue=6e-63,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=51.417004048583, Blast_Score=251, Evalue=3e-68,
Organism=Escherichia coli, GI1788728, Length=214, Percent_Identity=28.9719626168224, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789275, Length=263, Percent_Identity=27.7566539923954, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=287, Percent_Identity=49.8257839721254, Blast_Score=271, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6323273, Length=281, Percent_Identity=44.8398576512456, Blast_Score=238, Evalue=7e-64,
Organism=Drosophila melanogaster, GI21355531, Length=284, Percent_Identity=49.2957746478873, Blast_Score=271, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24583427, Length=279, Percent_Identity=43.7275985663082, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 31127; Mature: 30995

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPARTALSPGFLSPTLPVPAWIPRPEYVGKPTAQEGSESWVQTPEVVEKMRVAGRIAAGA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHH
LTEAGKAVAPGVTTDELDRIVHEYMVNHGAYPSTLGYKGYPKSCCTSLNEVICHGIPDST
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
VIADGDIVNIDVTAYIDGVHGDTNATFLSGDVSESHRLLVERTREATMRAINAVKPGRAL
EEECCCEEEEEEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHH
SIIGRVIESYANRFGYNVVRHFTGHGIGTTFHNGLVVLHYDQPFVTTIMQPGMTFTIEPM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEECCCHHHHHHCCCCEEEECCC
INLGTLDYEVWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTVQ
EECCCEEEEEECCCCEEEECCCEEEEEECEEEEEEECCEEEEEEC
>Mature Secondary Structure 
PARTALSPGFLSPTLPVPAWIPRPEYVGKPTAQEGSESWVQTPEVVEKMRVAGRIAAGA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHH
LTEAGKAVAPGVTTDELDRIVHEYMVNHGAYPSTLGYKGYPKSCCTSLNEVICHGIPDST
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
VIADGDIVNIDVTAYIDGVHGDTNATFLSGDVSESHRLLVERTREATMRAINAVKPGRAL
EEECCCEEEEEEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHH
SIIGRVIESYANRFGYNVVRHFTGHGIGTTFHNGLVVLHYDQPFVTTIMQPGMTFTIEPM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEECCCHHHHHHCCCCEEEECCC
INLGTLDYEVWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTVQ
EECCCEEEEEECCCCEEEECCCEEEEEECEEEEEEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]