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The map label for this gene is mmuM [H]

Identifier: 221230253

GI number: 221230253

Start: 1781255

End: 1782136

Strand: Direct

Name: mmuM [H]

Synonym: MLBr_01478

Alternate gene names: 221230253

Gene position: 1781255-1782136 (Clockwise)

Preceding gene: 221230237

Following gene: 221230259

Centisome position: 54.5

GC content: 66.21

Gene sequence:

>882_bases
GTGGGACTGGCTGTTCACAGCGAATCCGTGCTGATCAACGACGGTGGGTTGGCCACCGAGCTCGAAGCGCGCGGAAACGA
TCTATCCGATCCGTTGTGGTCGGCTAGACTGCTGACGGATGCCCCACAAGAAATCGTCGCGGTGCACGTCGCGTACTTTC
GCGCTGGCGCGACGATCGCGACAACCGTGAGCTACCAAGCATCGTTTGAAGGTTTTGCGGCACGCGGGATCGGCCGCGAT
CAGGCCATCCGGCTGATGCGCCGCAGCGTCGCACTTGCCAGCGCCGCGCGTGATGAGATCAGCGCGGGTGGTCTTTGCGT
CGCCGCCTCAGTCGGACCGTACGGCGCGGCGCTGGCCGACGGGTCGGAATACCGCGGACGCTACGGCCTGTCCGTCGCAG
CTCTGGCCCGATGGCATCGCCCGCGGCTGGAGGTACTGGCCGACGCCGGCGCGGACGTACTCGCCCTGGAAACCATCCCC
GACATCGACGAGGCAGAAGCGTTAGTCGACCTGGTACGCTCGGTCGGAGTGCCAGCGTGGCTCAGCTACACCATCAACGG
AACGCGGACCCGCGCCGGACAACCGCTTGCCGAGGCGTTCGCGGTGGCCGCCGGCGTCCCCAAGATTGTCGCGGTCGGCG
TCAATTGCTGCGCACCCGACGATGTGCTGGCGGCCATCCAGATCGCGAATATCGGCAAGCCGATCATCGTCTACCCGAAT
AGTGGAGAACGCTGGGATTACCGCACCTGGACAGGACCGCGTAGGTTTTCGGCGCAGCTCGCCCTGCAGTGGACGGCGGC
CGGGGCACGCATCGTCGGCGGATGCTGCCGGGTGCGGCCGGCGGATATCGCCGAATTGACGAAGGCACTGGCGAGCCGTT
AA

Upstream 100 bases:

>100_bases
GGTCGAGACGCGCAATCCGTGTCTCTGGCGTGTCGCGGTCGTTGCGTGACCGCCGCCCCTGAGTCGTCGAGCCTGCGCGT
AATCACCTTACAGTGGCCAA

Downstream 100 bases:

>100_bases
ACGGTCTGCGCGGAAAGCTTACGGTATTCCAACACAGTGTCGATAATACCGTAATCCTTGGCTTCTTCGGCGGTCAGGAT
TTTATCCCTGTCCGTGTCCT

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MGLAVHSESVLINDGGLATELEARGNDLSDPLWSARLLTDAPQEIVAVHVAYFRAGATIATTVSYQASFEGFAARGIGRD
QAIRLMRRSVALASAARDEISAGGLCVAASVGPYGAALADGSEYRGRYGLSVAALARWHRPRLEVLADAGADVLALETIP
DIDEAEALVDLVRSVGVPAWLSYTINGTRTRAGQPLAEAFAVAAGVPKIVAVGVNCCAPDDVLAAIQIANIGKPIIVYPN
SGERWDYRTWTGPRRFSAQLALQWTAAGARIVGGCCRVRPADIAELTKALASR

Sequences:

>Translated_293_residues
MGLAVHSESVLINDGGLATELEARGNDLSDPLWSARLLTDAPQEIVAVHVAYFRAGATIATTVSYQASFEGFAARGIGRD
QAIRLMRRSVALASAARDEISAGGLCVAASVGPYGAALADGSEYRGRYGLSVAALARWHRPRLEVLADAGADVLALETIP
DIDEAEALVDLVRSVGVPAWLSYTINGTRTRAGQPLAEAFAVAAGVPKIVAVGVNCCAPDDVLAAIQIANIGKPIIVYPN
SGERWDYRTWTGPRRFSAQLALQWTAAGARIVGGCCRVRPADIAELTKALASR
>Mature_292_residues
GLAVHSESVLINDGGLATELEARGNDLSDPLWSARLLTDAPQEIVAVHVAYFRAGATIATTVSYQASFEGFAARGIGRDQ
AIRLMRRSVALASAARDEISAGGLCVAASVGPYGAALADGSEYRGRYGLSVAALARWHRPRLEVLADAGADVLALETIPD
IDEAEALVDLVRSVGVPAWLSYTINGTRTRAGQPLAEAFAVAAGVPKIVAVGVNCCAPDDVLAAIQIANIGKPIIVYPNS
GERWDYRTWTGPRRFSAQLALQWTAAGARIVGGCCRVRPADIAELTKALASR

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=322, Percent_Identity=25.4658385093168, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786456, Length=294, Percent_Identity=49.6598639455782, Blast_Score=260, Evalue=7e-71,
Organism=Escherichia coli, GI1790450, Length=317, Percent_Identity=27.1293375394322, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322966, Length=316, Percent_Identity=29.746835443038, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324982, Length=322, Percent_Identity=27.0186335403727, Blast_Score=109, Evalue=4e-25,
Organism=Drosophila melanogaster, GI20129603, Length=326, Percent_Identity=35.2760736196319, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24585077, Length=314, Percent_Identity=32.484076433121, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 30779; Mature: 30648

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLAVHSESVLINDGGLATELEARGNDLSDPLWSARLLTDAPQEIVAVHVAYFRAGATIA
CCEEEECCEEEEECCCCEEEHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEE
TTVSYQASFEGFAARGIGRDQAIRLMRRSVALASAARDEISAGGLCVAASVGPYGAALAD
EEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
GSEYRGRYGLSVAALARWHRPRLEVLADAGADVLALETIPDIDEAEALVDLVRSVGVPAW
CHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEE
LSYTINGTRTRAGQPLAEAFAVAAGVPKIVAVGVNCCAPDDVLAAIQIANIGKPIIVYPN
EEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEECC
SGERWDYRTWTGPRRFSAQLALQWTAAGARIVGGCCRVRPADIAELTKALASR
CCCCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
GLAVHSESVLINDGGLATELEARGNDLSDPLWSARLLTDAPQEIVAVHVAYFRAGATIA
CEEEECCEEEEECCCCEEEHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEE
TTVSYQASFEGFAARGIGRDQAIRLMRRSVALASAARDEISAGGLCVAASVGPYGAALAD
EEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
GSEYRGRYGLSVAALARWHRPRLEVLADAGADVLALETIPDIDEAEALVDLVRSVGVPAW
CHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEE
LSYTINGTRTRAGQPLAEAFAVAAGVPKIVAVGVNCCAPDDVLAAIQIANIGKPIIVYPN
EEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEECC
SGERWDYRTWTGPRRFSAQLALQWTAAGARIVGGCCRVRPADIAELTKALASR
CCCCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]