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The map label for this gene is ndk

Identifier: 221230248

GI number: 221230248

Start: 1768087

End: 1768497

Strand: Reverse

Name: ndk

Synonym: MLBr_01469

Alternate gene names: 221230248

Gene position: 1768497-1768087 (Counterclockwise)

Preceding gene: 221230249

Following gene: 221230247

Centisome position: 54.11

GC content: 58.15

Gene sequence:

>411_bases
GTGACCGAACGGACTCTCGTGTTGATCAAACCGGATGCTGTGGAACGGCAATTGATTGGGGAGATCATCAGCCGCATCGA
ACGGAAGGGTCTCACCATCGCGGCGTTGGAACTTAGACAGGTCGGTGAGGAATTGGCCAGCCAGCATTACGCCGAGCACG
AGAGCAAGCCATTTTTTGGATCGTTATTGGAGTTTATCACCTCGGGTCCAGTGATGGCGGCGATCGTGGAGGGACCACGT
GCCGTTGCGGCGGTTCGCCAACTCACCGGGGGCACCGATCCGGTGGAGAAGGCGGCGCCGGGCACAATCCGGGGCGATTT
AGCGTTGGAAACGCAATTCAACTTGGTCCACGGTTCCGATTCGACTGCTTCGGCACAGCGCGAAATCGCGTTGTGGTTTC
CCGGCATTTAG

Upstream 100 bases:

>100_bases
GGATTGTGGGCGCTGATCGTGTATTTTCGGGCCGAGGTCAGTCGGCGTTAGGAATACTGCCGTCGAGCTGATCGGCGAGC
CGTTAGGTACGCTGTGCGCC

Downstream 100 bases:

>100_bases
CGCGTGGGTGAGAAGGGGCCCGTGCCGGGTTCCTAAACGGGCCGTGTTGTAGCCACATCAGGGGCGAGTGGACGCGCCGG
CAATGTGGGATACTGGTAGC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 136; Mature: 135

Protein sequence:

>136_residues
MTERTLVLIKPDAVERQLIGEIISRIERKGLTIAALELRQVGEELASQHYAEHESKPFFGSLLEFITSGPVMAAIVEGPR
AVAAVRQLTGGTDPVEKAAPGTIRGDLALETQFNLVHGSDSTASAQREIALWFPGI

Sequences:

>Translated_136_residues
MTERTLVLIKPDAVERQLIGEIISRIERKGLTIAALELRQVGEELASQHYAEHESKPFFGSLLEFITSGPVMAAIVEGPR
AVAAVRQLTGGTDPVEKAAPGTIRGDLALETQFNLVHGSDSTASAQREIALWFPGI
>Mature_135_residues
TERTLVLIKPDAVERQLIGEIISRIERKGLTIAALELRQVGEELASQHYAEHESKPFFGSLLEFITSGPVMAAIVEGPRA
VAAVRQLTGGTDPVEKAAPGTIRGDLALETQFNLVHGSDSTASAQREIALWFPGI

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=131, Percent_Identity=52.6717557251908, Blast_Score=147, Evalue=3e-36,
Organism=Homo sapiens, GI4826862, Length=131, Percent_Identity=47.3282442748092, Blast_Score=135, Evalue=9e-33,
Organism=Homo sapiens, GI4557797, Length=132, Percent_Identity=45.4545454545455, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI38045913, Length=132, Percent_Identity=45.4545454545455, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=45.8015267175573, Blast_Score=133, Evalue=5e-32,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=45.8015267175573, Blast_Score=133, Evalue=5e-32,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=45.8015267175573, Blast_Score=133, Evalue=5e-32,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=45.8015267175573, Blast_Score=133, Evalue=5e-32,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=45.8015267175573, Blast_Score=133, Evalue=5e-32,
Organism=Homo sapiens, GI37574614, Length=134, Percent_Identity=37.3134328358209, Blast_Score=90, Evalue=5e-19,
Organism=Homo sapiens, GI7019465, Length=134, Percent_Identity=37.3134328358209, Blast_Score=90, Evalue=6e-19,
Organism=Homo sapiens, GI5031951, Length=134, Percent_Identity=41.044776119403, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=32.1167883211679, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI30023828, Length=141, Percent_Identity=36.1702127659575, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788866, Length=131, Percent_Identity=45.8015267175573, Blast_Score=116, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17506807, Length=132, Percent_Identity=46.2121212121212, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=132, Percent_Identity=47.7272727272727, Blast_Score=139, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45549037, Length=131, Percent_Identity=45.0381679389313, Blast_Score=135, Evalue=6e-33,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=34.3283582089552, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_MYCLB (B8ZRN7)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503664.1
- ProteinModelPortal:   B8ZRN7
- SMR:   B8ZRN7
- EnsemblBacteria:   EBMYCT00000086071
- GeneID:   7326897
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000015870
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 14676; Mature: 14545

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERTLVLIKPDAVERQLIGEIISRIERKGLTIAALELRQVGEELASQHYAEHESKPFFG
CCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
SLLEFITSGPVMAAIVEGPRAVAAVRQLTGGTDPVEKAAPGTIRGDLALETQFNLVHGSD
HHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEEEEEEEEECCC
STASAQREIALWFPGI
CCCCCCCEEEEECCCC
>Mature Secondary Structure 
TERTLVLIKPDAVERQLIGEIISRIERKGLTIAALELRQVGEELASQHYAEHESKPFFG
CCCEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
SLLEFITSGPVMAAIVEGPRAVAAVRQLTGGTDPVEKAAPGTIRGDLALETQFNLVHGSD
HHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEEEEEEEEECCC
STASAQREIALWFPGI
CCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA