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The map label for this gene is proA

Identifier: 221230241

GI number: 221230241

Start: 1751680

End: 1752909

Strand: Reverse

Name: proA

Synonym: MLBr_01458

Alternate gene names: 221230241

Gene position: 1752909-1751680 (Counterclockwise)

Preceding gene: 221230242

Following gene: 221230240

Centisome position: 53.64

GC content: 61.71

Gene sequence:

>1230_bases
TTGCGTCAAGAAGTCCACGATGCTGCCCGGCGAGCCCGGGTCGCTGCTCGCGCTCTCGCAGTTATGCCGACGGTAGCTAA
GGACCATGCACTGCGGGCCGCAGCAACGGCGGTAACTGCTCACACCGAGGAGATCCTCGCGGCCAACGCCGAAGATCTGC
AGGCGGCTCGGGCCACCGACACACTGGCCGCGACGCTCGACAGGTTAGCTTTGGATAGGCAACGCATTGACCAAATCGCG
GGCGGTTTGCGTCAAGTCGCGGCGTTGCCCGACCCGATCGGGGAGGTGTTGCGCGGTTACACGCTACCTAATGGGCTGCA
GTTGCGCCAGCAGCGGGTTCCACTCGGCGTAGTGGGTATGATCTACGAGGGCCGGCCTAACATCACCGTTGACGCTTTCG
GACTGGCGTTCAAGTCAGGTAATGCGGCGTTGCTGCGTGGCAGCTCGTCAGCGGCGAAGTCCAACCAAGCGCTCGTAGAG
GTGTTGCACGCTGCGTTGGTTAGCGAAGACTTGCCCGCCGACGCGGTCCAGCTGCTTTCAGCTGCCGATAGATCCACGGT
CACCCACCTGATCCAAGCTCGCGGCCTGGTGGATGTGGTGATCCCGCGCGGGGGAGCGAACCTGATTGATGCGGTGGTCC
GTGACGCGCAAGTGCCTATTATCGAGACCGGTGTCGGCAACTGTCACGTCTACGTGCATCAGGCTGCTGACCTGGAGGTT
GCCGAACGGATCCTGCTGAACTCCAAGACCCGTCGGCCCAGTGTCTGCAATGCTGCCGAGACGCTGTTGATCGATGCAGC
GATTGCCGATCACACTATGCCTAGGTTGGTCGCTGCCTTGCAAGGTGCCGGAGTAACGGTGCACGGTGGTCTTTCGGGAG
ACCCGGACAAGGCTGACCTGTGTCGCGAATACCTGTCGATGGACATTGCCGTGGCGGTGGTCGATGGCGTCGACGCCGCA
ATTGCCCACATCAATGAGTACGGCACCGGACACACCGAGGCGATTGTGACCACCAATATGGCTGCCGCCCAACGGTTTGC
CGACGGAGTGGACTCGGCCACGGTGATGGTCAACGCATCGACGGCGTTCACTGATGGTGGGCAGTTCGGTTTCGGCGCCG
AGATCGGTATCTCCACCCAGAAATTGCATGCCCGTGGACCAATGGGACTGTCGGAAATGACCTCGACTAAGTGGATCGTG
TGGGGAGACGGTCAGATCCGACCGGCCTGA

Upstream 100 bases:

>100_bases
TCGCCCTGATACTGGCCCCCGACTAACGGGCGGTCGTAGCTGGCCAAGGAAAGCCCGATACCCTGAATTGATGAGTCTTG
AAGCACCATCGCGTACCAAC

Downstream 100 bases:

>100_bases
CCCTTCGATATTCGCCGGACACAACCAGCTTGGGAGCATACGATTGTGACTGTGCCAGCTCGTCCCATGTCTCTTGGTCG
ATATCCCCGACGTCTCGCGG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRQEVHDAARRARVAARALAVMPTVAKDHALRAAATAVTAHTEEILAANAEDLQAARATDTLAATLDRLALDRQRIDQIA
GGLRQVAALPDPIGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNITVDAFGLAFKSGNAALLRGSSSAAKSNQALVE
VLHAALVSEDLPADAVQLLSAADRSTVTHLIQARGLVDVVIPRGGANLIDAVVRDAQVPIIETGVGNCHVYVHQAADLEV
AERILLNSKTRRPSVCNAAETLLIDAAIADHTMPRLVAALQGAGVTVHGGLSGDPDKADLCREYLSMDIAVAVVDGVDAA
IAHINEYGTGHTEAIVTTNMAAAQRFADGVDSATVMVNASTAFTDGGQFGFGAEIGISTQKLHARGPMGLSEMTSTKWIV
WGDGQIRPA

Sequences:

>Translated_409_residues
MRQEVHDAARRARVAARALAVMPTVAKDHALRAAATAVTAHTEEILAANAEDLQAARATDTLAATLDRLALDRQRIDQIA
GGLRQVAALPDPIGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNITVDAFGLAFKSGNAALLRGSSSAAKSNQALVE
VLHAALVSEDLPADAVQLLSAADRSTVTHLIQARGLVDVVIPRGGANLIDAVVRDAQVPIIETGVGNCHVYVHQAADLEV
AERILLNSKTRRPSVCNAAETLLIDAAIADHTMPRLVAALQGAGVTVHGGLSGDPDKADLCREYLSMDIAVAVVDGVDAA
IAHINEYGTGHTEAIVTTNMAAAQRFADGVDSATVMVNASTAFTDGGQFGFGAEIGISTQKLHARGPMGLSEMTSTKWIV
WGDGQIRPA
>Mature_409_residues
MRQEVHDAARRARVAARALAVMPTVAKDHALRAAATAVTAHTEEILAANAEDLQAARATDTLAATLDRLALDRQRIDQIA
GGLRQVAALPDPIGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNITVDAFGLAFKSGNAALLRGSSSAAKSNQALVE
VLHAALVSEDLPADAVQLLSAADRSTVTHLIQARGLVDVVIPRGGANLIDAVVRDAQVPIIETGVGNCHVYVHQAADLEV
AERILLNSKTRRPSVCNAAETLLIDAAIADHTMPRLVAALQGAGVTVHGGLSGDPDKADLCREYLSMDIAVAVVDGVDAA
IAHINEYGTGHTEAIVTTNMAAAQRFADGVDSATVMVNASTAFTDGGQFGFGAEIGISTQKLHARGPMGLSEMTSTKWIV
WGDGQIRPA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=412, Percent_Identity=36.4077669902913, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI21361368, Length=412, Percent_Identity=36.4077669902913, Blast_Score=241, Evalue=8e-64,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=45.5882352941176, Blast_Score=352, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI17569967, Length=415, Percent_Identity=36.144578313253, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17569969, Length=415, Percent_Identity=36.144578313253, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=35.5971896955504, Blast_Score=246, Evalue=7e-66,
Organism=Drosophila melanogaster, GI21357643, Length=404, Percent_Identity=36.6336633663366, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_MYCLB (B8ZRN0)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503657.1
- ProteinModelPortal:   B8ZRN0
- SMR:   B8ZRN0
- EnsemblBacteria:   EBMYCT00000085856
- GeneID:   7326891
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000015663
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 42813; Mature: 42813

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQEVHDAARRARVAARALAVMPTVAKDHALRAAATAVTAHTEEILAANAEDLQAARATD
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TLAATLDRLALDRQRIDQIAGGLRQVAALPDPIGEVLRGYTLPNGLQLRQQRVPLGVVGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHCCCEEEEEE
IYEGRPNITVDAFGLAFKSGNAALLRGSSSAAKSNQALVEVLHAALVSEDLPADAVQLLS
EEECCCCEEEEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AADRSTVTHLIQARGLVDVVIPRGGANLIDAVVRDAQVPIIETGVGNCHVYVHQAADLEV
HCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCHHH
AERILLNSKTRRPSVCNAAETLLIDAAIADHTMPRLVAALQGAGVTVHGGLSGDPDKADL
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHH
CREYLSMDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNMAAAQRFADGVDSATVMVNAS
HHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCEEEEEECC
TAFTDGGQFGFGAEIGISTQKLHARGPMGLSEMTSTKWIVWGDGQIRPA
EEECCCCCCCCCCEECCCHHHHHCCCCCCHHHHCCCEEEEECCCCCCCC
>Mature Secondary Structure
MRQEVHDAARRARVAARALAVMPTVAKDHALRAAATAVTAHTEEILAANAEDLQAARATD
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TLAATLDRLALDRQRIDQIAGGLRQVAALPDPIGEVLRGYTLPNGLQLRQQRVPLGVVGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHCCCEEEEEE
IYEGRPNITVDAFGLAFKSGNAALLRGSSSAAKSNQALVEVLHAALVSEDLPADAVQLLS
EEECCCCEEEEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AADRSTVTHLIQARGLVDVVIPRGGANLIDAVVRDAQVPIIETGVGNCHVYVHQAADLEV
HCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCHHH
AERILLNSKTRRPSVCNAAETLLIDAAIADHTMPRLVAALQGAGVTVHGGLSGDPDKADL
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHH
CREYLSMDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNMAAAQRFADGVDSATVMVNAS
HHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCEEEEEECC
TAFTDGGQFGFGAEIGISTQKLHARGPMGLSEMTSTKWIVWGDGQIRPA
EEECCCCCCCCCCEECCCHHHHHCCCCCCHHHHCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA