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The map label for this gene is pbpB [H]

Identifier: 221229905

GI number: 221229905

Start: 1073875

End: 1075902

Strand: Direct

Name: pbpB [H]

Synonym: MLBr_00908

Alternate gene names: 221229905

Gene position: 1073875-1075902 (Clockwise)

Preceding gene: 221229904

Following gene: 221229906

Centisome position: 32.86

GC content: 60.11

Gene sequence:

>2028_bases
GTGAGACGCGGCGACGCTCACCGCCCATGCTCGTCGCGGTCGGCACAGTTGGGGAACAGCTCCAGCACACCGCCCGTTCG
GCAACCCAAGCGGCTTCGCCAACCAGAGAAAGCTAGGAAAGCCAAGGACACCAAAAAATCTCGCTCAGCAGTCGCGGCGG
ATGCAGTGACGGAGGGTCGTTCAGCTCGGAAGCGGCGCACCCGGCAGGTGGTCGAAATAGGAACTTACGGTCCATCTTTT
ATCTTCCGGCATCGGGGTGGCAACGTGGTTATCTTCGCGTTGATGCTGGTGGCGGCGACGCAGCTGTTCAACCTACAGGT
TTCAAATGCCGCGGGTCTGCGTGCTCAGGCGGCCGGACAGCTCAGGGTAACTGACGTCGAAAAGGCGGTTCGCGGCAGCA
TAACCGACCGCAACAACGAGCAACTTGCCTTCACTATCGAATCGCGCGCGTTGACGTTTCAGCCGAAGAAAATTCGCCAG
CAGCTGGAGGAAGCCAAACAGAAAACGCCATCCGCTCCTGACCCGCAGCAGCGCCTACAAGATATCGCCAAGGAGGTCGC
GGGTCGGTTGAGCAACAAGCCCGACGGTCCGTCGTTGCTGAAGAAGCTGCAAAGCAACGACAGTTTCGTCTATTTGGCGC
GCGCCGTCGATCCTGCCGTCGCCGAGGCGATCTCCGCCAAATATCCCGAAGTTGGTTCTGAACGGCAGGACCTGCGCCAG
TATCCGGGCGGATCACTAGCGGCCAACATCGTCGGCGGCATCGACTGGGACGGGCATGGATTGCTGGGTCTTGAGGACTC
CCTGGACTCCGTGTTGTCCGGAACCGACGGTTCGGTCACCTACGACCGCGGGTCCGACGGTGTGGTAATCCCGGGCAGCT
ACCGCAATCGGCACCGGGCGGTTAACGGCTCGACCGTCCAGCTCACCATCGACGACGACATCCAGTTCTACGTGCAGCAG
CAGGTGCAGCAGGCAAAGAACTTGTCCGGTGCCCATAATGTTTCGGCCGTCGTCCTGGATGCCAAGACTGGCGAAGTACT
TGCCATGGCCAACGACAACACCTTCGACCCGTCGCAAGACATTGGGCGCCAAGGTGGTAAGCAGCTGGGTAACTTGGCAG
TTTCCTCGCCATTTGAGCCGGGCTCGGTGAATAAGGTCATCACCGCATCCGCGGTCATTGAATATGGGCTGTCCACTCCC
GATGAGGTGCTGCAGGTTCCTGGCTCGATCCAGATGGGTGGTGTGTCCGTCCATGATGCGTGGGAGCACGGTGTGATGCC
CTATACCACCACTGGAGTGTTTGGAAAGTCTTCCAACGTCGGTACGTTGATGCTGGCCCAGCGTGTCGGTCCGGAACGCT
TTTACGACATGGTCCGCAAGTTCGGGTTAGGTCAACTCACCGGCGTGGGGCTGCCCGGTGAAAGCGAGGGGTTGGTACCG
TCCGTCGACCAATGGTCGGGCAGCACTTTTTCGAATTTGCCTATAGGGCAAGGTCTTTCGACGACTCTACTGCAGATGAC
CGGAATGTATCAAGTCATTGCCAATGACGGGGTGCGGATACCGCCGCGGATCATTAAGGCTACTAACGCAGCTGACGGTA
CGCGGACGCAAGAACCGCGGCCGGACGGCATTCGGGTGGTGTCGCCGCAGACTGCCCAGACCGTGCGGCAGATGCTGCGC
GCTGTGGTGCAAAAAGATCCGATGGGTTACCAGCAGGGTACTGGTCCCGCGGCCGGGGTGTCCGGCTATCAGATAGCCGG
CAAGACAGGTACTGCGCAGCAAGTTAATCCCGCCTGCAGATGCTACTTCGACGATGTCTACTGGATTACCTTTGCTGGAA
TGGCTACCGTCGACAATCCCCGCTACGTCATCGGCACCATGATGGACAACCCTGAGCGCAACGCGGACGGTACGCCCGGT
CACAGTGCGGCCCCACTTTTCCATAACGTCGCGGGCTGGCTGATGCAGCGTGAGAACGTGCCGCTGTCACCGGATCCGGG
ACCACCGTTGACGCTGCAGGCCACCTAG

Upstream 100 bases:

>100_bases
CCGCAGTCACGAGTCCGGTTATATCGACGAGCCCGGTGCCCACGCCGGTTAACAGCGAGCAGTTCGGCCCCGTCACGGCC
ACAGCGCCAGGGACGTCGCG

Downstream 100 bases:

>100_bases
CGGTGTGAGCGTAGCCGACATCGGCATTAGTGAGCGGTGACGTCTACTCGCTAATTTTCGCTTTAGCGGCGATTTCGCCG
CCCTGTGCTGGAGCCGGTGT

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MRRGDAHRPCSSRSAQLGNSSSTPPVRQPKRLRQPEKARKAKDTKKSRSAVAADAVTEGRSARKRRTRQVVEIGTYGPSF
IFRHRGGNVVIFALMLVAATQLFNLQVSNAAGLRAQAAGQLRVTDVEKAVRGSITDRNNEQLAFTIESRALTFQPKKIRQ
QLEEAKQKTPSAPDPQQRLQDIAKEVAGRLSNKPDGPSLLKKLQSNDSFVYLARAVDPAVAEAISAKYPEVGSERQDLRQ
YPGGSLAANIVGGIDWDGHGLLGLEDSLDSVLSGTDGSVTYDRGSDGVVIPGSYRNRHRAVNGSTVQLTIDDDIQFYVQQ
QVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGGKQLGNLAVSSPFEPGSVNKVITASAVIEYGLSTP
DEVLQVPGSIQMGGVSVHDAWEHGVMPYTTTGVFGKSSNVGTLMLAQRVGPERFYDMVRKFGLGQLTGVGLPGESEGLVP
SVDQWSGSTFSNLPIGQGLSTTLLQMTGMYQVIANDGVRIPPRIIKATNAADGTRTQEPRPDGIRVVSPQTAQTVRQMLR
AVVQKDPMGYQQGTGPAAGVSGYQIAGKTGTAQQVNPACRCYFDDVYWITFAGMATVDNPRYVIGTMMDNPERNADGTPG
HSAAPLFHNVAGWLMQRENVPLSPDPGPPLTLQAT

Sequences:

>Translated_675_residues
MRRGDAHRPCSSRSAQLGNSSSTPPVRQPKRLRQPEKARKAKDTKKSRSAVAADAVTEGRSARKRRTRQVVEIGTYGPSF
IFRHRGGNVVIFALMLVAATQLFNLQVSNAAGLRAQAAGQLRVTDVEKAVRGSITDRNNEQLAFTIESRALTFQPKKIRQ
QLEEAKQKTPSAPDPQQRLQDIAKEVAGRLSNKPDGPSLLKKLQSNDSFVYLARAVDPAVAEAISAKYPEVGSERQDLRQ
YPGGSLAANIVGGIDWDGHGLLGLEDSLDSVLSGTDGSVTYDRGSDGVVIPGSYRNRHRAVNGSTVQLTIDDDIQFYVQQ
QVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGGKQLGNLAVSSPFEPGSVNKVITASAVIEYGLSTP
DEVLQVPGSIQMGGVSVHDAWEHGVMPYTTTGVFGKSSNVGTLMLAQRVGPERFYDMVRKFGLGQLTGVGLPGESEGLVP
SVDQWSGSTFSNLPIGQGLSTTLLQMTGMYQVIANDGVRIPPRIIKATNAADGTRTQEPRPDGIRVVSPQTAQTVRQMLR
AVVQKDPMGYQQGTGPAAGVSGYQIAGKTGTAQQVNPACRCYFDDVYWITFAGMATVDNPRYVIGTMMDNPERNADGTPG
HSAAPLFHNVAGWLMQRENVPLSPDPGPPLTLQAT
>Mature_675_residues
MRRGDAHRPCSSRSAQLGNSSSTPPVRQPKRLRQPEKARKAKDTKKSRSAVAADAVTEGRSARKRRTRQVVEIGTYGPSF
IFRHRGGNVVIFALMLVAATQLFNLQVSNAAGLRAQAAGQLRVTDVEKAVRGSITDRNNEQLAFTIESRALTFQPKKIRQ
QLEEAKQKTPSAPDPQQRLQDIAKEVAGRLSNKPDGPSLLKKLQSNDSFVYLARAVDPAVAEAISAKYPEVGSERQDLRQ
YPGGSLAANIVGGIDWDGHGLLGLEDSLDSVLSGTDGSVTYDRGSDGVVIPGSYRNRHRAVNGSTVQLTIDDDIQFYVQQ
QVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGGKQLGNLAVSSPFEPGSVNKVITASAVIEYGLSTP
DEVLQVPGSIQMGGVSVHDAWEHGVMPYTTTGVFGKSSNVGTLMLAQRVGPERFYDMVRKFGLGQLTGVGLPGESEGLVP
SVDQWSGSTFSNLPIGQGLSTTLLQMTGMYQVIANDGVRIPPRIIKATNAADGTRTQEPRPDGIRVVSPQTAQTVRQMLR
AVVQKDPMGYQQGTGPAAGVSGYQIAGKTGTAQQVNPACRCYFDDVYWITFAGMATVDNPRYVIGTMMDNPERNADGTPG
HSAAPLFHNVAGWLMQRENVPLSPDPGPPLTLQAT

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=551, Percent_Identity=29.7640653357532, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI1786854, Length=572, Percent_Identity=25.1748251748252, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 72422; Mature: 72422

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRGDAHRPCSSRSAQLGNSSSTPPVRQPKRLRQPEKARKAKDTKKSRSAVAADAVTEGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCH
SARKRRTRQVVEIGTYGPSFIFRHRGGNVVIFALMLVAATQLFNLQVSNAAGLRAQAAGQ
HHHHHHHHHHEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHEEEECCCCCCCHHCCCC
LRVTDVEKAVRGSITDRNNEQLAFTIESRALTFQPKKIRQQLEEAKQKTPSAPDPQQRLQ
EEEEHHHHHHHCCCCCCCCCEEEEEEECCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHH
DIAKEVAGRLSNKPDGPSLLKKLQSNDSFVYLARAVDPAVAEAISAKYPEVGSERQDLRQ
HHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHH
YPGGSLAANIVGGIDWDGHGLLGLEDSLDSVLSGTDGSVTYDRGSDGVVIPGSYRNRHRA
CCCCCEEHHHCCCCCCCCCCEECCHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCCCEE
VNGSTVQLTIDDDIQFYVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQD
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHH
IGRQGGKQLGNLAVSSPFEPGSVNKVITASAVIEYGLSTPDEVLQVPGSIQMGGVSVHDA
HHHHHHHHHHCHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCEEECCEEEEHH
WEHGVMPYTTTGVFGKSSNVGTLMLAQRVGPERFYDMVRKFGLGQLTGVGLPGESEGLVP
HHCCCCCEEECCCCCCCCCCCEEEHHHHCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCC
SVDQWSGSTFSNLPIGQGLSTTLLQMTGMYQVIANDGVRIPPRIIKATNAADGTRTQEPR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCHHHHEECCCCCCCCCCCCC
PDGIRVVSPQTAQTVRQMLRAVVQKDPMGYQQGTGPAAGVSGYQIAGKTGTAQQVNPACR
CCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHCCCCCE
CYFDDVYWITFAGMATVDNPRYVIGTMMDNPERNADGTPGHSAAPLFHNVAGWLMQRENV
EEECCEEEEEEECEEECCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
PLSPDPGPPLTLQAT
CCCCCCCCCEEEEEC
>Mature Secondary Structure
MRRGDAHRPCSSRSAQLGNSSSTPPVRQPKRLRQPEKARKAKDTKKSRSAVAADAVTEGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCH
SARKRRTRQVVEIGTYGPSFIFRHRGGNVVIFALMLVAATQLFNLQVSNAAGLRAQAAGQ
HHHHHHHHHHEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHEEEECCCCCCCHHCCCC
LRVTDVEKAVRGSITDRNNEQLAFTIESRALTFQPKKIRQQLEEAKQKTPSAPDPQQRLQ
EEEEHHHHHHHCCCCCCCCCEEEEEEECCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHH
DIAKEVAGRLSNKPDGPSLLKKLQSNDSFVYLARAVDPAVAEAISAKYPEVGSERQDLRQ
HHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHH
YPGGSLAANIVGGIDWDGHGLLGLEDSLDSVLSGTDGSVTYDRGSDGVVIPGSYRNRHRA
CCCCCEEHHHCCCCCCCCCCEECCHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCCCEE
VNGSTVQLTIDDDIQFYVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQD
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHH
IGRQGGKQLGNLAVSSPFEPGSVNKVITASAVIEYGLSTPDEVLQVPGSIQMGGVSVHDA
HHHHHHHHHHCHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCEEECCEEEEHH
WEHGVMPYTTTGVFGKSSNVGTLMLAQRVGPERFYDMVRKFGLGQLTGVGLPGESEGLVP
HHCCCCCEEECCCCCCCCCCCEEEHHHHCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCC
SVDQWSGSTFSNLPIGQGLSTTLLQMTGMYQVIANDGVRIPPRIIKATNAADGTRTQEPR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCHHHHEECCCCCCCCCCCCC
PDGIRVVSPQTAQTVRQMLRAVVQKDPMGYQQGTGPAAGVSGYQIAGKTGTAQQVNPACR
CCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHCCCCCE
CYFDDVYWITFAGMATVDNPRYVIGTMMDNPERNADGTPGHSAAPLFHNVAGWLMQRENV
EEECCEEEEEEECEEECCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
PLSPDPGPPLTLQAT
CCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]