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The map label for this gene is fprA

Identifier: 221229755

GI number: 221229755

Start: 801985

End: 803355

Strand: Reverse

Name: fprA

Synonym: MLBr_00666

Alternate gene names: 221229755

Gene position: 803355-801985 (Counterclockwise)

Preceding gene: 221229762

Following gene: 221229752

Centisome position: 24.58

GC content: 61.27

Gene sequence:

>1371_bases
TTGCGTCCACACCACATACATCACATAGCCATAGTTGGCTCGGGGCCATCGGGATTTTTCGCCGCGGCATCCGTGTTGAA
GGCCGCTGACGCCTCCGACGAGATCAACGTTGCCGTCGACATGCTGGAGATGCTGCCCACCCCGTGGGGACTGGTCCGCT
CTGGTGTCGCACCCGATCACCCCAAGATCAAATCGATCAGCAAGCAGTTCGAGAAGACCGCTGAGGACCCGCGGTTCCGC
TTCTTCGGCAATGTGATTGTCGGTAAACACATCGAGCCTGCCGAACTCGCCGAACGCTACGATGCCGTGATATATGCTGT
CGGGGCGCAGTCCGACCGCGCTTTGAACATCCCCGGTGAAGACCTGCCAGGCAGTATCGCCGCTGTCGATTTCGTGGGTT
GGTATAACGCACACCCCAACTTCCACGAGAGGTCACCCGACCTTTCGGGCAGTCGCGCAGTGGTTATTGGCAACGGCAAC
GTCGCACTCGACGTCACACGCATCCTAATCACCGATCCCGACGTACTGGCATTCACCGATATCGCCGACCACGCACTAGA
GTCACTGCGCCCGCGCGGGATCGAGGAAGTGGTGATCGTTGGCCGCCGCGGGCCATTACAGACAGCGTTCACCACACTGG
AGCTGCGTGAGCTAGCAGACATCGAAGGGGTCGACGTGCTTGTCGATCCTGCCCAGCTGGAGGGCATCAGTGACGAGAAC
GCGGCCGCGGCGGGCAAGACGACCAGGCAGAACATCAAAGTGTTACGCGACTACACTGTGCGCACGCCCAAACCCGGCCA
TCGTCGGATTGTGTTCCGATTCCTGACTTCCCCAATTGAAATCAAAGGCAAAGGCAAGGTGGAGAGGATCGTTCTCGGTC
AAAACGAACTTGTCACCGACGACAACGGGCGGGTGGCAGCCAAAGACACCGGTGTTCGCGAGGAGCTGCCGGCTCAGTTG
ATTGTGCGGTCGATCGGTTATCGCGGCGTCCCTACGCCGGGGTTACCATTCGACGACAGTAGCGTAACCATCCCCAACAC
CAACGGCCGGGTGAACGGCAGCCGAAACGAGTACGTCGTCGGGTGGATCAAACGCGGGCCGACCGGGGTGATCGGCACCA
ACAAGAAGGACTCCCAAGACACTGTCGACACCTTGATGGAGAATCTGGCTGGCGCCAATGATACCGAAAAGTTCGGCGCA
GACCACGCCGACCGGCTGGCCGAGTGGCTGGCCGAACGGCAACCGAAGCTGGTCACGTCGGCGCACTGGCAGGCCATCGA
CCGCTTTGAGCGAGCGGCCGGCGAACCGCACGGCCGCCCCCGCGTTAAGCTGCCGAACCTCGCCGAGCTGCTGCGGATCG
GGCACGGCTGA

Upstream 100 bases:

>100_bases
AGCGATCGTCATGTGAGCGGCACCATAACGACGTGACCGCTCAATATATTCCAACGCCTCCAGCGCCACAGGAACCAAGC
ACGAACAGAAGGCTCAGGTA

Downstream 100 bases:

>100_bases
TCACAGGTCGACCAGTATCCCGGGGTTGACGCTCCCGGCCAGGTCCAGCACGGACTTCGCCGCACGCAGAGCTGCCACGA
AGAGGTCCGGGCGCTGCCGG

Product: putative NADPH-ferredoxin reductase

Products: NA

Alternate protein names: NFR

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MRPHHIHHIAIVGSGPSGFFAAASVLKAADASDEINVAVDMLEMLPTPWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFR
FFGNVIVGKHIEPAELAERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFHERSPDLSGSRAVVIGNGN
VALDVTRILITDPDVLAFTDIADHALESLRPRGIEEVVIVGRRGPLQTAFTTLELRELADIEGVDVLVDPAQLEGISDEN
AAAAGKTTRQNIKVLRDYTVRTPKPGHRRIVFRFLTSPIEIKGKGKVERIVLGQNELVTDDNGRVAAKDTGVREELPAQL
IVRSIGYRGVPTPGLPFDDSSVTIPNTNGRVNGSRNEYVVGWIKRGPTGVIGTNKKDSQDTVDTLMENLAGANDTEKFGA
DHADRLAEWLAERQPKLVTSAHWQAIDRFERAAGEPHGRPRVKLPNLAELLRIGHG

Sequences:

>Translated_456_residues
MRPHHIHHIAIVGSGPSGFFAAASVLKAADASDEINVAVDMLEMLPTPWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFR
FFGNVIVGKHIEPAELAERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFHERSPDLSGSRAVVIGNGN
VALDVTRILITDPDVLAFTDIADHALESLRPRGIEEVVIVGRRGPLQTAFTTLELRELADIEGVDVLVDPAQLEGISDEN
AAAAGKTTRQNIKVLRDYTVRTPKPGHRRIVFRFLTSPIEIKGKGKVERIVLGQNELVTDDNGRVAAKDTGVREELPAQL
IVRSIGYRGVPTPGLPFDDSSVTIPNTNGRVNGSRNEYVVGWIKRGPTGVIGTNKKDSQDTVDTLMENLAGANDTEKFGA
DHADRLAEWLAERQPKLVTSAHWQAIDRFERAAGEPHGRPRVKLPNLAELLRIGHG
>Mature_456_residues
MRPHHIHHIAIVGSGPSGFFAAASVLKAADASDEINVAVDMLEMLPTPWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFR
FFGNVIVGKHIEPAELAERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFHERSPDLSGSRAVVIGNGN
VALDVTRILITDPDVLAFTDIADHALESLRPRGIEEVVIVGRRGPLQTAFTTLELRELADIEGVDVLVDPAQLEGISDEN
AAAAGKTTRQNIKVLRDYTVRTPKPGHRRIVFRFLTSPIEIKGKGKVERIVLGQNELVTDDNGRVAAKDTGVREELPAQL
IVRSIGYRGVPTPGLPFDDSSVTIPNTNGRVNGSRNEYVVGWIKRGPTGVIGTNKKDSQDTVDTLMENLAGANDTEKFGA
DHADRLAEWLAERQPKLVTSAHWQAIDRFERAAGEPHGRPRVKLPNLAELLRIGHG

Specific function: May serve as electron transfer protein and supply electrons to P450 systems

COG id: COG0493

COG function: function code ER; NADPH-dependent glutamate synthase beta chain and related oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferredoxin--NADP reductase type 1 family

Homologues:

Organism=Homo sapiens, GI111118981, Length=475, Percent_Identity=40, Blast_Score=291, Evalue=8e-79,
Organism=Homo sapiens, GI111118983, Length=481, Percent_Identity=39.2931392931393, Blast_Score=285, Evalue=5e-77,
Organism=Escherichia coli, GI87082180, Length=167, Percent_Identity=28.7425149700599, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17543860, Length=454, Percent_Identity=33.2599118942731, Blast_Score=228, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6320584, Length=485, Percent_Identity=32.1649484536082, Blast_Score=209, Evalue=5e-55,
Organism=Drosophila melanogaster, GI17137178, Length=458, Percent_Identity=37.7729257641921, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPRA_MYCLE (O32886)

Other databases:

- EMBL:   Z98271
- EMBL:   AL583919
- PIR:   T45314
- RefSeq:   NP_301540.1
- ProteinModelPortal:   O32886
- SMR:   O32886
- EnsemblBacteria:   EBMYCT00000029407
- GeneID:   910559
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0666
- NMPDR:   fig|272631.1.peg.412
- Leproma:   ML0666
- GeneTree:   EBGT00050000014581
- HOGENOM:   HBG522200
- OMA:   EYVAGWI
- ProtClustDB:   CLSK872140
- BioCyc:   MLEP272631:ML0666-MONOMER
- BRENDA:   1.18.1.2
- GO:   GO:0005488
- InterPro:   IPR013027
- InterPro:   IPR021163
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000362

Pfam domain/function: PF07992 Pyr_redox_2

EC number: =1.18.1.2

Molecular weight: Translated: 49631; Mature: 49631

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: BINDING 17-17 BINDING 43-43 BINDING 51-51 BINDING 87-87 BINDING 113-113 BINDING 214-214 BINDING 362-362 BINDING 369-369

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPHHIHHIAIVGSGPSGFFAAASVLKAADASDEINVAVDMLEMLPTPWGLVRSGVAPDH
CCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCC
PKIKSISKQFEKTAEDPRFRFFGNVIVGKHIEPAELAERYDAVIYAVGAQSDRALNIPGE
CHHHHHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHCEEEEEECCCCCCEECCCCC
DLPGSIAAVDFVGWYNAHPNFHERSPDLSGSRAVVIGNGNVALDVTRILITDPDVLAFTD
CCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEEEECCCEEEEHH
IADHALESLRPRGIEEVVIVGRRGPLQTAFTTLELRELADIEGVDVLVDPAQLEGISDEN
HHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCCC
AAAAGKTTRQNIKVLRDYTVRTPKPGHRRIVFRFLTSPIEIKGKGKVERIVLGQNELVTD
CCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEECCCCEEEEEECCCCEEEC
DNGRVAAKDTGVREELPAQLIVRSIGYRGVPTPGLPFDDSSVTIPNTNGRVNGSRNEYVV
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEE
GWIKRGPTGVIGTNKKDSQDTVDTLMENLAGANDTEKFGADHADRLAEWLAERQPKLVTS
EEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHCCCCEEHH
AHWQAIDRFERAAGEPHGRPRVKLPNLAELLRIGHG
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MRPHHIHHIAIVGSGPSGFFAAASVLKAADASDEINVAVDMLEMLPTPWGLVRSGVAPDH
CCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCC
PKIKSISKQFEKTAEDPRFRFFGNVIVGKHIEPAELAERYDAVIYAVGAQSDRALNIPGE
CHHHHHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHCEEEEEECCCCCCEECCCCC
DLPGSIAAVDFVGWYNAHPNFHERSPDLSGSRAVVIGNGNVALDVTRILITDPDVLAFTD
CCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEEEECCCEEEEHH
IADHALESLRPRGIEEVVIVGRRGPLQTAFTTLELRELADIEGVDVLVDPAQLEGISDEN
HHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCCC
AAAAGKTTRQNIKVLRDYTVRTPKPGHRRIVFRFLTSPIEIKGKGKVERIVLGQNELVTD
CCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEECCCCEEEEEECCCCEEEC
DNGRVAAKDTGVREELPAQLIVRSIGYRGVPTPGLPFDDSSVTIPNTNGRVNGSRNEYVV
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEE
GWIKRGPTGVIGTNKKDSQDTVDTLMENLAGANDTEKFGADHADRLAEWLAERQPKLVTS
EEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHCCCCEEHH
AHWQAIDRFERAAGEPHGRPRVKLPNLAELLRIGHG
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002