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The map label for this gene is uppS

Identifier: 221229740

GI number: 221229740

Start: 766719

End: 767609

Strand: Direct

Name: uppS

Synonym: MLBr_00634

Alternate gene names: 221229740

Gene position: 766719-767609 (Clockwise)

Preceding gene: 221229739

Following gene: 221229741

Centisome position: 23.46

GC content: 59.37

Gene sequence:

>891_bases
GTGGTTAGGAACGAGCGCACGCTGAAGTCCACGGATTTTCCGCAGCTGCCCCCTGCGCCCGACGACTACCCGACCTTTCC
CGACAAGTCGACCTGGCCGGTTGTCTTCCCGATGCTGCCGCCATCACCCGACGGCGGGCCGAGGCGACCGCCGCAGCACA
CGTCAAAAGCTGTCGCTCCACGGCTCTCGGCCGCCCAATTGCCGACTCATGTCGCCATCGTGATGGACGGCAATGGCCGT
TGGGCTAACCAACGCGGACTGCACCGCACCGAGGGCCACAAGATGGGCGAAGCGGTGGTCATCGACGTTGCTTGCGGCGC
TATCGAACTCGGGATCAAATGGCTCAGTCTCTATGCTTTTTCTACTGAGAACTGGAAGCGGTCTGTCGAAGAGGTCCGTT
TCCTGATGGGTTTTAACCGCGATGTAGTGCGACGGCGTCGGGAGAATCTCAAGGAGATGGGGGTCCGGATCCGATGGGTA
GGGTCGCGACCGCGCTTATGGCGCAGCGTCATCAATGAATTGGCCATTGCGGAACACATGACGGCGGGCAACGACGTCAT
CACCATCAATTATTGTGTCAACTACGGTGGTCGCACTGAAATCGCAGAAGCTACAAGAGAAATTGCTCGTCTGGCAGCTG
CGGGCCGGCTCAATCCGGAGCGGATCACCGAGTCCACGATCACACGGCACTTGCAGCGGCCAGACATCCCCGATGTCGAT
CTCTTCGTGCGGACTTCGGGGGAGCAGCGGTCCAGCAATTTCATGTTGTGGCAGGCGGCGTATACTGAATACATTTTCCA
GGATAAGTTGTGGCCCGATTATGACCGCCGTGACTTGTGGGCGGCGTGTGAAGAATATGCGTCGCGCAATCGGCGCTTCG
GAAGCGCATAG

Upstream 100 bases:

>100_bases
CTGAAAACTTTACCTCTGGTGGAACGAACACATCAAGCATACCAGGTCGATCGTTCCATCGCGGAGCGGCGCGCAGCGCT
GGTCCGGCAAGATATGGCCT

Downstream 100 bases:

>100_bases
TGCACTCTTGACAAGAGCGACTCGCATTGGTCCTCCGCGTCGTGTTACTCACCGAGGAGGAAACCGACGGCGCGTTCACG
GTGAGAATTCACTGTACGTT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MVRNERTLKSTDFPQLPPAPDDYPTFPDKSTWPVVFPMLPPSPDGGPRRPPQHTSKAVAPRLSAAQLPTHVAIVMDGNGR
WANQRGLHRTEGHKMGEAVVIDVACGAIELGIKWLSLYAFSTENWKRSVEEVRFLMGFNRDVVRRRRENLKEMGVRIRWV
GSRPRLWRSVINELAIAEHMTAGNDVITINYCVNYGGRTEIAEATREIARLAAAGRLNPERITESTITRHLQRPDIPDVD
LFVRTSGEQRSSNFMLWQAAYTEYIFQDKLWPDYDRRDLWAACEEYASRNRRFGSA

Sequences:

>Translated_296_residues
MVRNERTLKSTDFPQLPPAPDDYPTFPDKSTWPVVFPMLPPSPDGGPRRPPQHTSKAVAPRLSAAQLPTHVAIVMDGNGR
WANQRGLHRTEGHKMGEAVVIDVACGAIELGIKWLSLYAFSTENWKRSVEEVRFLMGFNRDVVRRRRENLKEMGVRIRWV
GSRPRLWRSVINELAIAEHMTAGNDVITINYCVNYGGRTEIAEATREIARLAAAGRLNPERITESTITRHLQRPDIPDVD
LFVRTSGEQRSSNFMLWQAAYTEYIFQDKLWPDYDRRDLWAACEEYASRNRRFGSA
>Mature_296_residues
MVRNERTLKSTDFPQLPPAPDDYPTFPDKSTWPVVFPMLPPSPDGGPRRPPQHTSKAVAPRLSAAQLPTHVAIVMDGNGR
WANQRGLHRTEGHKMGEAVVIDVACGAIELGIKWLSLYAFSTENWKRSVEEVRFLMGFNRDVVRRRRENLKEMGVRIRWV
GSRPRLWRSVINELAIAEHMTAGNDVITINYCVNYGGRTEIAEATREIARLAAAGRLNPERITESTITRHLQRPDIPDVD
LFVRTSGEQRSSNFMLWQAAYTEYIFQDKLWPDYDRRDLWAACEEYASRNRRFGSA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=232, Percent_Identity=35.7758620689655, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI45580742, Length=232, Percent_Identity=35.7758620689655, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=42.0353982300885, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=34.7826086956522, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=35.2112676056338, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=223, Percent_Identity=30.9417040358744, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18857969, Length=217, Percent_Identity=36.405529953917, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_MYCLE (P38119)

Other databases:

- EMBL:   U00016
- EMBL:   AL583919
- PIR:   S72601
- RefSeq:   NP_301525.1
- ProteinModelPortal:   P38119
- SMR:   P38119
- EnsemblBacteria:   EBMYCT00000028492
- GeneID:   909416
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0634
- NMPDR:   fig|272631.1.peg.397
- Leproma:   ML0634
- GeneTree:   EBGT00050000016292
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14827
- BioCyc:   MLEP272631:ML0634-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 33891; Mature: 33891

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 76-76

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRNERTLKSTDFPQLPPAPDDYPTFPDKSTWPVVFPMLPPSPDGGPRRPPQHTSKAVAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHC
RLSAAQLPTHVAIVMDGNGRWANQRGLHRTEGHKMGEAVVIDVACGAIELGIKWLSLYAF
CCHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHEEE
STENWKRSVEEVRFLMGFNRDVVRRRRENLKEMGVRIRWVGSRPRLWRSVINELAIAEHM
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHH
TAGNDVITINYCVNYGGRTEIAEATREIARLAAAGRLNPERITESTITRHLQRPDIPDVD
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCE
LFVRTSGEQRSSNFMLWQAAYTEYIFQDKLWPDYDRRDLWAACEEYASRNRRFGSA
EEEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVRNERTLKSTDFPQLPPAPDDYPTFPDKSTWPVVFPMLPPSPDGGPRRPPQHTSKAVAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHC
RLSAAQLPTHVAIVMDGNGRWANQRGLHRTEGHKMGEAVVIDVACGAIELGIKWLSLYAF
CCHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHEEE
STENWKRSVEEVRFLMGFNRDVVRRRRENLKEMGVRIRWVGSRPRLWRSVINELAIAEHM
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHH
TAGNDVITINYCVNYGGRTEIAEATREIARLAAAGRLNPERITESTITRHLQRPDIPDVD
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCE
LFVRTSGEQRSSNFMLWQAAYTEYIFQDKLWPDYDRRDLWAACEEYASRNRRFGSA
EEEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002