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The map label for this gene is pgl

Identifier: 221229706

GI number: 221229706

Start: 703251

End: 703994

Strand: Reverse

Name: pgl

Synonym: MLBr_00579

Alternate gene names: 221229706

Gene position: 703994-703251 (Counterclockwise)

Preceding gene: 221229707

Following gene: 221229696

Centisome position: 21.54

GC content: 58.2

Gene sequence:

>744_bases
GTGAGCGCCAGTGTAGAGATCTTTTCAGACAGCAAGACCATGGTCGGAGCCGCCGGAAAACGACTTGCCAGCACCATCCA
ATCCGCCGTGGCTGCCAGAGAAAGGGCACTGATTGTGCTGACCGGTGGTAGCAGCGGCATTGGACTACTGCGGGATTTAG
CTACACGTGGACAGCAGATCGATTGGTCTAGGGTGCATCTATTCTGGGGCGACGAGCGCTACGTACCCAAAGACGACGAC
GAGCGCAACGAGAAACAGGCACGTGTAGCGTTGCTCGATCACATAGACATCCCGCCCAGCCAGGTGCACCCGATGCCTGC
GGGCGACGGTGAATTCGGCAACGATCTAGAAGCAGCGGCACTAGCTTACGAACAGCTGCTGGCTGCCTACGCCGCACCCG
GTTATCCCACCCCGAATTTTGATGTGCACCTGATGGGCATGGGACCCGAAGGACACATCAATTCGCTGTTCCCAAATACC
GTAGCTGTGCGCGAGACCAGTCGTATGGTGGTCGGAGTCAGGAACTCTCCAAAACCACCTCCAGAACGAATCACCTTGAC
ACTTAATGCCATTCAACGTTCTCGTGAGGTATGGCTGATGGTTTCCGGGACGGCAAAGGCCGACGCAGTGGCAGCCGCCA
TGGGTGGCGCTCCCTCTGCCTCAATACCGGCCGCCGGAGCTGTCGGGCTTGAAACCACACTCTGGCTGCTGGACGAAGAA
GCCGCAGCCAAGATTCCTGGCTAG

Upstream 100 bases:

>100_bases
GCAGGGAAGCCGAGGAGTTCCTAGCCGAAAATCTGCGACGACTGGATCCCGACAAGTTCTACTTCAATGCCTTCGAAGGC
ATTGAAAAGGTTCAGTACCT

Downstream 100 bases:

>100_bases
TGGCGTCATAATGACCTTCATGGCTGACAGAACCGTGCGCAGCAGACTGGAGCGAAGGCGATTATCTACAGAGATGATGC
TGTCGCGGTTATCAGCCACC

Product: putative 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MSASVEIFSDSKTMVGAAGKRLASTIQSAVAARERALIVLTGGSSGIGLLRDLATRGQQIDWSRVHLFWGDERYVPKDDD
ERNEKQARVALLDHIDIPPSQVHPMPAGDGEFGNDLEAAALAYEQLLAAYAAPGYPTPNFDVHLMGMGPEGHINSLFPNT
VAVRETSRMVVGVRNSPKPPPERITLTLNAIQRSREVWLMVSGTAKADAVAAAMGGAPSASIPAAGAVGLETTLWLLDEE
AAAKIPG

Sequences:

>Translated_247_residues
MSASVEIFSDSKTMVGAAGKRLASTIQSAVAARERALIVLTGGSSGIGLLRDLATRGQQIDWSRVHLFWGDERYVPKDDD
ERNEKQARVALLDHIDIPPSQVHPMPAGDGEFGNDLEAAALAYEQLLAAYAAPGYPTPNFDVHLMGMGPEGHINSLFPNT
VAVRETSRMVVGVRNSPKPPPERITLTLNAIQRSREVWLMVSGTAKADAVAAAMGGAPSASIPAAGAVGLETTLWLLDEE
AAAKIPG
>Mature_246_residues
SASVEIFSDSKTMVGAAGKRLASTIQSAVAARERALIVLTGGSSGIGLLRDLATRGQQIDWSRVHLFWGDERYVPKDDDE
RNEKQARVALLDHIDIPPSQVHPMPAGDGEFGNDLEAAALAYEQLLAAYAAPGYPTPNFDVHLMGMGPEGHINSLFPNTV
AVRETSRMVVGVRNSPKPPPERITLTLNAIQRSREVWLMVSGTAKADAVAAAMGGAPSASIPAAGAVGLETTLWLLDEEA
AAKIPG

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily

Homologues:

Organism=Homo sapiens, GI6912586, Length=243, Percent_Identity=32.9218106995885, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI52145310, Length=239, Percent_Identity=29.7071129707113, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI115533058, Length=255, Percent_Identity=27.843137254902, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115533060, Length=255, Percent_Identity=27.843137254902, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321687, Length=260, Percent_Identity=31.1538461538462, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324362, Length=215, Percent_Identity=33.0232558139535, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6321957, Length=256, Percent_Identity=26.5625, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319918, Length=219, Percent_Identity=32.8767123287671, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24641119, Length=202, Percent_Identity=36.1386138613861, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGL_MYCLE (Q49700)

Other databases:

- EMBL:   U00013
- EMBL:   AL583919
- PIR:   S72775
- RefSeq:   NP_301491.1
- ProteinModelPortal:   Q49700
- SMR:   Q49700
- EnsemblBacteria:   EBMYCT00000027976
- GeneID:   910133
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0579
- NMPDR:   fig|272631.1.peg.363
- Leproma:   ML0579
- GeneTree:   EBGT00050000017647
- HOGENOM:   HBG725991
- OMA:   PAICLTG
- ProtClustDB:   CLSK791167
- BioCyc:   MLEP272631:ML0579-MONOMER
- BRENDA:   3.1.1.31
- InterPro:   IPR005900
- InterPro:   IPR006148
- PANTHER:   PTHR11054
- TIGRFAMs:   TIGR01198

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.1.1.31

Molecular weight: Translated: 26161; Mature: 26030

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASVEIFSDSKTMVGAAGKRLASTIQSAVAARERALIVLTGGSSGIGLLRDLATRGQQI
CCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCC
DWSRVHLFWGDERYVPKDDDERNEKQARVALLDHIDIPPSQVHPMPAGDGEFGNDLEAAA
CCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCHHHHH
LAYEQLLAAYAAPGYPTPNFDVHLMGMGPEGHINSLFPNTVAVRETSRMVVGVRNSPKPP
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCEEEEEECCCCCCC
PERITLTLNAIQRSREVWLMVSGTAKADAVAAAMGGAPSASIPAAGAVGLETTLWLLDEE
CCEEEEEHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCH
AAAKIPG
HHCCCCC
>Mature Secondary Structure 
SASVEIFSDSKTMVGAAGKRLASTIQSAVAARERALIVLTGGSSGIGLLRDLATRGQQI
CCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCC
DWSRVHLFWGDERYVPKDDDERNEKQARVALLDHIDIPPSQVHPMPAGDGEFGNDLEAAA
CCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCHHHHH
LAYEQLLAAYAAPGYPTPNFDVHLMGMGPEGHINSLFPNTVAVRETSRMVVGVRNSPKPP
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCEEEEEECCCCCCC
PERITLTLNAIQRSREVWLMVSGTAKADAVAAAMGGAPSASIPAAGAVGLETTLWLLDEE
CCEEEEEHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCH
AAAKIPG
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002