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The map label for this gene is yebQ [C]

Identifier: 221229685

GI number: 221229685

Start: 673159

End: 674688

Strand: Reverse

Name: yebQ [C]

Synonym: MLBr_00556

Alternate gene names: 221229685

Gene position: 674688-673159 (Counterclockwise)

Preceding gene: 221229686

Following gene: 221229681

Centisome position: 20.64

GC content: 63.4

Gene sequence:

>1530_bases
ATGAGCACGCGGGCGGGACGCCGAGTTGCGATCAGCGCCGGCAGCCTCGCAGTACTGCTGGGGGCTCTGGACACCTATGT
CGTGGTCACCATCATGCGCGACATCATGCACGACGTTGGCATCCCGGTAAACCAGATGCAGCGGATCACCTGGATCGTCA
CGATGTATCTGCTGGGCTACATCGCCGCAATGCCGCTGCTGAGCCGAGCTTCCGACCGATTTGGCCGCAAGTTGCTGTTG
CAGGTCAGCTTGGCCGGATTCGCCATCGGGTCAGTGATGACCGCACTAGCCGGACAATTTGGCGACTTTCATATGCTGAT
CGCAGGCCGCACCATCCAGGGGGTCGCCAGCGGCGCGCTGCTACCGATCACCCTTGCACTGGGCGCCGACCTGTGGGCGC
AGCGCAACCGCGCTGGCGTGCTCGGTGGCATTGGCGCCGCGCAGGAGCTCGGCAGTGTGCTGGGTCCGCTGTACGGCATC
TTCATCGTTTGGCTATTCAGCGATTGGCGATACGTGTTCTGGATCAACATCCCGCTGACCGCGATCGCCATGCTGATGAT
CCAAGTCAGCCTGTCAGCGCACGACCGCGGTGACGAGCTGGAAAAGGTCGACGTGGTCGGCGGTGTGCTGTTGGCCATCG
CGCTGGGCCTGGTGGTCATCGGACTATACAATCCCCAACCCGACAGCAAACAGGTGCTGCCGAGCTATGGGGTGCCCGTA
CTGGTCGGGGGGATCGTCGCCACGGTGGCATTCGCGGTCTGGGAGCGCTGCGCACGCACCCGGCTGATCGACCCTGCCGG
TGTGCACATCCGACCGTTCCTGTCCGCACTGGGCGCATCGGTCGCTGCGGGCGCGGCGCTAATGGTGACACTGGTCAATG
TGGAGCTGTTCGGCCAGGGCGTGTTGGGAATGGACCAAACCCAAGCAGCCGGGCTGCTGGTGTGGTTTCTGATCGCGCTG
CCGATCGGGGCGGTGTTGGGCGGGTGGGGCGCCACCAAGGCTGGTGACCGCACGATGACCTTCGTCGGGCTGCTCATCAC
TGCGGGCGGCTATTGGCTGATCTCACATTGGCCAGTCGACTTGTTGAACTACCGGCGCAGCATCTTCGGGCTGTTCAGTG
TGCCCACGATGTACGCCGACCTGTTGGTGGCCGGCCTGGGACTTGGCCTGGTGATCGGTCCACTGTCTTCGGCTACCCTG
CGAGTTGTCCCGACGGCGCAGCACGGCATCGCCTCAGCGGCAGTGGTGGTCGCCAGGATGACCGGCATGTTGATCGGAGT
AGCCGCACTGACCGCCTGGGGGTTGTACCGGTTCAACCAGATCCTTGCGGGGTTGTCTACGGCGGTCCCGCCCGATGCCA
CCCTGATTGAACGCGCGGCTGCGGTAGCCGACCAGGCCAAACGTGCATACACGATGATGTACAGCGACATATTCATGATC
ACCGCCATCGTGTGTGTCATCGGAGCACTGCTGGGTCTGCTGATCAGCAGCCGCAAAGAACACGCGAGCGAGCCAAAAGT
CCCCGAGTAG

Upstream 100 bases:

>100_bases
CGCAGATCAGGATAGACAATAAGAGTTCGGGCAATTCCGTCCAGATGACACTGTCGAATTGGGATGAGCCGGTACAGGTA
ACCAAGCCCCAGGTGAGCTG

Downstream 100 bases:

>100_bases
CGGACCACAAAAGACCCAATGCCAACACCGTAACGGCTACGCGCTAACGCGTCACCAGACTAATCACTAAATCCGAGCCA
GCCCGGTCGATGCCGTCGAA

Product: putative integral membrane drug transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSTRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMHDVGIPVNQMQRITWIVTMYLLGYIAAMPLLSRASDRFGRKLLL
QVSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGALLPITLALGADLWAQRNRAGVLGGIGAAQELGSVLGPLYGI
FIVWLFSDWRYVFWINIPLTAIAMLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGLYNPQPDSKQVLPSYGVPV
LVGGIVATVAFAVWERCARTRLIDPAGVHIRPFLSALGASVAAGAALMVTLVNVELFGQGVLGMDQTQAAGLLVWFLIAL
PIGAVLGGWGATKAGDRTMTFVGLLITAGGYWLISHWPVDLLNYRRSIFGLFSVPTMYADLLVAGLGLGLVIGPLSSATL
RVVPTAQHGIASAAVVVARMTGMLIGVAALTAWGLYRFNQILAGLSTAVPPDATLIERAAAVADQAKRAYTMMYSDIFMI
TAIVCVIGALLGLLISSRKEHASEPKVPE

Sequences:

>Translated_509_residues
MSTRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMHDVGIPVNQMQRITWIVTMYLLGYIAAMPLLSRASDRFGRKLLL
QVSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGALLPITLALGADLWAQRNRAGVLGGIGAAQELGSVLGPLYGI
FIVWLFSDWRYVFWINIPLTAIAMLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGLYNPQPDSKQVLPSYGVPV
LVGGIVATVAFAVWERCARTRLIDPAGVHIRPFLSALGASVAAGAALMVTLVNVELFGQGVLGMDQTQAAGLLVWFLIAL
PIGAVLGGWGATKAGDRTMTFVGLLITAGGYWLISHWPVDLLNYRRSIFGLFSVPTMYADLLVAGLGLGLVIGPLSSATL
RVVPTAQHGIASAAVVVARMTGMLIGVAALTAWGLYRFNQILAGLSTAVPPDATLIERAAAVADQAKRAYTMMYSDIFMI
TAIVCVIGALLGLLISSRKEHASEPKVPE
>Mature_508_residues
STRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMHDVGIPVNQMQRITWIVTMYLLGYIAAMPLLSRASDRFGRKLLLQ
VSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGALLPITLALGADLWAQRNRAGVLGGIGAAQELGSVLGPLYGIF
IVWLFSDWRYVFWINIPLTAIAMLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGLYNPQPDSKQVLPSYGVPVL
VGGIVATVAFAVWERCARTRLIDPAGVHIRPFLSALGASVAAGAALMVTLVNVELFGQGVLGMDQTQAAGLLVWFLIALP
IGAVLGGWGATKAGDRTMTFVGLLITAGGYWLISHWPVDLLNYRRSIFGLFSVPTMYADLLVAGLGLGLVIGPLSSATLR
VVPTAQHGIASAAVVVARMTGMLIGVAALTAWGLYRFNQILAGLSTAVPPDATLIERAAAVADQAKRAYTMMYSDIFMIT
AIVCVIGALLGLLISSRKEHASEPKVPE

Specific function: Confers resistance to tetracycline and aminoglycosides such as streptomycin and gentamicin [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=432, Percent_Identity=25.462962962963, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789042, Length=266, Percent_Identity=25.9398496240602, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323735, Length=326, Percent_Identity=24.8466257668712, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=200, Percent_Identity=27.5, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53712; Mature: 53581

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMHDVGIPVNQMQRITWIVTMYLLGY
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
IAAMPLLSRASDRFGRKLLLQVSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCH
LPITLALGADLWAQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLFSDWRYVFWINIPLT
HHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHH
AIAMLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGLYNPQPDSKQVLPSYGVPV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
LVGGIVATVAFAVWERCARTRLIDPAGVHIRPFLSALGASVAAGAALMVTLVNVELFGQG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VLGMDQTQAAGLLVWFLIALPIGAVLGGWGATKAGDRTMTFVGLLITAGGYWLISHWPVD
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCHH
LLNYRRSIFGLFSVPTMYADLLVAGLGLGLVIGPLSSATLRVVPTAQHGIASAAVVVARM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHH
TGMLIGVAALTAWGLYRFNQILAGLSTAVPPDATLIERAAAVADQAKRAYTMMYSDIFMI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAIVCVIGALLGLLISSRKEHASEPKVPE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMHDVGIPVNQMQRITWIVTMYLLGY
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
IAAMPLLSRASDRFGRKLLLQVSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCH
LPITLALGADLWAQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLFSDWRYVFWINIPLT
HHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHH
AIAMLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGLYNPQPDSKQVLPSYGVPV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
LVGGIVATVAFAVWERCARTRLIDPAGVHIRPFLSALGASVAAGAALMVTLVNVELFGQG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VLGMDQTQAAGLLVWFLIALPIGAVLGGWGATKAGDRTMTFVGLLITAGGYWLISHWPVD
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCHH
LLNYRRSIFGLFSVPTMYADLLVAGLGLGLVIGPLSSATLRVVPTAQHGIASAAVVVARM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHH
TGMLIGVAALTAWGLYRFNQILAGLSTAVPPDATLIERAAAVADQAKRAYTMMYSDIFMI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAIVCVIGALLGLLISSRKEHASEPKVPE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]