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The map label for this gene is pepQ [H]

Identifier: 221229661

GI number: 221229661

Start: 631830

End: 632960

Strand: Direct

Name: pepQ [H]

Synonym: MLBr_00521

Alternate gene names: 221229661

Gene position: 631830-632960 (Clockwise)

Preceding gene: 221229659

Following gene: 221229662

Centisome position: 19.33

GC content: 63.57

Gene sequence:

>1131_bases
ATGACACATTCCCAGCGTCGAGACAATCTCAAGTCACAAATCGCGACCACCGGGCTGGACGCGATGCTGGTGACGTGCCT
GATCAATGTGCGCTACCTGTCAGGTTTCACTGGATCGAACGGTGCTTTGCTGGTGTTCGCCGACGAACGCGGCGCTGTGC
TCGCCACCGACGGCCGTTACCGGACTCAGGCTGCGCAGCAAGTACCCGAGCTCGAGGTCGCCATCGAGCAGTCCTGCGGG
CGCTATTTGGCTGGCCGGGCAGCCGACGACGGCGTGTGCATACTAGGCTTTGAAAGCCATGTGGTCACGGTCGACGGCCT
GGACGCGTTGACCGGCGAGCTCGAAGGCCGGCACACCGAGTTGGTGCGTGCCCCTGGAACCGTGGAGGTGCTGCGCGAGG
TCAAGGATGCTGGTGAGCTTGCGTTGCTGCGGTTGGCCGCCGAGGCGGCTGATGCCGCGCTGACGGAGCTGGTGGCGCGT
GGCGGAGTGCGGCCCGGTCTTACCGAACGTGAGGTGGGCCGCGAGTTGGAGGGGTTGATGCTCGACCACGGCGCTGACGC
GCTGTCGTTCGAGACGATTGTGGCCGCCGGGCCGAATTCGGCTATCCCGCACCACCGGCCGACCGACACGGTGCTGGCGG
CGGGCGATTTCGTCAAGATCGACTTTGGTGCGCTAGTAGCTGGATATCACTCCGACATGACTCGCACCTTTGTGCTGGGC
CCGGCTGCTGACTGGCAGCTGGAAATCTATCAACTGGTCGCCGATGCGCAACGTGCAGGTCGGAAGGCGTTGCGGCCGGG
TGCCAACCTGCGTGACGTGGACGCAGCGGCACGCCAACTGATCGTCGACGCGGGCTACGGCCAACAGTTCAGCCACGGTT
TGGGCCACGGCGTGGGCCTGGAAATCCACGAAGCGCCGGGTATCGGGACTACCTCTGCCGGTACACTACTCGCAGGTTCC
GTCGTGACCGTGGAGCCCGGTGTCTACTTATCTGGCCGAGGCGGTGTCCGGATCGAGGATACACTGGTGGTGGCCGCTAA
AGGAACGTCAGAGACGCCGATAACTTCTAGACCCACCGGGTTCATTCCGGAATTGTTGACCCGGTTCCCTAAAGAACTGG
CAATCCTGTAG

Upstream 100 bases:

>100_bases
CCTGCATCAGGCGGACAACGATCATCAGGGCGGCAAACACCAAACCGCGCAGCATCCAGTTATTCATGAGTCCTCAGCGT
AGCGAGTAGCGTCAACAGCT

Downstream 100 bases:

>100_bases
GAGACTCAGTACACTGTGGCGACCACTGCCGACTTCAAGAATGGGCTTGTGCTGGTAATCGATGGACAGCTTTGGACAAT
CATCGGGTTCCAGCACGTCA

Product: putative cytoplasmic peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTHSQRRDNLKSQIATTGLDAMLVTCLINVRYLSGFTGSNGALLVFADERGAVLATDGRYRTQAAQQVPELEVAIEQSCG
RYLAGRAADDGVCILGFESHVVTVDGLDALTGELEGRHTELVRAPGTVEVLREVKDAGELALLRLAAEAADAALTELVAR
GGVRPGLTEREVGRELEGLMLDHGADALSFETIVAAGPNSAIPHHRPTDTVLAAGDFVKIDFGALVAGYHSDMTRTFVLG
PAADWQLEIYQLVADAQRAGRKALRPGANLRDVDAAARQLIVDAGYGQQFSHGLGHGVGLEIHEAPGIGTTSAGTLLAGS
VVTVEPGVYLSGRGGVRIEDTLVVAAKGTSETPITSRPTGFIPELLTRFPKELAIL

Sequences:

>Translated_376_residues
MTHSQRRDNLKSQIATTGLDAMLVTCLINVRYLSGFTGSNGALLVFADERGAVLATDGRYRTQAAQQVPELEVAIEQSCG
RYLAGRAADDGVCILGFESHVVTVDGLDALTGELEGRHTELVRAPGTVEVLREVKDAGELALLRLAAEAADAALTELVAR
GGVRPGLTEREVGRELEGLMLDHGADALSFETIVAAGPNSAIPHHRPTDTVLAAGDFVKIDFGALVAGYHSDMTRTFVLG
PAADWQLEIYQLVADAQRAGRKALRPGANLRDVDAAARQLIVDAGYGQQFSHGLGHGVGLEIHEAPGIGTTSAGTLLAGS
VVTVEPGVYLSGRGGVRIEDTLVVAAKGTSETPITSRPTGFIPELLTRFPKELAIL
>Mature_375_residues
THSQRRDNLKSQIATTGLDAMLVTCLINVRYLSGFTGSNGALLVFADERGAVLATDGRYRTQAAQQVPELEVAIEQSCGR
YLAGRAADDGVCILGFESHVVTVDGLDALTGELEGRHTELVRAPGTVEVLREVKDAGELALLRLAAEAADAALTELVARG
GVRPGLTEREVGRELEGLMLDHGADALSFETIVAAGPNSAIPHHRPTDTVLAAGDFVKIDFGALVAGYHSDMTRTFVLGP
AADWQLEIYQLVADAQRAGRKALRPGANLRDVDAAARQLIVDAGYGQQFSHGLGHGVGLEIHEAPGIGTTSAGTLLAGSV
VTVEPGVYLSGRGGVRIEDTLVVAAKGTSETPITSRPTGFIPELLTRFPKELAIL

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=257, Percent_Identity=32.6848249027237, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI93141226, Length=255, Percent_Identity=32.156862745098, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI11559925, Length=255, Percent_Identity=27.0588235294118, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI149589008, Length=291, Percent_Identity=27.8350515463918, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI264681565, Length=254, Percent_Identity=30.7086614173228, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI260593665, Length=287, Percent_Identity=27.1777003484321, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI164420681, Length=254, Percent_Identity=23.6220472440945, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788728, Length=350, Percent_Identity=37.4285714285714, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789275, Length=250, Percent_Identity=32, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786364, Length=229, Percent_Identity=24.4541484716157, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17509539, Length=409, Percent_Identity=25.4278728606357, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17508215, Length=283, Percent_Identity=27.208480565371, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320922, Length=238, Percent_Identity=25.6302521008403, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322999, Length=263, Percent_Identity=28.5171102661597, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321118, Length=287, Percent_Identity=24.7386759581882, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19920384, Length=264, Percent_Identity=25.7575757575758, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357079, Length=407, Percent_Identity=26.044226044226, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39558; Mature: 39427

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00491 PROLINE_PEPTIDASE ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSQRRDNLKSQIATTGLDAMLVTCLINVRYLSGFTGSNGALLVFADERGAVLATDGRY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCEEEEEECCCCCEEEECCCH
RTQAAQQVPELEVAIEQSCGRYLAGRAADDGVCILGFESHVVTVDGLDALTGELEGRHTE
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHCCCCCCEE
LVRAPGTVEVLREVKDAGELALLRLAAEAADAALTELVARGGVRPGLTEREVGRELEGLM
EEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHE
LDHGADALSFETIVAAGPNSAIPHHRPTDTVLAAGDFVKIDFGALVAGYHSDMTRTFVLG
EECCCCCEEEEEEEEECCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHCCCCEEEEEC
PAADWQLEIYQLVADAQRAGRKALRPGANLRDVDAAARQLIVDAGYGQQFSHGLGHGVGL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEECCCCCHHHHCCCCCCCE
EIHEAPGIGTTSAGTLLAGSVVTVEPGVYLSGRGGVRIEDTLVVAAKGTSETPITSRPTG
EEECCCCCCCCCCCCEEECCEEEECCCEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCC
FIPELLTRFPKELAIL
HHHHHHHHCHHHHCCC
>Mature Secondary Structure 
THSQRRDNLKSQIATTGLDAMLVTCLINVRYLSGFTGSNGALLVFADERGAVLATDGRY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCEEEEEECCCCCEEEECCCH
RTQAAQQVPELEVAIEQSCGRYLAGRAADDGVCILGFESHVVTVDGLDALTGELEGRHTE
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHCCCCCCEE
LVRAPGTVEVLREVKDAGELALLRLAAEAADAALTELVARGGVRPGLTEREVGRELEGLM
EEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHE
LDHGADALSFETIVAAGPNSAIPHHRPTDTVLAAGDFVKIDFGALVAGYHSDMTRTFVLG
EECCCCCEEEEEEEEECCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHCCCCEEEEEC
PAADWQLEIYQLVADAQRAGRKALRPGANLRDVDAAARQLIVDAGYGQQFSHGLGHGVGL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEECCCCCHHHHCCCCCCCE
EIHEAPGIGTTSAGTLLAGSVVTVEPGVYLSGRGGVRIEDTLVVAAKGTSETPITSRPTG
EEECCCCCCCCCCCCEEECCEEEECCCEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCC
FIPELLTRFPKELAIL
HHHHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]