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The map label for this gene is ppiB

Identifier: 221229646

GI number: 221229646

Start: 598038

End: 598925

Strand: Reverse

Name: ppiB

Synonym: MLBr_00492

Alternate gene names: 221229646

Gene position: 598925-598038 (Counterclockwise)

Preceding gene: 221229660

Following gene: 221229640

Centisome position: 18.33

GC content: 57.77

Gene sequence:

>888_bases
GTGCCGACCAACGAACAGCGACGCGCAACAGCCAAGCGCAAACTGAAACGACAGCTGGAGCGCCGCGCTAAGCAGGCCCG
ATGGCGCCGAGTCCTGTTGATAAGCGGTGGCGTGGTAGTGGCAGTGGCCGTAATTATTACGGTAGTGGCTACCGTCGTGA
TCAGCAAGCTTGGCCACAAGCACGATACCGCTTCGTCGACCGCCAGTAACTCCCTGACAGCGACTAAGACTCCCGCCGTT
ACGCCGTCAGTTCTGCCATTGCCATCATTCCAACCGTCGACCAACCTGGGCGTCAACTGCCAGTACCCACCATCAGCGGA
CAAGGCCGCCAAGCCAGTCAAGCCGCCACGGGCCGGCAAGGTGCCGACCGATCCAGCCACAGTGAGCGCAAGTATGGCTA
CCAACCAGGGCAATATCGGTCTATTGCTAAACAATGCCGAATCACCTTGCACGGTAAATAGTTTCGCCAGTCTAACCGGC
CAGGGCTTTTTCAACAACACAAAATGTCATAGGTTGACCACTTCCCTGATGCTGGGCGTCTTACAGTGTGGCGACCCGAA
AGTCGACGGCACCGGCGGCCCAGGATACAAGTTCGCTAACGAGTACCCCACAGATCAGTACCCGCCCAACGACCCTAAAT
TGAAGCAACCTGTTCTGTATCCGCGTGGCACACTGGCAATGGCCAATAGCGGTCCGAACACCAATGGCAGCCAATTTTTT
CTAGTCTACCATGACTCACAGTTACCGCCTGAGTACACCGTCTTCGGCACGATCCAGGCTGACGGGCTGGCCACGCTGGA
CAAGATAGCTAAGGGCGGAATCGCCAGCGGCGGTGATGACGGGCCACCAGCCACCGAAGTTACCATCGAGTCGCTGCGGC
TCGACTAA

Upstream 100 bases:

>100_bases
CGCCGCGAAACAAAAACTTGACACAGGTCGAGGCGTTCACATTAGCCTTGGCTGGCAACTCGGCCCCAATTAATCGAACA
ACCATGGAGGCATACCGGAC

Downstream 100 bases:

>100_bases
AGCCGTCCGGTCATCCACGTCAAAGCAGAGGGGGATTTGCCGAGTAACCACCCGAACGTCAAGACGCAGACATCACCCGA
TAGACATCGTAAACGCCTTC

Product: putative peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MPTNEQRRATAKRKLKRQLERRAKQARWRRVLLISGGVVVAVAVIITVVATVVISKLGHKHDTASSTASNSLTATKTPAV
TPSVLPLPSFQPSTNLGVNCQYPPSADKAAKPVKPPRAGKVPTDPATVSASMATNQGNIGLLLNNAESPCTVNSFASLTG
QGFFNNTKCHRLTTSLMLGVLQCGDPKVDGTGGPGYKFANEYPTDQYPPNDPKLKQPVLYPRGTLAMANSGPNTNGSQFF
LVYHDSQLPPEYTVFGTIQADGLATLDKIAKGGIASGGDDGPPATEVTIESLRLD

Sequences:

>Translated_295_residues
MPTNEQRRATAKRKLKRQLERRAKQARWRRVLLISGGVVVAVAVIITVVATVVISKLGHKHDTASSTASNSLTATKTPAV
TPSVLPLPSFQPSTNLGVNCQYPPSADKAAKPVKPPRAGKVPTDPATVSASMATNQGNIGLLLNNAESPCTVNSFASLTG
QGFFNNTKCHRLTTSLMLGVLQCGDPKVDGTGGPGYKFANEYPTDQYPPNDPKLKQPVLYPRGTLAMANSGPNTNGSQFF
LVYHDSQLPPEYTVFGTIQADGLATLDKIAKGGIASGGDDGPPATEVTIESLRLD
>Mature_294_residues
PTNEQRRATAKRKLKRQLERRAKQARWRRVLLISGGVVVAVAVIITVVATVVISKLGHKHDTASSTASNSLTATKTPAVT
PSVLPLPSFQPSTNLGVNCQYPPSADKAAKPVKPPRAGKVPTDPATVSASMATNQGNIGLLLNNAESPCTVNSFASLTGQ
GFFNNTKCHRLTTSLMLGVLQCGDPKVDGTGGPGYKFANEYPTDQYPPNDPKLKQPVLYPRGTLAMANSGPNTNGSQFFL
VYHDSQLPPEYTVFGTIQADGLATLDKIAKGGIASGGDDGPPATEVTIESLRLD

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain

Homologues:

Organism=Homo sapiens, GI19557636, Length=148, Percent_Identity=38.5135135135135, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7706339, Length=143, Percent_Identity=35.6643356643357, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=33.9506172839506, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=141, Percent_Identity=36.1702127659575, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=172, Percent_Identity=30.2325581395349, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922376, Length=164, Percent_Identity=35.9756097560976, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357249, Length=163, Percent_Identity=32.5153374233129, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=34.3558282208589, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPIB_MYCLE (P46697)

Other databases:

- EMBL:   U00011
- EMBL:   AL023591
- EMBL:   AL583918
- PIR:   S72749
- RefSeq:   NP_301431.1
- ProteinModelPortal:   P46697
- SMR:   P46697
- EnsemblBacteria:   EBMYCT00000029334
- GeneID:   909245
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0492
- NMPDR:   fig|272631.1.peg.303
- Leproma:   ML0492
- GeneTree:   EBGT00050000015125
- HOGENOM:   HBG610621
- OMA:   GSQFFMV
- ProtClustDB:   CLSK791938
- BioCyc:   MLEP272631:ML0492-MONOMER
- BRENDA:   5.2.1.8
- InterPro:   IPR015891
- InterPro:   IPR002130
- Gene3D:   G3DSA:2.40.100.10
- PRINTS:   PR00153

Pfam domain/function: PF00160 Pro_isomerase; SSF50891 CSA_PPIase

EC number: =5.2.1.8

Molecular weight: Translated: 31178; Mature: 31047

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS00170 CSA_PPIASE_1; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTNEQRRATAKRKLKRQLERRAKQARWRRVLLISGGVVVAVAVIITVVATVVISKLGHK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCC
HDTASSTASNSLTATKTPAVTPSVLPLPSFQPSTNLGVNCQYPPSADKAAKPVKPPRAGK
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
VPTDPATVSASMATNQGNIGLLLNNAESPCTVNSFASLTGQGFFNNTKCHRLTTSLMLGV
CCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LQCGDPKVDGTGGPGYKFANEYPTDQYPPNDPKLKQPVLYPRGTLAMANSGPNTNGSQFF
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEECCCCCCCCCEEE
LVYHDSQLPPEYTVFGTIQADGLATLDKIAKGGIASGGDDGPPATEVTIESLRLD
EEEECCCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHEEEEEEECC
>Mature Secondary Structure 
PTNEQRRATAKRKLKRQLERRAKQARWRRVLLISGGVVVAVAVIITVVATVVISKLGHK
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCC
HDTASSTASNSLTATKTPAVTPSVLPLPSFQPSTNLGVNCQYPPSADKAAKPVKPPRAGK
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
VPTDPATVSASMATNQGNIGLLLNNAESPCTVNSFASLTGQGFFNNTKCHRLTTSLMLGV
CCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LQCGDPKVDGTGGPGYKFANEYPTDQYPPNDPKLKQPVLYPRGTLAMANSGPNTNGSQFF
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEECCCCCCCCCEEE
LVYHDSQLPPEYTVFGTIQADGLATLDKIAKGGIASGGDDGPPATEVTIESLRLD
EEEECCCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002