Click here to switch to the map view.

The map label for this gene is gabT

Identifier: 221229640

GI number: 221229640

Start: 588052

End: 589392

Strand: Reverse

Name: gabT

Synonym: MLBr_00485

Alternate gene names: 221229640

Gene position: 589392-588052 (Counterclockwise)

Preceding gene: 221229646

Following gene: 221229639

Centisome position: 18.03

GC content: 61.74

Gene sequence:

>1341_bases
GTGACCAGCGTCGAGCAGAGCCGTCAGCTGGTCACTGAAATCCCCGGCCCCGTGTCACTTGAACTAGCCAAACGCCTCAA
CGCGGCGGTGCCTCGTGGGGTGGGAGTCACCCTGCCAGTGTTTGTAACGCGCGCCGCCGGCGGCGTTATCGAGGACGTCG
ACGGGAACCGGCTTATCGACCTGGGTTCTGGAATCGCCGTCACCACAATCGGCAACTCGTCGCCTCGCGTTGTGGACGCG
GTGCGCGCCCAGGTGGCCGACTTTACCCACACCTGTTTCATAATCACACCTTACGAGGAGTACGTCGCCGTCACCGAGCA
ACTCAATCGAATTACCCCAGGATCCGGCGAGAAACGCTCGGTGCTGTTCAATTCCGGCGCCGAGGCAGTGGAGAATTCTA
TCAAGGTCGCACGTTCGTACACCCGCAAGCCCGCAGTGGTCGCGTTCGACCACGCCTACCACGGTCGCACCAACCTGACA
ATGGCACTGACCGCCAAGTCCATGCCGTACAAAAGCGGCTTTGGTCCTTTTGCGCCGGAGATCTACCGGGCGCCGCTGTC
CTACCCCTATCGGGACGGCCTGCTCAACAAAGACCTAGCCACCGACGGCAAGTTGGCCGGCGCACGGGCCATCAACGTCA
TTGAGAAGCAGGTTGGCGCCGATGACCTGGCTGCCGTGATCATTGAGCCGATCCAGGGCGAAGGCGGTTTCATCGTCCCG
GCCGAAGGGTTTTTAGCTACTTTGCTGGATTGGTGCCGCAAGAACAACGTGATGTTCATCGCCGATGAGGTGCAAACGGG
GTTTGCGCGTACCGGCGCCATGTTCGCCTGCGAGCACGATGGAATCGTGCCCGACCTGATCTGCACCGCCAAGGGCATCG
CCGACGGATTGCCGCTGGCGGCGGTAACCGGACGGGCTGAGATCATGAACGCCCCGCACGTCAGCGGCCTCGGTGGCACT
TTCGGCGGCAACCCGGTCGCCTGCGCGGCGGCTTTGGCAACCATCACGACCATCGAGAACGACGGCCTGATCCAGCGAGC
CCAACAGATCGAACGGCTGATCACCGACCGGTTGTTGCGACTTCAGGACGCCGACGATCGGATAGGTGACGTACGTGGCC
GGGGTGCCATGATCGCCGTCGAATTGGTAAAATCCGGCACGGCTGAGCCCGACCCCGAGCTGACCGAAAAAGTAGCCACC
GCAGCACACGCTACCGGCGTCATCATCTTGACGTGTGGCATGTTCGGCAACATCATCCGACTGCTGCCGCCTCTGACCAT
AAGCGACGAACTGTTGGCCGAAGGCCTTGACATCCTAAGCCGGATCCTGGGTGACTTCTAG

Upstream 100 bases:

>100_bases
CAGAGACGTGGCCTAGCCACACTCGCCCGGTGTGAGAACCCCGATAAAGGCTATGCTTTATCTGCGATACAACCGGCGTG
TCGTAGTCAGGAGGATCCAC

Downstream 100 bases:

>100_bases
ACTAGACCAAGAACCCCTGAAGTGGACGATCTCACATCTGTAACCCAGCCACTGAGGAATATTTTAGCACAGCTAATTTT
CTAATTGTCTGTGCCGTGTG

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTSVEQSRQLVTEIPGPVSLELAKRLNAAVPRGVGVTLPVFVTRAAGGVIEDVDGNRLIDLGSGIAVTTIGNSSPRVVDA
VRAQVADFTHTCFIITPYEEYVAVTEQLNRITPGSGEKRSVLFNSGAEAVENSIKVARSYTRKPAVVAFDHAYHGRTNLT
MALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLNKDLATDGKLAGARAINVIEKQVGADDLAAVIIEPIQGEGGFIVP
AEGFLATLLDWCRKNNVMFIADEVQTGFARTGAMFACEHDGIVPDLICTAKGIADGLPLAAVTGRAEIMNAPHVSGLGGT
FGGNPVACAAALATITTIENDGLIQRAQQIERLITDRLLRLQDADDRIGDVRGRGAMIAVELVKSGTAEPDPELTEKVAT
AAHATGVIILTCGMFGNIIRLLPPLTISDELLAEGLDILSRILGDF

Sequences:

>Translated_446_residues
MTSVEQSRQLVTEIPGPVSLELAKRLNAAVPRGVGVTLPVFVTRAAGGVIEDVDGNRLIDLGSGIAVTTIGNSSPRVVDA
VRAQVADFTHTCFIITPYEEYVAVTEQLNRITPGSGEKRSVLFNSGAEAVENSIKVARSYTRKPAVVAFDHAYHGRTNLT
MALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLNKDLATDGKLAGARAINVIEKQVGADDLAAVIIEPIQGEGGFIVP
AEGFLATLLDWCRKNNVMFIADEVQTGFARTGAMFACEHDGIVPDLICTAKGIADGLPLAAVTGRAEIMNAPHVSGLGGT
FGGNPVACAAALATITTIENDGLIQRAQQIERLITDRLLRLQDADDRIGDVRGRGAMIAVELVKSGTAEPDPELTEKVAT
AAHATGVIILTCGMFGNIIRLLPPLTISDELLAEGLDILSRILGDF
>Mature_445_residues
TSVEQSRQLVTEIPGPVSLELAKRLNAAVPRGVGVTLPVFVTRAAGGVIEDVDGNRLIDLGSGIAVTTIGNSSPRVVDAV
RAQVADFTHTCFIITPYEEYVAVTEQLNRITPGSGEKRSVLFNSGAEAVENSIKVARSYTRKPAVVAFDHAYHGRTNLTM
ALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLNKDLATDGKLAGARAINVIEKQVGADDLAAVIIEPIQGEGGFIVPA
EGFLATLLDWCRKNNVMFIADEVQTGFARTGAMFACEHDGIVPDLICTAKGIADGLPLAAVTGRAEIMNAPHVSGLGGTF
GGNPVACAAALATITTIENDGLIQRAQQIERLITDRLLRLQDADDRIGDVRGRGAMIAVELVKSGTAEPDPELTEKVATA
AHATGVIILTCGMFGNIIRLLPPLTISDELLAEGLDILSRILGDF

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI4557809, Length=423, Percent_Identity=29.3144208037825, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI13994255, Length=418, Percent_Identity=29.9043062200957, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI37574042, Length=417, Percent_Identity=29.2565947242206, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI226442705, Length=417, Percent_Identity=29.0167865707434, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI24119277, Length=445, Percent_Identity=28.5393258426966, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=29.7927461139896, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI284507298, Length=333, Percent_Identity=30.3303303303303, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI188536080, Length=476, Percent_Identity=27.5210084033613, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI38679950, Length=476, Percent_Identity=27.5210084033613, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI38679946, Length=476, Percent_Identity=27.5210084033613, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1789016, Length=426, Percent_Identity=42.7230046948357, Blast_Score=355, Evalue=2e-99,
Organism=Escherichia coli, GI1787560, Length=430, Percent_Identity=42.7906976744186, Blast_Score=344, Evalue=5e-96,
Organism=Escherichia coli, GI145693181, Length=390, Percent_Identity=34.1025641025641, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789759, Length=421, Percent_Identity=30.6413301662708, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1788044, Length=408, Percent_Identity=31.3725490196078, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1786991, Length=424, Percent_Identity=29.9528301886792, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI1786349, Length=333, Percent_Identity=28.5285285285285, Blast_Score=115, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=432, Percent_Identity=31.0185185185185, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI25144271, Length=424, Percent_Identity=28.3018867924528, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=29.5612009237875, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25144274, Length=305, Percent_Identity=30.4918032786885, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=481, Percent_Identity=25.987525987526, Blast_Score=119, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324432, Length=414, Percent_Identity=30.9178743961353, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6323470, Length=425, Percent_Identity=28.7058823529412, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324386, Length=456, Percent_Identity=26.0964912280702, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321456, Length=461, Percent_Identity=25.5965292841649, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21356575, Length=406, Percent_Identity=32.512315270936, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI21357415, Length=420, Percent_Identity=28.0952380952381, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28574759, Length=424, Percent_Identity=32.311320754717, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=31.0904872389791, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI281366494, Length=480, Percent_Identity=23.5416666666667, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667139, Length=480, Percent_Identity=23.5416666666667, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667143, Length=480, Percent_Identity=23.5416666666667, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GABT_MYCLE (P40829)

Other databases:

- EMBL:   U00011
- EMBL:   AL023591
- EMBL:   AL583918
- PIR:   S72743
- RefSeq:   NP_301425.1
- ProteinModelPortal:   P40829
- SMR:   P40829
- EnsemblBacteria:   EBMYCT00000027903
- GeneID:   909237
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0485
- NMPDR:   fig|272631.1.peg.297
- Leproma:   ML0485
- GeneTree:   EBGT00050000015339
- HOGENOM:   HBG725944
- OMA:   AEIWDKE
- ProtClustDB:   PRK06058
- BioCyc:   MLEP272631:ML0485-MONOMER
- BRENDA:   2.6.1.19
- BRENDA:   2.6.1.22
- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00700

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.19; =2.6.1.22

Molecular weight: Translated: 47216; Mature: 47085

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVEQSRQLVTEIPGPVSLELAKRLNAAVPRGVGVTLPVFVTRAAGGVIEDVDGNRLID
CCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEE
LGSGIAVTTIGNSSPRVVDAVRAQVADFTHTCFIITPYEEYVAVTEQLNRITPGSGEKRS
ECCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCE
VLFNSGAEAVENSIKVARSYTRKPAVVAFDHAYHGRTNLTMALTAKSMPYKSGFGPFAPE
EEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCHH
IYRAPLSYPYRDGLLNKDLATDGKLAGARAINVIEKQVGADDLAAVIIEPIQGEGGFIVP
HHHCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHEEHHEEEECCCCCEEEE
AEGFLATLLDWCRKNNVMFIADEVQTGFARTGAMFACEHDGIVPDLICTAKGIADGLPLA
CHHHHHHHHHHHHCCCEEEEEECHHCCHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCCE
AVTGRAEIMNAPHVSGLGGTFGGNPVACAAALATITTIENDGLIQRAQQIERLITDRLLR
EECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHH
LQDADDRIGDVRGRGAMIAVELVKSGTAEPDPELTEKVATAAHATGVIILTCGMFGNIIR
HCCCCCHHHCCCCCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHH
LLPPLTISDELLAEGLDILSRILGDF
HCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSVEQSRQLVTEIPGPVSLELAKRLNAAVPRGVGVTLPVFVTRAAGGVIEDVDGNRLID
CCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEE
LGSGIAVTTIGNSSPRVVDAVRAQVADFTHTCFIITPYEEYVAVTEQLNRITPGSGEKRS
ECCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCE
VLFNSGAEAVENSIKVARSYTRKPAVVAFDHAYHGRTNLTMALTAKSMPYKSGFGPFAPE
EEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCHH
IYRAPLSYPYRDGLLNKDLATDGKLAGARAINVIEKQVGADDLAAVIIEPIQGEGGFIVP
HHHCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHEEHHEEEECCCCCEEEE
AEGFLATLLDWCRKNNVMFIADEVQTGFARTGAMFACEHDGIVPDLICTAKGIADGLPLA
CHHHHHHHHHHHHCCCEEEEEECHHCCHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCCE
AVTGRAEIMNAPHVSGLGGTFGGNPVACAAALATITTIENDGLIQRAQQIERLITDRLLR
EECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHH
LQDADDRIGDVRGRGAMIAVELVKSGTAEPDPELTEKVATAAHATGVIILTCGMFGNIIR
HCCCCCHHHCCCCCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHH
LLPPLTISDELLAEGLDILSRILGDF
HCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002