BacMap

Definition	Mycobacterium leprae Br4923 chromosome, complete genome.
Accession	NC_011896
Length	3,268,071

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The map label for this gene is mntB [H]

Identifier: 221229570

GI number: 221229570

Start: 425736

End: 426563

Strand: Reverse

Name: mntB [H]

Synonym: MLBr_00336

Alternate gene names: 221229570

Gene position: 426563-425736 (Counterclockwise)

Preceding gene: 221229571

Following gene: 221229569

Centisome position: 13.05

GC content: 62.8

Gene sequence:

>828_bases
GTGGCGGTTGAAAATCTCGACGCGGTCTCGAGACGACCGCAGTCCGCGGACAACGATGCCCGCACGATCTCGCTTAGCGG
CGCACGGCTGGCGTTCGGCGATCAAACGCTTTGGGATCACCTCGACCTATCGGTGTCGGCGGGAGAGTTTATCGCGGTGC
TGGGCCCCAACGGCACCGGTAAGACGTCGTTACTCAAGGTGCTGCTCGGACAACTGGAGCTCAGTGCCGGCGTTGCGCGG
GTGGAGGGCAAGCGGATCACCGCTGGCAGTCCACGCATAGGCTACGTGCCGCAACACCGCCCAATCGATCGTGAAGTACT
GCTGCGCGGTCGTGATCTGGTTAGACTAGGCATCGACGGACGCCGCTGGGGCGCCCTGCCGCTGCGATCCGCCGATCGAG
CTCGCCGGCGCGAGGCCGTATTCACGGCGCTGCAGCAAGTAAATGGCGAGCAGCTGGCTGATGTCCGAGTCGGGGTAATG
TCGGGCGGCGAGTTGCAGCGCATCCGCATCGCTCAGGCGCTGGTCAACGACCCGACGCTGCTGCTATGCGACGAACCTTT
GCTGACATTGGACCCGGCCAACGCCAAGCTGGTATCGACGTTGATCGACCGTCGCCGCCGGGAAGCCGGCACCACGGTGC
TTGTCGTCACCCACGAGATCAACCCGCTCCTGCCGTATGTGGACCGAGTGCTCTATCTGGTCGACGGCCGATTCCTGATC
GGCACTGTCGAACAGGTTATGACCACCGAGAGGCTGTCAACGCTTTACCAGGCAAACATCCGGGTGGTGAAGGTCGAGGA
TCATTACATTGTGGTTGGCGAGCCTTGA

Upstream 100 bases:

>100_bases
TGTTGCCGAACGACACCGATTACCTTACCTGGCAACGTAACACGATCGATCAGCTGCTCACTGCGCTGCAATCGAACCGA
TCACCCCGATAATCTTTGCC

Downstream 100 bases:

>100_bases
TGGATGACCGACTCGCTCACATGTGGAACCACCTGTTCTCCTTTGACATAACTACACATTTGCTCAGTCACAACTTCGTC
CAGCAGGCACTGCTGGCGGC

Product: putative ABC-tranporter ATP-binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MAVENLDAVSRRPQSADNDARTISLSGARLAFGDQTLWDHLDLSVSAGEFIAVLGPNGTGKTSLLKVLLGQLELSAGVAR
VEGKRITAGSPRIGYVPQHRPIDREVLLRGRDLVRLGIDGRRWGALPLRSADRARRREAVFTALQQVNGEQLADVRVGVM
SGGELQRIRIAQALVNDPTLLLCDEPLLTLDPANAKLVSTLIDRRRREAGTTVLVVTHEINPLLPYVDRVLYLVDGRFLI
GTVEQVMTTERLSTLYQANIRVVKVEDHYIVVGEP

Sequences:

>Translated_275_residues
MAVENLDAVSRRPQSADNDARTISLSGARLAFGDQTLWDHLDLSVSAGEFIAVLGPNGTGKTSLLKVLLGQLELSAGVAR
VEGKRITAGSPRIGYVPQHRPIDREVLLRGRDLVRLGIDGRRWGALPLRSADRARRREAVFTALQQVNGEQLADVRVGVM
SGGELQRIRIAQALVNDPTLLLCDEPLLTLDPANAKLVSTLIDRRRREAGTTVLVVTHEINPLLPYVDRVLYLVDGRFLI
GTVEQVMTTERLSTLYQANIRVVKVEDHYIVVGEP
>Mature_274_residues
AVENLDAVSRRPQSADNDARTISLSGARLAFGDQTLWDHLDLSVSAGEFIAVLGPNGTGKTSLLKVLLGQLELSAGVARV
EGKRITAGSPRIGYVPQHRPIDREVLLRGRDLVRLGIDGRRWGALPLRSADRARRREAVFTALQQVNGEQLADVRVGVMS
GGELQRIRIAQALVNDPTLLLCDEPLLTLDPANAKLVSTLIDRRRREAGTTVLVVTHEINPLLPYVDRVLYLVDGRFLIG
TVEQVMTTERLSTLYQANIRVVKVEDHYIVVGEP

Specific function: This protein is probably a component of a manganese permease, a binding protein-dependent, ATP-driven transport system. Probably responsible for energy coupling to the transport system [H]

COG id: COG1121

COG function: function code P; ABC-type Mn/Zn transport systems, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI116734710, Length=209, Percent_Identity=29.6650717703349, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI105990541, Length=215, Percent_Identity=29.3023255813954, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI45446740, Length=213, Percent_Identity=28.6384976525822, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI47078218, Length=229, Percent_Identity=27.9475982532751, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI9955970, Length=200, Percent_Identity=33, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI150417984, Length=204, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI27881501, Length=218, Percent_Identity=24.7706422018349, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI30795238, Length=218, Percent_Identity=24.7706422018349, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI31657092, Length=247, Percent_Identity=26.7206477732794, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI27436953, Length=208, Percent_Identity=27.8846153846154, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI157502203, Length=240, Percent_Identity=27.9166666666667, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI157502201, Length=240, Percent_Identity=27.9166666666667, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI46592898, Length=210, Percent_Identity=27.1428571428571, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI46592964, Length=210, Percent_Identity=27.1428571428571, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI46592956, Length=210, Percent_Identity=27.1428571428571, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI46592915, Length=210, Percent_Identity=27.1428571428571, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI46592978, Length=210, Percent_Identity=27.1428571428571, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI46592971, Length=210, Percent_Identity=27.1428571428571, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI156105685, Length=233, Percent_Identity=27.8969957081545, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI62526033, Length=202, Percent_Identity=28.2178217821782, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1788165, Length=234, Percent_Identity=31.6239316239316, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1786803, Length=252, Percent_Identity=28.968253968254, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787370, Length=215, Percent_Identity=31.1627906976744, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790544, Length=245, Percent_Identity=28.9795918367347, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788761, Length=219, Percent_Identity=29.6803652968037, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1786563, Length=205, Percent_Identity=31.7073170731707, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787712, Length=219, Percent_Identity=30.1369863013699, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786345, Length=251, Percent_Identity=31.4741035856574, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081709, Length=248, Percent_Identity=28.6290322580645, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789593, Length=234, Percent_Identity=28.2051282051282, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787029, Length=219, Percent_Identity=26.4840182648402, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787164, Length=230, Percent_Identity=31.304347826087, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790739, Length=235, Percent_Identity=28.936170212766, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1790467, Length=219, Percent_Identity=26.027397260274, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87081834, Length=208, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786398, Length=223, Percent_Identity=27.3542600896861, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786253, Length=231, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786975, Length=221, Percent_Identity=28.9592760180996, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081791, Length=259, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788002, Length=240, Percent_Identity=27.5, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788472, Length=222, Percent_Identity=26.5765765765766, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789864, Length=237, Percent_Identity=27.0042194092827, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789873, Length=210, Percent_Identity=35.2380952380952, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082267, Length=227, Percent_Identity=28.1938325991189, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081782, Length=212, Percent_Identity=27.3584905660377, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790190, Length=209, Percent_Identity=26.3157894736842, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787758, Length=209, Percent_Identity=29.6650717703349, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786703, Length=209, Percent_Identity=29.1866028708134, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082268, Length=242, Percent_Identity=26.4462809917355, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786872, Length=194, Percent_Identity=27.8350515463918, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789672, Length=226, Percent_Identity=26.5486725663717, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI48994943, Length=262, Percent_Identity=24.0458015267176, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI48995001, Length=231, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789586, Length=210, Percent_Identity=27.1428571428571, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787500, Length=234, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789891, Length=236, Percent_Identity=27.1186440677966, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787105, Length=212, Percent_Identity=25.9433962264151, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786654, Length=259, Percent_Identity=26.6409266409266, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789991, Length=225, Percent_Identity=24.4444444444444, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786319, Length=185, Percent_Identity=27.027027027027, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1789032, Length=217, Percent_Identity=23.5023041474654, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17538654, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565586, Length=244, Percent_Identity=25.4098360655738, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510237, Length=254, Percent_Identity=22.8346456692913, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115533608, Length=204, Percent_Identity=24.5098039215686, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71992290, Length=232, Percent_Identity=28.0172413793103, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17541710, Length=213, Percent_Identity=27.6995305164319, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71983516, Length=228, Percent_Identity=25.4385964912281, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983510, Length=228, Percent_Identity=25.4385964912281, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=228, Percent_Identity=25.4385964912281, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=231, Percent_Identity=25.1082251082251, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17569145, Length=239, Percent_Identity=23.8493723849372, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71984940, Length=221, Percent_Identity=28.9592760180996, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6324498, Length=259, Percent_Identity=25.4826254826255, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85725262, Length=188, Percent_Identity=29.2553191489362, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24643674, Length=240, Percent_Identity=24.5833333333333, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28574150, Length=233, Percent_Identity=25.7510729613734, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI116007328, Length=233, Percent_Identity=25.7510729613734, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45552335, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24582014, Length=189, Percent_Identity=28.042328042328, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24582012, Length=189, Percent_Identity=28.042328042328, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24666092, Length=243, Percent_Identity=27.1604938271605, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45552337, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45552345, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45552363, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45552347, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45552341, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45552339, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45552351, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45552343, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583969, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45552359, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45550972, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45552357, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45552353, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45552361, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45552355, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45552349, Length=246, Percent_Identity=27.6422764227642, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17647959, Length=208, Percent_Identity=30.2884615384615, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221512771, Length=209, Percent_Identity=25.3588516746411, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28574744, Length=195, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281363262, Length=255, Percent_Identity=27.4509803921569, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24653245, Length=255, Percent_Identity=27.4509803921569, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 30218; Mature: 30087

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVENLDAVSRRPQSADNDARTISLSGARLAFGDQTLWDHLDLSVSAGEFIAVLGPNGTG
CCCCCCHHHHCCCCCCCCCCEEEEECCCEEEECCCHHHHHCCEEECCCCEEEEECCCCCC
KTSLLKVLLGQLELSAGVARVEGKRITAGSPRIGYVPQHRPIDREVLLRGRDLVRLGIDG
HHHHHHHHHHHHHHHCCEEEECCCEEECCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCC
RRWGALPLRSADRARRREAVFTALQQVNGEQLADVRVGVMSGGELQRIRIAQALVNDPTL
CEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCCEE
LLCDEPLLTLDPANAKLVSTLIDRRRREAGTTVLVVTHEINPLLPYVDRVLYLVDGRFLI
EEECCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCEEE
GTVEQVMTTERLSTLYQANIRVVKVEDHYIVVGEP
HHHHHHHHHHHHHHHHHCCEEEEEEECCEEEEECC
>Mature Secondary Structure 
AVENLDAVSRRPQSADNDARTISLSGARLAFGDQTLWDHLDLSVSAGEFIAVLGPNGTG
CCCCCHHHHCCCCCCCCCCEEEEECCCEEEECCCHHHHHCCEEECCCCEEEEECCCCCC
KTSLLKVLLGQLELSAGVARVEGKRITAGSPRIGYVPQHRPIDREVLLRGRDLVRLGIDG
HHHHHHHHHHHHHHHCCEEEECCCEEECCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCC
RRWGALPLRSADRARRREAVFTALQQVNGEQLADVRVGVMSGGELQRIRIAQALVNDPTL
CEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCCEE
LLCDEPLLTLDPANAKLVSTLIDRRRREAGTTVLVVTHEINPLLPYVDRVLYLVDGRFLI
EEECCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCEEE
GTVEQVMTTERLSTLYQANIRVVKVEDHYIVVGEP
HHHHHHHHHHHHHHHHHCCEEEEEEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]