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The map label for this gene is clpC [H]

Identifier: 221229510

GI number: 221229510

Start: 306018

End: 308564

Strand: Direct

Name: clpC [H]

Synonym: MLBr_00235

Alternate gene names: 221229510

Gene position: 306018-308564 (Clockwise)

Preceding gene: 221229509

Following gene: 221229513

Centisome position: 9.36

GC content: 60.19

Gene sequence:

>2547_bases
ATGTTCGAAAGATTTACCGATCGTGCCCGCAGGGTGGTCGTCCTGGCACAGGAAGAGGCCCGGATGCTCAACCATAACTA
CATCGGCACCGAGCACATTTTGCTGGGTCTTATCCACGAAGGCGAAGGTGTCGCGGCGAAATCGTTGGATTCGTTGGGGA
TTTCACTTGAAGCCGTTCGCAGTCAGGTCGAAGATATTATCGGCCAGGGTCAGCAGGCGCCGTCGGGGCATATCCCGTTT
ACGCCTCGTGCCAAGAAGGTTCTTGAGCTGAGCTTGCGTGAGGCGCTGCAGCTCGGCCATAATTACATCGGCACCGAGCA
CATTTTGCTGGGCCTTATCCGGGAGGGAGAGGGTGTGGCCGCCCAGGTGCTGGTCAAGTTGGGCGCCGAGCTGACCCGAG
TGCGCCAGCAGGTGATCCAGCTGCTAAGTGGCTACCAGGGCAAAGAAGCTGCTGAAGCGGGCACTGGAGGCCGGGGTGGC
GAATCCGGTAGTCCATCTACATCTCTGGTGCTCGACCAGTTCGGTCGAAACCTGACGGCTGCTGCGATGGAGAGCAAGCT
GGATCCGGTCATTGGCCGCGAAAAGGAAATCGAGCGGGTGATGCAGGTGCTGAGCCGGCGCACCAAGAACAACCCGGTGT
TGATCGGCGAGCCTGGCGTCGGCAAGACCGCTGTCGTCGAGGGTCTTGCGCAGGCCATCGTGCACGGTGAGGTTCCCGAG
ACGCTGAAAGACAAGCAGCTTTACACACTTGACCTGGGCTCGTTGGTAGCCGGCTCGCGCTACCGCGGTGACTTCGAGGA
GCGCCTGAAGAAGGTACTCAAGGAGATCAACACCCGCGGTGACATAATCTTGTTCATCGATGAGCTGCACACCCTGGTAG
GTGCCGGTGCCGCCGAGGGGGCGATCGATGCCGCGTCGATCCTCAAGCCCAAGCTGGCCCGCGGTGAGCTGCAAACCATT
GGCGCTACCACCCTCGACGAATATCGCAAGTACATCGAGAAAGACGCCGCCCTGGAGCGCCGCTTCCAGCCGGTGCAGGT
GGGTGAGCCAACGGTGGAGCACACTATCGAGATTCTCAAGGGCCTGCGGGACCGCTACGAGGCCCACCATCGGGTGTCGA
TCACCGACTCGGCGATGGTGGCCGCCGCCACTCTGGCCGATCGCTACATCAATGACCGATTCCTCCCGGACAAGGCGATC
GACCTGATTGACGAAGCAGGCGCCCGGATGCGGATTCGCCGAATGACCGCGCCACCAGATCTGCGTGAGTTCGACGAGAA
GATCGCCGAAGCCCGCCGGGAGAAAGAGTCGGCGATCGACGCCCAGGATTTCGAGAAGGCGGCTAGCCTACGCGACCGGG
AGAAGCAACTGGTAGCTCAGCGTGCAGAACGCGAAAAGCAATGGCGTTCAGGCGATCTCGATGTTATTGCGGAAGTTGAC
GACGAGCAAATTGCCGAGGTGCTGGGCAACTGGACCGGTATACCGGTGTTCAAGCTCACCGAGGCTGAGACTACCCGGCT
GCTCCGTATGGAGGAGGAGCTGCACAAACGGATTATCGGCCAGGAGGATGCTGTTAAGGCCGTGTCCAAGGCGATCCGTC
GTACCCGCGCCGGGCTAAAAGACCCCAAGCGCCCGTCGGGTTCGTTCATCTTCGCCGGCCCGTCCGGTGTCGGTAAGACT
GAACTGTCTAAGGCGCTGGCCAACTTTTTGTTTGGCGACGACGACGCGCTCATCCAGATCGATATGGGCGAGTTCCACGA
CCGGTTCACCGCGTCGCGGCTTTTTGGTGCTCCGCCGGGATACGTCGGCTACGAGGAGGGCGGTCAGCTCACCGAGAAGG
TGCGGCGCAAGCCGTTCTCGGTGGTGCTGTTCGACGAGATCGAAAAAGCGCATCAGGAGATCTATAACAGCCTGTTGCAG
GTGCTTGAAGACGGGCGGCTCACCGATGGGCAGGGTCGCACGGTGGACTTCAAAAACACCGTGCTGATCTTTACATCCAA
CCTTGGTACCTCCGACATCTCCAAGCCGGTCGGTCTGGGCTTCACCCAAGGTAGTGGTGAGAACGACTACGAGCGGATGA
AGCAGAAGGTCAACGATGAGCTGAAGAAGCACTTCCGCCCAGAGTTCCTCAACCGCATCGACGACATCATCGTCTTCCAC
CAACTGAGCCGTGATGAGATCATCCGGATGGTCGATCTCATGATTAGCCGGGTTGCTAACCAGCTCAAGGTCAAAGACAT
GACGCTGGAGTTGACAAACAAGGCTAAGGCCTTGTTGGCTAAGCGTGGCTTCGATCCGGTGCTGGGTGCTCGCCCGCTGC
GGCGTACTATCCAACGCGAGATCGAGGACCAGCTCTCGGAGAAGATCCTCTTCGAGGAAGTCGGGCCGGGACAGGTCGTC
ACCGTCGACGTCGACAACTGGGATGGCGAAGGCCCCGGTGAGGACGTGAAGTTCACTTTCACTGGGATCCGCAAGCCGTC
GACAGAGCCGGATCTGGCTAAGGCCGGAGTGCACAGCGCTGGCGGGCCTGAGCCGGTCGAGCAGTAG

Upstream 100 bases:

>100_bases
CAATATTGCCGACCATTACAGTGGACGGCAGGTACACGGTTCGGGTCCCATGGGCTGGAACGGGTCGTATGGATGGTGTA
GGGAGAGCAGGTAACCGCCG

Downstream 100 bases:

>100_bases
GCCAAGCCATCCAGCTTGGCTAACGTTGTTAATTGCGTACCTCGCTACGTACGCGGCCAGGTATCAGGAAAGCATCGCTG
GAGCTGTGATTATTCTTGAC

Product: putative ATP-dependent Clp protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 848; Mature: 848

Protein sequence:

>848_residues
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLDSLGISLEAVRSQVEDIIGQGQQAPSGHIPF
TPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGG
ESGSPSTSLVLDQFGRNLTAAAMESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPE
TLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTI
GATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKAI
DLIDEAGARMRIRRMTAPPDLREFDEKIAEARREKESAIDAQDFEKAASLRDREKQLVAQRAEREKQWRSGDLDVIAEVD
DEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKT
ELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQ
VLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKPVGLGFTQGSGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFH
QLSRDEIIRMVDLMISRVANQLKVKDMTLELTNKAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQVV
TVDVDNWDGEGPGEDVKFTFTGIRKPSTEPDLAKAGVHSAGGPEPVEQ

Sequences:

>Translated_848_residues
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLDSLGISLEAVRSQVEDIIGQGQQAPSGHIPF
TPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGG
ESGSPSTSLVLDQFGRNLTAAAMESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPE
TLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTI
GATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKAI
DLIDEAGARMRIRRMTAPPDLREFDEKIAEARREKESAIDAQDFEKAASLRDREKQLVAQRAEREKQWRSGDLDVIAEVD
DEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKT
ELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQ
VLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKPVGLGFTQGSGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFH
QLSRDEIIRMVDLMISRVANQLKVKDMTLELTNKAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQVV
TVDVDNWDGEGPGEDVKFTFTGIRKPSTEPDLAKAGVHSAGGPEPVEQ
>Mature_848_residues
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLDSLGISLEAVRSQVEDIIGQGQQAPSGHIPF
TPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGG
ESGSPSTSLVLDQFGRNLTAAAMESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPE
TLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTI
GATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKAI
DLIDEAGARMRIRRMTAPPDLREFDEKIAEARREKESAIDAQDFEKAASLRDREKQLVAQRAEREKQWRSGDLDVIAEVD
DEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKT
ELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQ
VLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKPVGLGFTQGSGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFH
QLSRDEIIRMVDLMISRVANQLKVKDMTLELTNKAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQVV
TVDVDNWDGEGPGEDVKFTFTGIRKPSTEPDLAKAGVHSAGGPEPVEQ

Specific function: Part Of A Stress-Induced Multi-Chaperone System, It Is Involved In The Recovery Of The Cell From Heat-Induced Damage, In Cooperation With Dnak, Dnaj And Grpe. Acts Before Dnak, In The Processing Of Protein Aggregates. Protein Binding Stimulates The Atpase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=299, Percent_Identity=36.1204013377926, Blast_Score=194, Evalue=3e-49,
Organism=Escherichia coli, GI1788943, Length=876, Percent_Identity=46.0045662100457, Blast_Score=731, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=819, Percent_Identity=37.7289377289377, Blast_Score=506, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6320464, Length=697, Percent_Identity=47.4892395982783, Blast_Score=608, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6323002, Length=885, Percent_Identity=37.2881355932203, Blast_Score=499, Evalue=1e-142,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 94003; Mature: 94003

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLDSLGISLEAVR
CCCHHHHHCCEEEEEEHHHHHHHHCCCCCHHHHHEEEEECCCCCHHHHHHHHCCHHHHHH
SQVEDIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVA
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHCCCCHH
AQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGGESGSPSTSLVLDQFGRNLTA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHH
AAMESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPE
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCH
TLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEG
HHCCCEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCC
AIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILK
CHHHHHHHCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
GLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMTAPPD
HHHHHHHHCCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCC
LREFDEKIAEARREKESAIDAQDFEKAASLRDREKQLVAQRAEREKQWRSGDLDVIAEVD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
DEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLK
HHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
DPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPG
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCC
YVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQVLEDGRLTDGQGRTVDFKNT
CCCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCE
VLIFTSNLGTSDISKPVGLGFTQGSGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFH
EEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QLSRDEIIRMVDLMISRVANQLKVKDMTLELTNKAKALLAKRGFDPVLGARPLRRTIQRE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
IEDQLSEKILFEEVGPGQVVTVDVDNWDGEGPGEDVKFTFTGIRKPSTEPDLAKAGVHSA
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHCCCCC
GGPEPVEQ
CCCCCCCC
>Mature Secondary Structure
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLDSLGISLEAVR
CCCHHHHHCCEEEEEEHHHHHHHHCCCCCHHHHHEEEEECCCCCHHHHHHHHCCHHHHHH
SQVEDIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVA
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHCCCCHH
AQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGGESGSPSTSLVLDQFGRNLTA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHH
AAMESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPE
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCH
TLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEG
HHCCCEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCC
AIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILK
CHHHHHHHCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
GLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMTAPPD
HHHHHHHHCCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCC
LREFDEKIAEARREKESAIDAQDFEKAASLRDREKQLVAQRAEREKQWRSGDLDVIAEVD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
DEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLK
HHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
DPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPG
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCC
YVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQVLEDGRLTDGQGRTVDFKNT
CCCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCE
VLIFTSNLGTSDISKPVGLGFTQGSGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFH
EEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QLSRDEIIRMVDLMISRVANQLKVKDMTLELTNKAKALLAKRGFDPVLGARPLRRTIQRE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
IEDQLSEKILFEEVGPGQVVTVDVDNWDGEGPGEDVKFTFTGIRKPSTEPDLAKAGVHSA
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHCCCCC
GGPEPVEQ
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]