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The map label for this gene is rmlB2 [C]

Identifier: 221229487

GI number: 221229487

Start: 275064

End: 276023

Strand: Direct

Name: rmlB2 [C]

Synonym: MLBr_00204

Alternate gene names: 221229487

Gene position: 275064-276023 (Clockwise)

Preceding gene: 221229485

Following gene: 221229489

Centisome position: 8.42

GC content: 61.46

Gene sequence:

>960_bases
ATGTATGGTGAGCCGGTGCGCGCACTAGTCACTGGGGCAGCCGGTTTCATTGGTTCGACGCTTGTAGACCGCCTGCTGGC
GGATGGCCATACGGTGGTGGGACTCGACAATTTCGCAACCGGTCATGCGGCCAACCTCGAGCATCTTGCCAGTACTCCTG
CGCTCGCCTTCGTTGAGGCCGATATTGTGACCGCGGACCTGCAGACAATCCTCGATGAGCATCGGCCTGAGGTTGTGTTC
CACCTGGCGGCGCAAATCGACGTGCGCCACTCGGTCGTCGACCCGCAATTCGACGCATCGGTCAACGTCATCGGCACGGT
GCGGCTAGCGGAAGCCGCACGCCACACTGGGGTGCGGAAAATCGTGCACACCTCGTCGGGAGGATCCATCTACGGCACAC
CCTCACAATACCCAACTCCTGAAACAGTGCCCACCGACCCGACGTCGCCGTACGCTGCCGGCAAGGTAGCAGGGGAGATC
TACCTGAATACGTTTCGCCACCTCTGCGGCCTAGACTGCTCGCATATCGCTCCGGCCAACGTCTATGGCCCCCGTCAAGA
TCCGTACGGTGAAGCGGGTGTGGTGGCCATCTTCGTCCAGGCGTTGCTGTCGGATAGACCCACAAAAGTGTTCGGCGACG
GCACCCACACCCGTGACTACGTGTTCGTCGACGACGTGGTCGATGCTTTCATCAAGGCTTCCGGCGATGCGGGCGGTGGC
CAGCGTTTCAACATCGGTACCGGGATAGAGACGTCAGACCGCCAACTGCACACCGCGGTCTCGGCTGCCGTCGGGGGACC
TGACGATCCTGAATTTCATCCGCCGCGCCTGGGTGACCTGAAGCGGTCCTGCCTTGATATCGGCTTAGCGACAACGGTTT
TAGGCTGGAGTCCACAAGTTCAGCTGGACGACGGGGTACGGCGCACGGTCGAGTATTTCCGTGCCGCTCAGCGCTCCTAG

Upstream 100 bases:

>100_bases
TCCTATCAGGATCAGGTCGTCCCAATAGAAGTAGCCACGAAACGCTAGCACTGTGCGGATCCCTAGCTGCAGCGCGATCA
ATACTGCGACGGCTACTCCT

Downstream 100 bases:

>100_bases
GGTGGTGGTGTTGTGGTGGGCTGGTGGGGTGTGGGTGGTTGATCTGCGCTAGAAGGTTGCCGTATGTGCCGCCGACGGCC
GGATCATCGATGCACTGTTC

Product: putative sugar-nucleotide dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTADLQTILDEHRPEVVF
HLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTGVRKIVHTSSGGSIYGTPSQYPTPETVPTDPTSPYAAGKVAGEI
YLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAGVVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGGG
QRFNIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPRLGDLKRSCLDIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS

Sequences:

>Translated_319_residues
MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTADLQTILDEHRPEVVF
HLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTGVRKIVHTSSGGSIYGTPSQYPTPETVPTDPTSPYAAGKVAGEI
YLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAGVVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGGG
QRFNIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPRLGDLKRSCLDIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS
>Mature_319_residues
MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTADLQTILDEHRPEVVF
HLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTGVRKIVHTSSGGSIYGTPSQYPTPETVPTDPTSPYAAGKVAGEI
YLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAGVVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGGG
QRFNIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPRLGDLKRSCLDIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS

Specific function: DTDP-L-RHAMNOSE BIOSYNTHESIS WITHIN THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE BIOSYNTHESIS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=318, Percent_Identity=29.2452830188679, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI42516563, Length=314, Percent_Identity=28.6624203821656, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI56237023, Length=328, Percent_Identity=30.4878048780488, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI56118217, Length=328, Percent_Identity=30.4878048780488, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI189083684, Length=328, Percent_Identity=30.4878048780488, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4504031, Length=349, Percent_Identity=26.0744985673352, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI48994969, Length=339, Percent_Identity=28.023598820059, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1788353, Length=339, Percent_Identity=26.2536873156342, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786974, Length=332, Percent_Identity=31.6265060240964, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1788366, Length=353, Percent_Identity=26.628895184136, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788365, Length=236, Percent_Identity=25.8474576271186, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539532, Length=325, Percent_Identity=31.0769230769231, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17568069, Length=331, Percent_Identity=29.0030211480363, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71982035, Length=329, Percent_Identity=31.9148936170213, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71982038, Length=331, Percent_Identity=31.7220543806647, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI115532424, Length=330, Percent_Identity=26.6666666666667, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI133901788, Length=348, Percent_Identity=25.2873563218391, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539424, Length=348, Percent_Identity=25.2873563218391, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539422, Length=348, Percent_Identity=25.2873563218391, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901786, Length=348, Percent_Identity=25.2873563218391, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=348, Percent_Identity=25.2873563218391, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=340, Percent_Identity=24.1176470588235, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=332, Percent_Identity=28.0120481927711, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21356223, Length=318, Percent_Identity=30.8176100628931, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI19923002, Length=341, Percent_Identity=28.4457478005865, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24158427, Length=352, Percent_Identity=24.1477272727273, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 33891; Mature: 33891

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCEEEEEH
DIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTGVRK
HHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
IVHTSSGGSIYGTPSQYPTPETVPTDPTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPAN
EEEECCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VYGPRQDPYGEAGVVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGGG
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEHHHHHHHHHHCCCCCCCC
QRFNIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPRLGDLKRSCLDIGLATTVLGWSPQV
CEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
QLDDGVRRTVEYFRAAQRS
EECHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCEEEEEH
DIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTGVRK
HHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
IVHTSSGGSIYGTPSQYPTPETVPTDPTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPAN
EEEECCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VYGPRQDPYGEAGVVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGGG
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEHHHHHHHHHHCCCCCCCC
QRFNIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPRLGDLKRSCLDIGLATTVLGWSPQV
CEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
QLDDGVRRTVEYFRAAQRS
EECHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]