Click here to switch to the map view.

The map label for this gene is 221229440

Identifier: 221229440

GI number: 221229440

Start: 175468

End: 176616

Strand: Direct

Name: 221229440

Synonym: MLBr_00131

Alternate gene names: NA

Gene position: 175468-176616 (Clockwise)

Preceding gene: 221229437

Following gene: 221229441

Centisome position: 5.37

GC content: 57.18

Gene sequence:

>1149_bases
GTGGCTGGATTTCGTTTCGGCTTTGTTGATGCGCTTGTGCATACGCTATTTCCACCAAGCCTGCCGGCGCGGGCCAGTAT
CGTGTCCGGCGCAGTACTGGGCGCTGATTCGTACTGGGTCGGCGATCATTTGAACGCGCTGGTGCCGCGTTCAGTCGCAA
CACCTAAATACCTCGGAGTTGCGGCGAAGGTGGTACCCAAGATCGACGCCAACTATGAGCCGTGGACGATGCTGGGAAAC
CTCGCCGCTGGGAATCGGCTCAACGGCCTGCGACTGGGTGTGTGCGTCACTGACGCTGGTCGCCGCAATCCAGCAGTCAC
GGCGCAAGCCGCTGCTACTCTGCATCTACTTACCCGGGGCAAAGCCATGCTTGGTATCGGTGTTGGGGAGCGTGAAGGCA
ACGAGCCTTACGGCGTAGAGTGGACAAAGCCCGTTGCGCGGTTCCAAGAAGCTTTGGCTACAATTCGCGCGTTGTGGGAT
TCAAACGGGGAACTGGTTTCGCGTGAATCTCAATTCTTTCCTCTACATAACGCCTTGTTCGATCTTCCGCCATATCGTGG
GAAATGGCCCGAAATCTGGGTCGCGGCACACGGGCCGCGGATGCTGCAGGCCACTGGACGCTATGCCGACGCCTGGATTC
CGATTGTTTTGGTTCGTCCCACCGACTACAGTTGTGCACTCGAAGTTGTGCGTACCGCGGCGTCCGACGCTGGACGTGAC
CCAATGTCGATTACCCCTGCTGCTGTGCGCGGTATCATCACTGGTCGGACTCGCGATGACGTGGATGAGGCGTTGGACTC
TGTCCTCGTGAGAATGATCGCGCTCGGAGTACCTGGGGAAGCTTGGGCGCGCCACGGTGTTGAGCATCCAATGGGAGCCG
ATTTCGCTGGTGTGCAGGACATCATTCCTCAAACCATAGATGAGGAGACAGTTGTGTCATATGCGGCTAAAGTCCCGGCC
GCACTTATGAAAGAAGTCCTTTTTAGTGGGACGCCTGAGGAAGTCATCGATCAAGTAGCGGAATGGCGCGATCACGGCCT
GAAGTATCTAGTTGTTATCAACGGCAGTCTAGTTAACTCGAGTTTGCGTAAGACTGTTTCGGCGCTCCTGCCGCACGCCA
GGGTACTGCGTGGACTCAAGAAACTGTGA

Upstream 100 bases:

>100_bases
GAGGCGTTGTTTGGAATGCCTGGGCGCAGGAAGCGGCTGCCGCTGCGGTAATGTCGTCGACATGACGTTAGTCGACAGCA
CGGAACGGGGACAATGAGCT

Downstream 100 bases:

>100_bases
CCGACTCAAGAAGTTGTGATCTACCCCATCATGGGTAGAAGATGTTAGGTAGTCTGACCTAGGCTGTTTAGCGCGCCAAA
AACGGCTAGTGGTAGGTCGT

Product: putative oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAGFRFGFVDALVHTLFPPSLPARASIVSGAVLGADSYWVGDHLNALVPRSVATPKYLGVAAKVVPKIDANYEPWTMLGN
LAAGNRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGKAMLGIGVGEREGNEPYGVEWTKPVARFQEALATIRALWD
SNGELVSRESQFFPLHNALFDLPPYRGKWPEIWVAAHGPRMLQATGRYADAWIPIVLVRPTDYSCALEVVRTAASDAGRD
PMSITPAAVRGIITGRTRDDVDEALDSVLVRMIALGVPGEAWARHGVEHPMGADFAGVQDIIPQTIDEETVVSYAAKVPA
ALMKEVLFSGTPEEVIDQVAEWRDHGLKYLVVINGSLVNSSLRKTVSALLPHARVLRGLKKL

Sequences:

>Translated_382_residues
MAGFRFGFVDALVHTLFPPSLPARASIVSGAVLGADSYWVGDHLNALVPRSVATPKYLGVAAKVVPKIDANYEPWTMLGN
LAAGNRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGKAMLGIGVGEREGNEPYGVEWTKPVARFQEALATIRALWD
SNGELVSRESQFFPLHNALFDLPPYRGKWPEIWVAAHGPRMLQATGRYADAWIPIVLVRPTDYSCALEVVRTAASDAGRD
PMSITPAAVRGIITGRTRDDVDEALDSVLVRMIALGVPGEAWARHGVEHPMGADFAGVQDIIPQTIDEETVVSYAAKVPA
ALMKEVLFSGTPEEVIDQVAEWRDHGLKYLVVINGSLVNSSLRKTVSALLPHARVLRGLKKL
>Mature_381_residues
AGFRFGFVDALVHTLFPPSLPARASIVSGAVLGADSYWVGDHLNALVPRSVATPKYLGVAAKVVPKIDANYEPWTMLGNL
AAGNRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGKAMLGIGVGEREGNEPYGVEWTKPVARFQEALATIRALWDS
NGELVSRESQFFPLHNALFDLPPYRGKWPEIWVAAHGPRMLQATGRYADAWIPIVLVRPTDYSCALEVVRTAASDAGRDP
MSITPAAVRGIITGRTRDDVDEALDSVLVRMIALGVPGEAWARHGVEHPMGADFAGVQDIIPQTIDEETVVSYAAKVPAA
LMKEVLFSGTPEEVIDQVAEWRDHGLKYLVVINGSLVNSSLRKTVSALLPHARVLRGLKKL

Specific function: Catalyzes the reduction of the keto moiety of phthiodiolone dimycocerosates (DIM B) and glycosylated phenolphthiodiolone dimycocerosates to form the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycocerosates during phthiocerol d

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mer family. Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHKR_MYCLE (Q9CD85)

Other databases:

- EMBL:   AL583917
- PIR:   C86925
- RefSeq:   NP_301225.1
- ProteinModelPortal:   Q9CD85
- EnsemblBacteria:   EBMYCT00000028360
- GeneID:   908434
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0131
- NMPDR:   fig|272631.1.peg.97
- Leproma:   ML0131
- GeneTree:   EBGT00050000014764
- HOGENOM:   HBG567930
- OMA:   MGVTQIV
- ProtClustDB:   CLSK792185
- BioCyc:   MLEP272631:ML0131-MONOMER
- InterPro:   IPR011251
- InterPro:   IPR016048
- Gene3D:   G3DSA:3.20.20.30

Pfam domain/function: PF00296 Bac_luciferase; SSF51679 Luciferase_like

EC number: NA

Molecular weight: Translated: 41258; Mature: 41127

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGFRFGFVDALVHTLFPPSLPARASIVSGAVLGADSYWVGDHLNALVPRSVATPKYLGV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCEECCCCEECCCHHHHHCCCCCCCCHHHHH
AAKVVPKIDANYEPWTMLGNLAAGNRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTRG
HHHHHHCCCCCCCCHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCC
KAMLGIGVGEREGNEPYGVEWTKPVARFQEALATIRALWDSNGELVSRESQFFPLHNALF
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHH
DLPPYRGKWPEIWVAAHGPRMLQATGRYADAWIPIVLVRPTDYSCALEVVRTAASDAGRD
CCCCCCCCCCEEEEEECCCHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
PMSITPAAVRGIITGRTRDDVDEALDSVLVRMIALGVPGEAWARHGVEHPMGADFAGVQD
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCHHH
IIPQTIDEETVVSYAAKVPAALMKEVLFSGTPEEVIDQVAEWRDHGLKYLVVINGSLVNS
HHHHHCCHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECHHHHH
SLRKTVSALLPHARVLRGLKKL
HHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
AGFRFGFVDALVHTLFPPSLPARASIVSGAVLGADSYWVGDHLNALVPRSVATPKYLGV
CCCHHHHHHHHHHHHCCCCCCCHHHHHHCCEECCCCEECCCHHHHHCCCCCCCCHHHHH
AAKVVPKIDANYEPWTMLGNLAAGNRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTRG
HHHHHHCCCCCCCCHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCC
KAMLGIGVGEREGNEPYGVEWTKPVARFQEALATIRALWDSNGELVSRESQFFPLHNALF
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHH
DLPPYRGKWPEIWVAAHGPRMLQATGRYADAWIPIVLVRPTDYSCALEVVRTAASDAGRD
CCCCCCCCCCEEEEEECCCHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
PMSITPAAVRGIITGRTRDDVDEALDSVLVRMIALGVPGEAWARHGVEHPMGADFAGVQD
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCHHH
IIPQTIDEETVVSYAAKVPAALMKEVLFSGTPEEVIDQVAEWRDHGLKYLVVINGSLVNS
HHHHHCCHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECHHHHH
SLRKTVSALLPHARVLRGLKKL
HHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002