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The map label for this gene is mutL [H]

Identifier: 220932941

GI number: 220932941

Start: 2289494

End: 2290837

Strand: Reverse

Name: mutL [H]

Synonym: Hore_21090

Alternate gene names: 220932941

Gene position: 2290837-2289494 (Counterclockwise)

Preceding gene: 220932942

Following gene: 220932940

Centisome position: 88.86

GC content: 45.24

Gene sequence:

>1344_bases
ATGGATCTGGATCTATTAATAGCCGAAATAGGGAGCACAACGACCGTAGTTAACGGGTTTACCGGGATAAAAAAGGGCAC
TCCCCGCTTAAAAGGACAGGGTCTGGCTCCGACTACAGTACTCGAGGGAGATGTTACGGTAGGTTTGAATAATGCTATTG
AAAACCTGAAGGAAGTCCTGGGAGCAGATGACCTGACCTGGTCTGAGTTTATGGCTACCAGCAGTGCTGCCGGGGGGTTG
AAGATGACTGTTCACGGACTGGTTAAAGATATGACTGTTAAAGCTGCCCGGGAGGCAGCCCTCGGGGCCGGTGCTGTTAT
CAAAATGGTTACAGCCGGTAAACTCCGGGAATCTAAATTAAATAAGATAAAAGAGATCAACCCCAACATTATCCTGCTGG
CCGGTGGGGTTGACTATGGGGAAGAAGAGGTTATTCTCCACAATGCCAGGCTTCTGGCTCAAATGAAATTAAATGTTCCT
ATAATTTATGCCGGGAATAAAGCCATTCAGGACGAAGTCAGGGATATCTTTGACAATAGCCAGCAGGATATTCTTATAAC
TGATAATGTTTATCCAGAAATTGATACCCTGAATATCGAACCAACCCGGAGACTGATTCAACAGGTCTTTGCCCGTCATA
TTATTAAAGCTCCGGGTATGGAAAAGATAAAACCGATGTTAAGTTCTGAAATGATGCCAACTCCGGGGGCTGTTATGAAG
TCTGCCCGGTTGTTACGGGAGGATATCGGTAATCTGGTGGTTATTGATATCGGAGGGGCCACTACTGATGTTCATTCGGT
GACAGAAGATACCCCCGGGGTTAAACAGGTTTTAATTAACCCTGAACCGGTAGCCAAAAGAACAGTGGAAGGGGATCTGG
GGGTTTTTATTAATGCCCCCCATGTTTTTAAATTAATAGAAGAAACCCGGAAGAATGGGTATGAATATAAAGAAGTTAAA
GCTATACCAGGTAATGAAAAAGAGAGGGGCTTTGTCCGACTTCTGGCAGAAACAGCAGCCCTGACTGCAATAAAAAGGCA
TGCCGGCCGGCTCAGGGATTTTTTTGGACCCCAGGGCAGGCAAACGGTGGCTGAAGGTAAGGATTTAAGTGGTGTTAGAT
GGGTTATCGGAACCGGTGGCGCTTTAACCAGGCTTGGCCGGGGTGATGAAGTATTAACCAGAGTTATTGAATACCGGGGT
TCGAGACTTTTTCCTCCTGAAGATGCTAAAATTCTTATTGACAGGAATTATATTATGGCTGCTATGGGCATATTGAGTGA
AAAATACCCCGATAAAGCCCTGAGATTATTAAAAGAAAGCCTGGGGTTGGATATTGAGGATTAA

Upstream 100 bases:

>100_bases
ATTAACAGAAGAAGAAATTAAGTTTCTATCTGAAGAGATTAATGAAAGCCAGTCAGTAGTGAAAAGGATGCTGGATGAGA
TAGAATAAGGGGGTTCAGGT

Downstream 100 bases:

>100_bases
TAAAATATCAGGATGGGATTTAAGTCAGGGAAGGAGGAAAATTATGGGGATTAAAAGAGAAGATGATTTTGAGCAGAGGA
GAAAACACCTTAAGGAGCTT

Product: DNA mismatch repair protein MutL

Products: L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MDLDLLIAEIGSTTTVVNGFTGIKKGTPRLKGQGLAPTTVLEGDVTVGLNNAIENLKEVLGADDLTWSEFMATSSAAGGL
KMTVHGLVKDMTVKAAREAALGAGAVIKMVTAGKLRESKLNKIKEINPNIILLAGGVDYGEEEVILHNARLLAQMKLNVP
IIYAGNKAIQDEVRDIFDNSQQDILITDNVYPEIDTLNIEPTRRLIQQVFARHIIKAPGMEKIKPMLSSEMMPTPGAVMK
SARLLREDIGNLVVIDIGGATTDVHSVTEDTPGVKQVLINPEPVAKRTVEGDLGVFINAPHVFKLIEETRKNGYEYKEVK
AIPGNEKERGFVRLLAETAALTAIKRHAGRLRDFFGPQGRQTVAEGKDLSGVRWVIGTGGALTRLGRGDEVLTRVIEYRG
SRLFPPEDAKILIDRNYIMAAMGILSEKYPDKALRLLKESLGLDIED

Sequences:

>Translated_447_residues
MDLDLLIAEIGSTTTVVNGFTGIKKGTPRLKGQGLAPTTVLEGDVTVGLNNAIENLKEVLGADDLTWSEFMATSSAAGGL
KMTVHGLVKDMTVKAAREAALGAGAVIKMVTAGKLRESKLNKIKEINPNIILLAGGVDYGEEEVILHNARLLAQMKLNVP
IIYAGNKAIQDEVRDIFDNSQQDILITDNVYPEIDTLNIEPTRRLIQQVFARHIIKAPGMEKIKPMLSSEMMPTPGAVMK
SARLLREDIGNLVVIDIGGATTDVHSVTEDTPGVKQVLINPEPVAKRTVEGDLGVFINAPHVFKLIEETRKNGYEYKEVK
AIPGNEKERGFVRLLAETAALTAIKRHAGRLRDFFGPQGRQTVAEGKDLSGVRWVIGTGGALTRLGRGDEVLTRVIEYRG
SRLFPPEDAKILIDRNYIMAAMGILSEKYPDKALRLLKESLGLDIED
>Mature_447_residues
MDLDLLIAEIGSTTTVVNGFTGIKKGTPRLKGQGLAPTTVLEGDVTVGLNNAIENLKEVLGADDLTWSEFMATSSAAGGL
KMTVHGLVKDMTVKAAREAALGAGAVIKMVTAGKLRESKLNKIKEINPNIILLAGGVDYGEEEVILHNARLLAQMKLNVP
IIYAGNKAIQDEVRDIFDNSQQDILITDNVYPEIDTLNIEPTRRLIQQVFARHIIKAPGMEKIKPMLSSEMMPTPGAVMK
SARLLREDIGNLVVIDIGGATTDVHSVTEDTPGVKQVLINPEPVAKRTVEGDLGVFINAPHVFKLIEETRKNGYEYKEVK
AIPGNEKERGFVRLLAETAALTAIKRHAGRLRDFFGPQGRQTVAEGKDLSGVRWVIGTGGALTRLGRGDEVLTRVIEYRG
SRLFPPEDAKILIDRNYIMAAMGILSEKYPDKALRLLKESLGLDIED

Specific function: May play a role in glutamate fermentation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006230
- InterPro:   IPR002821 [H]

Pfam domain/function: PF01968 Hydantoinase_A [H]

EC number: 5.4.99.1

Molecular weight: Translated: 48688; Mature: 48688

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLDLLIAEIGSTTTVVNGFTGIKKGTPRLKGQGLAPTTVLEGDVTVGLNNAIENLKEVL
CCHHEEHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEECCCEEECHHHHHHHHHHHH
GADDLTWSEFMATSSAAGGLKMTVHGLVKDMTVKAAREAALGAGAVIKMVTAGKLRESKL
CCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHH
NKIKEINPNIILLAGGVDYGEEEVILHNARLLAQMKLNVPIIYAGNKAIQDEVRDIFDNS
HHHHHCCCCEEEEECCCCCCCCEEEEEHHHEEEEEECCEEEEECCCHHHHHHHHHHHCCC
QQDILITDNVYPEIDTLNIEPTRRLIQQVFARHIIKAPGMEKIKPMLSSEMMPTPGAVMK
CCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHH
SARLLREDIGNLVVIDIGGATTDVHSVTEDTPGVKQVLINPEPVAKRTVEGDLGVFINAP
HHHHHHHHHCCEEEEEECCCCCHHHHHCCCCCCCCEEEECCCHHHHHCCCCCCEEEECCH
HVFKLIEETRKNGYEYKEVKAIPGNEKERGFVRLLAETAALTAIKRHAGRLRDFFGPQGR
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QTVAEGKDLSGVRWVIGTGGALTRLGRGDEVLTRVIEYRGSRLFPPEDAKILIDRNYIMA
CHHHCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHH
AMGILSEKYPDKALRLLKESLGLDIED
HHHHHHHCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDLDLLIAEIGSTTTVVNGFTGIKKGTPRLKGQGLAPTTVLEGDVTVGLNNAIENLKEVL
CCHHEEHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEECCCEEECHHHHHHHHHHHH
GADDLTWSEFMATSSAAGGLKMTVHGLVKDMTVKAAREAALGAGAVIKMVTAGKLRESKL
CCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHH
NKIKEINPNIILLAGGVDYGEEEVILHNARLLAQMKLNVPIIYAGNKAIQDEVRDIFDNS
HHHHHCCCCEEEEECCCCCCCCEEEEEHHHEEEEEECCEEEEECCCHHHHHHHHHHHCCC
QQDILITDNVYPEIDTLNIEPTRRLIQQVFARHIIKAPGMEKIKPMLSSEMMPTPGAVMK
CCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHH
SARLLREDIGNLVVIDIGGATTDVHSVTEDTPGVKQVLINPEPVAKRTVEGDLGVFINAP
HHHHHHHHHCCEEEEEECCCCCHHHHHCCCCCCCCEEEECCCHHHHHCCCCCCEEEECCH
HVFKLIEETRKNGYEYKEVKAIPGNEKERGFVRLLAETAALTAIKRHAGRLRDFFGPQGR
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QTVAEGKDLSGVRWVIGTGGALTRLGRGDEVLTRVIEYRGSRLFPPEDAKILIDRNYIMA
CHHHCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHH
AMGILSEKYPDKALRLLKESLGLDIED
HHHHHHHCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-threo-3-methylaspartate

Specific reaction: L-threo-3-methylaspartate = L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8428631 [H]